Fibrosis
View article: Supplementary Table 3 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Supplementary Table 3 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
List of primers used for quantitative real time PCR
View article: Fig. S7 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S7 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Figure S7 shows western blots for p-AKT/AKT, p-S6/S6, b tubulin, p-ERK/ERK, P-p-38/p-38, b catenin, p62 and b tubulin
View article: Supplementary Table 1 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Supplementary Table 1 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
List of Differentially Expressed Genes from RNA Seq analysis
View article: Fig. S2 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S2 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Figure S2 shows body weight changes, liver weight changes, Transcript levels of Il1b and H&E staining for showing KC population
View article: Fig. S6 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S6 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Fig S6 shows ingenuity pathway analysis for canonical pathways and upstream regulators
View article: Supplementary Table 2 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Supplementary Table 2 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
List of significantly altered transcripts from RNA Seq analysis
View article: Fig. S5 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S5 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Figure S5 shows images of liver nodules, transcript levels of AFP
View article: Fig. S3 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S3 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Fig S3 shows flow cytometry data for CD45, gating strategy and transcript levels of CD68 and TLR4
View article: Fig. S1 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S1 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Figure S1 shows the experimental plan of the study, IHC staining for Ripk3, Transcript levels of Mlkl and Ripk3, Western blots for Cleaved and Total Caspase 3
View article: Supplementary Data Legends from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Supplementary Data Legends from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Supplementary Figures 1 -7 and Supplementary Tables 1 - 3 legends
View article: Fig. S4 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Fig. S4 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis Open
Fig S4 shows transcript levels of Col1a1, western blots for Desmin, a-SMA and b-tubulin, Transcript levels of TGFb
View article: Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis
Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis Open
Background Current treatments for cirrhosis-a progressive disease marked by fibrosis and inflammation-are limited and non-specific. Jinqiancao granules (JQC), a traditional Chinese medicine used for hepatobiliary diseases, could provide a …
View article: Extracellular matrix anchored neutrophils drive pulmonary fibrosis in mice
Extracellular matrix anchored neutrophils drive pulmonary fibrosis in mice Open
View article: Comparison of 1.7 mm and 1.9 mm Cryoprobes in Specimen Quality for Fibrotic Interstitial Lung Disease
Comparison of 1.7 mm and 1.9 mm Cryoprobes in Specimen Quality for Fibrotic Interstitial Lung Disease Open
View article: Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p
Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p Open
View article: Particulate Matter Increases Bone Morphogenetic Protein 2 in Lung Fibroblasts
Particulate Matter Increases Bone Morphogenetic Protein 2 in Lung Fibroblasts Open
Particulate matter less than 2.5 μm (PM 2.5 ) contributes to many chronic respiratory disorders, but the mechanisms for this are not fully understood. The actions of PM 2.5 on lung epithelial cells have been well studied, but their effect …
View article: Shear wave elastography in healthy patients: Pancreatic stiffness is less reliable than liver and spleen measurements
Shear wave elastography in healthy patients: Pancreatic stiffness is less reliable than liver and spleen measurements Open
BACKGROUND Shear wave elastography (SWE) is a non-invasive ultrasound-based technique used to assess tissue stiffness, which reflects underlying pathological changes. While SWE has been widely applied for liver fibrosis evaluation, its app…
View article: Synthesis and anti-liver fibrotic activity study of a chalcone derivative through anti-inflammatory effects and inhibition of JNK/NF-κB signaling pathways
Synthesis and anti-liver fibrotic activity study of a chalcone derivative through anti-inflammatory effects and inhibition of JNK/NF-κB signaling pathways Open
Liver fibrosis is a progressive disease caused by chronic inflammation and the activation of hepatic stellate cells (HSCs). This disease manifests as the abnormal proliferation and migration of HSCs, as well as the excessive deposition of …
View article: Association Between Left Ventricular Global Longitudinal Strain and Hepatic Inflammation and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease
