Alanine aminotransferase
View article: Effect of Type 2 Diabetes Mellitus on the Efficacy of Nucleoside (Acid) Analogues in the Treatment of Chronic Hepatitis B
Effect of Type 2 Diabetes Mellitus on the Efficacy of Nucleoside (Acid) Analogues in the Treatment of Chronic Hepatitis B Open
Background Nucleoside (acid) analogues (NAs) have become the primary treatment for chronic hepatitis B (CHB), but the impact of type 2 diabetes (T2DM) on the efficacy was unclear. Objective To identify the effect of T2DM on the efficacy of…
View article: PHARMACOLOGICAL EVALUATION OF BOSWELLIA SERRATA AGAINST ISONIAZID-RIFAMPIN INDUCED HEPATOTOXICITY IN LABORATORY RATS
PHARMACOLOGICAL EVALUATION OF BOSWELLIA SERRATA AGAINST ISONIAZID-RIFAMPIN INDUCED HEPATOTOXICITY IN LABORATORY RATS Open
In laboratory rats, the hepatoprotective effect of Boswellia serrata, a traditional Ayurvedic remedy, against isoniazid-rifampin-induced hepatotoxicity has been assessed. The purpose of the study was to look into how Boswellia serrat…
View article: PHARMACOLOGICAL EVALUATION OF BOSWELLIA SERRATA AGAINST ISONIAZID-RIFAMPIN INDUCED HEPATOTOXICITY IN LABORATORY RATS
PHARMACOLOGICAL EVALUATION OF BOSWELLIA SERRATA AGAINST ISONIAZID-RIFAMPIN INDUCED HEPATOTOXICITY IN LABORATORY RATS Open
In laboratory rats, the hepatoprotective effect of Boswellia serrata, a traditional Ayurvedic remedy, against isoniazid-rifampin-induced hepatotoxicity has been assessed. The purpose of the study was to look into how Boswellia serrata extr…
View article: Changes in Hematobiochemical Parameters with Aging in Afshari Sheep
Changes in Hematobiochemical Parameters with Aging in Afshari Sheep Open
The Afshari sheep, valued for their adaptability and productivity, are vital to Iran's livestock sector, especially in the Mashhad region. This study examines the effects of age on biochemical and hematological parameters in eighteen clini…
View article: Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling
Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling Open
Lead (Pb) toxicity is a global health concern that primarily affects the liver. This study explored the protective effects of lactobacilli against Pb(II)-induced hepatotoxicity in mice. Three strains of lactobacilli— Lacticaseibacillus par…
View article: Supplementary Table S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S1 shows results of univariate analysis for 77 chronically elevated serum alanine aminotransferase (cALT)-defined nonalcoholic fatty liver disease SNPs in the Pancreatic Cancer Cohort Consortium (PanScan) data
View article: Supplementary Table S5 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S5 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S5 shows results of univariate analysis for 77 chronically elevated serum alanine aminotransferase (cALT)-defined nonalcoholic fatty liver disease in the Pancreatic Cancer Case-Control Consortium (PanC4) data
View article: Association Between Left Ventricular Global Longitudinal Strain and Hepatic Inflammation and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease
Association Between Left Ventricular Global Longitudinal Strain and Hepatic Inflammation and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Background/Objectives: Cardiovascular disease is the leading cause of mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), which includes simple steatosis (metabolic dysfunction-associated steatotic …
View article: Fontan‐Associated Liver Disease: Trends Over Time and Relationship With Outcomes
Fontan‐Associated Liver Disease: Trends Over Time and Relationship With Outcomes Open
Background Fontan associated liver disease is a poorly understood complication of long‐term single ventricle palliation. This study sought to describe serial liver function changes in patients with a Fontan circulation from 2014 to 2020 an…
View article: Association between serum uric acid to serum creatinine ratio and in-hospital mortality in patients with severe acute pancreatitis: a retrospective study
Association between serum uric acid to serum creatinine ratio and in-hospital mortality in patients with severe acute pancreatitis: a retrospective study Open
View article: Dietary Azolla meal enhances growth, immune status, and liver health in thin-lip grey mullet (Liza ramada) fingerlings: a sustainable approach to Aquafeed optimization
