Monocyte
View article: Supplementary Video 3 (DARA) from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Video 3 (DARA) from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Supplementary Video 3
View article: Myeloid GPSM1 regulates atherosclerosis progression by governing monocyte and macrophage activation and chemotaxis
Myeloid GPSM1 regulates atherosclerosis progression by governing monocyte and macrophage activation and chemotaxis Open
The activation of blood monocytes and the infiltration of monocyte-derived macrophages into the vessel walls are the central part of atherosclerosis. However, the mechanisms underlying the processes remain unclear. Here, we report that G-p…
View article: Supplementary Figure 5 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Figure 5 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Control staining for CD19 and MDC8 on human tissue sections.
View article: Glucocorticoid-mediated suppression of the CCL2-CCR2 axis drives monocyte dysfunction in severe pneumonia among immunocompromised hosts
Glucocorticoid-mediated suppression of the CCL2-CCR2 axis drives monocyte dysfunction in severe pneumonia among immunocompromised hosts Open
View article: Supplementary Figure 3 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Figure 3 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Confocal and immunofluorescence microscopy images of slan+-monocytes cocultured with Daudi cells.
View article: TNF-α-Driven Systemic Inflammasome Hyperactivity Links Psoriatic Inflammation to monocyte inflammatory response and platelet activation
TNF-α-Driven Systemic Inflammasome Hyperactivity Links Psoriatic Inflammation to monocyte inflammatory response and platelet activation Open
Psoriasis is a chronic skin disease mediated by Th1 and Th17 immune responses and is classified as a systemic inflammatory disorder. Notably, psoriasis is an independent risk factor for myocardial infarction, stroke, and cardiovascular mor…
View article: Interferon gamma stimulates coordinated changes in LRRK2, GCase, and cathepsin activities in idiopathic and genetic Parkinson’s disease monocytes
Interferon gamma stimulates coordinated changes in LRRK2, GCase, and cathepsin activities in idiopathic and genetic Parkinson’s disease monocytes Open
View article: Supplementary Video 2 (5F9) from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Video 2 (5F9) from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Supplementary Video 2
View article: Supplementary Figure 2 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Figure 2 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Phagocytosis of RTX- and/or 5F9/Magrolimab-coated Daudi cells by in vitro generated slan+- macrophages
View article: Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction
Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction Open
Modulating the balance between pro- and anti-inflammatory monocyte subsets holds therapeutic promise in acute myocardial infarction (AMI); however, effective and selective strategies are still lacking. In this study, we are the first to id…
View article: Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis Open
Introduction Skin lesions in atopic dermatitis (AD) are characterized by elevated levels of both Th1 and Th2 cytokines, along with increased concentrations of inflammatory mediators such as cysteinyl leukotrienes (CysLTs). The enzymes 5-li…
View article: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa
Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa Open
Background The role of plasma and its components in the progression of aortic stenosis (AS) remains insufficiently investigated. This study aimed to assess whether plasma from patients with AS induces oxidative stress and contributes to va…
View article: Figure S3 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Figure S3 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance Open
Supplementary Figure S3. Anti-VISTA-induced changes to tumor-infiltrating immune cells in MB49. B6 mice were injected intra-dermally with 100k MB49 cells and treated when tumors reached a size of 100mm3 with isotype (I) or anti-VISTA (V). …
View article: Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells
Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cells Open
Arterial aging is associated with enhanced angiotensin II (Ang II) signaling via Ang II type 1 receptor (AT1R) and with microRNA-34a (miR-34a) increased expression. AT1R-associated protein (ATRAP/Agtrap) binds to AT1R, promotes its interna…
View article: Clinical and laboratory markers of lung damage in SARS-CoV-2 infection (omicron variant) in patients with end-stage chronic kidney disease
Clinical and laboratory markers of lung damage in SARS-CoV-2 infection (omicron variant) in patients with end-stage chronic kidney disease Open
Prior to the Omicron variant of SARS-CoV-2, COVID-19 was characterized by a severe course and unfavorable prognosis, including fatal outcomes, in a significant proportion of patients with end-stage chronic kidney disease undergoing renal r…
View article: Supplementary Video 1 (RTX) from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Video 1 (RTX) from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Supplementary Video 1
View article: Immune Cell Type‐Specific DNA Methylation Regions Associate With 24‐Hour Blood Pressure Regulation in Black People
Immune Cell Type‐Specific DNA Methylation Regions Associate With 24‐Hour Blood Pressure Regulation in Black People Open
Background DNA methylation and immune cells have been linked to blood pressure (BP) regulation and the development of hypertension. However, the immune cell profiles and the cell type‐specific DNA methylation associated with BPs remain unc…
View article: Supplementary Figure 4 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Figure 4 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
Assessment of ADCC and trogocytosis exerted by NK cells, as well as of pathways required for ADCC mediated by slan+-monocytes.
