Cocaine use
View article: Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report
Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report Open
Background: Cocaine is a potent psychostimulant known to precipitate acute psychiatric manifestations, including manic or psychotic episodes. Hematological complications are rare but increasingly described, particularly thrombocytopenia as…
View article: Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report
Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report Open
Background: Cocaine is a potent psychostimulant known to precipitate acute psychiatric manifestations, including manic or psychotic episodes. Hematological complications are rare but increasingly described, particularly …
View article: Impacts of Disruptive Events on Addictive Behavioral Patterns: A Cross‐Sectional Study of Methadone Maintenance Therapy During the COVID‐19 Pandemic in Iran
Impacts of Disruptive Events on Addictive Behavioral Patterns: A Cross‐Sectional Study of Methadone Maintenance Therapy During the COVID‐19 Pandemic in Iran Open
Background and Aims The COVID‐19 pandemic disrupted healthcare delivery and posed challenges for addiction treatment, particularly methadone maintenance therapy (MMT). This study examined changes in methadone use, behavioral patterns, and …
View article: Acute Cocaine Intoxication Leading to Multiorgan Dysfunction: A Case Report on Concealed Cocaine Use
Acute Cocaine Intoxication Leading to Multiorgan Dysfunction: A Case Report on Concealed Cocaine Use Open
View article: What are the pathophysiological mechanisms by which cocaine use can lead to chest pain?
What are the pathophysiological mechanisms by which cocaine use can lead to chest pain? Open
Cocaine use can lead to chest pain through mechanisms like coronary vasospasm, increased myocardial demand, and direct cardiotoxicity, often resulting in myocardial ischemia and infarction.
View article: What are the pathophysiological mechanisms by which cocaine use can lead to chest pain?
What are the pathophysiological mechanisms by which cocaine use can lead to chest pain? Open
Cocaine use can lead to chest pain through mechanisms like coronary vasospasm, increased myocardial demand, and direct cardiotoxicity, often resulting in myocardial ischemia and infarction.
View article: What are the physiological mechanisms by which cocaine use leads to chest pain?
What are the physiological mechanisms by which cocaine use leads to chest pain? Open
Cocaine use induces chest pain primarily through sympathetic stimulation, coronary vasospasm, increased myocardial demand, and arrhythmogenic effects, compounded by oxidative stress and structural heart changes.
View article: Examining predictors of substance use and treatment adequacy among formerly incarcerated individuals with a history of opioid and cocaine use: research protocol
Examining predictors of substance use and treatment adequacy among formerly incarcerated individuals with a history of opioid and cocaine use: research protocol Open
The proposed research will identify substance use treatment gaps and influential factors that are amenable to intervention in the interest of informing effective responses to the current opioid crisis.
View article: What are the physiological mechanisms by which cocaine use leads to chest pain?
What are the physiological mechanisms by which cocaine use leads to chest pain? Open
Cocaine use induces chest pain primarily through sympathetic stimulation, coronary vasospasm, increased myocardial demand, and arrhythmogenic effects, compounded by oxidative stress and structural heart changes.
View article: Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report
Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report Open
Background: Cocaine is a potent psychostimulant known to precipitate acute psychiatric manifestations, including manic or psychotic episodes. Hematological complications are rare but increasingly described, particularly thrombocytopenia as…
View article: Subtypes of cocaine use disorder and their neurobehavioral profiles
Subtypes of cocaine use disorder and their neurobehavioral profiles Open
Cocaine Use Disorder (CUD) afflicts over 1.4 million individuals in the United States alone. However, current treatments are largely ineffective, with up to 85% returning to use long-term. We posit that addressing functional heterogeneity …
View article: Concurrent Alcohol and Marijuana Use Patterns Among High School Seniors in the United States
Concurrent Alcohol and Marijuana Use Patterns Among High School Seniors in the United States Open
Concurrent alcohol and marijuana use is common. Knowledge about whether adolescents differ in use frequency across single vs. concurrent use is limited. This study examined past 30-day use patterns by frequency (frequent [20+ occasions] vs…
View article: Prenatal Cocaine Exposure, Perinatal Risks, and Mediators to Preadolescent Attention Deficit Hyperactivity Disorder (ADHD)
Prenatal Cocaine Exposure, Perinatal Risks, and Mediators to Preadolescent Attention Deficit Hyperactivity Disorder (ADHD) Open
Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral problem in children. Multiple risk factors, including prenatal substance exposure, have been associated with this disorder. Objectives: We determined (1) the rat…
View article: Cannabis in road traffic – a retrospective analysis to identify possible cut-off-values
Cannabis in road traffic – a retrospective analysis to identify possible cut-off-values Open
In light of the recent partial legalization of cannabis in Germany and the associated adjustment of the legal threshold for THC serum concentration from 1 ng/ml to 3.5 ng/ml, we investigated whether a specific THC serum concentration or ca…
View article: Quality-of-life improvements associated with reductions in cocaine-positive urine drug screens.
