Lipid metabolism
View article: Endometrium metabolomic profiling in implantation disorders points to a disruption of fatty acids metabolism in unexplained recurrent pregnancy loss
Endometrium metabolomic profiling in implantation disorders points to a disruption of fatty acids metabolism in unexplained recurrent pregnancy loss Open
View article: Supplementary Table 4 from LncRNA-Encoded Micropeptide ACLY-BP Drives Lipid Deposition and Cell Proliferation in Clear Cell Renal Cell Carcinoma via Maintenance of ACLY Acetylation
Supplementary Table 4 from LncRNA-Encoded Micropeptide ACLY-BP Drives Lipid Deposition and Cell Proliferation in Clear Cell Renal Cell Carcinoma via Maintenance of ACLY Acetylation Open
Sequences of shRNAs and siRNAs used in this study
View article: Supplementary Figure S6 from A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
Supplementary Figure S6 from A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells Open
Supplementary Figure S6 shows IHC staining for 4-HNE in SUM159PT tumors, demonstrating that co-targeting CAIX/XII activity and GSH synthesis increases lipid peroxidation in vivo.
View article: Figure S2 from JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer
Figure S2 from JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer Open
JMJD6 regulates lipid metabolism in MCF7 cells. A) Immunohistochemistry staining for ANXA1 (brown) combined with Oil red-O staining (pink) for lipid droplets visualization in wild-type MCF7 cells B) Gene set enrichment plot for 'Hallmark o…
View article: Ferroptosis in Human Diseases: Fundamental Roles and Emerging Therapeutic Perspectives
Ferroptosis in Human Diseases: Fundamental Roles and Emerging Therapeutic Perspectives Open
Ferroptosis is a novel iron-sensitive subtype of regulated cell death (RCD), persisting under extreme lipid peroxidation and iron/redox imbalances. Unlike apoptosis, necroptosis, and pyroptosis, ferroptosis is a signaling-driven process me…
View article: Random Forest-Assisted Widely Targeted Lipidomic Reveals Differences in Tan Lamb Meat Quality in Different Regions
Random Forest-Assisted Widely Targeted Lipidomic Reveals Differences in Tan Lamb Meat Quality in Different Regions Open
This study aims to elucidate the quality differences among Tan lamb from three major production regions and investigate the influence and regulation of lipids on regional sheep meat quality. The Ningxia Tan lamb exhibited higher pH values,…
View article: Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets
Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets Open
View article: Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified by 1H‑NMR metabolomics in obesity-matched African‑American children and young adults
Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified by 1H‑NMR metabolomics in obesity-matched African‑American children and young adults Open
View article: <b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b>
<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Impact of betaine on laying hens’ productive and physiological reactions at the late stage of production
Impact of betaine on laying hens’ productive and physiological reactions at the late stage of production Open
Introduction Due to the anti-inflammatory, antioxidant, and antibacterial properties of betaine, it may serve as a beneficial feed supplement for laying hens. This research aimed to evaluate whether betaine enhances the productive, reprodu…
View article: The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review
The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review Open
Background High fructose corn syrup (HFCS) is a dietary sweetener that is used in a substantial portion of food and beverages. Recent evidence has cited dietary HFCS as a risk factor in the development of obesity, metabolic syndrome, and l…
View article: Historical overview of lipid biochemistry research: from initial hypotheses to understanding the biological role of N-acylethanolamines
Historical overview of lipid biochemistry research: from initial hypotheses to understanding the biological role of N-acylethanolamines Open
In the Department of Lipid Biochemistry at the Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, a systematic approach to studying the functional role of lipids and investigating the lipidome of mammals and…
View article: Dietary fiber modulates gut microbiota and lipid metabolism ameliorating Alzheimer’s pathology in 5xFAD mice
Dietary fiber modulates gut microbiota and lipid metabolism ameliorating Alzheimer’s pathology in 5xFAD mice Open
View article: Association between KCNC1 gene polymorphism and blood lipid levels in determining the efficacy of high-intensity interval training
Association between KCNC1 gene polymorphism and blood lipid levels in determining the efficacy of high-intensity interval training Open
Objective: The potassium voltage-gated channel subfamily C member 1 (KCNC1) gene plays a crucial role in both neural excitability and lipid metabolism. However, the impact of its genetic polymorphisms on individual blood lipid levels and t…
View article: Optimal Dietary α-Starch Requirement and Its Effects on Growth and Metabolic Regulation in Chinese Hook Snout Carp (Opsariichthys bidens)
Optimal Dietary α-Starch Requirement and Its Effects on Growth and Metabolic Regulation in Chinese Hook Snout Carp (Opsariichthys bidens) Open
This study investigated the effects of dietary carbohydrate levels on growth performance, body composition, and hepatic expression of metabolic genes in Chinese hook snout carp (Opsariichthys bidens). Fish were fed five isonitrogenous diet…
