Biosafety
View article: Biosafety assessment of engineered CCL20 locked dimers in vivo
Biosafety assessment of engineered CCL20 locked dimers in vivo Open
View article: Biosafety assessment of engineered CCL20 locked dimers in vivo
Biosafety assessment of engineered CCL20 locked dimers in vivo Open
View article: A Novel Laboratory Protocol for Pollen Viability Assessment to Inform Biosafety Evaluation of Transgenic Rice (Oryza sativa L.)
A Novel Laboratory Protocol for Pollen Viability Assessment to Inform Biosafety Evaluation of Transgenic Rice (Oryza sativa L.) Open
Rice (Oryza sativa L.) is a vital staple crop, and the environmental risk assessment of transgenic varieties is crucial for formulating biosafety policies. Rice pollen grains are spherical, with an average diameter of 40.03 ± 2.75 μm. This…
View article: Occupational hazards in autopsy laboratories: An integrative analysis of biosafety measures
Occupational hazards in autopsy laboratories: An integrative analysis of biosafety measures Open
The present study aimed to analyze the biosafety measures implemented in autopsy laboratories, with emphasis on identifying the main occupational risks and evaluating the preventive strategies adopted to reduce professionals’ exposure to i…
View article: Navigating the aflatoxin and cyanide challenge in traditionally-processed garri: a mechanistic review of cyanide-aflatoxin trade-off, balancing contamination reduction and food safety risks
Navigating the aflatoxin and cyanide challenge in traditionally-processed garri: a mechanistic review of cyanide-aflatoxin trade-off, balancing contamination reduction and food safety risks Open
Background Cassava flakes, known locally as garri, represent a cornerstone of food security for hundreds of millions in tropical and subtropical Africa. However, this vital staple is frequently contaminated by aflatoxigenic fungi, primaril…
View article: Graphene oxide/zein nanocomposites loaded with rotenone: Synergistically enhancing the pesticidal activity and biosafety of rotenone
Graphene oxide/zein nanocomposites loaded with rotenone: Synergistically enhancing the pesticidal activity and biosafety of rotenone Open
Nanomaterials have been widely applied as pesticide carriers, representing an important approach to enhancing insecticidal efficacy against target pests, improving safety for non-target organisms, and further mitigating environmental pollu…
View article: Harnessing microbial communities to enhance seed germination: a review of opportunities and challenges
Harnessing microbial communities to enhance seed germination: a review of opportunities and challenges Open
Seed-associated microorganisms, including bacteria, fungi, archaea, and viruses, play diverse roles in seed physiology, influencing germination, seedling vigor, and long-term plant resilience. With increasing pressure to reduce synthetic i…
View article: Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials
Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials Open
The accelerating emergence of antibiotic‐resistant bacteria has intensified the need for innovative antimicrobial strategies. Among promising candidates, black phosphorus (BP) and violet phosphorus (VP) nanosheets have garnered significant…
View article: Environmental monitoring and equipment sanitation to mitigate <i>Listeria</i> risks in a soil-based controlled environment agriculture system
Environmental monitoring and equipment sanitation to mitigate <i>Listeria</i> risks in a soil-based controlled environment agriculture system Open
Controlled environment agriculture (CEA) offers protection from external contaminants but introduces unique food safety challenges, particularly related to equipment sanitation. This study evaluated the occurrence and persistence of Lister…
View article: Traceable and Biocompatible Carbon Dots from Simple Precursors: A Pre-Deployment Safety Baseline
Traceable and Biocompatible Carbon Dots from Simple Precursors: A Pre-Deployment Safety Baseline Open
Carbon dots (CDs) are promising for agro-environmental applications; however, clear connections between synthesis, photophysical properties, size, and biosafety are often not well established. In this study, we map these relationships for …
View article: Biosafety Risks and Transparency Deficits in EnteroMix: A Multivirus Oncolytic Therapy
Biosafety Risks and Transparency Deficits in EnteroMix: A Multivirus Oncolytic Therapy Open