Dietary Azolla meal enhances growth, immune status, and liver health in thin-lip grey mullet (Liza ramada) fingerlings: a sustainable approach to Aquafeed optimization Open
View article: Gut microbial tyramine facilitates intestinal damage and metabolic dysfunction-associated steatotic liver disease development
Gut microbial tyramine facilitates intestinal damage and metabolic dysfunction-associated steatotic liver disease development Open
View article: Resmetirom for Metabolic Dysfunction-Associated Steatohepatitis: Systematic Review with Meta-Analysis
Resmetirom for Metabolic Dysfunction-Associated Steatohepatitis: Systematic Review with Meta-Analysis Open
Objectives: To evaluate the evidence on the efficacy, safety, and cost-effectiveness of res-metirom for metabolic dysfunction-associated steatohepatitis (MASH). Methods: A syste-matic review with meta-analysis of randomized clinical trials…
View article: A comparative study on the effect of sodium valproate therapy on liver enzyme levels in children with seizure disorder compared to other antiepileptic drugs
A comparative study on the effect of sodium valproate therapy on liver enzyme levels in children with seizure disorder compared to other antiepileptic drugs Open
Background: Sodium valproate is a commonly prescribed antiepileptic drug known for its effectiveness in controlling seizures in pediatric patients but is also associated with concerns over altered liver enzyme levels and rarely hepatotoxic…
View article: Innovative Albuvirtide-Based Combination Regimen in Critically Ill HIV-1-Infected Patients: Evidence of Viral Suppression and Safety Outcomes
Innovative Albuvirtide-Based Combination Regimen in Critically Ill HIV-1-Infected Patients: Evidence of Viral Suppression and Safety Outcomes Open
Background To control HIV-1 viral load, reduce drug resistance, and maintain optimal immune function, albuvirtide (ABT) combined with antiretroviral therapy (ART) is used in designated AIDS hospitals in China. However, the standard weekly …
View article: The impact of semaglutide on liver outcomes in patients with or at risk of MASH: a dose and duration response meta-analysis of randomized trials
The impact of semaglutide on liver outcomes in patients with or at risk of MASH: a dose and duration response meta-analysis of randomized trials Open
Summary Background Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease associated with significant morbidity and mortality, yet management options remain limited. Although glucagon-like peptide-1 receptor…
View article: Clinical efficacy and safety of endoscopic retrograde cholangiopancreatography versus laparoscopic surgery in the management of acute obstructive suppurative cholangitis: A retrospective comparative study
Clinical efficacy and safety of endoscopic retrograde cholangiopancreatography versus laparoscopic surgery in the management of acute obstructive suppurative cholangitis: A retrospective comparative study Open
Introduction: Acute obstructive suppurative cholangitis (AOSC) is a life-threatening biliary tract infection requiring urgent intervention. With the advancement of endoscopic techniques, endoscopic retrograde cholangiopancreatography (ERCP…
View article: ANALYSIS OF TOTAL CHOLESTEROL, BILIRUBIN, AND ALANINE TRANSAMINASE (ALT) IN CHOLELITHIASIS PATIENTS
ANALYSIS OF TOTAL CHOLESTEROL, BILIRUBIN, AND ALANINE TRANSAMINASE (ALT) IN CHOLELITHIASIS PATIENTS Open
View article: Wolfberry prevented liver damage caused by anti-tuberculosis drugs associated with the YAP1/FXR pathway through gut microbiota
Wolfberry prevented liver damage caused by anti-tuberculosis drugs associated with the YAP1/FXR pathway through gut microbiota Open
Background The prevalence of anti-tuberculosis drug-induced liver injury (AT-DILI) is significant, with severe cases potentially leading to liver failure or mortality. Research indicates that first-line anti-tuberculosis drugs (ATDs), incl…
View article: The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies
The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies Open
Background The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rising sharply, driven by modern lifestyle and dietary changes. As MASLD threatens public health, exploring effective treatments is urg…