View article: How exosomal platelet-derived miRNAs can lead to spontaneous osteoclastogenesis in osteoporosis: a new mechanistic viewpoint
How exosomal platelet-derived miRNAs can lead to spontaneous osteoclastogenesis in osteoporosis: a new mechanistic viewpoint Open
Osteoporosis is a chronic bone disease characterized by impaired bone remodeling and increased fracture risk. While classical mechanisms implicate estrogen deficiency, aging, and altered receptor activator of the nuclear factor-κB ligand (…
View article: A study on the value of the relationship between newly occurring microinfarctions after stent-assisted treatment for unruptured intracranial aneurysms and systemic inflammatory immune indices
A study on the value of the relationship between newly occurring microinfarctions after stent-assisted treatment for unruptured intracranial aneurysms and systemic inflammatory immune indices Open
Background A paucity of studies has been conducted on the relationship between new microinfarctions following stent-assisted treatment for unruptured intracranial aneurysms (UIA) and systemic inflammatory indices (SII) derived from complet…
View article: Prognostic value of monocyte chemoattractant protein-1 in sepsis: a systematic review and meta-analysis
Prognostic value of monocyte chemoattractant protein-1 in sepsis: a systematic review and meta-analysis Open
View article: Supplementary Figure 1 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Supplementary Figure 1 from slan<sup>+</sup> Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis Open
slan+-monocytes and NK cells require FcγRIII/CD16 engagement for their ADCC, although relying on different killing mechanisms.
View article: Supplementary Figure 2 from Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated <i>SPP1</i><sup>+</sup> Macrophages and Fibroblasts
Supplementary Figure 2 from Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated <i>SPP1</i><sup>+</sup> Macrophages and Fibroblasts Open
Heatmap depicting cell states from monocytes and macrophages identified using Ecotyper NMF analysis, annotated by condition and genes with highest fold change in each state. Data from seven mCRCs, five paired normal liver tissue and two pa…
View article: Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy
Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy Open
CD5‐ and CD7‐directed chimeric antigen receptor T‐cell (5CAR and 7CAR) therapies for T‐cell malignancies carry the risk of life‐threatening infection. Although depletion of target‐positive lymphocytes is expected, the contribution of resid…
View article: Improved antitumor activity of IL-12-secreting CAR-T cells targeting CD176 across different carcinomas
Improved antitumor activity of IL-12-secreting CAR-T cells targeting CD176 across different carcinomas Open
Introduction Effective therapeutic options for advanced solid tumors remain severely limited, causing high fatality rates especially after metastasis. The carbohydrate structure CD176 has been identified as a promising target for precise i…
View article: Figure S4 from The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma
Figure S4 from The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma Open
Supplemental Figure 4: Combination of XVir-N-31 and CDK4/6 inhibitor LEE011 induces an abscopal effect, induces monocyte infiltration and increases M1/M2 macrophage ratio in injected tumors.
View article: Lipid deprivation amplifies type I IFN responses in monocytes through prenylation: insights from familial combined hypolipidemia type 2
Lipid deprivation amplifies type I IFN responses in monocytes through prenylation: insights from familial combined hypolipidemia type 2 Open
Familial Combined Hypolipidemia (FHBL2) is a genetic disorder caused by loss-of-function mutations in the Angiopoietin-like 3 ( ANGPTL3 ) gene. FHBL2 subjects exhibit hypolipidemia and protection from atherosclerotic cardiovascular disease…
View article: Harnessing mRNA technology against Fasciola hepatica: Immunological insights from a fatty acid binding protein vaccine
Harnessing mRNA technology against Fasciola hepatica: Immunological insights from a fatty acid binding protein vaccine Open
mRNA platforms offer a promising strategy to overcome limitations in helminth vaccinology. We used the helminth Fasciola hepatica , which is a major veterinary and zoonotic pathogen for which no licensed vaccine exists, as a test case. We …
View article: Supplementary Figure S2 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Supplementary Figure S2 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies Open
Supplementary Figure S2. Proportions of T cells, monocytes and neutrophils in human whole blood after treatment with 0.2 μg/mL CD20-TCB
View article: Targeting the TNFα/TNFR1 axis alleviates the experimental acute pancreatitis
Targeting the TNFα/TNFR1 axis alleviates the experimental acute pancreatitis Open
Objective : Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that can lead to life-threatening systemic inflammation and multiple organ failure with high mortality. The binding of tumor necrosis factor α (TNFα) to its re…