EnteroMix is a Russian-developed multivirus oncolytic therapy currently in Phase I clinical trials. According to available public information, the formulation involves intravenous co-administration of four replication-competent enterovirus…
View article: Isolation, preliminary In Vitro screening, and In Vivo biosafety evaluation of a Siphoviridae bacteriophage against drug-resistant Salmonella Typhimurium
Isolation, preliminary In Vitro screening, and In Vivo biosafety evaluation of a Siphoviridae bacteriophage against drug-resistant Salmonella Typhimurium Open
View article: Biosafety Risks and Transparency Deficits in EnteroMix: A Multivirus Oncolytic Therapy
Biosafety Risks and Transparency Deficits in EnteroMix: A Multivirus Oncolytic Therapy Open
EnteroMix is a Russian-developed multivirus oncolytic therapy currently in Phase I clinical trials. According to available public information, the formulation involves intravenous co-administration of four replica…
View article: CRISPR-Engineered Smart Probiotics: A Novel Approach to Targeted Gut Therapeutics
CRISPR-Engineered Smart Probiotics: A Novel Approach to Targeted Gut Therapeutics Open
The human gastrointestinal tract harbors a complex microbial ecosystem that profoundly influences host metabolism, immunity, and overall homeostasis. Conventional probiotics have long been employed to support gut health; however, the…
View article: Microbial Remediation of Agrochemical-Contaminated Soils: Enzymatic Mechanisms, Quorum Sensing, and Emerging Opportunities
Microbial Remediation of Agrochemical-Contaminated Soils: Enzymatic Mechanisms, Quorum Sensing, and Emerging Opportunities Open
The intensive and repeated use of agrochemicals, including synthetic pesticides, herbicides, and fertilisers, has led to persistent contamination of agricultural soils, endangering soil health, ecosystem services, biodiversity, and sustain…
View article: Smart Textiles with Living Interfaces: Microbiome–Electronics Integration for Advanced Skin Health Management
Smart Textiles with Living Interfaces: Microbiome–Electronics Integration for Advanced Skin Health Management Open
Smart textiles have emerged as a transformative class of materials that extend the role of conventional fabrics into personalized health management. This evolution is driven by the seamless integration of textiles with flexible electronics…
View article: Pathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4′-fluorouridine therapy
Pathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4′-fluorouridine therapy Open
The Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a widespread tick-borne agent that causes severe disease in humans. Its expanding geographic range poses a significant public health threat. Although animal models for CCHFV in…
View article: Beyond Herbicides: Emerging Biotechnology Solutions for Environmentally Safe Weed Management
Beyond Herbicides: Emerging Biotechnology Solutions for Environmentally Safe Weed Management Open
Invasive weeds continue to pose a major threat to global agriculture, causing substantial yield losses, intensifying production costs, and destabilizing ecosystems. The effectiveness of conventional chemical herbicides is inc…
View article: Field trials of the novel varroacide, 1-allyloxy-4-propoxybenzene, against Varroa destructor in Western Canada
Field trials of the novel varroacide, 1-allyloxy-4-propoxybenzene, against Varroa destructor in Western Canada Open
Varroa destructor is an ectoparasite of western honey bees ( Apis mellifera ), substantially damaging managed colonies worldwide. Various chemical “varroacides” have been developed to help beekeepers combat infestations of these mites. Nev…
View article: Antimicrobial resistance at a turning point: microbial drivers, one health, and global futures
Antimicrobial resistance at a turning point: microbial drivers, one health, and global futures Open
Antimicrobial resistance (AMR) is a major health threat of the 21st century, undermining the effectiveness of modern medical interventions and reversing decades of progress in infection control. Its drivers include microbial evolution, hor…
View article: What biosafety strategies are effective for gene drives? A focus on genetic biocontainment
What biosafety strategies are effective for gene drives? A focus on genetic biocontainment Open
