Lactic acidosis
View article: Targeting lactic acidosis in the tumor microenvironment: Enhancing tace efficacy in hepatocellular carcinoma
Targeting lactic acidosis in the tumor microenvironment: Enhancing tace efficacy in hepatocellular carcinoma Open
View article: DiseaseOntology/HumanDiseaseOntology: DO November 2025 Release
DiseaseOntology/HumanDiseaseOntology: DO November 2025 Release Open
This release of the Human Disease Ontology includes 11,997 disease classes, 9,713 with textual definitions (81.0%). Translation files now include 11,824 labels (98.6%), 11,483 synonyms (59.1%), and 6,409 definitions (66.0%) in Spanish. New…
View article: Metformin-Induced Lactic Acidosis Following Intentional Overdose: A Case Report and Mini Review
Metformin-Induced Lactic Acidosis Following Intentional Overdose: A Case Report and Mini Review Open
View article: Safety profile of metformin in adolescents with type 2 diabetes: A pharmacovigilance analysis of the FDA Adverse Event Reporting System
Safety profile of metformin in adolescents with type 2 diabetes: A pharmacovigilance analysis of the FDA Adverse Event Reporting System Open
Background Although metformin is the first-line medicine for type 2 diabetes (T2D), its safety profile in adolescents remains poorly understood. This study seeks to investigate the adverse events linked to metformin use in adolescents diag…
View article: Lactic Acidosis: A Major Metabolic Disorder in Cattle
Lactic Acidosis: A Major Metabolic Disorder in Cattle Open
For ruminants fed diets high in concentrate, acute and chronic acidosis conditions that result from consuming excessive amounts of rapidly fermented carbohydrates are major production issues. Chronic acidosis can persist throughout the fee…
View article: Lactic Acidosis: A Major Metabolic Disorder in Cattle
Lactic Acidosis: A Major Metabolic Disorder in Cattle Open
For ruminants fed diets high in concentrate, acute and chronic acidosis conditions that result from consuming excessive amounts of rapidly fermented carbohydrates are major production issues. Chronic acidosis can persist throughout the fee…
View article: What is the use of Metformin in a patient with type 2 diabetes after nephrectomy?
What is the use of Metformin in a patient with type 2 diabetes after nephrectomy? Open
Metformin can be used in patients with type 2 diabetes after nephrectomy if renal function is carefully monitored and dosing is adjusted accordingly. The primary concern is the potential risk of lactic acidosis due to compromised renal fun…
View article: What is the use of Metformin in a patient with type 2 diabetes after nephrectomy?
What is the use of Metformin in a patient with type 2 diabetes after nephrectomy? Open
Metformin can be used in patients with type 2 diabetes after nephrectomy if renal function is carefully monitored and dosing is adjusted accordingly. The primary concern is the potential risk of lactic acidosis due to compromised renal fun…
View article: Afebrile Recurrent Cellulitis Complicated by Linezolid-Induced Lactic Acidosis in an Elderly Patient
Afebrile Recurrent Cellulitis Complicated by Linezolid-Induced Lactic Acidosis in an Elderly Patient Open
View article: Intraoperative lactate level and lactate clearance is associated with long-term mortality in liver transplant recipients
Intraoperative lactate level and lactate clearance is associated with long-term mortality in liver transplant recipients Open
Background: Hyperlactatemia has been associated with poor outcomes in various clinical settings including liver transplantation (LT). However, the impact of intraoperative lactate levels and lactate clearance on long-term mortality in LT r…
View article: Spontaneous tumor lysis syndrome following liver biopsy: a case report and literature review
Spontaneous tumor lysis syndrome following liver biopsy: a case report and literature review Open
Background Tumor lysis syndrome (TLS), characterized by electrolyte imbalances and acute kidney injury, predominantly occurs following cytotoxic chemotherapy in hematologic malignancies. Spontaneous TLS (STLS) in solid tumors remains rare.…
View article: Converging Mechanisms of Basal Ganglia Calcification, Mitochondrial Dysfunction, and Metabolic Encephalopathy in Fahr's Disease, Canavan Disease, and Leigh Syndrome: A Comparative Review of Pathophysiology, Diagnostic Modalities, and Emerging Therapeutic Strategies in Rare Neurodegeneration
