Crypt
View article: Magnesium-L-theanine complex protects against liver and intestinal damage caused by chronic variable stress
Magnesium-L-theanine complex protects against liver and intestinal damage caused by chronic variable stress Open
Chronic stress can lead to serious health problems, including elevated blood glucose, intestinal dysbiosis, villous shortening, decreased enzyme activity and hepatic steatosis. Here, we investigate the protective effects of the magnesium-L…
View article: PAR(2) Framework for Crypt Homeostasis
PAR(2) Framework for Crypt Homeostasis Open
This archive contains the Python source code and discovery results for the Phase-Gated Order-2 Autoregressive (PAR(2)) model. The code reproduces the key finding that the Ccnd1 (Cyclin D1) renewal hazard is significantly phase-gated by the…
View article: PAR(2) Framework for Crypt Homeostasis
PAR(2) Framework for Crypt Homeostasis Open
This archive contains the Python source code and discovery results for the Phase-Gated Order-2 Autoregressive (PAR(2)) model. The code reproduces the key finding that the Ccnd1 (Cyclin D1) renewal hazard is significantly phase-gated by the…
View article: Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury Open
Intestinal stem cells (ISCs) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses, such as interferon γ (IFNγ)-m…
View article: Rare non-neoplastic gastrointestinal diseases–drugs and bugs
Rare non-neoplastic gastrointestinal diseases–drugs and bugs Open
Rare diseases of the gastrointestinal (GI) tract present a significant diagnostic challenge. This paper focusses on two particular groups of conditions: drug-induced injuries and parasitic infections. With aging populations and increased u…
View article: A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts
A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts Open
This manuscript introduces a Phase-Gated Autoregressive model of order 2 (PAR(2)) as a novel temporal framework for colonic crypt renewal, directly complementing Boman’s established spatial Fibonacci tissue code. The PAR(2)model unifies ci…
View article: A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts
A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts Open
This manuscript introduces a Phase-Gated Autoregressive model of order 2 (PAR(2)) as a novel temporal framework for colonic crypt renewal, directly complementing Boman’s established spatial Fibonacci tissue code. The PAR(2)model unifies ci…
View article: Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair
Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair Open
Supported by Beijing Natural Science Foundation (7242034, 7242092, L232077), National Natural Science Foundation of China (81870393, 81970500, 82473154, 81970500, and 82203559), and Jiangsu Province Basic Research Special Fund (BK20240117).
View article: A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis
A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis Open
Our Goal is to identify how colorectal cancer (CRC) arises in the single-layered-cell epithelium (simple columnar epithelium) that lines the luminal surface of the large intestine. We recently reported that the dynamic organization of cell…
View article: A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts
A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts Open
This document introduces a Phase-Gated Autoregressive model of order 2 (PAR(2)) as a temporal framework for understanding colonic crypt renewal, complementing Bruce M. Boman's spatial Fibonacci tissue code. The PAR(2) model uses circadian …
View article: A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts
A Phase-Gated AR(2) Framework for Colonic Crypt Renewal: A Temporal Analogue to Fibonacci Tissue Codes with Tuft Cell Readouts Open
This document introduces a Phase-Gated Autoregressive model of order 2 (PAR(2)) as a temporal framework for understanding colonic crypt renewal, complementing Bruce M. Boman's spatial Fibonacci tissue code. The PAR(2) model uses circadian …
View article: Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways
Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways Open
Background The benefits of Vitamin K (VK) in mitigating inflammation have been well-established, while the underlying mechanisms remain not yet fully elucidated. This study aimed to investigate its protective effects and underlying mechani…
View article: Essential role of single-stranded DNA-binding proteins Ssb1 and Ssb2 in maintaining intestinal epithelial homeostasis
Essential role of single-stranded DNA-binding proteins Ssb1 and Ssb2 in maintaining intestinal epithelial homeostasis Open
Ssb1 and Ssb2 are single-stranded DNA-binding proteins with overlapping roles in genome stability. Both contain an OB-fold domain and interact with C9orf80 and IntS3, components of the Integrator complex which regulates snRNA processing, e…
View article: Melatonin Improves Intestinal Barrier Impairment in a Mouse Model of Autism Spectrum Disorder
Melatonin Improves Intestinal Barrier Impairment in a Mouse Model of Autism Spectrum Disorder Open
Autism spectrum disorder (ASD) is a neurodevelopmental condition mainly characterized by social impairments and repetitive behaviors. An altered intestinal barrier morphology and increased transmucosal leaks have also been implicated in AS…
View article: TSLP links intestinal nutrient sensing with amplification of the ILC2–tuft cell circuit
TSLP links intestinal nutrient sensing with amplification of the ILC2–tuft cell circuit Open
Group 2 innate lymphocytes (ILC2s) are prevalent in small intestine but their role during homeostasis is unclear. Here we show that thymic stromal lymphopoietin (TSLP)—a cytokine implicated in ILC2 activation—is expressed constitutively in…
View article: Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury
Targeting C5aR1 Reveals Protective Macrophage Maturation States in Intestinal Injury Open
