Reactive oxygen species
View article: Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer
Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer Open
View article: Comparative Analysis of Oxidative Stress Induced by Chemical and Surgical Castration in Male Dogs
Comparative Analysis of Oxidative Stress Induced by Chemical and Surgical Castration in Male Dogs Open
This study was conducted to investigate the effects of chemical and surgical castration on oxidative stress in male dogs. A total of ten healthy male dogs, aged between 1 and 3 years, were assigned to two distinct groups: Group Surg underw…
View article: Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury
Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury Open
Dopaminergic neurodegeneration is associated with oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell death. Allopregnanolone, a multifunctional neurosteroid, is involved in various biological processes within the body…
View article: Supplemental Figure 8 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Supplemental Figure 8 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells Open
S8. Mitochondrial uncoupling inhibits proliferation upon anchorage-independent growth.
View article: Supplemental Figure 1 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Supplemental Figure 1 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells Open
S1. Mitochondrial uncoupler NEN increases cellular NAD+/NADH ratio and inhibits reductive carboxylation.
View article: Resveratrol Attenuates Cisplatin-Induced Oxidative Stress: Combined Effects in MDA-MB-231 Breast Cancer Cells
Resveratrol Attenuates Cisplatin-Induced Oxidative Stress: Combined Effects in MDA-MB-231 Breast Cancer Cells Open
Cisplatin, widely preferred in cancer treatment, is known to inhibit neoplastic cell proliferation while simultaneously causing harmful effects in normal cells. Various research has indicated that cisplatin-induced cytotoxicity is closely …
View article: Hesperidin and Its Polylactic- <i>co</i> -glycolic Acid-Nanoformulation Mitigate Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Stress and Inflammation in BALB/c Mice
Hesperidin and Its Polylactic- <i>co</i> -glycolic Acid-Nanoformulation Mitigate Rhabdomyolysis-Induced Acute Kidney Injury via Attenuation of Oxidative Stress and Inflammation in BALB/c Mice Open
View article: Melatonin mitigates cadmium-induced oxidative damage and modulates polysaccharide biosynthesis in Bletilla striata
Melatonin mitigates cadmium-induced oxidative damage and modulates polysaccharide biosynthesis in Bletilla striata Open
Introduction Cadmium (Cd), a highly toxic heavy metal, threatens ecosystems and human health. Bletilla striata ( B . striata ), a medicinal plant valued for its polysaccharide-rich rhizomes, exhibits significant tolerance to Cd stress. Mel…
View article: Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans
Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans Open
Paramylon (PM), an insoluble β-1,3-glucan produced by Euglena gracilis , reportedly possesses immunomodulatory and metabolic regulatory effects. However, its effect on longevity remains unclear. For this study, using Caenorhabditis elegans…
View article: Integrated Antioxidants, Nanoparticle, and Antifreeze Protein Strategies Synergistically Enhance Cryotop Vitrification Outcomes of Porcine Parthenogenetic Embryos
Integrated Antioxidants, Nanoparticle, and Antifreeze Protein Strategies Synergistically Enhance Cryotop Vitrification Outcomes of Porcine Parthenogenetic Embryos Open
Porcine embryo cryopreservation remains challenging due to high lipid content, oxidative stress, and ice recrystallization that compromise post-thaw survival and developmental competence. We evaluated an integrated vitrification approach c…
View article: Engineered resveratrol nanoantioxidants: intestinal targeted oral delivery system of mesalazine for inflammatory bowel disease via spatiotemporal-ecological regulation
Engineered resveratrol nanoantioxidants: intestinal targeted oral delivery system of mesalazine for inflammatory bowel disease via spatiotemporal-ecological regulation Open
Inflammatory bowel disease (IBD) is a life-threatening condition associated with excessive reactive oxygen species (ROS), chronic mucosal inflammation, and gut microbiota dysbiosis. The therapeutic potential of resveratrol (Rv) and mesalaz…
View article: Response mechanisms of Polygonatum kingianum to temperature stress: implications for cultivation practices
Response mechanisms of Polygonatum kingianum to temperature stress: implications for cultivation practices Open
Polygonatum kingianum , a medicinally significant herb indigenous to Yunnan, China, exhibits pronounced sensitivity to temperature affecting its bioactive compound accumulation and growth. However, the molecular mechanisms underlying its r…
View article: Plant derived and synthetical antihypoxic agents in cardiovascular diseases: Mechanisms, key pathways and therapeutic potential
Plant derived and synthetical antihypoxic agents in cardiovascular diseases: Mechanisms, key pathways and therapeutic potential Open
Antihypoxic drugs are vital for protecting cells from oxygen deprivation in ischemia, stroke and heart failure. Despite their clinical potential, a unified understanding of their mechanisms and optimization strategies remains limited. This…
View article: Genome-Wide Identification and Characterization of the Xyloglucan Endotransglucosylase/Hydrolase (XTH) Gene Family in Camellia oleifera and the Function of CoXTH1 During Drought Stress
Genome-Wide Identification and Characterization of the Xyloglucan Endotransglucosylase/Hydrolase (XTH) Gene Family in Camellia oleifera and the Function of CoXTH1 During Drought Stress Open
Xyloglucan endotransglucosylase/hydrolase (XTH) plays a significant role in plant responses and adaptation to abiotic stresses. However, the XTH gene family in Camellia oleifera remains largely unknown. Herein, 31 CoXTH genes from the C. o…
View article: Identification of a putative RBOHD-FERONIA-CRK10-PIP2;6 plasma membrane complex that interacts with phyB to regulate ROS production in Arabidopsis thaliana
Identification of a putative RBOHD-FERONIA-CRK10-PIP2;6 plasma membrane complex that interacts with phyB to regulate ROS production in Arabidopsis thaliana Open
