Pulmonary function testing
View article: Combining Pirfenidone With Mycophenolate Mofetil for Systemic Sclerosis–Related Interstitial Lung Disease (Scleroderma Lung Study <scp>III</scp> ): An Investigator‐Initiated, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial
Combining Pirfenidone With Mycophenolate Mofetil for Systemic Sclerosis–Related Interstitial Lung Disease (Scleroderma Lung Study <span>III</span> ): An Investigator‐Initiated, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial Open
Objective Mycophenolate mofetil (MMF) can stabilize or improve lung function in systemic sclerosis–related interstitial lung disease (SSc‐ILD). We hypothesized that combining MMF with pirfenidone (PFD) would produce a significantly more ra…
View article: A Retrospective Observational Study of Pulmonary Impairments in Long COVID Patients
A Retrospective Observational Study of Pulmonary Impairments in Long COVID Patients Open
Background: Pulmonary impairments have been identified as some of the most complex and debilitating post-acute sequelae of SARS-CoV-2 infection (PASC) or long COVID. This study identified and characterised the specific forms of pulmonary i…
View article: Miller Fisher syndrome in a patient with pulmonary tuberculosis
Miller Fisher syndrome in a patient with pulmonary tuberculosis Open
View article: Altitude‐Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study
Altitude‐Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study Open
Background Residence at high altitudes (HAs) may increase cardiovascular risk due to hypobaric hypoxia, but its synergy with pulmonary hypertension cause is unclear. This study compared clinical profile and biventricular remodeling in pati…
View article: PO:25:073 | Pulmonary involvement and progressive interstitial lung disease in anti-synthetase syndrome: a single-center retrospective study
PO:25:073 | Pulmonary involvement and progressive interstitial lung disease in anti-synthetase syndrome: a single-center retrospective study Open
Background. Anti-synthetase syndrome (ASS) is a systemic autoimmune disease frequently associated with lung involvement. This single-center retrospective study aimed to longitudinally assess the clinical and instrumental evolution of patie…
View article: Efficacy of lung surfactant combined with budesonide in improving bronchopulmonary dysplasia and growth of very low birth weight infants
Efficacy of lung surfactant combined with budesonide in improving bronchopulmonary dysplasia and growth of very low birth weight infants Open
Background There is few treatments for bronchopulmonary dysplasia (BPD), and systemic glucocorticoid therapy has serious side effects. Methods Low birth weight infants were classified randomly into control group administered with pulmonary…
View article: The influencing factors of chronic obstructive pulmonary disease concomitant with pulmonary heart disease and the diagnostic value of myocardial markers
The influencing factors of chronic obstructive pulmonary disease concomitant with pulmonary heart disease and the diagnostic value of myocardial markers Open
View article: PO:22:039 | A rare form of interstitial lung disease: granulomatous and lymphocytic interstitial lung disease
PO:22:039 | A rare form of interstitial lung disease: granulomatous and lymphocytic interstitial lung disease Open
Background. In August 2024, a 48-year-old man presented to the emergency department with worsening dyspnea and oxygen desaturation. His medical history was remarkable only for IgA deficiency, but he reported recurrent episodes of pneumonia…
View article: Clinical and prognostic characteristics of stable bronchiectasis in adults with pseudomonas aeruginosa colonization: a prospective cohort study
Clinical and prognostic characteristics of stable bronchiectasis in adults with pseudomonas aeruginosa colonization: a prospective cohort study Open
Background: Bacterial infection and colonization are gradually associated with disease severity and prognosis in bronchiectasis. The impact of Pseudomonas aeruginosa (PA) colonization on the clinical features and disease progression in sta…
View article: Comparison of the safety and efficacy of desflurane versus sevoflurane on postoperative cognitive function and early recovery quality in elderly orthopedic patients: a prospective, randomized controlled trial
Comparison of the safety and efficacy of desflurane versus sevoflurane on postoperative cognitive function and early recovery quality in elderly orthopedic patients: a prospective, randomized controlled trial Open
Objective Desflurane is the most commonly suitable volatile anesthetic for elderly patients due to its low blood solubility, suggesting faster induction and awakening time. This study compared the safety and efficacy of desflurane versus s…
View article: PO:25:082 | Progressive interstitial lung disease secondary to Sjögren's disease in a patient with inclusion body myositis complicated by dysphagia: a multidisciplinary approach and therapeutic challenges
PO:25:082 | Progressive interstitial lung disease secondary to Sjögren's disease in a patient with inclusion body myositis complicated by dysphagia: a multidisciplinary approach and therapeutic challenges Open
Background. Inclusion Body Myositis (IBM) is a rare idiopathic inflammatory myopathy, characterized by an insidious onset with progressive muscle weakness and dysphagia. While its association with Sjögren’s syndrome (pSS) has been reported…
View article: Lung function assessment by electrical impedance tomography among obese patients
