Treatment effect
View article: semiparametric doubly-robust quantile treatment effect estimator and empirical data on environmental regulation's impact on corporate digital transformation.
semiparametric doubly-robust quantile treatment effect estimator and empirical data on environmental regulation's impact on corporate digital transformation. Open
The research data encompass simulated data, simulation code, and an empirical dataset. The simulated data generate potential outcomes, observed outcomes, propensity scores, and treatment assignments under three distinct designs. The first …
View article: semiparametric doubly-robust quantile treatment effect estimator and empirical data on environmental regulation's impact on corporate digital transformation.
semiparametric doubly-robust quantile treatment effect estimator and empirical data on environmental regulation's impact on corporate digital transformation. Open
The research data encompass simulated data, simulation code, and an empirical dataset. The simulated data generate potential outcomes, observed outcomes, propensity scores, and treatment assignments under three distinct designs. The first …
View article: Primary treatment of fishery wastewater using chemical and natural coagulants
Primary treatment of fishery wastewater using chemical and natural coagulants Open
View article: Quantifying treatment value under IRA: a case study of rifaximin for the treatment of overt hepatic encephalopathy using QALY and non-QALY measures
Quantifying treatment value under IRA: a case study of rifaximin for the treatment of overt hepatic encephalopathy using QALY and non-QALY measures Open
Rifaximin is a cost-effective treatment for preventing OHE recurrence in adults using QALY and non-QALY health benefit measures.
View article: Treatment effect estimation by comparing observed and predicted outcomes: theory and practical illustration in radiotherapy
Treatment effect estimation by comparing observed and predicted outcomes: theory and practical illustration in radiotherapy Open
Prediction models developed before the introduction of a new treatment may be used to estimate treatment effects of newly introduced treatments. One approach, known as model-based clinical evaluation in radiotherapy, does this by comparing…
View article: Improving the efficiency of drug resistant tuberculosis treatment trials: a time-to-event alternative marker for bacteriological response and adaptive minimization for randomization
Improving the efficiency of drug resistant tuberculosis treatment trials: a time-to-event alternative marker for bacteriological response and adaptive minimization for randomization Open
Background Establishing the efficacy of new treatments for rifampicin-resistant tuberculosis (RR-TB) is challenging due to the long-term clinical endpoints of two-year relapse-free survival. This study aimed to evaluate the effect of an al…
View article: Analysis of the causal effect of fungicide seed treatments on soybean yield in the US Midwest
Analysis of the causal effect of fungicide seed treatments on soybean yield in the US Midwest Open
This repository contains the pre-processed data files and R code necessary to reproduce analyses on the causal effect of fungicide seed treatments on soybean yield in the US Midwest. The focus is on methods to estimate the average treatmen…
View article: Arbitrated Indirect Treatment Comparisons
Arbitrated Indirect Treatment Comparisons Open
Matching-adjusted indirect comparison (MAIC) has been increasingly employed in health technology assessments (HTA). By reweighting subjects from a trial with individual participant data (IPD) to match the covariate summary statistics of an…
View article: Evaluation of Long-Term Outcomes of Enamel Matrix Derivative in the Treatment of Peri-Implant Disease: A Systematic Review and Meta-Analysis
Evaluation of Long-Term Outcomes of Enamel Matrix Derivative in the Treatment of Peri-Implant Disease: A Systematic Review and Meta-Analysis Open
Enamel matrix derivative (EMD) has been proposed as an adjunctive treatment for peri-implantitis, a prevalent complication of dental implants characterized by inflammatory responses and progressive bone loss around the implant site. This s…
View article: Clarifying identification and estimation of treatment effects in the Sequential Parallel Comparison Design
Clarifying identification and estimation of treatment effects in the Sequential Parallel Comparison Design Open
Sequential parallel comparison design (SPCD) clinical trials aim to adjust active treatment effect estimates for placebo response to minimize the impact of placebo responders on the estimates. This is potentially accomplished using a two s…
View article: Cost-Effectiveness of Electrical Stimulation Therapy in the Treatment of Chronic Wounds: A Systematic Review, Meta-Analysis and Economic Analysis
Cost-Effectiveness of Electrical Stimulation Therapy in the Treatment of Chronic Wounds: A Systematic Review, Meta-Analysis and Economic Analysis Open
Hard-to-heal wounds are a major burden to healthcare systems. Electrical stimulation therapy (EST) is known to improve clinical outcomes, but cost-effectiveness analysis is lacking. The aim was to explore the cost-effectiveness of EST with…
View article: Estimation of Multi-Treatment Effects from Observational Data with Application to Diabetes Mellitus [Methods Study], 2014-2021
Estimation of Multi-Treatment Effects from Observational Data with Application to Diabetes Mellitus [Methods Study], 2014-2021 Open
Comparative effectiveness research compares two or more treatments to see which one works best for which patients. But patient traits, such as age or income, may affect patients' treatment choices. These traits may also affect patients' re…
View article: Can we detect treatment effect waning from time-to-event data?
