Biomarker
View article: Early and persistent thalamic astrocytic reactivity is a hallmark of post-traumatic epilepsy in mice
Early and persistent thalamic astrocytic reactivity is a hallmark of post-traumatic epilepsy in mice Open
Post-traumatic epilepsy (PTE) is a debilitating outcome of traumatic brain injury (TBI), but treatment remains elusive due to a limited understanding of its pathophysiology and the lack of reliable biomarkers. Reactive astrogliosis is a ha…
View article: Imbalance between skeletal muscle and intermuscular fat predicts treatment failure in Crohn's disease: an imaging biomarker for risk stratification.
Imbalance between skeletal muscle and intermuscular fat predicts treatment failure in Crohn's disease: an imaging biomarker for risk stratification. Open
Skeletal muscle-IMAT imbalance independently predicts treatment escalation in CD, offering superior prognostic utility to traditional sarcopenia measures.
View article: The Role of Regulatory T Cell Dysregulation in the Development of Autoimmune Diseases
The Role of Regulatory T Cell Dysregulation in the Development of Autoimmune Diseases Open
Background: The regulatory T cells (Tregs), especially theCD4⁺ CD25^hi CD127^lo FOXP3⁺ Tregs subpopulation is principal in the process of ensuring the immune toleration and prevention of autoimmune diseases. Their impaired frequency, stabi…
View article: Evaluation of ct-DNA and Mutational Status in Liquid Biopsy of Patients with Metastatic Colorectal Cancer
Evaluation of ct-DNA and Mutational Status in Liquid Biopsy of Patients with Metastatic Colorectal Cancer Open
Introduction Liquid biopsy has become an increasingly important tool in clinical oncology due to the utility of circulating tumor DNA (ct-DNA). Plasma ct-DNA levels reflect a patient’s tumor burden and provide valuable information for pers…
View article: Hemoglobin to red blood cell distribution width ratio inversely associated with heart failure in NHANES 2011–2018
Hemoglobin to red blood cell distribution width ratio inversely associated with heart failure in NHANES 2011–2018 Open
Hemoglobin-to-red cell distribution width ratio (HRR), a composite index reflecting both oxygen-carrying capacity and erythrocyte heterogeneity, has recently been proposed as a prognostic biomarker in cardiovascular disease. However, its a…
View article: Supplementary Figure S6 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer
Supplementary Figure S6 from Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer Open
Individual MLAST curves and biomarker staining from G12C KP animals treated with vehicle, Compound A, and sotorasib
View article: Figure S9 from Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors
Figure S9 from Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors Open
Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response as measured by the macrophage polarization score in histoculture explant cultures.
View article: Supplementary Figure 1 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Supplementary Figure 1 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression Open
Figure S1. (A) Representative images of triple IHC staining of Integrin αvβ3 (green), Gal-3 (red), and E-cadherin (brown) in normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ3 ar…
View article: Supplementary Data for: Scalp Tape-Strip RNA Sequencing Captures Disease and Treatment-Responsive Signatures in Alopecia Areata
Supplementary Data for: Scalp Tape-Strip RNA Sequencing Captures Disease and Treatment-Responsive Signatures in Alopecia Areata Open
This dataset accompanies the manuscript “Scalp Tape-Strip RNA Sequencing Captures Disease and Treatment-Responsive Signatures in Alopecia Areata”. It provides the processed transcriptomic data and analysis scripts used to characterize the …
View article: Supplementary Table S3 from Safety and Tolerability of a Novel Anti-HER2 Antibody–Drug Conjugate (PF-06804103) in Patients with HER2-Expressing Solid Tumors: A Phase 1 Dose-Escalation Study
Supplementary Table S3 from Safety and Tolerability of a Novel Anti-HER2 Antibody–Drug Conjugate (PF-06804103) in Patients with HER2-Expressing Solid Tumors: A Phase 1 Dose-Escalation Study Open
Supplementary Table S3 shows the biomarker results
View article: Metabolite-mediated mechanisms linking the urinary microbiome to bladder cancer
Metabolite-mediated mechanisms linking the urinary microbiome to bladder cancer Open
Bladder cancer is the most common malignancy of the urinary tract and is a major health burden globally. Recent advances in microbiome research have revealed that the urinary tract harbors a resident microbial community, overturning the lo…
View article: Supplementary Figure 3 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Supplementary Figure 3 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression Open
Figure S3. (A) Representative images of triple IHC staining of Integrin αvβ6 (green), Gal-3 (brown), and Na+/K+-ATPase (red) in normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ6…
View article: Evaluation of ct-DNA and Mutational Status in Liquid Biopsy of Patients with Metastatic Colorectal Cancer
Evaluation of ct-DNA and Mutational Status in Liquid Biopsy of Patients with Metastatic Colorectal Cancer Open
Introduction Liquid biopsy has become an increasingly important tool in clinical oncology due to the utility of circulating tumor DNA (ct-DNA). Plasma ct-DNA levels reflect a patient’s tumor burden and provide valuable information for pers…
View article: Supplementary Figure 2 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Supplementary Figure 2 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression Open
Figure S2. (A) Representative images of triple IHC staining of Integrin αvβ5 (green), Gal-3 (red), and E-cadherin (brown) in the normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ…
View article: Supplementary Table from Underutilization of Guideline-Recommended Mismatch Repair/Microsatellite Instability Biomarker Testing in Advanced Colorectal Cancer
Supplementary Table from Underutilization of Guideline-Recommended Mismatch Repair/Microsatellite Instability Biomarker Testing in Advanced Colorectal Cancer Open
Supplementary Table from Underutilization of Guideline-Recommended Mismatch Repair/Microsatellite Instability Biomarker Testing in Advanced Colorectal Cancer
View article: Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis
Secure Ileal Pouch–Anal Anastomosis for Histologic Indeterminate Colitis Open
Background/Objectives: Indeterminate colitis (IC) is an erroneous diagnosis for predominantly colonic inflammatory bowel disease (IBD) when there is a non-definitive foundation of the benchmark for ulcerative colitis (UC) and Crohn’s colit…
View article: Supplementary Data from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis
Supplementary Data from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis Open
Supplementary Data from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis
View article: Supplementary Figure S2 from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study
Supplementary Figure S2 from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study Open
Supplementary Figure S2 shows pre-surgery and 12-month biomarker concentrations correlated with the CTXD 12 months after surgery at Heidelberg.
