Fulminant
View article: The Nipah Virus: A Review of Epidemiology, Pathophysiology, and Management
The Nipah Virus: A Review of Epidemiology, Pathophysiology, and Management Open
The zoonotic pathogen Nipah virus (NiV) has emerged as a significant global health threat, provoking outbreaks characterised by high mortality and substantial transmission potential. First identified in 1998–1999 in Malaysia and Singapore …
View article: Fulminant Immune Checkpoint Inhibitor-Induced Myocarditis and Complete Heart Block in Advanced Melanoma: A Case Report
Fulminant Immune Checkpoint Inhibitor-Induced Myocarditis and Complete Heart Block in Advanced Melanoma: A Case Report Open
View article: Primary Sjögren’s Syndrome Presenting With Hypokalemic Rhabdomyolysis, Distal Renal Tubular Acidosis, and Fulminant Necrotizing Vasculitis: A Case Report
Primary Sjögren’s Syndrome Presenting With Hypokalemic Rhabdomyolysis, Distal Renal Tubular Acidosis, and Fulminant Necrotizing Vasculitis: A Case Report Open
View article: Naive vs Memory Immune Programs as the Determinants of Early Febrile Phenotypes: A Modern Physiologic Interpretation of the Shanghan–Zhongfeng Dichotomy
Naive vs Memory Immune Programs as the Determinants of Early Febrile Phenotypes: A Modern Physiologic Interpretation of the Shanghan–Zhongfeng Dichotomy Open
Early febrile illness frequently presents with strikingly divergent clinical phenotypes despite identical pathogen exposure—ranging from high fever with chills, rigor, and myalgia to mild warmth with spontaneous sweating and rapid recovery…
View article: TAP-I Deficiency Presenting With Chronic Granulomatous Rubella Virus-Driven Cutaneous Ulceration: A Case Report and Scoping Literature Review
TAP-I Deficiency Presenting With Chronic Granulomatous Rubella Virus-Driven Cutaneous Ulceration: A Case Report and Scoping Literature Review Open
Autosomal recessive mutations in TAP1, TAP2, TAPBP, or B2M , are associated with major histocompatibility complex (MHC) class I deficiency. Individuals may present with granulomatous skin ulceration, but the underlying antigenic triggers r…
View article: Naive vs Memory Immune Programs as the Determinants of Early Febrile Phenotypes: A Modern Physiologic Interpretation of the Shanghan–Zhongfeng Dichotomy
Naive vs Memory Immune Programs as the Determinants of Early Febrile Phenotypes: A Modern Physiologic Interpretation of the Shanghan–Zhongfeng Dichotomy Open
Abstract Early febrile illness frequently presents with strikingly divergent clinical phenotypes despite identical pathogen exposure—ranging from high fever with chills, rigor, and myalgia…
View article: Nasal Septal perforation: Iatrogenic, Autoimmune or Infective? A diagnostic Challenge
Nasal Septal perforation: Iatrogenic, Autoimmune or Infective? A diagnostic Challenge Open
Introduction:Nasal septal perforation is a rare but significant clinical condition that may present with symptoms such as nasal discharge, crusting, bleeding, and deformity. Its etiology can be diverse ranging from trauma and infection to …
View article: Risk factors for unfavorable outcomes after conservative management of severe ulcerative, pseudomembranous, and ischemic colitis: a single-center retrospective comparative cohort study
Risk factors for unfavorable outcomes after conservative management of severe ulcerative, pseudomembranous, and ischemic colitis: a single-center retrospective comparative cohort study Open
Introduction: Severe forms of ulcerative colitis (UC), pseudomembranous colitis (PMC), and ischemic colitis (IC) often exhibit clinical and morphological mimicry, complicating the differential diagnosis. In severe and fulminant cases, path…
View article: Explainable Machine Learning Models Using Routine Clinical Data for Early Prediction of Necrotizing Fasciitis: A Single‐Center Retrospective Study
Explainable Machine Learning Models Using Routine Clinical Data for Early Prediction of Necrotizing Fasciitis: A Single‐Center Retrospective Study Open
Background Necrotizing fasciitis (NF), a fulminant soft tissue infection manifesting acute onset and rapid progression with substantial mortality risks, poses diagnostic challenges due to its predominant reliance on clinical evaluation dur…
