Sialic acid
View article: Development and Use of Oral Microbiome Optimised Oxford Nanopore 16S Primers to Elucidate the Effect of Sialidase Inhibitors on a Plaque Community Biofilm Model
Development and Use of Oral Microbiome Optimised Oxford Nanopore 16S Primers to Elucidate the Effect of Sialidase Inhibitors on a Plaque Community Biofilm Model Open
The oral microbiome is a diverse ecosystem that plays a critical role in health and disease and contains numerous bacterial species capable of metabolizing host-derived glycans, particularly sialic acids. Sialidase enzymes can be produced …
View article: The hemagglutinin-like proteins of basal vertebrate influenza-like viruses exhibit sialic-acid receptor binding disparity and their structural bases
The hemagglutinin-like proteins of basal vertebrate influenza-like viruses exhibit sialic-acid receptor binding disparity and their structural bases Open
In 2018, two novel influenza-like virus genomes were first identified in basal vertebrates: the Asiatic toads ( Bufo gargarizans ) and spiny eels ( Mastacembelus aculeatus ). Their hemagglutinin (HA) proteins exhibit remarkably low amino a…
View article: Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus
Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus Open
Paramyxoviral transmission between hosts may be, in part, attributed to the ability of the viral envelope-displayed receptor-binding protein (RBP) to bind to cell surface receptors of different host species. We sought to elucidate the arch…
View article: The efficiency of rotavirus A spread to extraintestinal tissues is not determined by the levels of its replication in the gut
The efficiency of rotavirus A spread to extraintestinal tissues is not determined by the levels of its replication in the gut Open
Rotavirus A (RVA) spreads to multiple extraintestinal organs; however, it is not well understood what viral or host characteristics regulate the efficiency of this spread. We conducted this study to determine whether more efficient intesti…
View article: Self-assembled phenylboronic acid nanomedicine targets sialic acid to synergistically activate ferroptosis via RRM1 suppression and GPX4 Inhibition for precision colon cancer therapy
Self-assembled phenylboronic acid nanomedicine targets sialic acid to synergistically activate ferroptosis via RRM1 suppression and GPX4 Inhibition for precision colon cancer therapy Open
View article: Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid
Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid Open
Some viruses, such as mumps virus (MuV), possess sialidases that cleave terminal sialic acids, primarily N -acetylneuraminic acid (Neu5Ac), from glycans. Previously, we developed a sialidase fluorescent imaging probe (BTP3-Neu5Ac) and visu…
View article: Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant <i>Clostridium tertium</i> Strain
Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant <i>Clostridium tertium</i> Strain Open
Clostridium tertium is a pathogenic bacterium that directly colonizes the gastrointestinal mucosa, causing inflammation and neutropenia. The virulence factors and pathogenic mechanisms of C. tertium are not well known. In this study, C. te…
View article: Distinct roles of glycocalyx components in regulating endothelial functions in a perfused three-dimensional human endothelium-on-a-chip
Distinct roles of glycocalyx components in regulating endothelial functions in a perfused three-dimensional human endothelium-on-a-chip Open
Increased degradation of the endothelial glycocalyx (EGX) is associated with cardiovascular disease. However, whether EGX impairment drives endothelial dysfunction or reflects disease severity remains unclear. Prior studies investigating E…
View article: Identification of sialic acid linkage profiles in primary liver cancers
Identification of sialic acid linkage profiles in primary liver cancers Open
Cholangiocarcinoma (CCA), also known as bile duct cancer, is the second most common form of primary liver cancer after hepatocellular carcinoma (HCC). Subtypes of CCA are diagnosed according to the anatomic location within the biliary tree…
View article: Cancer-specific sialylation of insulin-like growth factor 1 receptor impairs therapeutic antibody binding and efficacy
Cancer-specific sialylation of insulin-like growth factor 1 receptor impairs therapeutic antibody binding and efficacy Open
