Procalcitonin
View article: Correlation of TSH Levels with Inflammatory Markers in COVID-19 Patients: A Retrospective Study
Correlation of TSH Levels with Inflammatory Markers in COVID-19 Patients: A Retrospective Study Open
Background: COVID-19 caused by SARS-CoV-2 is an acute disease which may lead to severe systemic inflammation, causing multi-organ dysfunction and death. Studies indicated that thyroid-stimulating hormone (TSH) levels were lower when the in…
View article: Mapping Interactions Between Cytokines, Chemokines, Growth Factors, and Conventional Biomarkers in COVID-19 ICU-Patients
Mapping Interactions Between Cytokines, Chemokines, Growth Factors, and Conventional Biomarkers in COVID-19 ICU-Patients Open
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyperinflammation with cytokine and chemokine release, alongside elevations in conventional laboratory biomarkers such as C-reactive protein (CRP), ferritin, and proca…
View article: Serum vitamin D and inflammatory markers in SARS-CoV-2 positive pregnant women
Serum vitamin D and inflammatory markers in SARS-CoV-2 positive pregnant women Open
Objectives The SARS-CoV-2 pandemic was declared by World Health Organisation (WHO) in March 2020, causing health and economic disruptions and millions of deaths. Pregnant women represent a vulnerable group, as COVID-19 during pregnancy inc…
View article: Serum zinc dynamics as a diagnostic and immunomodulatory biomarker in neonatal sepsis
Serum zinc dynamics as a diagnostic and immunomodulatory biomarker in neonatal sepsis Open
This study aimed to investigate serum zinc levels in term neonates with sepsis, evaluate its correlation with immune parameters, and assess zinc's diagnostic efficacy in identifying neonatal sepsis. A prospective cohort study was conducted…
View article: Apolipoprotein A-I: a non-negligible marker in hypertriglyceridemia-induced acute pancreatitis
Apolipoprotein A-I: a non-negligible marker in hypertriglyceridemia-induced acute pancreatitis Open
ApoA-I was a promising early biomarker for HTG-AP severity and prognosis.
View article: Effects of endoscopic mucosal resection and argon plasma coagulation on postoperative recovery and complications in elderly colon polyp patients
Effects of endoscopic mucosal resection and argon plasma coagulation on postoperative recovery and complications in elderly colon polyp patients Open
BACKGROUND Colon polyps represent a significant clinical challenge in elderly patients. While endoscopic mucosal resection (EMR) and argon plasma coagulation (APC) are widely used, their comparative effectiveness in elderly populations rem…
View article: New issues in the focus of biological therapy in the treatment of rhinosinusitis with nasal polyps and T2-associated inflammatory diseases: A review
New issues in the focus of biological therapy in the treatment of rhinosinusitis with nasal polyps and T2-associated inflammatory diseases: A review Open
Peripheral blood eosinophils are now seen as an important marker in determining the leading endotype of the inflammatory response in patients with severe uncontrolled rhinosinusitis polyposa. The T2-endotype of inflammation is dominant in …
View article: A comparative study of the injury patterns and inflammatory response between suicidal and unintentional falls from height in Germany
A comparative study of the injury patterns and inflammatory response between suicidal and unintentional falls from height in Germany Open
Background Patients who have fallen from great height with suicidal intent present unique challenges, including delayed medical attention, injury patterns that are often difficult to detect, severe hypothermia, and difficulties obtaining i…
View article: Risk factors and outcomes for advanced cancer with steroid-refractory immune-related hepatotoxicity
Risk factors and outcomes for advanced cancer with steroid-refractory immune-related hepatotoxicity Open
Immune-related hepatotoxicity (IRH) represents one of common immune-related adverse events. Some patients with steroid-refractory IRH (Ref-IRH) are potentially life-threatening. This study was designed to determine the risk factors and out…
View article: Predictive Value of Serum Procalcitonin and APACHE-II Score for Acute Kidney Injury in Critically Ill Patients: A Prospective Cohort Study
Predictive Value of Serum Procalcitonin and APACHE-II Score for Acute Kidney Injury in Critically Ill Patients: A Prospective Cohort Study Open
Background: Acute kidney injury (AKI) is a common and highly fatal condition among patients treated in intensive care units (ICUs). This study aimed to investigate whether procalcitonin (PCT) levels and APACHE-II scores can predict the dev…
View article: Serum renin levels refine acute kidney injury prediction in critically ill children
Serum renin levels refine acute kidney injury prediction in critically ill children Open
Background Studies demonstrate that elevated renin is associated with adverse outcomes in critical illness. We aimed to evaluate whether serum renin enhances acute kidney injury (AKI) risk stratification in critically ill children. Methods…
View article: Pulmonary lesion volume ratio and laboratory parameters as risk factors for plastic bronchitis in pediatric refractory Mycoplasma pneumoniae pneumonia
Pulmonary lesion volume ratio and laboratory parameters as risk factors for plastic bronchitis in pediatric refractory Mycoplasma pneumoniae pneumonia Open
