Chordoma
View article: CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma
CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma Open
View article: Table S1-S5 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Table S1-S5 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Table S1. Genes included in the targeted DNA panel sequencing. Table S2. Differences in clinical characteristics by molecular subtype. Table S3. Distributions of mutation status in PBRM1 and SETD2 by molecular subtype in RNASeq and Nanostr…
View article: Supplementary fig 3 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Supplementary fig 3 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Figure S3. Gene expression profiling based on the NanoString panel in 23 skull-base (top) and 25 non-skull-base (bottom) chordoma patients from North America.
View article: INFLUENCE OF DOSE-AVERAGED LINEAR ENERGY TRANSFER AND BIOLOGICAL EQUIVALENT DOSE ON TUMOUR CONTROL AFTER CARBON-ION RADIOTHERAPY FOR UNRESECTABLE SACROCOCCYGEAL CHORDOMA
INFLUENCE OF DOSE-AVERAGED LINEAR ENERGY TRANSFER AND BIOLOGICAL EQUIVALENT DOSE ON TUMOUR CONTROL AFTER CARBON-ION RADIOTHERAPY FOR UNRESECTABLE SACROCOCCYGEAL CHORDOMA Open
View article: OPTIMIZING LINEAR ENERGY TRANSFER TO PROTECT ORGANS-AT-RISK DURING CLIVAL CHORDOMA PROTON RADIOTHERAPY
OPTIMIZING LINEAR ENERGY TRANSFER TO PROTECT ORGANS-AT-RISK DURING CLIVAL CHORDOMA PROTON RADIOTHERAPY Open
View article: Supplementary fig 5 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Supplementary fig 5 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Figure S5. SNAI1, SNAI3, and TWIST expression in CC1 and CC2 tumors.
View article: Supplementary Legend 1 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Supplementary Legend 1 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Supplementary Legend
View article: Supplementary fig 2 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Supplementary fig 2 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Figure S2. A. Contributions of small indel (ID) signatures (A and E) between CC1 and CC2; B. Number of mutations in small indel (ID) signatures (A and E) between CC1 and CC2.
View article: PENCIL-BEAM-SCANNING (PBS) PROTONTHERAPY FOR SKULL-BASE CHORDOMA AND CHONDROSARCOMA: LONG-TERM OUTCOMES.
PENCIL-BEAM-SCANNING (PBS) PROTONTHERAPY FOR SKULL-BASE CHORDOMA AND CHONDROSARCOMA: LONG-TERM OUTCOMES. Open
View article: CELLULARITY-GUIDED DOSE PAINTING IN CARBON ION RADIOTHERAPY FOR LARGE SACRAL CHORDOMAS TO MAXIMIZE TUMOR CONTROL PROBABILITY
CELLULARITY-GUIDED DOSE PAINTING IN CARBON ION RADIOTHERAPY FOR LARGE SACRAL CHORDOMAS TO MAXIMIZE TUMOR CONTROL PROBABILITY Open
View article: Supplementary fig 4 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Supplementary fig 4 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Figure S4. Expression of selected markers in relation to overall survival (left) and recurrence-free survival (right) in Chinese chordoma patients with long-term follow-up data. A. CLDN11; B. GLI1; C. EPHA3; D. LEF1.
View article: Supplementary fig 1 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Supplementary fig 1 from Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes Open
Figure S1. A. PBRM1 and SETD2 expression between CC1 and CC2; B. PBRM1 and SETD2 expression between NCC1 and NCC2.