Converging Mechanisms of Basal Ganglia Calcification, Mitochondrial Dysfunction, and Metabolic Encephalopathy in Fahr's Disease, Canavan Disease, and Leigh Syndrome: A Comparative Review of Pathophysiology, Diagnostic Modalities, and Emerging Therapeutic Strategies in Rare Neurodegeneration Open
Background Fahr’s Disease, Canavan Disease, and Leigh Syndrome represent rare but devastating neurodegenerative and metabolic encephalopathies characterized by overlapping neuropathological hallmarks such as basal ganglia calcification, mi…
View article: Converging Mechanisms of Basal Ganglia Calcification, Mitochondrial Dysfunction, and Metabolic Encephalopathy in Fahr's Disease, Canavan Disease, and Leigh Syndrome: A Comparative Review of Pathophysiology, Diagnostic Modalities, and Emerging Therapeutic Strategies in Rare Neurodegeneration
Converging Mechanisms of Basal Ganglia Calcification, Mitochondrial Dysfunction, and Metabolic Encephalopathy in Fahr's Disease, Canavan Disease, and Leigh Syndrome: A Comparative Review of Pathophysiology, Diagnostic Modalities, and Emerging Therapeutic Strategies in Rare Neurodegeneration Open
Background Fahr’s Disease, Canavan Disease, and Leigh Syndrome represent rare but devastating neurodegenerative and metabolic encephalopathies characterized by overlapping neuropathological hallmarks such as basal ganglia calcification, mi…
View article: Persistent lactic acidosis without shock in ALK-positive anaplastic large cell lymphoma: A case report and literature review
Persistent lactic acidosis without shock in ALK-positive anaplastic large cell lymphoma: A case report and literature review Open
Background: Type B lactic acidosis in malignancy, often driven by the Warburg effect (aerobic glycolysis), is a rare but critical oncologic emergency. It poses a significant diagnostic and therapeutic challenge, particularly when it domina…
View article: Persistent lactic acidosis without shock in ALK-positive anaplastic large cell lymphoma: A case report and literature review
Persistent lactic acidosis without shock in ALK-positive anaplastic large cell lymphoma: A case report and literature review Open
Background: Type B lactic acidosis in malignancy, often driven by the Warburg effect (aerobic glycolysis), is a rare but critical oncologic emergency. It poses a significant diagnostic and therapeutic challenge, particularly when it domina…
View article: Hyperlactatemia Post-CABG: Case Studies in Three Patients
Hyperlactatemia Post-CABG: Case Studies in Three Patients Open
Introduction: Hyperlactatemia after CABG may signal intra- or postoperative complications by reflecting a mismatch between tissue oxygen supply and metabolic demand, with potential for organ dysfunction and worse outcomes. This case report…
View article: Recurrent Cardiac Tamponade as the Initial Presentation of MTO1-Associated Mitochondrial Cardiomyopathy (COXPD10) in a Four-Month-Old Infant: A Case Report
Recurrent Cardiac Tamponade as the Initial Presentation of MTO1-Associated Mitochondrial Cardiomyopathy (COXPD10) in a Four-Month-Old Infant: A Case Report Open
We report a four-month-old girl who presented in sudden cardiorespiratory collapse to illustrate an uncommon cardiac first sign of MTO1-related disease. The infant arrived hypotensive and obtunded with severe metabolic acidosis (pH 6.59; l…
View article: Methanol Poisoning Presenting with Bilateral Basal Ganglia Hemorrhage: A Case Report
Methanol Poisoning Presenting with Bilateral Basal Ganglia Hemorrhage: A Case Report Open
Background Methanol is a highly toxic, colorless, volatile alcohol that is present in homemade beverages, paint removers, windshield liquid, anti-freeze, shellac, and perfumes. Although uncommon in the United States, methanol poisoning can…
View article: Immune Checkpoint Inhibitor-Induced Acute Kidney Injury with Multisystem Involvement Mimicking Septic Shock in a Patient with Advanced Melanoma: A Diagnostic Challenge
Immune Checkpoint Inhibitor-Induced Acute Kidney Injury with Multisystem Involvement Mimicking Septic Shock in a Patient with Advanced Melanoma: A Diagnostic Challenge Open