Lung function assessment by electrical impedance tomography among obese patients Open
Obesity is a growing problem worldwide. It is well reported that obesity is associated with various degrees of respiratory function compromise, which could be contributed by mechanical factors as well as co-morbid diseases such as asthma. …
View article: Comorbid depression and autonomic dysfunction reduce lung function in patients with chronic obstructive pulmonary disease
Comorbid depression and autonomic dysfunction reduce lung function in patients with chronic obstructive pulmonary disease Open
The high comorbidity rates of depression and chronic obstructive pulmonary disease (COPD) have garnered widespread attention. As a refractory disease, its long-term stress effects exacerbate the coexistence of depression. Depression is lin…
View article: Effect of stratified management and stepwise training on pulmonary rehabilitation in older patients with liver cancer
Effect of stratified management and stepwise training on pulmonary rehabilitation in older patients with liver cancer Open
BACKGROUND Older patients with liver cancer often experience impaired pulmonary function post-surgery, increasing complications and recovery challenges. AIM To investigate the effects of evidence-based stratified management and stepwise tr…
View article: Spirometric Assessment of Lung Function Impairment Among Brick Kiln Workers in Bahawalpur, Pakistan
Spirometric Assessment of Lung Function Impairment Among Brick Kiln Workers in Bahawalpur, Pakistan Open
Background: Brick kiln workers in Pakistan are chronically exposed to particulate matter, smoke, and combustion emissions, which may impair respiratory function. Spirometry is a standard tool to assess pulmonary health. This study evaluate…
View article: Measuring the Frequency of Exacerbation among Patients with Obstructive Airway Disease and the Factors Associated with It
Measuring the Frequency of Exacerbation among Patients with Obstructive Airway Disease and the Factors Associated with It Open
Background: Obstructive airway diseases such as asthma and chronic obstructive pulmonary disease are marked by the episodes of worsening symptoms that drive morbidity and healthcare utilization. Understanding how often these exacerbations …
View article: The lung function after mine explosion wounds
The lung function after mine explosion wounds Open
Background. Combined gunshot wounds (GSWs) causes hypoxic disorders, most pronounced in cases of damage to the chest. However, with any severe gunshot injury, all the organs are susceptible to varying degrees of contusion injury, and massi…
View article: Cardiopulmonary function in special operations forces compared to conventional infantry soldiers
Cardiopulmonary function in special operations forces compared to conventional infantry soldiers Open
Fitness is essential to military personnel in general, especially in the special operations forces (SOF), where the demanding tasks require a high level of physical fitness and mental robustness. However, little research has been done on S…
View article: Long-term outcomes and patterns of failure after empiric SBRT for presumed early-stage lung tumors
Long-term outcomes and patterns of failure after empiric SBRT for presumed early-stage lung tumors Open
Background Stereotactic body radiation therapy (SBRT) is the established standard of care for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC). When a biopsy is unfeasible, it is often delivered empirically, yet long-…
View article: Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease
Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease Open
BACKGROUND Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) experience not only progressive respiratory impairment but also a significant psychological burden. The prevalence and impact of anxiety and …
View article: Supplementary Information from Dual Impact of IGF2 on Alveolar Stem Cell Function during Tobacco-Induced Injury Repair and Development of Pulmonary Emphysema and Cancer
Supplementary Information from Dual Impact of IGF2 on Alveolar Stem Cell Function during Tobacco-Induced Injury Repair and Development of Pulmonary Emphysema and Cancer Open
Supplementary Methods, Tables, and Figures
View article: Ventilation and Perfusion Defects on Phase‐Resolved Functional Lung ( <scp>PREFUL</scp> ) <scp>MRI</scp> Predict Silicosis Progression: A Prospective Pilot Study
Ventilation and Perfusion Defects on Phase‐Resolved Functional Lung ( <span>PREFUL</span> ) <span>MRI</span> Predict Silicosis Progression: A Prospective Pilot Study Open
Background Silicosis is an occupational lung disease characterized by inflammation and fibrosis. As it is irreversible, early identification of high‐risk individuals is clinically important, but biomarkers for progression remain lacking. P…
View article: Impact on Body Composition After Two Years of Elexacaftor–Tezacaftor–Ivacaftor Therapy in Children with Cystic Fibrosis
Impact on Body Composition After Two Years of Elexacaftor–Tezacaftor–Ivacaftor Therapy in Children with Cystic Fibrosis Open
Background: Triple therapy with cystic fibrosis transmembrane conductance regulator (CFTR) modulators in patients with cystic fibrosis (CF) has led to a shift in the nutritional management of the disease. Correct assessment of nutritional …
View article: Occupational exposure to welding fumes associated with pulmonary surfactant lipid compositional changes, inflammatory activity and pulmonary functioning.