Can we detect treatment effect waning from time-to-event data? Open
Understanding how the causal effect of a treatment evolves over time, including the potential for waning, is important for informed decisions on treatment discontinuation or repetition. For example, waning vaccine protection influences boo…
View article: An Alternative Treatment Effect Measure for Time-to-Event Oncology Randomized Trials
An Alternative Treatment Effect Measure for Time-to-Event Oncology Randomized Trials Open
Background/Objectives: Time-to-event endpoints such as Overall Survival (OS), Progression-Free Survival (PFS), and Event-Free Survival (EFS) are central in phase III oncology trials. Hazard ratios from Cox proportional hazards models and l…
View article: Estimation of Multi-Treatment Effects from Observational Data with Application to Diabetes Mellitus [Methods Study], 2014-2021
Estimation of Multi-Treatment Effects from Observational Data with Application to Diabetes Mellitus [Methods Study], 2014-2021 Open
Comparative effectiveness research compares two or more treatments to see which one works best for which patients. But patient traits, such as age or income, may affect patients' treatment choices. These traits may also affect patients' re…
View article: Can we detect treatment effect waning from time-to-event data?
Can we detect treatment effect waning from time-to-event data? Open
Understanding how the causal effect of a treatment evolves over time, including the potential for waning, is important for informed decisions on treatment discontinuation or repetition. For example, waning vaccine protection influences boo…
View article: Reliable Selection of Heterogeneous Treatment Effect Estimators
Reliable Selection of Heterogeneous Treatment Effect Estimators Open
We study the problem of selecting the best heterogeneous treatment effect (HTE) estimator from a collection of candidates in settings where the treatment effect is fundamentally unobserved. We cast estimator selection as a multiple testing…
View article: Fu’s subcutaneous needling-assisted conservative treatment for distal radius fracture healing: protocol for a randomized controlled trial
Fu’s subcutaneous needling-assisted conservative treatment for distal radius fracture healing: protocol for a randomized controlled trial Open
This study is expected to validate the clinical value of FSN therapy as a safe and effective adjunctive approach for rehabilitation following DRFs, bridging the technical gap between conventional conservative treatment and functional recov…
View article: Reliable Selection of Heterogeneous Treatment Effect Estimators
Reliable Selection of Heterogeneous Treatment Effect Estimators Open
We study the problem of selecting the best heterogeneous treatment effect (HTE) estimator from a collection of candidates in settings where the treatment effect is fundamentally unobserved. We cast estimator selection as a multiple testing…
View article: Corrigendum to ’An electronic nose combined with qualitative-quantitative two-stage hybrid model for wastewater detection in wastewater treatment plants’ [Sens. Actuators B: Chem., 449 (2026) 139115]
Corrigendum to ’An electronic nose combined with qualitative-quantitative two-stage hybrid model for wastewater detection in wastewater treatment plants’ [Sens. Actuators B: Chem., 449 (2026) 139115] Open
View article: A sensitivity analysis for non-inferiority studies with non-randomised data
A sensitivity analysis for non-inferiority studies with non-randomised data Open
Background: Non-inferiority studies based on non-randomised data are increasingly used in clinical research but remain prone to unmeasured confounding. The classical E-value offers a simple way to quantify such bias but has been applied al…
View article: A sensitivity analysis for non-inferiority studies with non-randomised data
A sensitivity analysis for non-inferiority studies with non-randomised data Open