Background Refractory Mycoplasma pneumoniae pneumonia (RMPP) frequently leads to complications, including plastic bronchitis (PB). This study aimed to identify clinical risk factors for PB development in pediatric RMPP. Methods A total of …
View article: Impact of medical history of severe COVID-19 infection on serum cytokine levels and prognosis in patients with sepsis: A prospective observational study
Impact of medical history of severe COVID-19 infection on serum cytokine levels and prognosis in patients with sepsis: A prospective observational study Open
A history of severe COVID-19 may have lasting effects on immune and coagulation dysfunction, potentially influencing sepsis outcomes. This study investigates the impact of severe COVID-19 history on inflammatory markers, coagulation parame…
View article: Piperacillin-tazobactam-induced hemophagocytic lymphohistiocytosis in a patient with community-acquired pneumonia: A case report and literature review on diagnostic challenges of elevated procalcitonin
Piperacillin-tazobactam-induced hemophagocytic lymphohistiocytosis in a patient with community-acquired pneumonia: A case report and literature review on diagnostic challenges of elevated procalcitonin Open
Rationale: piperacillin-tazobactam, a widely used broad-spectrum antibiotic, carries a risk of severe adverse reactions, including rare but life-threatening hemophagocytic lymphohistiocytosis (HLH). Elevated procalcitonin (PCT), typically …
View article: Retrospective comparative study of thoracoscopic lobectomy vs. segmentectomy: Enhancing recovery and lung function in early-stage non-small cell lung cancer
Retrospective comparative study of thoracoscopic lobectomy vs. segmentectomy: Enhancing recovery and lung function in early-stage non-small cell lung cancer Open
Surgical resection remains the key treatment for early stage non-small cell lung cancer (NSCLC), with thoracoscopic lobectomy and segmentectomy being the primary surgical techniques. However, evidence comparing the efficacy, safety, and ef…
View article: Divergent Inflammatory Trajectories: Independent Predictive Value of Admission Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratios for Acute Ischemic Stroke Severity in a Southeast Asian Cohort
Divergent Inflammatory Trajectories: Independent Predictive Value of Admission Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratios for Acute Ischemic Stroke Severity in a Southeast Asian Cohort Open
Background: Systemic sterile inflammation acts as a critical pathophysiological driver in the acute phase of ischemic stroke, mediating secondary brain injury through blood-brain barrier disruption and microvascular thrombosis. While the N…
View article: Serum Procalcitonin as an Early Predictor of Postoperative Complications Following Liver Resection: A Prospective Observational Study
Serum Procalcitonin as an Early Predictor of Postoperative Complications Following Liver Resection: A Prospective Observational Study Open
Postoperative complications (POC) following liver resection (LR) can significantly affect patient outcomes, and early predictors are crucial for timely intervention, particularly in resource-limited settings such as Bangladesh. In this pro…
View article: Prognostic utility of procalcitonin and lactate clearance for in-hospital mortality in sepsis
Prognostic utility of procalcitonin and lactate clearance for in-hospital mortality in sepsis Open
Background Sepsis remains a significant global health burden and a leading cause of in-hospital mortality. Recent research has focused on the prognostic value of biomarker kinetics, particularly clearance rates and inflammatory markers suc…
View article: Prospective Evaluation of Blood-based and Microbiological Early Indicators of In-hospital Infectious Complications After Open Cystectomy
Prospective Evaluation of Blood-based and Microbiological Early Indicators of In-hospital Infectious Complications After Open Cystectomy Open
View article: Serum Procalcitonin: A Novel Tumor Biomarker for Diagnosis and Follow-Up in Fibrolamellar Hepatocellular Carcinoma
Serum Procalcitonin: A Novel Tumor Biomarker for Diagnosis and Follow-Up in Fibrolamellar Hepatocellular Carcinoma Open
Introduction Fibrolamellar carcinoma (FLC) is a rare primary liver cancer that predominantly affects young patients with normal known serum tumor biomarkers (alpha-fetoprotein (AFP) and CA19-9). An observation of a markedly elevated procal…
View article: Predicting Mortality in Intensive Care Unit Patients with Allergic Bronchopulmonary Aspergillosis (ABPA) Using an Interpretable Machine Learning Model: A Retrospective Cohort Study
Predicting Mortality in Intensive Care Unit Patients with Allergic Bronchopulmonary Aspergillosis (ABPA) Using an Interpretable Machine Learning Model: A Retrospective Cohort Study Open
Background Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease caused by Aspergillus infection, with severe cases often requiring admission to the intensive care unit (ICU). Early prediction of in-hospital mor…
View article: The role of Serum Procalcitonin (PCT) in Predicting 28 Days Mortality in Critically ill Patients with Sepsis Admitted to the Intensive Care Unit
The role of Serum Procalcitonin (PCT) in Predicting 28 Days Mortality in Critically ill Patients with Sepsis Admitted to the Intensive Care Unit Open
Objective: To assess the relationship between Serum Procalcitonin (PCT) and 28-day mortality in critically ill patients with sepsis admitted to the ICU. Study Design: Cohort study. Place and Duration of Study: This study was conducted at t…
View article: Neonatal Sepsis: Any Role for Procalcitonin as a Diagnostic Marker?