Occupational exposure to welding fumes associated with pulmonary surfactant lipid compositional changes, inflammatory activity and pulmonary functioning. Open
Objective To investigate alterations in the respiratory tract lining fluid phospholipids and their association with pulmonary function in welding fume-exposed workers. Method Particles in exhaled air were collected from 134 subjects. Pulmo…
View article: Pneumocystis jirovecii pneumonia in a patient with Mycobacterium intracellulare pulmonary disease: a case report
Pneumocystis jirovecii pneumonia in a patient with Mycobacterium intracellulare pulmonary disease: a case report Open
This report details the case of a 77-year-old female with Mycobacterium intracellulare pulmonary disease and history of bladder tumor surgery. The patient initially presented to our hospital with a one-day history of fever. After receiving…
View article: Interrogating pulmonary diffusing capacity in long COVID: insights from DLCO and DLNO testing
Interrogating pulmonary diffusing capacity in long COVID: insights from DLCO and DLNO testing Open
Introduction The lingering respiratory effects of COVID-19, particularly in patients with Long COVID, remain poorly understood, prompting a comprehensive evaluation of lung function in this population. Methods Simultaneous measurements of …
View article: A Silent Intruder: Case Report of Primary Pulmonary Follicular Lymphoma Mimicking Infectious Lung Disease in a Patient with Autoimmune Comorbidities
A Silent Intruder: Case Report of Primary Pulmonary Follicular Lymphoma Mimicking Infectious Lung Disease in a Patient with Autoimmune Comorbidities Open
Primary pulmonary follicular lymphoma (PPFL) is an exceptionally rare subtype of non-Hodgkin lymphoma that arises within the lung parenchyma without nodal or extrapulmonary involvement at diagnosis. Its nonspecific clinical and radiologica…
View article: Improvement of Cystic Fibrosis-Associated Liver Disease in Adults on Long-Term Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators
Improvement of Cystic Fibrosis-Associated Liver Disease in Adults on Long-Term Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators Open
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators have been reported to improve lung function and reduce CF exacerbations. We aimed to investigate the efficacy of CFTR-modulators in CF-associated liver disease (CFL…
View article: A Novel FAPI-Based Radiopharmaceutical for SPECT Imaging of Fibrotic Interstitial Lung Disease
A Novel FAPI-Based Radiopharmaceutical for SPECT Imaging of Fibrotic Interstitial Lung Disease Open
Objectives: Early and noninvasive detection of fibrotic interstitial lung disease (fILD) is a critical but unmet clinical necessity. This study aimed to evaluate the feasibility of using 99mTc-HYNIC-Glu(PEG4-oncoFAPi)2 (denoted as 99mTc-H-…
View article: Correlation Between Oscillometry and Spirometry Parameters in Assessing Pulmonary Function in Pediatric Pulmonary Tuberculosis Survivor
Correlation Between Oscillometry and Spirometry Parameters in Assessing Pulmonary Function in Pediatric Pulmonary Tuberculosis Survivor Open
Introduction : Despite successful treatment, pulmonary tuberculosis (TB) survivors often have lasting respiratory issues. Spirometry is the standard tool for assessing pulmonary function, but its utility is limited in pediatric populations…