Barrier function
View article: Development and modulation of gut microbe-host interactions in chickens and piglets
Development and modulation of gut microbe-host interactions in chickens and piglets Open
Increasing evidence suggests that gut microbes and their metabolites, i.e., short-chain fatty acids (SCFA), have beneficial effects on the gut function and health of monogastric farm animals, particularly chickens and pigs. Nevertheless, m…
View article: Ingestion of BPA-containing breast milk disturbs the cecum microbiota and intestinal barrier contributing to growth inhibition of pre-weaning rabbits
Ingestion of BPA-containing breast milk disturbs the cecum microbiota and intestinal barrier contributing to growth inhibition of pre-weaning rabbits Open
View article: MANAGEMENT OF SKIN AGING AS A MODIFIABLE CONDITION THROUGH THE APPLICATION OF INNO TDS DNA PEPT HA FOR AN INTEGRATIVE APPROACH USING SONOPHORESIS. CADAVER ANALYSIS
MANAGEMENT OF SKIN AGING AS A MODIFIABLE CONDITION THROUGH THE APPLICATION OF INNO TDS DNA PEPT HA FOR AN INTEGRATIVE APPROACH USING SONOPHORESIS. CADAVER ANALYSIS Open
Abstract The facial region presents a complex anatomical stratigraphy that organizes its structures in distinct planes, facilitating the application of treatments while presenting textural variations tha…
View article: The Significance and Protection of the Skin Barrier in Newborn Care
The Significance and Protection of the Skin Barrier in Newborn Care Open
The newborn skin barrier undergoes significant structural and functional changes during the transition from the intrauterine to extrauterine environment. This review examines the unique characteristics of neonatal skin, particularly in pre…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus tha…
View article: Butyrate combined with niacin promotes colonic metabolism and antimicrobial peptide expression to alleviate ETEC-induced colonic barrier dysfunction in weaned piglets
Butyrate combined with niacin promotes colonic metabolism and antimicrobial peptide expression to alleviate ETEC-induced colonic barrier dysfunction in weaned piglets Open
Background Butyrate is the primary energy substrate in the colon, whereas niacin can enhance energy metabolic flux by increasing nicotinamide adenine dinucleotide (NAD) synthesis. Therefore, this study aimed to investigate the effects of c…
View article: Tannic acid attenuate DSS-induced ulcerative colitis in mice via Antioxidation, anti-inflammation and microbiota regulation
Tannic acid attenuate DSS-induced ulcerative colitis in mice via Antioxidation, anti-inflammation and microbiota regulation Open
View article: An Ovine Intestinal Organoid–Macrophage Co-Culture Model to Test the Effects of Ovine Colostrum Exosomes on Intestinal Barrier Function and Inflammation
An Ovine Intestinal Organoid–Macrophage Co-Culture Model to Test the Effects of Ovine Colostrum Exosomes on Intestinal Barrier Function and Inflammation Open
Ovine colostrum exosomes obtained from nutritionally programmed dairy ewes (F0) may present modifications in microRNAs, thus having consequences for the intestinal barrier function and immunity parameters of lambs (F1). To test this hypoth…
View article: Loss of function of Adducin 3 (ADD3) causes abnormal development and impaired barrier function of human and mouse bile duct cells resulting in increased incidence and severity of Biliary Atresia
Loss of function of Adducin 3 (ADD3) causes abnormal development and impaired barrier function of human and mouse bile duct cells resulting in increased incidence and severity of Biliary Atresia Open
View article: Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes – an observational study
Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes – an observational study Open
Background Our study aimed to evaluate the epidermal barrier function in children with type 1 diabetes. To the author’s knowledge, no studies have been conducted on epidermal barrier parameters, including TEWL and measurement of epidermal …
View article: Type I interferons in inflammatory bowel diseases: balancing barrier integrity, repair and inflammation in the intestinal epithelium
Type I interferons in inflammatory bowel diseases: balancing barrier integrity, repair and inflammation in the intestinal epithelium Open
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are persistent, relapsing immune mediated disorders of the gastrointestinal tract associated with significant morbidity and considerable health-care costs…
