Rat model
View article: Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis
Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis Open
Background Current treatments for cirrhosis-a progressive disease marked by fibrosis and inflammation-are limited and non-specific. Jinqiancao granules (JQC), a traditional Chinese medicine used for hepatobiliary diseases, could provide a …
View article: Pressure effects on angiogenesis and tissue proliferation in NPWT-treated wounds
Pressure effects on angiogenesis and tissue proliferation in NPWT-treated wounds Open
Background Negative - pressure wound therapy (NPWT) has shown efficacy in promoting wound healing in clinical settings. The therapeutic effect of NPWT varies with the value of negative pressure. We hypothesized that this might be a result …
View article: [18F]Fluorodeoxyglucose Positron Emission Tomography for diagnosis and monitoring of acute <i>Staphylococcus aureus</i> vascular graft infection in a rat model
[18F]Fluorodeoxyglucose Positron Emission Tomography for diagnosis and monitoring of acute <i>Staphylococcus aureus</i> vascular graft infection in a rat model Open
Objectives Vascular graft or endograft infections (VGEI) pose a detrimental complication when using vascular grafts and are challenging to diagnose and treat. This study examined the progression of infection and the antimicrobial response …
View article: Correction: A pilot study on the effect of severe sleep fragmentation on aorta remodelling, neuroinflammation in a rat model
Correction: A pilot study on the effect of severe sleep fragmentation on aorta remodelling, neuroinflammation in a rat model Open
View article: Low-temperature plasma improves the healing process of Achilles tendinopathy in a rat model
Low-temperature plasma improves the healing process of Achilles tendinopathy in a rat model Open
Background Tendinopathy is a prevalent condition in orthopedics that significantly impairs tendon function. Recently, Low-temperature plasma (LTP) has emerged as an innovative treatment approach, showing promise in reducing inflammation an…
View article: Alternate-Day Fasting Modulates Serum Leptin and SOCS3 Levels and Attenuates Inflammation in an Adult Rat Model of Osteoarthritis
Alternate-Day Fasting Modulates Serum Leptin and SOCS3 Levels and Attenuates Inflammation in an Adult Rat Model of Osteoarthritis Open
Objective: This study investigated the effects of alternate-day fasting (ADF), a nonpharmacological intervention, on inflammation, oxidative stress, and lipid metabolism in adult rats with experimental knee osteoarthritis (KOA), with a par…
View article: Rat models of lactose intolerance: sexually dimorphic comorbidities with neuropsychiatric disorders modulated by tryptophan hydroxylase and the dopaminergic system
Rat models of lactose intolerance: sexually dimorphic comorbidities with neuropsychiatric disorders modulated by tryptophan hydroxylase and the dopaminergic system Open
View article: Kölliker–Fuse/Parabrachial Complex PACAP—Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension
Kölliker–Fuse/Parabrachial Complex PACAP—Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension Open
The calyx of Held is a giant axo-somatic synapse classically confined to the auditory brainstem. We recently identified morphologically similar calyx-like terminals in the extended amygdala (EA) that arise from the ventrolateral parabrachi…
View article: Therapeutic effects of ginseng and its major components on ischaemic stroke in vitro and in silico
Therapeutic effects of ginseng and its major components on ischaemic stroke in vitro and in silico Open
This study elucidates the molecular mechanisms by which ginseng exerts its therapeutic effects on IS. The identification of key active ingredients and their targets offers new insights into the development of effective treatments for IS.
View article: Neuroregenerative effects of cardamonin in a rat model of sciatic nerve crush injury
Neuroregenerative effects of cardamonin in a rat model of sciatic nerve crush injury Open
Cardamonin promotes peripheral nerve regeneration and functional recovery after sciatic nerve crush injury through anti-inflammatory, neurotrophic, and anti-apoptotic effects.
View article: Integrative network pharmacology, transcriptomics, and microbiomics elucidate the therapeutic mechanism of Polygala tenuifolia Willd water extract in chronic obstructive pulmonary disease
Integrative network pharmacology, transcriptomics, and microbiomics elucidate the therapeutic mechanism of Polygala tenuifolia Willd water extract in chronic obstructive pulmonary disease Open
Background Polygala tenuifolia Willd (PT) is a plant with both medicinal and edible values. Traditionally, it has been used for sedation, enhancing cognition, resolving phlegm, and relieving cough. However, its protective effects and mecha…
View article: Correlation between anxiety-depression disorders and brain structural connectivity abnormalities after subarachnoid hemorrhage
Correlation between anxiety-depression disorders and brain structural connectivity abnormalities after subarachnoid hemorrhage Open
BACKGROUND Subarachnoid hemorrhage (SAH) is associated with high incidence of anxiety and depression disorders (27%-54% and 20%-42%, respectively), significantly affecting patient quality of life. However, the pathophysiological mechanisms…
View article: Botulinum Toxin Combined with Robot-Assisted Therapy for Post-Stroke Spasticity: A Systematic Review
Botulinum Toxin Combined with Robot-Assisted Therapy for Post-Stroke Spasticity: A Systematic Review Open
(1) Background: Post-stroke spasticity limits motor recovery and independence. Combining botulinum toxin type-A (BoNT-A) injection with intensive, task-specific robot-assisted therapy (RAT) might enhance neuroplasticity and functional gain…
View article: Quercetin hybrid-hydrogel microparticles modulate gut microbiota and improve memory in an antibiotic-induced dysbiosis rat model
Quercetin hybrid-hydrogel microparticles modulate gut microbiota and improve memory in an antibiotic-induced dysbiosis rat model Open
