Threshold of pain
View article: Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons
Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons Open
Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upre…
View article: Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence
Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence Open
Introduction Neonatal intensive care units (NICUs) provide life-saving care for preterm and sick neonates, but many medical procedures are painful and stress-inducing. Even a routine NICU procedure, such as the “heel lancing” blood-draw pr…
View article: EXPRESS: Exploring circRNA_19601 as a therapeutic target in diabetic neuropathic pain: insights from rat and cell models
EXPRESS: Exploring circRNA_19601 as a therapeutic target in diabetic neuropathic pain: insights from rat and cell models Open
Background: Diabetic neuropathic pain (DNP) is a common complication of diabetes with significant impact on patients' quality of life. Current treatments have limitations, and exploring new mechanisms and targets is crucial. Objective: Our…
View article: Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials
Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials Open
Sensorimotor synchronization to music, referring to the temporal alignment of movement with auditory rhythms, has been associated with immersive engagement and enhanced pleasure. In the present study, we investigated its analgesic effects …
View article: Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome
Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Open
Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to PCS. Quantitative s…
View article: Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing
Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing Open
This study investigated the effects of experimentally induced acute pain on body image and sensory testing. A total of 91 pain-free participants were randomly assigned to 1 of 3 groups: injection (pain), sham injection, or control. Measure…
View article: Threshold-Anchored Mechanomyography Metrics for Patient Stratification in Spinal Decompression: Associations with Early Pain Outcomes
Threshold-Anchored Mechanomyography Metrics for Patient Stratification in Spinal Decompression: Associations with Early Pain Outcomes Open
Background/Objectives: Spinal decompression surgery shows variable outcomes, with reoperation rates up to 37.5%. Surgeons lack objective intraoperative tools to assess decompression adequacy. Mechanomyography (MMG) measures nerve excitabil…
View article: Short-term effect after soft tissue manipulation session on subjective and objective parameters in office workers with chronic low back pain: A randomized clinical trial
Short-term effect after soft tissue manipulation session on subjective and objective parameters in office workers with chronic low back pain: A randomized clinical trial Open
Background The very frequent occurrence of low back pain (LBP) among office workers forces the search for effective therapeutic tools. The aim of this study was to assess the effectiveness of soft tissue manipulation (Deep Tissue Massage –…
View article: Exploratory Pain Profiling With Quantitative Sensory Testing ( <scp>QST</scp> ) in Episodic and Chronic Migraine
Exploratory Pain Profiling With Quantitative Sensory Testing ( <span>QST</span> ) in Episodic and Chronic Migraine Open
Background Migraine pain profiling studies vary by sensory modalities, methods, anatomical sites and characteristics. This exploratory study aimed to identify pain profiling parameters using quantitative sensory testing (QST) for episodic …
View article: GsMTx-4 reduces mechanical allodynia in a model of schwannomatosis-related pain
GsMTx-4 reduces mechanical allodynia in a model of schwannomatosis-related pain Open
View article: Controllability changes pain perception by increasing the precision of expectations
Controllability changes pain perception by increasing the precision of expectations Open
The ability to exert control over an intensely unpleasant experience, such as pain, can modulate its perception. It is often assumed that control exerts this modulatory effect through a specific control mechanism. We revisit this issue usi…
View article: Sex‐dependent effects of alcohol intake on pain‐related functional activation
Sex‐dependent effects of alcohol intake on pain‐related functional activation Open
Background Alcohol analgesia (AA) is a well‐established phenomenon and important motivator of pain self‐medication with alcohol. Alcohol intoxication produces widespread alterations in many brain areas involved in pain processing. Sex and …
View article: PIL012_Auswertung_Schmerzevaluierung_Piritramid_LZ_05-2024.xlsx
PIL012_Auswertung_Schmerzevaluierung_Piritramid_LZ_05-2024.xlsx Open
Data concerning the following project/manuscript: Oral Self-Administration of Piritramide in C57BL/6JRj Mice Following Laparotomy: Cage-Side Pain Assessment Evaluation Lena Zachhuber, Claudia Kuntner, Thomas Wanek, Aylina Glasenapp, Marion…
View article: Impact of repeated exposure to CPM on CPM efficiency and pain sensitivity in healthy adults: a randomized controlled trial
Impact of repeated exposure to CPM on CPM efficiency and pain sensitivity in healthy adults: a randomized controlled trial Open
Conditioned pain modulation (CPM) is a behavioral measure of diffuse noxious inhibitory control (DNIC), an endogenous central pain modulatory mechanism in which one pain stimulus suppresses the perception of another. CPM efficiency is redu…
View article: Trauma and psychological impact in fibromyalgia and other central sensitization syndromes: the role of anxiety and pain acceptance
Trauma and psychological impact in fibromyalgia and other central sensitization syndromes: the role of anxiety and pain acceptance Open
View article: Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis Open
Protectin DX (PDX) is a member of the superfamily of specialized pro-resolving mediators (SPMs) and exerts anti-inflammatory actions in animal models; but the specific signaling pathways involved in its actions have not been fully elucidat…
View article: Pathophysiology of subacromial pain syndrome: contributions of rotator cuff-related factors and pain sensitization