Despite extensive efforts to develop insulin-like growth factor (IGF1R)-targeted therapies for various malignancies, none has received clinical approval in the past two decades. Here, we reveal that N-glycan sialylation significantly decre…
View article: Evaluation of Methods to Quantify Sialic Acid on Glycomacropeptide
Evaluation of Methods to Quantify Sialic Acid on Glycomacropeptide Open
Glycomacropeptide (GMP) is isolated from whey and used as an ingredient in phenylketonuria-safe foods because it does not contain phenylalanine. GMP is highly glycosylated and has several sites where N-acetylneuraminic acid (NANA) is bound…
View article: Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer
Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer Open
Background Dysregulated tumour metabolism is increasingly recognised as a central driver of malignant phenotypes. Against this background, the aberrant metabolism of N-acetylneuraminic acid (Neu5Ac), a core constituent of the sialic acid f…
View article: Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment
Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment Open
Cognitive impairment is a frequent outcome of chronic viral infections linked to premature aging, including HIV. The mechanisms underlying this decline remain poorly understood. Here, we identify pro-inflammatory glycan degradation, charac…
View article: Sialic acid-receptor targeted Epirubicin and Naringin-loaded sialic acid-conjugated silk fibroin nanoparticles for enhanced lung cancer treatment
Sialic acid-receptor targeted Epirubicin and Naringin-loaded sialic acid-conjugated silk fibroin nanoparticles for enhanced lung cancer treatment Open
Lack of specificity, high burden of toxicity, and low bioavailability are the significant hurdles of conventional chemotherapies. Upregulated sialic acid receptors on the plasma membrane of lung cancer cells could be promising drug deliver…
View article: Photo‐Controlled MUC1 Ablation via Steric Locking of Turn‐On Reactors Enhances Pyroptosis‐Immunotherapy of Triple Negative Breast Cancer
Photo‐Controlled MUC1 Ablation via Steric Locking of Turn‐On Reactors Enhances Pyroptosis‐Immunotherapy of Triple Negative Breast Cancer Open
Mucin 1 (MUC1) is aberrantly upregulated in triple‐negative breast cancer (TNBC) cells and presents major roles in orchestrating TNBC pathogenesis and therapeutic resistance. Herein, a bioorthogonal MUC1‐binding strategy is reported to ins…
View article: Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism
Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism Open
Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP), a significant global health burden. While glycosylation plays a key role in cellular signaling and inflammation, its role in IVD degeneration remains poorly un…
View article: Inhibition of hypersialylation in human intervertebral disc degeneration modulates inflammation and metabolism
Inhibition of hypersialylation in human intervertebral disc degeneration modulates inflammation and metabolism Open
Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP), a significant global health burden. While glycosylation plays a key role in cellular signaling and inflammation, its role in IVD degeneration remains poorly un…
View article: Chemoenzymatically Synthesized <i>O</i> ‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context
Chemoenzymatically Synthesized <i>O</i> ‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context Open
Gangliosides are a class of sialic acid‐containing glycosphingolipids involved in a wide range of biological processes. The terminal sialic acid of gangliosides can be O ‐acetylated at C7 and/or C9 hydroxyl, contributing to ganglioside str…
View article: Morphology regulation and aminophenylboronic acid-functionalized 1,5-diaminoanthraquinone microrod films for capture of circulating tumor cells
Morphology regulation and aminophenylboronic acid-functionalized 1,5-diaminoanthraquinone microrod films for capture of circulating tumor cells Open
The capture of circulating tumor cells (CTCs) is important for the early diagnosis and prognosis of tumor patients. The most related research is mainly focused on epithelial cell adhesion molecule (EpCAM)-positive CTCs. The capture of EpCA…
View article: Towards the Structural Analysis of Polysialic Acid Binding Proteins