Gut microbiota plays a pivotal role in maintaining human health and well-being. Antibiotic-induced dysbiosis disrupts microbial balance and diversity leading to compromised physiological functions and adverse health outcomes. The present s…
View article: Role of HMGB1 in ischemia/reperfusion injury in a rat model of myocardial infarction
Role of HMGB1 in ischemia/reperfusion injury in a rat model of myocardial infarction Open
Myocardial infarction (MI) results from the abrupt interruption of coronary blood flow, leading to ischaemia and cardiac tissue necrosis. High mobility group box 1 (HMGB1), a damage-associated molecular pattern, plays a dual role in MI, of…
View article: Therapeutic timing limitations of postnatal darbepoetin in a valproic acid rat model of Autism Spectrum Disorder
Therapeutic timing limitations of postnatal darbepoetin in a valproic acid rat model of Autism Spectrum Disorder Open
Autism spectrum disorder (ASD) arises from complex genetic and environmental factors that disrupt neural development during early brain maturation. Erythropoietin (EPO) has been studied for its neuroprotective effects and more recently for…
View article: Supplementary Table S1 from Chemopreventive Effect of Cinnamon and Its Bioactive Compounds in a Rat Model of Premalignant Prostate Carcinogenesis
Supplementary Table S1 from Chemopreventive Effect of Cinnamon and Its Bioactive Compounds in a Rat Model of Premalignant Prostate Carcinogenesis Open
Supplementary Table S1: Rat primer sequences used for qPCR in prostate tissue of the different groups
View article: 296 NLRP1 activation in a skin model reveals a novel disease-relevant proinflammatory axis
296 NLRP1 activation in a skin model reveals a novel disease-relevant proinflammatory axis Open
View article: Assessment of Capsaicin Liposomes in a Rat Model of Diabetes-induced Peripheral Neuropathy
Assessment of Capsaicin Liposomes in a Rat Model of Diabetes-induced Peripheral Neuropathy Open
Background Diabetic peripheral neuropathy is a major complication arising from diabetes mellitus. It is accelerated by oxidative stress, inflammation, ER stress, and mitochondrial dysfunction. Capsaicin possesses antioxidant, anti-inflamma…
View article: 474 Smart-FAT: an innovative and predictive screening model mimicking cross-talk between human sensory neurons and adipocyte progenitors
474 Smart-FAT: an innovative and predictive screening model mimicking cross-talk between human sensory neurons and adipocyte progenitors Open
View article: Supplementary Table S2 from Chemopreventive Effect of Cinnamon and Its Bioactive Compounds in a Rat Model of Premalignant Prostate Carcinogenesis
Supplementary Table S2 from Chemopreventive Effect of Cinnamon and Its Bioactive Compounds in a Rat Model of Premalignant Prostate Carcinogenesis Open
Supplementary Table S2: Hematological and bone related parameters in the different groups of rats
View article: Neuroprotective effects of ceftriaxone after severe traumatic brain injury in male rats: a behavioral, biochemical, and histological study
Neuroprotective effects of ceftriaxone after severe traumatic brain injury in male rats: a behavioral, biochemical, and histological study Open
Background: Only a limited number of animal studies have demonstrated the neuroprotective effects of single dose of ceftriaxone (CTX) in traumatic brain injury (TBI). Consequently, the present study seeks to fill these research gaps by exa…
View article: Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats
Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats Open
Day and night neurobehavioral tests were performed for Spontaneously Hypertensive rats (SHR) and Wistar Kyoto rats (WKY) to establish an optimal testing window. Also, blood–brain barrier (BBB) integrity in brain areas related to cognition …
View article: New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems
New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems Open
As the leading cause of maternal mortality, the pathogenesis of postpartum hemorrhage (PPH), with 60%–70% cases of uterine atony, remains unclear due to a fundamental lack of animal models for studying. Our study develops a novel placenta‐…
View article: Astragaloside IV-preconditioned neural stem cell transplantation promotes neurogenesis and functional recovery via the miR-199a-5p/Caveolin-1 pathway in a rat model of ischemic stroke
Astragaloside IV-preconditioned neural stem cell transplantation promotes neurogenesis and functional recovery via the miR-199a-5p/Caveolin-1 pathway in a rat model of ischemic stroke Open
View article: L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model
L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model Open
View article: CORRECTION OF HISTOLOGICAL CHANGES IN RAT LIVER TISSUE UNDER THE INFLUENCE OF NaNO2 UNDER THE INFLUENCE OF PROVIDIN
CORRECTION OF HISTOLOGICAL CHANGES IN RAT LIVER TISSUE UNDER THE INFLUENCE OF NaNO2 UNDER THE INFLUENCE OF PROVIDIN Open
This article examined the corrective effects of providin substance on histological changes in rat liver tissue caused by NaNO2. In experiments, provodin was found to have a corrective effect on deformational changes in liver tissue and cel…
View article: Corrigendum: Survivin (BIRC5) regulates bladder fibrosis in a rat model of partial bladder outlet obstruction
Corrigendum: Survivin (BIRC5) regulates bladder fibrosis in a rat model of partial bladder outlet obstruction Open
View article: Evaluating the evidence for dietary nitrate to impact skeletal muscle blood flow in a rat model of pulmonary hypertension
Evaluating the evidence for dietary nitrate to impact skeletal muscle blood flow in a rat model of pulmonary hypertension Open
View article: Vitamin D3 ameliorates inflammation and autonomic dysfunction in a rat model of reflux esophagitis via modulation of IL-6 and TNF-α
Vitamin D3 ameliorates inflammation and autonomic dysfunction in a rat model of reflux esophagitis via modulation of IL-6 and TNF-α Open
Gastroesophageal reflux disease (GERD) and its manifestation as reflux esophagitis (RE) involves mucosal inflammation and autonomic dysfunction. Vitamin D3 deficiency is increasingly implicated in gastrointestinal inflammation and immune i…