Pathophysiology of subacromial pain syndrome: contributions of rotator cuff-related factors and pain sensitization Open
Introduction: Subacromial pain syndrome (SAPS) is complex and multifactorial condition traditionally attributed to structural abnormalities such as rotator cuff tears and tendinopathy. However, pain severity in SAPS cannot be fully explain…
View article: Macrophage-derived small extracellular vesicles as a therapeutic for postoperative pain and inflammation 9004
Macrophage-derived small extracellular vesicles as a therapeutic for postoperative pain and inflammation 9004 Open
Description Surgeries induce post-operative pain that must be alleviated to limit suffering and promote recovery. Post-operative pain is not effectively managed in > 80% of patients in the US. Opioids are the standard of care for periop…
View article: Homer1a inhibits caspase-6 signaling to attenuate inflammatory pain in the spinal dorsal horn
Homer1a inhibits caspase-6 signaling to attenuate inflammatory pain in the spinal dorsal horn Open
Objective This study aimed to investigate the effect of Homer1a on caspase-6/tumor necrosis factor-alpha signaling pathway in an inflammatory pain model. We sought to determine whether Homer1a could alleviate nociceptive hypersensitivity b…
View article: Adult Attachment Is Not Associated With Conditioned Pain Modulation in Healthy Females in a Neutral Social Context
Adult Attachment Is Not Associated With Conditioned Pain Modulation in Healthy Females in a Neutral Social Context Open
Background Individuals with chronic pain are both more likely to have an insecure adult attachment style and impaired conditioned pain modulation (CPM) than pain‐free individuals. This study investigated whether impaired CPM is seen in pai…
View article: Depression Enhances Visceral Pain and Alters Behavioral Patterns in Chronic Pancreatitis Mice: An Objective Evaluation
Depression Enhances Visceral Pain and Alters Behavioral Patterns in Chronic Pancreatitis Mice: An Objective Evaluation Open
Chronic pancreatitis (CP) is frequently associated with persistent visceral pain, which significantly impairs patients' quality of life. Depression, a prevalent comorbidity of chronic visceral pain, has been implicated as a potential risk …
View article: Effect of Combined Local-Point Electroacupuncture and Auricular Acupuncture Therapy on Pain Scale and Straight Leg Raise (SLR) Changes in Farmers with Radiating Low Back Pain at the Healthy Family Independent Acupuncture Practice, Kepahiang, Bengkulu
Effect of Combined Local-Point Electroacupuncture and Auricular Acupuncture Therapy on Pain Scale and Straight Leg Raise (SLR) Changes in Farmers with Radiating Low Back Pain at the Healthy Family Independent Acupuncture Practice, Kepahiang, Bengkulu Open
Low back pain radiating to the legs, or radiculopathy, is a condition that involves multiple nerve roots, resulting in pain as well as motor and sensory disturbances. Electroacupuncture and auricular acupuncture are known to reduce pro-inf…
View article: Pain is inevitable, suffering is optional: The effect of stress on pain tolerance
Pain is inevitable, suffering is optional: The effect of stress on pain tolerance Open
Stress and pain tolerance are known to have a causal and even a circular causality relationship. However, current evidence shows contradictory results. Researchers believe that stress could reduce pain tolerance, yet others believe the opp…
View article: Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia
Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia Open
Fibromyalgia syndrome (FM) is characterized by widespread pain and fatigue. People living with FM also experience tactile allodynia, cold-evoked pain, paraesthesia and dysaesthesia. There is evidence of small fibre neuropathy and hyperexci…
View article: Influence of Pre-Existing Pain on the Body’s Response to External Pain Stimuli: Experimental Study
Influence of Pre-Existing Pain on the Body’s Response to External Pain Stimuli: Experimental Study Open
Background Accurately assessing pain severity is essential for effective pain treatment and desirable patient outcomes. In clinical settings, pain intensity assessment relies on self-reporting methods, which are subjective to individuals a…
View article: The effect of over-the-counter analgesics on changes to the sensory sensitivity of patients treated with transcutaneous electrical nerve stimulation
The effect of over-the-counter analgesics on changes to the sensory sensitivity of patients treated with transcutaneous electrical nerve stimulation Open
View article: Reliability of the use of foot pressure pain threshold in adults: a test-retest analysis
Reliability of the use of foot pressure pain threshold in adults: a test-retest analysis Open
Background Foot pain is very common, affecting 24% of the adult population over 45 years old. Mechanical stimulation devices, such as pressure algometers, are used for the precise and objective quantification of the pain threshold (minimum…
View article: Sex differences in the relationship between pain and autonomic outflow during a cold pressor test
Sex differences in the relationship between pain and autonomic outflow during a cold pressor test Open
Background Chronic pain is partly maintained by the sympathetic nervous system, whose activity is best measured by muscle sympathetic nerve activity (MSNA). MSNA responses to acute pain have been thoroughly investigated, whereas MSNA respo…
View article: Effect of virtual walk in green or urban spaces on pain perception among healthy adults
Effect of virtual walk in green or urban spaces on pain perception among healthy adults Open
Humans are deeply rooted in the natural environment. Contact with a green natural environment can affect pain perception. There are indications that a virtual analog of the natural environment may have a beneficial effect on pain perceptio…
View article: Anti-nociceptive properties of cardiopulmonary baroreceptors in patients with chronic back pain
Anti-nociceptive properties of cardiopulmonary baroreceptors in patients with chronic back pain Open
Introduction Reduced pain perception following a persistent noxious stimulus during a study session (short-term habituation) is believed to be partially mediated by descending inhibitory mechanisms, although these mechanisms have not been …