View article: Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness Open
Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium. However, during aging, their regenerative capacity wanes, possibly through senescence and chronic inflammation, albeit little is known about how aging-associa…
View article: Filovirus Infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids
Filovirus Infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids Open
Gastrointestinal (GI) dysfunction, characterized by severe diarrhea and dehydration, is a central contributor to morbidity and mortality in filovirus disease in patients, yet the role of the epithelium in this clinical outcome remains poor…
View article: Gut-Protective and Multifunctional Exopolysaccharide from Enterococcus faecium HDRsEf1: Structural Characterization and Protective Effects Against Enteropathogenic E. coli-Induced Intestinal Inflammation
Gut-Protective and Multifunctional Exopolysaccharide from Enterococcus faecium HDRsEf1: Structural Characterization and Protective Effects Against Enteropathogenic E. coli-Induced Intestinal Inflammation Open
Background: Enteropathogenic Escherichia coli (EPEC) disrupts intestinal barrier integrity by adhering to epithelial cells, leading to diarrhea, impaired nutrient absorption, oxidative stress, and intestinal inflammation in young animals. …
View article: 040 Restoration of Skin Barrier Function by Difamilast in Tmem79-/- Mice with Spontaneous Dermatitis
040 Restoration of Skin Barrier Function by Difamilast in Tmem79-/- Mice with Spontaneous Dermatitis Open
View article: Adipose-derived stem cell extracellular vesicles attenuate liver fibrosis via restoration of gut barrier function and modulation of gut microbiota
Adipose-derived stem cell extracellular vesicles attenuate liver fibrosis via restoration of gut barrier function and modulation of gut microbiota Open
Aim: Liver fibrosis (LF) is a major pathological stage that may progress to end-stage chronic liver injury but currently lacks effective treatment strategies. Previous studies have shown that adipose-derived stem cell extracellular vesicle…
View article: 370 Urban Skin Defense: Upcycled Natural Innovation reduces inflammation and Preserves Barrier Function During Daily Cleansing in Polluted Cities
370 Urban Skin Defense: Upcycled Natural Innovation reduces inflammation and Preserves Barrier Function During Daily Cleansing in Polluted Cities Open
View article: Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction
Targeting CCDC90B restores intestinal stem cell function and ameliorates hyperuricemia induced intestinal dysfunction Open
Hyperuricemia (HUA) affects diverse biological processes and signaling pathways across multiple organ systems; however, its impact on the intestine remains poorly understood. Here, we show that HUA disrupts intestinal barrier function prim…
View article: Gut Microbe Fermentation of <i>Moringa oleifera</i> Leaf Extract Increases Measurable Polyphenols and Improves Barrier Function in a Cell Culture Model
Gut Microbe Fermentation of <i>Moringa oleifera</i> Leaf Extract Increases Measurable Polyphenols and Improves Barrier Function in a Cell Culture Model Open
Moringa oleifera is associated with several nutritional and therapeutic benefits. However, there is limited research on how much these health benefits are mediated directly by the plant or through fermentation with intestinal microbes. We …
View article: Short Chain Fatty Acids Lower Inflammation and Restore Intestinal Integrity and Function Markers in Mycobacterium paratuberculosis—Infection In Vitro Model
Short Chain Fatty Acids Lower Inflammation and Restore Intestinal Integrity and Function Markers in Mycobacterium paratuberculosis—Infection In Vitro Model Open
Background: Infection with Mycobacterium avium paratuberculosis (MAP) is closely associated with Crohn’s disease (CD) development, where excessive inflammation and marked intestinal damage are observed. Objectives: In this study, the role …
View article: Investigating the Mechanism of Ultrasonic Lysis of Enterococcus faecium F11.1G in Repairing LPS-Induced Inflammatory Damage in IECs via LC-MS
Investigating the Mechanism of Ultrasonic Lysis of Enterococcus faecium F11.1G in Repairing LPS-Induced Inflammatory Damage in IECs via LC-MS Open