Background: Non-inferiority studies based on non-randomised data are increasingly used in clinical research but remain prone to unmeasured confounding. The classical E-value offers a simple way to quantify such bias but has been applied al…
View article: Impact of statins on short and long term mortality in severe community acquired pneumonia in the intensive care unit
Impact of statins on short and long term mortality in severe community acquired pneumonia in the intensive care unit Open
Severe community-acquired pneumonia (sCAP) carries high mortality. While co-adjuvant therapies remain limited, statins have shown potential benefits. This study simulated a randomised controlled trial (RCT) using real-world data to evaluat…
View article: Estimating treatment effect in randomised controlled trials with continuous outcomes subject to non-compliance: a logistic regression-based multiple imputation approach
Estimating treatment effect in randomised controlled trials with continuous outcomes subject to non-compliance: a logistic regression-based multiple imputation approach Open
Non-compliance in randomised controlled trials poses a significant challenge to accurately estimate treatment effects. Traditional methods of analysis, such as intention-to-treat (ITT) and per-protocol (PP) analyses, are known to have limi…
View article: New Analytic Approach for Valid Comparative Effectiveness Research [Methods Study], United Kingdom, 2015-2020
New Analytic Approach for Valid Comparative Effectiveness Research [Methods Study], United Kingdom, 2015-2020 Open
Comparative effectiveness research compares two or more treatments to see which treatment works better for which patients. Such research may include Randomized controlled trials, or RCTs. Researchers assign patients to a treatment by chanc…
View article: New Analytic Approach for Valid Comparative Effectiveness Research [Methods Study], United Kingdom, 2015-2020
New Analytic Approach for Valid Comparative Effectiveness Research [Methods Study], United Kingdom, 2015-2020 Open
Comparative effectiveness research compares two or more treatments to see which treatment works better for which patients. Such research may include Randomized controlled trials, or RCTs. Researchers assign patients to a treatment by chanc…
View article: A case-controlled cost and clinical outcomes analysis comparing transvaginal radiofrequency conservative treatment of uterine myomas and surgical treatment by myomectomy or hysterectomy in a teaching hospital
A case-controlled cost and clinical outcomes analysis comparing transvaginal radiofrequency conservative treatment of uterine myomas and surgical treatment by myomectomy or hysterectomy in a teaching hospital Open
Radiofrequency ablation emerges as a promising, less invasive alternative to conventional surgery for the first-line treatment of symptomatic uterine fibroids, offering a lower overall cost.
View article: A case of radiation treatment effect mimicking viable, recurrent meningioma on DOTATATE PET imaging
A case of radiation treatment effect mimicking viable, recurrent meningioma on DOTATATE PET imaging Open
View article: Effect of edible coating chitosan and citronella to reduce weight loss and discoloration of banana fruits during storage
Effect of edible coating chitosan and citronella to reduce weight loss and discoloration of banana fruits during storage Open
Citronella (Cymbopogon nardus L.) is a plant that produces essential oil and has an antibacterial activity, which can be applied in post-harvest handling of fruit to extend shelf life. This study aimed to identify the combination of citron…
View article: Feasibility evaluation of flowback and produced water treatment via interfacial solar evaporation: Experimental validation and techno-economic analysis
Feasibility evaluation of flowback and produced water treatment via interfacial solar evaporation: Experimental validation and techno-economic analysis Open