Association Between Left Ventricular Global Longitudinal Strain and Hepatic Inflammation and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Background/Objectives: Cardiovascular disease is the leading cause of mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), which includes simple steatosis (metabolic dysfunction-associated steatotic …
View article: THE BIOLOGICAL MECHANISMS UNDERLYING THE DEVELOPMENT OF DIABETIC NEPHROPATHY
THE BIOLOGICAL MECHANISMS UNDERLYING THE DEVELOPMENT OF DIABETIC NEPHROPATHY Open
Diabetic nephropathy (DN) represents one of the most severe and progressive microvascular complications of diabetes mellitus, ultimately leading to chronic kidney disease and end-stage renal failure if left untreated. Despite decades of re…
View article: Type V Collagen as a Critical Regulator of Fibrillar Matrix Remodeling in a Murine Model of Systemic Sclerosis
Type V Collagen as a Critical Regulator of Fibrillar Matrix Remodeling in a Murine Model of Systemic Sclerosis Open
Type V collagen (Col V) has been implicated in the development of fibrosis in systemic sclerosis (SSc). In this study, we aimed to investigate the role of Col V in fibrillar matrix remodeling and fibroblast differentiation using an experim…
View article: Mesenchymal stem cells alleviate pulmonary fibrosis and gut microbiota dysbiosis in systemic sclerosis
Mesenchymal stem cells alleviate pulmonary fibrosis and gut microbiota dysbiosis in systemic sclerosis Open
Introduction Mesenchymal stem cells (MSCs) have shown the potential to alleviate systemic sclerosis (SSc) tissue fibrosis. However, our knowledge of the effects of MSCs on gut microbiota remains limited. Methods In this study, we employed …
View article: Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis
Association between spicy food consumption and the risk of non-alcoholic fatty liver disease/metabolic dysfunction-associated steatotic liver disease and liver fibrosis Open
Introduction Evidence suggested that capsaicin may protect against steatotic liver disease (SLD), but these findings lack validation in population-based studies. This research aimed to explore the association between spicy food consumption…
View article: Tinkering with Blood: Optimizing the Coagulation System for Therapeutic Purposes
Tinkering with Blood: Optimizing the Coagulation System for Therapeutic Purposes Open
Blood is a multitask, fluid tissue that is considered as an endless goldmine for regenerative therapies. This connective tissue carries myriad multidomain proteins as the workhorse of biological functions integrated in complex molecular ne…
View article: Sex differences in alcohol-related liver disease, viral hepatitis, metabolic dysfunction-associated steatotic liver disease, and hepatocellular carcinoma
Sex differences in alcohol-related liver disease, viral hepatitis, metabolic dysfunction-associated steatotic liver disease, and hepatocellular carcinoma Open
Females are more susceptible to alcohol-related liver disease (ALD) owing to increased risk of alcohol dependence; decreased gastric first-pass effect and increased risk of producing hepatotoxic metabolites, higher alcohol bioavailability,…
View article: Combining transcriptomics with network pharmacology to explore the mechanism of Yiqi Huoxue decoction against liver fibrosis
Combining transcriptomics with network pharmacology to explore the mechanism of Yiqi Huoxue decoction against liver fibrosis Open
Background Clinical practice commonly uses the Yi-qi Huo-xue formula (YQHX), a traditional Chinese herbal medicine comprising eight herbal components, to treat liver fibrosis resulting from various etiologies. Nevertheless, this formula’s …
View article: Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells
Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells Open
Hepatic fibrosis is a pathological process characterized by an imbalance between the deposition and degradation of extracellular matrix components. This process is initiated by chronic liver injuries resulting from viral infections, alcoho…
View article: FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis
FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis Open
The progression of osteoarthritis (OA) is fundamentally characterized by the aberrant transformation of chondrocytes into a fibrotic phenotype, although the precise molecular mechanisms involved remain inadequately understood. In this stud…
View article: Inhibiting peripheral serotonin activates liver AMPK and reduces monocyte-derived macrophages and fibrosis
Inhibiting peripheral serotonin activates liver AMPK and reduces monocyte-derived macrophages and fibrosis Open
View article: Capns1 Specific Deletion in Macrophage Attenuates Skin Inflammation and Fibrosis in Systemic Sclerosis by Suppressing SHP2
Capns1 Specific Deletion in Macrophage Attenuates Skin Inflammation and Fibrosis in Systemic Sclerosis by Suppressing SHP2 Open
Background: In systemic sclerosis (SSc), Capns1 is largely up-regulated in dermal tissue to control calpain activities, thus providing pro-inflammatory and pro-fibrotic effect. However, the mechanisms under this process still remain unknow…