Neonatal Sepsis: Any Role for Procalcitonin as a Diagnostic Marker? Open
Introduction In low and middle-income countries, a key driver of neonatal morbidity and mortality is neonatal sepsis. Rapid and precise diagnosis of neonatal sepsis remains a critical challenge due to limited laboratory facilities. Blood c…
View article: Silent Threats: Understanding the Impact of Respiratory Viruses on the Ageing Population
Silent Threats: Understanding the Impact of Respiratory Viruses on the Ageing Population Open
Respiratory viruses are an important cause of acute respiratory illnesses in older adults. The spectrum of illness may range from pneumonia to an exacerbation of underlying respiratory disease or acute bronchitis. Respiratory viruses can a…
View article: EVD-Associated Infections in Subarachnoid Hemorrhage: Risk Factors and Clinical Predictions—A Retrospective Single-Center Study
EVD-Associated Infections in Subarachnoid Hemorrhage: Risk Factors and Clinical Predictions—A Retrospective Single-Center Study Open
Background and Objectives: External ventricular drain (EVD)-associated infections are a serious complication in subarachnoid hemorrhage (SAH) patients, with reported incidence rates of 1–45%. Existing prediction models show limited perform…
View article: Machine learning-based prediction model for chronic brucellosis: a multi-feature approach using clinical and laboratory data
Machine learning-based prediction model for chronic brucellosis: a multi-feature approach using clinical and laboratory data Open
Background Chronic progression is a major clinical challenge in human brucellosis (HB), affecting nearly one-third of patients and leading to long-term disability. Reliable early prediction tools are lacking, hindering timely risk stratifi…
View article: Development of a risk prediction model for acute kidney injury in liver transplant recipients
Development of a risk prediction model for acute kidney injury in liver transplant recipients Open
Objective To develop and internally validate a nomogram for early postoperative prediction of acute kidney injury (AKI) within 7 days after orthotopic liver transplantation (LT). Methods We retrospectively analyzed 500 orthotopic liver tra…
View article: Intra-peritoneal abscess as a rare complication of preterm premature rupture of the membranes
Intra-peritoneal abscess as a rare complication of preterm premature rupture of the membranes Open
Septic abortion is one the leading causes of maternal morbidity and mortality, due to severe complications including pelvic inflammatory disease and sepsis. Preterm premature rupture of the membranes may initiate intrauterine infection whi…
View article: Integration of Clinical Indicators and Multiple Machine Learning Algorithms for Prognostic Evaluation in Sepsis Patients with Different BMI: Model Construction and Validation
Integration of Clinical Indicators and Multiple Machine Learning Algorithms for Prognostic Evaluation in Sepsis Patients with Different BMI: Model Construction and Validation Open
Objective Sepsis is a leading cause of intensive care unit (ICU) mortality, with body mass index (BMI) contributing to prognostic heterogeneity through the so-called "obesity paradox." This study aimed to develep and validate a BMI-stratif…
View article: Comparison of the predictive value of different non-insulin-based insulin resistance indices for acute kidney injury in patients with sepsis: a retrospective study
Comparison of the predictive value of different non-insulin-based insulin resistance indices for acute kidney injury in patients with sepsis: a retrospective study Open
Objective Insulin resistance (IR) is closely related to the development of acute kidney injury (AKI), but the preferred surrogate markers of IR have not been validated in patients with sepsis. This study aimed to evaluate the predictive va…