Lipopolysaccharide (LPS)-induced damage to the intestinal epithelial barrier is pivotal in intestinal inflammation pathogenesis. While lactic acid bacteria (LAB) and their derivatives show probiotic promise, the mechanisms, particularly th…
View article: Exploring Microbial and Biophysical Aspects of Dry Skin: In Vivo Test of a Novel Skincare Formulation
Exploring Microbial and Biophysical Aspects of Dry Skin: In Vivo Test of a Novel Skincare Formulation Open
Background Dry skin is a prevalent dermatological concern influenced by environmental factors and characterized by compromised skin barrier integrity. In addition to this, skin microbiota is involved and plays a crucial role in maintaining…
View article: Age Versus Immunity: Dietary Influences on Immunosenescence
Age Versus Immunity: Dietary Influences on Immunosenescence Open
Background: Immunosenescence, or the age-related weakening of the immune system, leads to greater susceptibility to chronic diseases, infections, and metabolic disorders. This process involves changes in the number and function of lymphocy…
View article: The Effects of Naringin on Antioxidant Function, Intestinal Barrier and Immune Response in Broilers Challenged with Lipopolysaccharide
The Effects of Naringin on Antioxidant Function, Intestinal Barrier and Immune Response in Broilers Challenged with Lipopolysaccharide Open
This study aimed to investigate the effects of naringin (NG) on growth performance, antioxidant status, intestinal barrier function, and immune stress in broilers challenged with lipopolysaccharide (LPS). A total of 144 one-day-old Ross 30…
View article: Lactobacillus helveticus Alleviates Collagen-Induced Arthritis in Rats Through Inflammation Modulation and Gut Microbiota Regulation
Lactobacillus helveticus Alleviates Collagen-Induced Arthritis in Rats Through Inflammation Modulation and Gut Microbiota Regulation Open
Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic synovitis, with growing evidence underscoring the role of gut microbiota dysbiosis and impaired intestinal barrier function in driving inflamma…
View article: Impacts of conditionally essential amino acids, cysteine, and tyrosine on intestinal inflammation in celiac disease
Impacts of conditionally essential amino acids, cysteine, and tyrosine on intestinal inflammation in celiac disease Open
Celiac disease (CD) is a chronic autoimmune disorder characterized by gluten-induced intestinal inflammation, epithelial barrier dysfunction, and malabsorption of nutrients, including amino acids (AAs). While essential AAs have been extens…
View article: PET/CT Diagnostics of Bladder Wall Barrier Function Disorders Using Cystoscopic and Ultrastructural 3D Reconstructions (pilot study)
PET/CT Diagnostics of Bladder Wall Barrier Function Disorders Using Cystoscopic and Ultrastructural 3D Reconstructions (pilot study) Open
Aim. To evaluate bladder wall barrier dysfunction using 11C-choline positron emission tomography/computed tomography using 3D reconstructive techniques based on visual cystoscopy and scanning electron microscopy of bladder wall tissue biop…
View article: LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease
LZR‑1SJ: Dual‑Axis In-Silico Autoimmune Resilience for Sjögren's Disease Open
Background: Sjögren’s disease is a chronic autoimmune condition marked by lymphocytic infiltration of exocrine glands, epithelial stress and barrier fragility, and interferon‑skewed cytokine milieus tha…
View article: Tumor exosomal miR-221-3p induces glycolysis through the LIFR/GLUT1 pathway to destroy the cerebral vascular endothelial cell barrier and promote breast cancer brain metastasis
Tumor exosomal miR-221-3p induces glycolysis through the LIFR/GLUT1 pathway to destroy the cerebral vascular endothelial cell barrier and promote breast cancer brain metastasis Open
Background Tumor-derived exosomal microRNAs mediate intercellular communication between malignant cells and distant organs and play a pivotal role in metastatic dissemination. Breast cancer brain metastasis (BCBM) poses a significant clini…
View article: Glutamine alters the response to stress in mice with diet-induced obesity in a sex-dependent manner
Glutamine alters the response to stress in mice with diet-induced obesity in a sex-dependent manner Open
Rationale Patients with class III obesity often suffer from irritable bowel syndrome (IBS) while obesity and IBS share common pathophysiological mechanisms such as altered intestinal barrier function and gut microbiota dysbiosis. Oral glut…