View article: Mesenchymal stem cells alleviate pulmonary fibrosis and gut microbiota dysbiosis in systemic sclerosis
Mesenchymal stem cells alleviate pulmonary fibrosis and gut microbiota dysbiosis in systemic sclerosis Open
Introduction Mesenchymal stem cells (MSCs) have shown the potential to alleviate systemic sclerosis (SSc) tissue fibrosis. However, our knowledge of the effects of MSCs on gut microbiota remains limited. Methods In this study, we employed …
View article: Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets
Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets Open
Lipid metabolism and lipid-derived signaling together ensure cellular and systemic homeostasis. Their dysregulation causes obesity, type 2 diabetes, cardiovascular disease, NAFLD/MASH, and neurodegeneration throughout life. This review int…
View article: The Effect of Lipid Extract of Nannochloropsis oceanica Marine Microalgae on Glutathione and Thioredoxin-Dependent Antioxidant Systems in UVB-Irradiated Keratinocytes
The Effect of Lipid Extract of Nannochloropsis oceanica Marine Microalgae on Glutathione and Thioredoxin-Dependent Antioxidant Systems in UVB-Irradiated Keratinocytes Open
UVB radiation present in sunlight is the main pro-oxidative and pro-inflammatory factor that reaches human skin cells, including keratinocytes. Therefore, protective compounds eliminating the negative impact of UVB radiation are constantly…
View article: The impact of sublethal antimicrobial blue light on lipidomic changes of Escherichia coli and Salmonella Typhimurium
The impact of sublethal antimicrobial blue light on lipidomic changes of Escherichia coli and Salmonella Typhimurium Open
Antimicrobial blue light (aBL) is an effective non-thermal disinfection method against foodborne bacterial pathogens. While aBL-induced oxidative stress is known to cause cell membrane damage, its specific effects on bacterial lipid compos…
View article: FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation
FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation Open
View article: The molecular interplay among gut dysbiosis, adipose tissue, and metabolite-derived damage-associated molecular patterns in metainflammation and atherogenesis
The molecular interplay among gut dysbiosis, adipose tissue, and metabolite-derived damage-associated molecular patterns in metainflammation and atherogenesis Open
Metainflammation is a low-grade systemic inflammatory response that can persist for months or even years, during which monocytes, macrophages, and other immune cells become hyperactivated, contributing to metabolic disease and atherogenesi…
View article: Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice
Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: ATG2 is a triglyceride transfer protein
ATG2 is a triglyceride transfer protein Open
Bridge-like lipid transfer proteins (BLTPs) are established to function in phospholipid transport between bilayers at organelle–organelle contact sites. However, the BLTP ATG2A also associates with lipid droplets in cells, which present a …
View article: Ferroptosis in Neonatal Hypoxic-Ischemic Encephalopathy: Mechanisms and the Therapeutic Potential of Vitamin D/VDR Signaling
Ferroptosis in Neonatal Hypoxic-Ischemic Encephalopathy: Mechanisms and the Therapeutic Potential of Vitamin D/VDR Signaling Open
As a major neonatal brain disorder, hypoxic-ischemic encephalopathy(HIE) presents with elevated risks of long-term disability and neonatal death. Ferroptosis is a distinct mode of regulated cell death marked by excess intracellular iron, o…
View article: <b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b>
<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Alternate-Day Fasting Modulates Serum Leptin and SOCS3 Levels and Attenuates Inflammation in an Adult Rat Model of Osteoarthritis
Alternate-Day Fasting Modulates Serum Leptin and SOCS3 Levels and Attenuates Inflammation in an Adult Rat Model of Osteoarthritis Open
Objective: This study investigated the effects of alternate-day fasting (ADF), a nonpharmacological intervention, on inflammation, oxidative stress, and lipid metabolism in adult rats with experimental knee osteoarthritis (KOA), with a par…
View article: Natural products intervene in non-alcoholic fatty liver disease by regulating the AMPK signaling pathway: preclinical evidence and mechanism
Natural products intervene in non-alcoholic fatty liver disease by regulating the AMPK signaling pathway: preclinical evidence and mechanism Open
Non-alcoholic fatty liver disease (NAFLD) is characterized by core pathological features such as hepatic lipid accumulation, oxidative stress, and inflammatory responses. Its pathogenesis is closely associated with dysregulated energy meta…
View article: Biochemical Insights into Lipid Remodeling in Wheat Anthers Under High-Temperature Stress
Biochemical Insights into Lipid Remodeling in Wheat Anthers Under High-Temperature Stress Open
High-temperature (HT) stress during flowering significantly impairs anther development and pollen fertility, leading to substantial yield loss in wheat. A key aspect of plant adaptation to temperature stress concerns remodeling of lipid me…
View article: Phytosphingosine contributes gut microbiota metabolism to alleviate low-grade endotoxemia-induced mastitis
Phytosphingosine contributes gut microbiota metabolism to alleviate low-grade endotoxemia-induced mastitis Open
View article: Aberrant lipid metabolism renders an aggressive behavior of T-lymphoblastic lymphoma in a MASH model
Aberrant lipid metabolism renders an aggressive behavior of T-lymphoblastic lymphoma in a MASH model Open