View article: Spinal intraosseous schwannoma: a retrospective study of 63 cases focusing on diagnosis, surgical strategies, and prognosis
Spinal intraosseous schwannoma: a retrospective study of 63 cases focusing on diagnosis, surgical strategies, and prognosis Open
Purpose To investigate the clinical diagnosis, surgical treatment strategies, and prognosis of spinal intraosseous schwannoma (SIS). Methods A retrospective analysis of clinical data from SIS patients treated at our hospital was conducted.…
View article: Stereotactic radiotherapy with CyberKnife-M6 for patients with clivus chordoma
Stereotactic radiotherapy with CyberKnife-M6 for patients with clivus chordoma Open
Objectives Chordomas are rare tumors and have high rates of local recurrences despite aggressive surgery and conventional radiotherapy (RT). Technological advances allow delivery of higher RT doses more safely. The aim was to evaluate the …
View article: Application of a rapid and accurate safe-margin volume generation method in computer-assisted bone tumor resection surgery
Application of a rapid and accurate safe-margin volume generation method in computer-assisted bone tumor resection surgery Open
View article: A case report and literature review: an intra-abdominal epithelioid neoplasm with EWSR1::CREB fusions originating from the kidney
A case report and literature review: an intra-abdominal epithelioid neoplasm with EWSR1::CREB fusions originating from the kidney Open
Background EWSR1::CREB fusion is a newly identified group of aggressive tumors with epithelioid morphology and multiple growth patterns. These tumors are often located in the abdominal cavity and frequently show cytokeratin expression immu…
View article: Pediatric Head and Neck Chordomas: A National Analysis of Prognostic Indicators and Survival Outcomes
Pediatric Head and Neck Chordomas: A National Analysis of Prognostic Indicators and Survival Outcomes Open
Objective To identify prognostic factors among pediatric patients with head and neck chordomas. Study Design Cross‐sectional analysis. Setting The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) 22 database. …
View article: Surgical Management of Spinal Chordomas: A Narrative Review
Surgical Management of Spinal Chordomas: A Narrative Review Open
Background: Chordomas are rare malignant tumors derived from notochordal remnants, accounting for 1–4% of skeletal malignancies. These slow-growing tumors most commonly affect the sacrum, skull base, and spine, posing significant challenge…
View article: Recurrent Nasopharyngeal Chordoma Stabilized With Afatinib: A Case Report
Recurrent Nasopharyngeal Chordoma Stabilized With Afatinib: A Case Report Open
View article: Quality of Life and Clinical Outcomes in Patients with Skull Base Chordoma and Chondrosarcoma Treated with Pencil-Beam Scanning Proton Therapy
Quality of Life and Clinical Outcomes in Patients with Skull Base Chordoma and Chondrosarcoma Treated with Pencil-Beam Scanning Proton Therapy Open
Background: skull base chordoma (Ch) and chondrosarcoma (ChSa) are rare neoplasms prone to local relapse. Alongside surgery, proton therapy (PT) is a well-established treatment for them. Given the relatively long patient survival expectanc…
View article: Muscle-specific MRI grading of soft tissue involvement provides additional prognostic value beyond skull base criteria in nasopharyngeal carcinoma: a retrospective study
Muscle-specific MRI grading of soft tissue involvement provides additional prognostic value beyond skull base criteria in nasopharyngeal carcinoma: a retrospective study Open
View article: IMG-119. “The Spine’s Silent Aggressor: Imaging and Molecular Profile of <i>MYCN</i> -Amplified Ependymoma”
IMG-119. “The Spine’s Silent Aggressor: Imaging and Molecular Profile of <i>MYCN</i> -Amplified Ependymoma” Open
BACKGROUND MYCN-amplified spinal ependymoma is a recently classified, rare, and aggressive subtype of spinal cord tumor, first defined by the 2021 WHO CNS5 classification. It predominantly affects adults in their 30s, with a slight female …
View article: SPCT-02 CERVICAL SPINE CHORDOMA MIMICKING A METASTASIS.