View article: ANALYSIS OF TOTAL CHOLESTEROL, BILIRUBIN, AND ALANINE TRANSAMINASE (ALT) IN CHOLELITHIASIS PATIENTS
ANALYSIS OF TOTAL CHOLESTEROL, BILIRUBIN, AND ALANINE TRANSAMINASE (ALT) IN CHOLELITHIASIS PATIENTS Open
View article: Evaluation of Serum Alanine Aminotransferase Level in Areca Nut Chewers
Evaluation of Serum Alanine Aminotransferase Level in Areca Nut Chewers Open
Background: Areca nut chewing is a common social tradition in many regions of the world particularly in Southeast Asia. It is one of the addictive substances that have toxic manifestations in immune, hepatic and other defense systems. Obje…
View article: Biochemical Markers of Organ Injury in Animals
Biochemical Markers of Organ Injury in Animals Open
Biochemical markers are crucial tools for assessing the functional integrity of organs in veterinary medicine. Damage to tissues or organs releases specific enzymes and metabolites into circulation, which can be quantified to assess severi…
View article: Dietary curcumin alleviates aflatoxin <scp> B <sub>1</sub> </scp> ‐induced liver injury and improves growth performance in broilers via Nrf2 activation and <scp>NLRP3</scp> inflammasome inhibition
Dietary curcumin alleviates aflatoxin <span> B <sub>1</sub> </span> ‐induced liver injury and improves growth performance in broilers via Nrf2 activation and <span>NLRP3</span> inflammasome inhibition Open
BACKGROUND Aflatoxin B 1 (AFB 1 ), a potent mycotoxin frequently detected in improperly stored poultry feed, induces hepatic oxidative stress, inflammation, and growth retardation in broilers. Curcumin (CUR), a polyphenolic compound derive…
View article: Biochemical Markers of Organ Injury in Animals
Biochemical Markers of Organ Injury in Animals Open
Biochemical markers are crucial tools for assessing the functional integrity of organs in veterinary medicine. Damage to tissues or organs releases specific enzymes and metabolites into circulation, which can be quantified to assess severi…
View article: Effects of Ferrous Nanoparticles of Psidium guajava (Linn.) Leaf on Liver Functions in Male Wistar Rats
Effects of Ferrous Nanoparticles of Psidium guajava (Linn.) Leaf on Liver Functions in Male Wistar Rats Open
This study evaluated the effects of ferrous nanoparticles (FeNPs) derived from Psidium guajava L. leaves on liver function in male Wistar rats. Fresh leaves were harvested from the Government Reservation Area (G.R.A), Wukari, Taraba State,…
View article: Evaluation of portal venous flow velocity before and after direct acting antiviral therapy in chronic hepatitis C: A cohort study
Evaluation of portal venous flow velocity before and after direct acting antiviral therapy in chronic hepatitis C: A cohort study Open
This study aimed to evaluate the changes in portal venous flow velocity before and after direct-acting antiviral (DAA) therapy in patients diagnosed with chronic hepatitis C (CHC). A total of 53 CHC patients (36 males, 17 females; mean age…
View article: Population-Specific Biomarker Dataset for Alcohol Use Disorder in Uzbekistan
Population-Specific Biomarker Dataset for Alcohol Use Disorder in Uzbekistan Open
This dataset contains anonymized hematological, biochemical, anthropometric and clinical data collected from 292 male patients with stage II alcohol use disorder (AUD) and 49 healthy controls in Uzbekistan. The dataset includes two patient…
View article: From weight loss to muscle loss: rhabdomyolysis linked to semaglutide
From weight loss to muscle loss: rhabdomyolysis linked to semaglutide Open
Rhabdomyolysis is a clinical syndrome characterized by the breakdown of skeletal muscle, leading to the release of creatine kinase (CK), myoglobin, and electrolytes into the circulation. This can result in acute kidney injury and other com…
View article: Profile of Patients with Primary Biliary Cholangitis and Evaluation of Response to Ursodeoxycholic Acid in a Romanian Center—Retrospective Study
Profile of Patients with Primary Biliary Cholangitis and Evaluation of Response to Ursodeoxycholic Acid in a Romanian Center—Retrospective Study Open
Background: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease, characterized by cholestasis and fibrosis. Ursodeoxycholic acid (UDCA) is the first-line treatment for normalizing markers, slowing progression, and impro…