View article: Supplementary Table 3. from Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study
Supplementary Table 3. from Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study Open
Geometric mean and 95% confidence intervals for urinary biomarkers of smoking-related toxicants among the Multiethnic Cohort (MEC) subcohort of current smokers and incident lung cancer cases
View article: PO:14:207 | Nailfold capillaroscopy in systemic lupus erythematosus: microvascular alterations and their clinical relevance
PO:14:207 | Nailfold capillaroscopy in systemic lupus erythematosus: microvascular alterations and their clinical relevance Open
Background. Nailfold videocapillaroscopy (NVC) is a valuable tool for assessing microvascular abnormalities in connective tissue diseases. While well established in systemic sclerosis, its role in systemic lupus erythematosus (SLE) remains…
View article: FSTL1 is a prognostic marker and promotes invasion and metastasis of colon cancer
FSTL1 is a prognostic marker and promotes invasion and metastasis of colon cancer Open
In summary, the findings of the study indicate that elevated FSTL1 expression could serve as a prognostic biomarker for unfavorable outcomes in colorectal cancer (CRC) diagnosis and may also identify potential targets for immunotherapy in …
View article: Serum Alkaline Phosphatase as a Biomarker for Skeletal Maturity Assessment and Growth Prediction in Individuals Aged 7 to 17 Years
Serum Alkaline Phosphatase as a Biomarker for Skeletal Maturity Assessment and Growth Prediction in Individuals Aged 7 to 17 Years Open
This study explored the association between serum alkaline phosphatase (ALP) levels and skeletal maturity and assess its potential as a hypothesis-generating adjunctive biomarker. One-hundred fifty-one subjects aged 7 ‒ 17 years who underw…
View article: Supplementary Figure from Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening
Supplementary Figure from Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening Open
Supplementary Figure from Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening
View article: Novel Biomarkers and Innovative Diagnostic Strategies in Polycystic Ovary Syndrome
Novel Biomarkers and Innovative Diagnostic Strategies in Polycystic Ovary Syndrome Open
Polycystic ovarian syndrome (PCOS) is a multifactorial endocrine disorder characterized by significant clinical and metabolic variability, which often results in a delayed diagnosis and insufficient therapy. With an emphasis on hormonal, m…
View article: Cross-species validation of a 6-miRNA blood signature for Parkinson’s disease: from MPTP mice to human PBMC and serum exosomes
Cross-species validation of a 6-miRNA blood signature for Parkinson’s disease: from MPTP mice to human PBMC and serum exosomes Open
Introduction Early detection of Parkinson’s disease (PD) remains challenging due to the lack of reliable blood-based biomarkers. While microRNAs (miRNAs) show promise as circulating biomarkers, translating preclinical discoveries to clinic…
View article: Data from Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements
Data from Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements Open
Background:Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies.Materials and Methods:We used Mendelian randomiza…
View article: Supplementary Data from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis
Supplementary Data from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis Open
Supplementary Data from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis
View article: SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity
SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity Open
Background The comorbidity of rheumatoid arthritis (RA), a chronic autoimmune disease, with cervical cancer has garnered a lot of attention. Cervical cancer is much more common in RA patients than in the general population, which may be ca…
View article: Data from Longitudinal Changes in Immune Activation Serum Biomarkers Prior to Diagnosis and Risk of B-cell NHL Subtypes
Data from Longitudinal Changes in Immune Activation Serum Biomarkers Prior to Diagnosis and Risk of B-cell NHL Subtypes Open
Background:To examine the contribution of B-cell activation molecules to B-cell follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), a prospective study was conducted using pre-diagnosis serial serum samples from the US Depa…
View article: Figure 4 from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis
Figure 4 from The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis Open
Forest plots from random-effects meta-analysis of the association between metabolism-related biomarkers and PDAC risk. A, Total cholesterol; B, folate; C, total homocysteine.