Reactive oxygen species (ROS) regulate plant growth, development, and responses to the environment. ROS production by the RESPIRATORY BURST OXIDASE PROTEIN D (RBOHD) protein was recently shown to be regulated by PHYTOCHROME B (phyB), and p…
View article: β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies
β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies Open
Mitochondria are essential for β-cell function, coupling glucose metabolism to ATP production and insulin secretion. In diabetes, β-cell mitochondrial dysfunction arises from oxidative stress, impaired quality control and disrupted dynamic…
View article: Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes
Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes Open
Type 1 and type 2 diabetes are characterized by a profound loss of functional β-cell mass, driven by mechanisms that are still not fully understood. A spectrum of β-cell stressors drives this loss, including oxidative stress (OS). Unlike m…
View article: Comparative transcriptomics reveals key regulatory networks underlying cold stress adaptation in oil palm (Elaeis guineensis)
Comparative transcriptomics reveals key regulatory networks underlying cold stress adaptation in oil palm (Elaeis guineensis) Open
Introduction Climate change has exacerbated cold stress, which severely impairs plant development. Oil palm ( Elaeis guineensis ), a tropical crop highly sensitive to low temperatures, exhibits stunted growth and yield reductions under suc…
View article: Synthesis and anti-liver fibrotic activity study of a chalcone derivative through anti-inflammatory effects and inhibition of JNK/NF-κB signaling pathways
Synthesis and anti-liver fibrotic activity study of a chalcone derivative through anti-inflammatory effects and inhibition of JNK/NF-κB signaling pathways Open
Liver fibrosis is a progressive disease caused by chronic inflammation and the activation of hepatic stellate cells (HSCs). This disease manifests as the abnormal proliferation and migration of HSCs, as well as the excessive deposition of …
View article: NF-κB is a central regulator of hypoxia-induced gene expression
NF-κB is a central regulator of hypoxia-induced gene expression Open
Hypoxia is both a physiological and pathological signal in cells. Changes in gene expression play a critical role in the cellular response to hypoxia, enabling cells to adapt to reduced oxygen availability. These changes are primarily medi…
View article: Toxicity evaluation of laser-synthesized pro-angiogenic carbon monoxide-rich gold nanoparticles in vitro and in vivo
Toxicity evaluation of laser-synthesized pro-angiogenic carbon monoxide-rich gold nanoparticles in vitro and in vivo Open
Introduction The safety profile of gold nanoparticles remains a concern and depends on dose, size, surface chemistry and charge. This study evaluated through in vitro and in vivo methods the cytotoxicity, oxidative stress and genotoxicity …
View article: An updated look into reactive oxygen species and cyclophosphamide-induced ovarian damage
An updated look into reactive oxygen species and cyclophosphamide-induced ovarian damage Open
View article: Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers
Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers Open
Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for methods for assessing the initial toleranc…
View article: The Effect of Lipid Extract of Nannochloropsis oceanica Marine Microalgae on Glutathione and Thioredoxin-Dependent Antioxidant Systems in UVB-Irradiated Keratinocytes
The Effect of Lipid Extract of Nannochloropsis oceanica Marine Microalgae on Glutathione and Thioredoxin-Dependent Antioxidant Systems in UVB-Irradiated Keratinocytes Open
UVB radiation present in sunlight is the main pro-oxidative and pro-inflammatory factor that reaches human skin cells, including keratinocytes. Therefore, protective compounds eliminating the negative impact of UVB radiation are constantly…
View article: Nanozyme conjugated chitosan nanoparticles improve buffalo bull sperm cryopreservation by enhancing antioxidant defense and mitochondrial function
Nanozyme conjugated chitosan nanoparticles improve buffalo bull sperm cryopreservation by enhancing antioxidant defense and mitochondrial function Open
Introduction Cryopreservation is commonly used to preserve fertility and support genetic improvement in livestock. However, it often compromises sperm function and quality due to the excessive generation of oxidative stress. Nanozymes, a c…
View article: The impact of sublethal antimicrobial blue light on lipidomic changes of Escherichia coli and Salmonella Typhimurium
The impact of sublethal antimicrobial blue light on lipidomic changes of Escherichia coli and Salmonella Typhimurium Open
Antimicrobial blue light (aBL) is an effective non-thermal disinfection method against foodborne bacterial pathogens. While aBL-induced oxidative stress is known to cause cell membrane damage, its specific effects on bacterial lipid compos…
View article: The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress Open
The TrxR/Trx inhibitor butaselen suppresses lung cancer by triggering ROS-induced apoptosis. This study provides a novel and effective regimen for treating lung cancer.
View article: KEAP1/NRF2 Mediated Activation of Oxidative Stress in Aflatoxin B1 Induced Early and Advanced Stage of Hepatocellular Carcinoma
KEAP1/NRF2 Mediated Activation of Oxidative Stress in Aflatoxin B1 Induced Early and Advanced Stage of Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer in humans and is frequently caused by excessive alcohol intake and the eating of foods contaminated with aflatoxin. The most dangerous kind of aflatoxin, AFB1, …
View article: Stigmasterol exerts antioxidant effects through activation of the Keap1/Nrf2 signaling pathway in Parkinson’s disease model
Stigmasterol exerts antioxidant effects through activation of the Keap1/Nrf2 signaling pathway in Parkinson’s disease model Open
View article: FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis
FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis Open
The progression of osteoarthritis (OA) is fundamentally characterized by the aberrant transformation of chondrocytes into a fibrotic phenotype, although the precise molecular mechanisms involved remain inadequately understood. In this stud…