SPCT-02 CERVICAL SPINE CHORDOMA MIMICKING A METASTASIS. Open
Background Chordomas are rare tumors derived from the notochord and growing close to the axial skeleton. The cervical location of chordomas represents 30% of vertebral locations. A chordoma is a locally aggressive malignant lesion, origina…
View article: INNV-29. Clinical and imaging response to ivosidenib for progressive isocitrate dehydrogenase-1 (IDH-1) mutated clival chordoma
INNV-29. Clinical and imaging response to ivosidenib for progressive isocitrate dehydrogenase-1 (IDH-1) mutated clival chordoma Open
BACKGROUND Chordoma is a rare but aggressive malignant tumor that occurs in the skull base and spine. Currently, there are no FDA approved drug therapies to treat chordoma. Tissue molecular profile testing may help illuminate potential tar…
View article: IMMU-50. Spatial Immunophenotypic Characterization of Immune Exclusion and Dysfunction via Collagen-Rich Fibrous Septa in Chordomas
IMMU-50. Spatial Immunophenotypic Characterization of Immune Exclusion and Dysfunction via Collagen-Rich Fibrous Septa in Chordomas Open
Chordomas are malignant notochordal remnant tumors resistant to standard therapies. Using single-cell RNA-sequencing and spatial transcriptomics, we identified that the chordoma immune landscape is marked by macrophage-rich infiltrates and…
View article: IMG-126. Bony Metastatic Extra-Axial Invasion of Primary Glioblastoma: A Case Series and Review of the Literature
IMG-126. Bony Metastatic Extra-Axial Invasion of Primary Glioblastoma: A Case Series and Review of the Literature Open
Glioblastoma is the most common primary malignant CNS neoplasm. It typically presents as an intra-axial lesion with central necrosis, heterogeneous enhancement with surrounding edema. Glioblastomas can very rarely be found extra-axial or e…
View article: PATH-38. Rare co-occurrence of a clival chordoma and Tetralogy of Fallot in a pediatric patient: A role for T-Box transcription factors?
PATH-38. Rare co-occurrence of a clival chordoma and Tetralogy of Fallot in a pediatric patient: A role for T-Box transcription factors? Open
Chordomas are rare slow-growing malignant bone tumors of notochord origin, with incidence of 0.08 per 100,000/year and median 5-year survival of 67%. Fewer than 5% occur before age 20. Most pediatric chordomas arise from the skull-base. Te…
View article: EXTH-19. The oncolytic adenovirus Delta-24-RGD achieves antitumor polarization of the chordoma tumor microenvironment in human and murine models of chordoma
EXTH-19. The oncolytic adenovirus Delta-24-RGD achieves antitumor polarization of the chordoma tumor microenvironment in human and murine models of chordoma Open
Chordomas are locally aggressive neoplasms accounting for approximately 20% of primary spinal tumors. Patients experience high rates of disease progression and limited treatment options, highlighting an unmet clinical need and the importan…
View article: SPCT-06 CHALLENGES AND OUTCOMES OF PATIENTS WITH SPINE TUMORS IN A TERTIARY CENTRE IN EAST AFRICA: A SINGLE-CENTRE RETROSPECTIVE STUDY.
SPCT-06 CHALLENGES AND OUTCOMES OF PATIENTS WITH SPINE TUMORS IN A TERTIARY CENTRE IN EAST AFRICA: A SINGLE-CENTRE RETROSPECTIVE STUDY. Open
Background and Aims both primary and metastatic spine tumors are often diagnosed late in low- and middle-income countries, leading to severe neurologic deficits and poor outcomes. This is mainly attributed to inadequate imaging modalities,…
View article: SBPS-02 PREDICTORS OF OPERATIVE ISCHEMIC CEREBROVASCULAR COMPLICATIONS IN SKULL BASE TUMOR RESECTIONS: EXPERIENCE IN LOW-RESOURCE SETTING
SBPS-02 PREDICTORS OF OPERATIVE ISCHEMIC CEREBROVASCULAR COMPLICATIONS IN SKULL BASE TUMOR RESECTIONS: EXPERIENCE IN LOW-RESOURCE SETTING Open
Background & Aim Ischemic cerebrovascular complications following skull base tumor resections remain a significant factor impacting both short-term and long-term patient outcomes. This study aims to improve risk stratification, surgical de…