View article: Pankreatik Nekroz ve Tedavisi
Pankreatik Nekroz ve Tedavisi Open
Akut pankreatit temel olarak pankreas dokusunun inflamasyonudur ve hafif interstisyel (ödematöz) pankreatitten, önemli lokal veya sistemik komplikasyonlarla beraber ciddi oranda morbidite ve mortalitesi olan şiddetli hastalığa kadar ilerle…
View article: Multimorbidity: The New Frontier in Internal Medicine
Multimorbidity: The New Frontier in Internal Medicine Open
Multimorbidity, defined as the coexistence of multiple chronic or acute disorders in a single individual, is emerging as one of the most challenging aspects of modern internal medicine. In younger patients, its presentation can be particul…
View article: Tuberculosis-triggered cytokine storm with hemophagocytic lymphohistiocytosis and tuberculous spondylitis in an apparently immunocompetent host: a case report and literature review
Tuberculosis-triggered cytokine storm with hemophagocytic lymphohistiocytosis and tuberculous spondylitis in an apparently immunocompetent host: a case report and literature review Open
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated tuberculosis (TB) is a rare, life-threatening hyperinflammatory syndrome. We present a 60-year-old man with recurrent fever and syncope. Workup revealed cytopenias, hyperfe…
View article: Prognostic nutritional index in risk of mortality following fulminant myocarditis
Prognostic nutritional index in risk of mortality following fulminant myocarditis Open
Fulminant myocarditis (FM) is an acute fatal inflammation disease, but its chronic phase is unclear. A Japanese nationwide registry evaluated the long-term mortality in FM patients using a prognostic nutritional index (PNI). The retrospect…
View article: Cerebral vasculitis as a severe complication of acute infectious meningoencephalitis—a case series of five different pathogens
Cerebral vasculitis as a severe complication of acute infectious meningoencephalitis—a case series of five different pathogens Open
Summary Background Acute infectious meningoencephalitis is a severe condition caused by bacterial, viral, fungal, or parasitic infections of the central nervous system (CNS). A rare but severe complication is cerebral vasculitis with ische…
View article: Tislelizumab-induced fulminant type 1 diabetes mellitus (FT1D): A case report and literature review
Tislelizumab-induced fulminant type 1 diabetes mellitus (FT1D): A case report and literature review Open
Rationale: Immune checkpoint inhibitors, such as tislelizumab, are widely used in oncology but can cause serious immune-related adverse events. Endocrine disorders are common, with fulminant type 1 diabetes mellitus (FT1D) being a rare but…
View article: Rapidly Progressive Merkel Cell Carcinoma with Atypical Metastatic Pattern—A Case Report and Brief Literature Review
Rapidly Progressive Merkel Cell Carcinoma with Atypical Metastatic Pattern—A Case Report and Brief Literature Review Open
Background and Clinical Significance: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy with increasing incidence among elderly, immunocompromised patients or individuals exposed to ultraviolet radiation…
View article: Fulminant hepatitis during treatment for per-extensively drug-resistant tuberculosis: A case report and call for improved patient monitoring
Fulminant hepatitis during treatment for per-extensively drug-resistant tuberculosis: A case report and call for improved patient monitoring Open
Rationale: Drug therapy is the most effective therapy for tuberculosis; however, it can also lead to a common and serious adverse reaction known as antituberculosis drug–induced liver injury. The incidence of antituberculosis drug–induced …
View article: Fulminant and fatal <i>Trypanosoma cruzi</i> reactivation in a patient with lymphoma
Fulminant and fatal <i>Trypanosoma cruzi</i> reactivation in a patient with lymphoma Open
Background Trypanosoma cruzi is a protozoan parasite and the causative agent of Chagas disease. This case describes a fulminant and fatal reactivation of T. cruzi after immunosuppression in a patient with a history of follicular lymphoma, …
View article: How should immune checkpoint inhibitor myocarditis be treated?