Background Immune-checkpoint inhibitors (ICIs), including nivolumab, have revolutionized the treatment of advanced melanoma. However, their expanding use has led to a rise in the incidence of immune-related adverse events (irAEs), which ca…
View article: Unmasking the Hidden Culprit: A Presentation of Euglycemic DKA
Unmasking the Hidden Culprit: A Presentation of Euglycemic DKA Open
Background Euglycemic diabetic ketoacidosis (DKA) is a unique variant of diabetic ketoacidosis that presents in patients with normal or mildly elevated blood glucose levels, defined as a serum glucose concentration < 250 mg/dL. As euglycem…
View article: Fatal Neonatal-onset Glutaric Acidemia Type IIc Masquerading as Neonatal Sepsis: A Case Report
Fatal Neonatal-onset Glutaric Acidemia Type IIc Masquerading as Neonatal Sepsis: A Case Report Open
Background: Glutaric acidemia type II (GA-II) is a rare neonatal metabolic disorder that presents with nonspecific features, often posing a diagnostic challenge. Clinical Description: A late preterm neonate, born out of nonconsanguineous m…
View article: A narrative review on the lactic acidosis and hypoglycemia in burkitt lymphoma: navigating metabolic changes
A narrative review on the lactic acidosis and hypoglycemia in burkitt lymphoma: navigating metabolic changes Open
Background: Burkitt lymphoma is a highly aggressive B-cell non-Hodgkin lymphoma closely associated with Epstein-Barr virus (EBV) infection and driven by MYC oncogene overexpression. It presents in three clinical forms: endemic, sporadic, a…
View article: Metformin-Associated Lactic Acidosis: A Case Report
Metformin-Associated Lactic Acidosis: A Case Report Open
Metformin is a widely prescribed and effective oral antidiabetic agent used in the treatment of type 2 diabetes mellitus (DM). Although generally well tolerated, metformin-associated lactic acidosis (MALA) is a rare but potentially fatal c…
View article: Neuroimaging in Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-Like Episodes (MELAS): Authors’ Reply
Neuroimaging in Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-Like Episodes (MELAS): Authors’ Reply Open
View article: Visual Loss and Rhabdomyolysis: A Case of Acute Methanol Intoxication
Visual Loss and Rhabdomyolysis: A Case of Acute Methanol Intoxication Open
Methanol toxicity is a rare but potentially fatal condition, often associated with accidental or intentional ingestion of adulterated alcohol. Complications include high anion gap metabolic acidosis, visual disturbances, central nervous sy…
View article: Neuroimaging in Mitochondrial Encephalomyopathy with Lactic Acidosis with Stroke-Like Episodes (MELAS): Correspondence
Neuroimaging in Mitochondrial Encephalomyopathy with Lactic Acidosis with Stroke-Like Episodes (MELAS): Correspondence Open
View article: P06 | Development of wet beriberi with prolonged Qtc and severe LVEF in a Wernicke’s encephalopathy patient
P06 | Development of wet beriberi with prolonged Qtc and severe LVEF in a Wernicke’s encephalopathy patient Open
Background: Severe thiamine deficiency, generally associated with alcohol-related disorders and malnutrition, can cause cognitive impairment (Wernicke’s encephalopathy, WE), peripheral neuropathy (dry beriberi) or heart failure (wet beribe…
View article: Neonatal Presentation of a Case of Carbonic Anhydrase VA Deficiency
Neonatal Presentation of a Case of Carbonic Anhydrase VA Deficiency Open
Carbonic anhydrase VA (CA-VA) deficiency is a rare mitochondrial disorder affecting bicarbonate-dependent metabolic pathways. It commonly presents in neonates with hyperammonemia, lactic acidosis, and metabolic crisis, often mimicking more…
View article: Lactic acidosis in hemophagocytic syndrome: diagnostic and therapeutic challenges in the intensive care unit—a case series
Lactic acidosis in hemophagocytic syndrome: diagnostic and therapeutic challenges in the intensive care unit—a case series Open
Extreme lactic acidosis in intensive care unit patients should prompt urgent hemophagocytic lymphohistiocytosis evaluation, particularly in Chinese populations. Etoposide is effective for malignancy-associated hemophagocytic lymphohistiocy…
View article: Facial epilepsia partialis continua in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes
Facial epilepsia partialis continua in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes Open