As gene drive technologies advance, ensuring their safe and controlled use is a global priority. This article examines genetic biocontainment strategies designed to prevent unintended spread and mitigate ecological risks. I categorize exis…
View article: Rethinking gene-edited crop regulation: advancing a Principle-based framework for modern biotechnology governance
Rethinking gene-edited crop regulation: advancing a Principle-based framework for modern biotechnology governance Open
Gene editing (GEd) technologies are rapidly transforming agricultural biotechnology; however, their regulatory treatment remains ambiguous under international instruments such as the Cartagena Protocol on Biosafety (CPB), which was origina…
View article: Crude and Nanosynthesized Selected Medicinal Plants Demonstrate Low Acute Toxicity and Hematopoietic Efficacy in Wistar Rats
Crude and Nanosynthesized Selected Medicinal Plants Demonstrate Low Acute Toxicity and Hematopoietic Efficacy in Wistar Rats Open
This study evaluated the in vivo biosafety profile of extracts from Hibiscus sabdariffa, Justicia carnea, Zingiber officinale and honey alongside their nanosynthesized extracts. Acute (single-dose) and 28-day sub-chronic (100, 200, and 400…
View article: Raw data underlying the publication: Eco-Evolutionary Divergence in Pantoea ananatis Unveils Intrinsic Genomic-Metabolic
Raw data underlying the publication: Eco-Evolutionary Divergence in Pantoea ananatis Unveils Intrinsic Genomic-Metabolic Open
The dataset encompasses genomic, metabolomic, and phenotypic data from 18 Pantoea ananatis isolates derived from mulberry (Morus spp.), focusing on eco-evolutionary mechanisms underlying their pathogen-probiotic duality. …
View article: Raw data underlying the publication: Eco-Evolutionary Divergence in Pantoea ananatis Unveils Intrinsic Genomic-Metabolic
Raw data underlying the publication: Eco-Evolutionary Divergence in Pantoea ananatis Unveils Intrinsic Genomic-Metabolic Open
The dataset encompasses genomic, metabolomic, and phenotypic data from 18 Pantoea ananatis isolates derived from mulberry (Morus spp.), focusing on eco-evolutionary mechanisms underlying their pathogen-probiotic duality. …
View article: Can Oncogenic Animal Viruses Pose a Threat to Humans?
Can Oncogenic Animal Viruses Pose a Threat to Humans? Open
Oncogenic viruses are well-established contributors to cancer development in both humans and animals. While many animal oncogenic viruses exhibit strong host specificity, concerns remain about their potential to cross species barriers and …
View article: Join the Green and Sustainable Team: Magnesium Oxide Nanoparticles Boost Broad‐Spectrum Viral Resistance in Solanaceae Plants
Join the Green and Sustainable Team: Magnesium Oxide Nanoparticles Boost Broad‐Spectrum Viral Resistance in Solanaceae Plants Open
Plant viruses are so harmful to crops. It is an urgent need to develop modern, environment‐friendly, and sustainable plant viral epidemic‐management strategies that are safe for both human health and the environment. The field of nanotechn…
View article: Artificial Intelligence (AI) in biosafety regulation: A practical agenda for inclusive integration
Artificial Intelligence (AI) in biosafety regulation: A practical agenda for inclusive integration Open
This poster, presented at the International Symposium on Biosafety Research (ISBR 2025), introduces a proposed practical agenda for AI in biosafety regulation developed within the ICGEB Regulatory Science Group. It outlines emerging opport…
View article: Artificial Intelligence (AI) in biosafety regulation: A practical agenda for inclusive integration
Artificial Intelligence (AI) in biosafety regulation: A practical agenda for inclusive integration Open
This poster, presented at the International Symposium on Biosafety Research (ISBR 2025), introduces a proposed practical agenda for AI in biosafety regulation developed within the ICGEB Regulatory Science Group. It outlines emergi…
View article: Isolation of viable <i>Mycobacterium bovis</i> from faeces of naturally infected free-ranging rural domestic cattle ( <i>Bos taurus</i> )
Isolation of viable <i>Mycobacterium bovis</i> from faeces of naturally infected free-ranging rural domestic cattle ( <i>Bos taurus</i> ) Open
Aims This study investigated the presence of viable M. bovis in faecal samples collected from 79 free-ranging domestic cattle in rural KwaZulu-Natal, South Africa. Methods and Results Faecal samples were processed under biosafety level 3 (…