How should immune checkpoint inhibitor myocarditis be treated? Open
Immune checkpoint inhibitors (ICIs) have significantly advanced cancer therapy. However, these therapies can disrupt immune self-tolerance, leading to immune-related adverse events, among which immune checkpoint inhibitor-related myocardit…
View article: Extensive Myocardial Calcification Following Fulminant Neonatal Enteroviral Myocarditis
Extensive Myocardial Calcification Following Fulminant Neonatal Enteroviral Myocarditis Open
View article: Use of Rituximab for fulminant and refractory cases of Immune Checkpoint Inhibitor (ICI) induced myocyte injury clinically presenting with features of Myasthenia gravis: A Case Series
Use of Rituximab for fulminant and refractory cases of Immune Checkpoint Inhibitor (ICI) induced myocyte injury clinically presenting with features of Myasthenia gravis: A Case Series Open
Background Immune checkpoint inhibitor-related overlap syndromes are serious and potentially life-threatening complications of immunotherapy. The available evidence is scarce to guide treatment for refractory cases, and patients often expe…
View article: Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient
Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient Open
Introduction Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that can lead to multiorgan failure, including acute liver failure. While varicella infection in leukemia patients in remission is not u…
View article: Necrotizing Fasciitis With Pelvic Osteomyelitis: A Fulminant Disease
Necrotizing Fasciitis With Pelvic Osteomyelitis: A Fulminant Disease Open
View article: Uncommon yet impactful — case-based reflections on rare neurologic disorders
Uncommon yet impactful — case-based reflections on rare neurologic disorders Open
Rare diseases (RDs) are a heterogeneous group of disorders defined by their low prevalence - affecting fewer than 1 in 2,000 individuals in Europe and fewer than 200,000 people in the US. Although individually uncommon, rare diseases colle…
View article: Molecular Mechanisms, Diagnosis, and Management of Chemotherapy Related Cardiotoxicity
Molecular Mechanisms, Diagnosis, and Management of Chemotherapy Related Cardiotoxicity Open
Cardiotoxicity remains a major limitation of contemporary cancer therapy, affecting both traditional cytotoxic agents and novel targeted and immunotherapeutic drugs. This review summarizes current understanding of the molecular and clinica…
View article: Fulminant Giant Cell Myocarditis Following Vaccination Against Herpes Zoster
Fulminant Giant Cell Myocarditis Following Vaccination Against Herpes Zoster Open
View article: A rare form of acne fulminans. Management of a complex patient
A rare form of acne fulminans. Management of a complex patient Open
The article presents the successful treatment of patient S. 15 years old with fulminant acne which may have developed due to an error in the simultaneous administration of doxycycline and isotretinoin. Despite a severe complication charact…
View article: Severe mitral valve papillary muscle rupture of isolated Whipple's endocarditis: a case report and review of the literature
Severe mitral valve papillary muscle rupture of isolated Whipple's endocarditis: a case report and review of the literature Open
Background Tropheryma whipplei endocarditis (TWE) is rarely reported. Diagnosis is particularly challenging when it occurs as isolated TWE without classical manifestations of Whipple's disease. Case presentation A 35-year-old Asian female …
View article: Management of Fournier's Gangrene Defects: A Retrospective Surgical Case Series of 23 Patients and review of Surgical Strategies
Management of Fournier's Gangrene Defects: A Retrospective Surgical Case Series of 23 Patients and review of Surgical Strategies Open
Fournier's Gangrene (FG) is a fulminant necrotizing fasciitis that necessitates immediate, aggressive surgical debridement to ensure patient survival. This life-saving measure often results in extensive soft-tissue defects of the genitoper…
View article: Postpartum pneumoperitoneum without any visceral perforation: a case report and literature review
Postpartum pneumoperitoneum without any visceral perforation: a case report and literature review Open
Introduction and Importance: Spontaneous postpartum pneumoperitoneum (SPPP) is extraordinarily uncommon; fewer than ten cases are documented but radiographically it imitates visceral perforation, the archetypal surgical catastrophe. Prompt…