Towards the Structural Analysis of Polysialic Acid Binding Proteins Open
Polysialic acid (polySia) is a polymeric glycan made of α2,8-linked sialic acid moieties. It is found as a posttranslational modification on few proteins throughout the human body, but its prevalence is upregulated during embryogenesis and…
View article: TMET-44. ST6Gal1 Mediated α2,6 Sialylation Regulates Glioblastoma Metabolism and GLUT3 Dynamics
TMET-44. ST6Gal1 Mediated α2,6 Sialylation Regulates Glioblastoma Metabolism and GLUT3 Dynamics Open
Unlike other post translational modifications like phosphorylation, glycosylation has often been overlooked as a critical regulator of cell signaling in cancers, including brain tumors. One form of glycosylation is sialylation, or the addi…
View article: Hijacking haemagglutinin-sialic acid influenza viral entry 2899
Hijacking haemagglutinin-sialic acid influenza viral entry 2899 Open
Description Influenza Viruses (IV) use haemagglutinin (HA) to bind sialic acid (SA) on cell receptors for infection. While mutations, antigenic drifts and shifts which allow for IV to cross species, become more pathogenic, evade the immune…
View article: STEM-25. ST6GAL1 MEDIATED REGULATION OF THE GLIOBLASTOMA SECRETOME
STEM-25. ST6GAL1 MEDIATED REGULATION OF THE GLIOBLASTOMA SECRETOME Open
Glioblastoma (GBM) secreted factors have been identified as key mediators of cellular crosstalk enabling tumor progression. Secreted proteins may be glycosylated, and one form of glycosylation is sialylation. We recently determined that br…
View article: Influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock in the US 9374
Influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock in the US 9374 Open
Description The spread of the Highly Pathogenic Avian Influenza (HPAI) H5N1 virus into dairy cattle, particularly affecting the mammary gland and milk, underscores the remarkable adaptability of Influenza A Viruses (IAV) to infect non-trad…
View article: Deciphering the Glycan and Protein Interactome of Siglec-15: Unraveling its Role in Tumor-Associated Immunosuppression 2949
Deciphering the Glycan and Protein Interactome of Siglec-15: Unraveling its Role in Tumor-Associated Immunosuppression 2949 Open
Description Immunotherapy has revolutionized cancer treatment, driving interest in strategies to counteract immune suppression within the tumor microenvironment. Siglec-15, a member of the sialic acid-binding immunoglobulin-like lectin fam…
View article: TMIC-72. Glioma-associated myeloid cells promote B cell inhibition
TMIC-72. Glioma-associated myeloid cells promote B cell inhibition Open
Glioblastoma (GBM) is the deadliest primary brain tumor, characterized by immunosuppression, low infiltration of lymphocytes, and lack of response to immune checkpoint blockade (ICB) therapies. In other solid tumors, the presence of functi…
View article: Investigating binding specificities of human and mouse galectin family members 3539
Investigating binding specificities of human and mouse galectin family members 3539 Open
Description Galectins are a family of immune checkpoint soluble proteins that bind β-galactoside-containing glycans on and within cells. These proteins are widely expressed in tumor microenvironments and have been shown to promote cancer g…
View article: ST8Sia6 regulates TNF signaling and CCL5-mediated immune cell migration to restrain inflammatory bowel disease 4245
ST8Sia6 regulates TNF signaling and CCL5-mediated immune cell migration to restrain inflammatory bowel disease 4245 Open
Description Inflammatory bowel disease (IBD) affects between 1-3 million people in the United States, and patients present with symptoms including diarrhea, rectal bleeding, and fatigue. ST8Sia6 is a sialic acid transferase that adds termi…
View article: Regulation of anti-tumor immunity by B7-H3 binding to Siglec-9 4287
Regulation of anti-tumor immunity by B7-H3 binding to Siglec-9 4287 Open
Description B7-H3 is a member of the B7 superfamily, which includes co-inhibitory receptors such as B7-H1/PD-L1 and co-stimulatory receptors such as B7-1/CD80 and B7-2/CD86. B7-H3 is upregulated by almost all types of tumors and is associa…
View article: Targeting sialic acid catabolism with polyvalent sialidase inhibitors to mitigate bacterial inflammation in the gut
Targeting sialic acid catabolism with polyvalent sialidase inhibitors to mitigate bacterial inflammation in the gut Open