Inflammatory intestinal injury, which may occur following cytotoxic cancer treatments such as radiotherapy, compromises homeostasis when intestinal stem cells undergo apoptosis and regeneration programmes are not effectively engaged. Recen…
View article: Epithelial and stromal remodeling in murine Crohn’s disease-like ileitis
Epithelial and stromal remodeling in murine Crohn’s disease-like ileitis Open
Background and Aims Inflammatory bowel disease is characterized by progressive epithelial, immune, and stromal dysfunction. Human datasets yield important insights yet are inherently descriptive, requiring animal models for in vivo mechani…
View article: PAR2 Framework for Phase-Gated Renewal: Applications Across Tissue Systems
PAR2 Framework for Phase-Gated Renewal: Applications Across Tissue Systems Open
The Phase-Gated Order-2 Autoregressive (PAR2) framework, originally developed to resolve paradoxes in colonic crypt renewal dynamics, represents a generalizable mathematical and biological paradigm applicable to any stem cell or progenitor…
View article: PAR2 Framework for Phase-Gated Renewal: Applications Across Tissue Systems
PAR2 Framework for Phase-Gated Renewal: Applications Across Tissue Systems Open
The Phase-Gated Order-2 Autoregressive (PAR2) framework, originally developed to resolve paradoxes in colonic crypt renewal dynamics, represents a generalizable mathematical and biological paradigm applicable to any stem cell or progenitor…
View article: Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt Short: Hepatitis E virus infects the intestinal crypt
Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt Short: Hepatitis E virus infects the intestinal crypt Open
The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Although most HEV infections are self-limiting, zoonotic genotypes can establish persistent infections in immunocompromised individuals. Transmitted via the fecal…
View article: Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt Short: Hepatitis E virus infects the intestinal crypt
Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt Short: Hepatitis E virus infects the intestinal crypt Open
The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Although most HEV infections are self-limiting, zoonotic genotypes can establish persistent infections in immunocompromised individuals. Transmitted via the fecal…
View article: Mouse Macrophage galactose-type lectin (mMGL)1 receptor exhibits immunosuppressive and inflammatory properties in colorectal cancer 4000
Mouse Macrophage galactose-type lectin (mMGL)1 receptor exhibits immunosuppressive and inflammatory properties in colorectal cancer 4000 Open
Description Cancer-associated aberrant glycosylation can be detected by the MGL receptor; however, whether this interaction enhances or deadens cancer development has not been well established. To determine the role of mouse MGL1 in coliti…
View article: Complement C3a-C3aR signaling in the colon epithelium 4117
Complement C3a-C3aR signaling in the colon epithelium 4117 Open
Description The liver-derived complement system has been considered the body’s main source for the complement cascade. Recently, complement C3 was found to be expressed in the gut under steady-state conditions and during inflammatory condi…
View article: Panaxynol Preserves Gut Architecture, Reduces Colitis-Associated Microbes, and Modulates Immune Response to Alleviate Colitis 9222
Panaxynol Preserves Gut Architecture, Reduces Colitis-Associated Microbes, and Modulates Immune Response to Alleviate Colitis 9222 Open
Description Ulcerative colitis (UC) is a chronic inflammatory disease of the large intestine affecting millions globally. Current treatments often have off-target effects, highlighting the need for safer, more effective alternatives. This …
View article: Intestinal epithelial ERBB3 maintains intraepithelial lymphocyte populations by modulating immune signaling pathways 2697
Intestinal epithelial ERBB3 maintains intraepithelial lymphocyte populations by modulating immune signaling pathways 2697 Open
Description Intraepithelial lymphocytes (IELs) of gut mucosa maintain intestinal immunity. Imbalanced IEL subsets can compromise epithelial integrity and promote inflammation. IELs are known to crosstalk with intestinal epithelial cells (I…
View article: Vitamin D-mediated Regulation of Intestinal Stem Cells 2297
Vitamin D-mediated Regulation of Intestinal Stem Cells 2297 Open
Description We recently reported that de novo synthesis of locally high 1,25(OH)2D concentrations enhanced the differentiation of Lgr5+ intestinal stem cells (ISCs) in vitro and in vivo. Importantly, it does not cause hypercalcemia. Hyperc…
View article: Altered Mucin Expression Detected in the Pathogenesis of Necrotizing Enterocolitis
Altered Mucin Expression Detected in the Pathogenesis of Necrotizing Enterocolitis Open
Title Altered Mucin Expression Detected in the Pathogenesis of Necrotizing Enterocolitis Background Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease affecting premature infants, marked by severe intestinal inflamma…
View article: Targeted deletion of Cyp24a1 in the intestine reduces mucosal injury and preserves epithelial proliferation after 5-fluorouracil treatment
Targeted deletion of Cyp24a1 in the intestine reduces mucosal injury and preserves epithelial proliferation after 5-fluorouracil treatment Open
Vitamin D has been proposed to attenuate chemotherapy-induced gastrointestinal mucositis (GM). In the intestine, local catabolism of active vitamin D [1,25-dihydroxyvitamin D₃] is mediated by the enzyme Cyp24a1. This study assessed whether…
View article: Sterile Nasal Septal Abscess in Ulcerative Colitis With Crypt Abscess‐Like Neutrophilic Infiltration
Sterile Nasal Septal Abscess in Ulcerative Colitis With Crypt Abscess‐Like Neutrophilic Infiltration Open
We report a rare case of a sterile nasal septal abscess (NSA) occurring as an extraintestinal manifestation of ulcerative colitis (UC), accompanied by a novel histopathologic finding. A 40‐year‐old woman with relapsed UC presented with nas…
View article: Crypt from Chkhuteli
Crypt from Chkhuteli Open