Quality-of-life improvements associated with reductions in cocaine-positive urine drug screens. Open
These findings indicate that reducing cocaine use improves quality-of-life outcomes in people with cocaine use disorder. These results also extend prior research on more robust health improvements that emerge when participants attain 75% n…
View article: Cocaine seeking and consumption are oppositely regulated by mesolimbic dopamine in male rats
Cocaine seeking and consumption are oppositely regulated by mesolimbic dopamine in male rats Open
View article: Chemical profiling of cocaine using portable spectroscopic techniques: Towards timely illicit drug intelligence
Chemical profiling of cocaine using portable spectroscopic techniques: Towards timely illicit drug intelligence Open
View article: Combining ethanol and cocaine exposure during adolescence increased cocaine reward sensitivity in adult rats as evaluated by a single exposure place preference paradigm
Combining ethanol and cocaine exposure during adolescence increased cocaine reward sensitivity in adult rats as evaluated by a single exposure place preference paradigm Open
There is an urgent need for better understanding the long-term impact of polysubstance use initiation during adolescence. Our preclinical study examined the combined impact of ethanol and cocaine during a vulnerable window in adolescence o…
View article: Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis
Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis Open
Trajectories of craving/drug use in clinical trials for cocaine use disorder are heterogeneous. Participants experiencing the greatest reduction in cocaine craving/use experienced the greatest improvement in other measures of drug use and …
View article: Associations Between Self-Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices
Associations Between Self-Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices Open
In forensic toxicology, it has been debated if hair testing allows an estimation of the intensity of cocaine use—an assumption that may have risen because self-reports in a forensic setting are of uncertain validity per se. We therefore in…
View article: Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study
Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study Open
View article: Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis Open
We report two cases of cocaine-associated dermatoses: pyoderma gangrenosum and linear IgA bullous dermatosis. These cases highlight the importance of considering less common associations with drug use in the development of certain dermatos…
View article: CHANTER syndrome in a cocaine positive patient
CHANTER syndrome in a cocaine positive patient Open
CHANTER syndrome is a rare pattern of neurotoxicity characterized by restricted diffusion on magnetic resonance imaging in the cerebellum, hippocampi, and basal nuclei in a severe and symmetrical pattern. Multiple case studies have explore…
View article: Cocaine use during pregnancy and its relationship with eclampsia: an interdisciplinary approach
Cocaine use during pregnancy and its relationship with eclampsia: an interdisciplinary approach Open
In Argentina, the prevalence of cocaine use among pregnant women varied according to the studies carried out and the methodologies applied. The detection of these cases was probably underestimated due to the social stigma and the lack of a…
View article: Impact of coca leaf flour candy consumption on cocaine and benzoylecgonine levels: The role of hygrine and cuscohygrine in distinguishing licit from illicit cocaine use
Impact of coca leaf flour candy consumption on cocaine and benzoylecgonine levels: The role of hygrine and cuscohygrine in distinguishing licit from illicit cocaine use Open
The consumption of coca leaf products, a traditional practice in several Latin American countries, raises forensic challenges in distinguishing legal consumption from illicit cocaine use. This study investigates the implications of consumi…
View article: The Unsolved Problem of Attrition Rates on Randomized Clinical Trials for Cocaine Use Disorders: A Scoping Review
The Unsolved Problem of Attrition Rates on Randomized Clinical Trials for Cocaine Use Disorders: A Scoping Review Open
Background: Cocaine use disorder (CUD) is a significant and insufficiently studied public health issue, especially considering that the global prevalence of CUD is estimated to be higher than ever. There is still no consensus on effective …
View article: Cocaine-Induced Cardiac Alterations: Histological and Immunohistochemical Post-Mortem Analysis
Cocaine-Induced Cardiac Alterations: Histological and Immunohistochemical Post-Mortem Analysis Open
Background: Cocaine abuse represents a serious health issue. The cardiovascular system is one of the main sites on which cocaine elicits its toxicity, as indicated by deadly events mainly related to myocardial infarction. The main aim of t…
View article: Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study
Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study Open
Background: Increased cocaine supply has coincided with increased global cocaine use. In 2019 Ireland had one of the highest last-year rates of cocaine use in Europe. However, there is a lack of data on the health-related impacts of cocain…
View article: Misdiagnosis of ANCA-associated vasculitis in patients with cocaine/levamisole –associated autoimmune syndrome and Cocaine-Induced Midline Destructive Lesions: A case series.
Misdiagnosis of ANCA-associated vasculitis in patients with cocaine/levamisole –associated autoimmune syndrome and Cocaine-Induced Midline Destructive Lesions: A case series. Open
View article: Bilateral globi pallidi infarctions from opioid and cocaine use
Bilateral globi pallidi infarctions from opioid and cocaine use Open
The globi pallidi (GP) are paired structures present in the basal ganglia of the brain. Their primary function is to regulate motor movement. Due to their high metabolic activity, the GP are highly susceptible to injury from hypoxia and ot…