Photoacoustic tomography
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Fully Dense UNet for 2-D Sparse Photoacoustic Tomography Artifact Removal Open
Photoacoustic imaging is an emerging imaging modality that is based upon the photoacoustic effect. In photoacoustic tomography (PAT), the induced acoustic pressure waves are measured by an array of detectors and used to reconstruct an imag…
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A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo Open
An imaging-guided ingestible microrobotic system enables deep tissue navigation and enhances targeted retention in vivo.
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Tutorial on photoacoustic tomography Open
Photoacoustic tomography (PAT) has become one of the fastest growing fields in biomedical optics. Unlike pure optical imaging, such as confocal microscopy and two-photon microscopy, PAT employs acoustic detection to image optical absorptio…
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Model-Based Learning for Accelerated, Limited-View 3-D Photoacoustic Tomography Open
Recent advances in deep learning for tomographic reconstructions have shown great potential to create accurate and high quality images with a considerable speed up. In this paper, we present a deep neural network that is specifically desig…
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Recent advances toward preclinical and clinical translation of photoacoustic tomography: a review Open
Photoacoustic imaging is an emerging hybrid imaging modality that can provide multicontrast, multiscale imaging of biological features ranging from organelles to organs. The three major embodiments of photoacoustic imaging are microscopy, …
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Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging Open
Photoacoustic imaging is a rapidly maturing imaging modality in biological research and medicine. This modality uses the photoacoustic effect ("light in, sound out") to combine the contrast and specificity of optical imaging with the high …
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High‐resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography <i>in vivo</i> Open
Photoacoustic computed tomography (PACT) is a non‐invasive imaging technique offering high contrast, high resolution, and deep penetration in biological tissues. We report a PACT system equipped with a high frequency linear transducer arra…
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Photoacoustic imaging with low-cost sources; A review Open
Benefitting from advantages of optical and ultrasound imaging, photoacoustic imaging (PAI) has demonstrated potentials in a wide range of medical applications. In order to facilitate clinical applications of PAI and encourage its applicati…
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Overview of Ultrasound Detection Technologies for Photoacoustic Imaging Open
Ultrasound detection is one of the major components of photoacoustic imaging systems. Advancement in ultrasound transducer technology has a significant impact on the translation of photoacoustic imaging to the clinic. Here, we present an o…
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Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode Open
Photoacoustic tomography (PAT), a promising medical imaging method that combines optical and ultrasound techniques, has been developing for decades mostly in preclinical application. A recent trend is to utilize the economical laser source…
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Assessing breast tumor margin by multispectral photoacoustic tomography Open
An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin…
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Determining both sound speed and internal source in thermo- and photo-acoustic tomography Open
This paper concerns thermoacoustic tomography and photoacoustic tomography,\ntwo couple-physics imaging modalities that attempt to combine the high\nresolution of ultrasound and the high contrast capabilities of electromagnetic\nwaves. We …
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Optical-resolution photoacoustic endomicroscopy in vivo Open
Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all tabl…
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Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system Open
Photoacoustic imaging (PAI) is an emerging functional and molecular imaging technology that has attracted much attention in the past decade. Recently, many researchers have used the vantage system from Verasonics for simultaneous ultrasoun…
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Photoacoustic tomography: principles and advances. Open
Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endog…
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Impact of System Factors on the Performance of Photoacoustic Tomography Scanners Open
High-performance imaging is essential for widespread applications of photoacoustic tomography (PAT) in biomedicine. So far, no comprehensive studies are reported on the impact of system factors on imaging performance, in spite of their imp…
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Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer Open
An NIR ultrahigh absorbing croconium dye for amyloid (CDA) was designed and synthesized .
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Multiscale Functional and Molecular Photoacoustic Tomography Open
Photoacoustic tomography (PAT) combines rich optical absorption contrast with the high spatial resolution of ultrasound at depths in tissue. The high scalability of PAT has enabled anatomical imaging of biological structures ranging from o…
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Towards Clinical Translation of LED-Based Photoacoustic Imaging: A Review Open
Photoacoustic imaging, with the capability to provide simultaneous structural, functional, and molecular information, is one of the fastest growing biomedical imaging modalities of recent times. As a hybrid modality, it not only provides g…
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Oxygen Saturation Imaging Using LED-Based Photoacoustic System Open
Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this techn…
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Photoacoustic computed tomography for functional human brain imaging [Invited] Open
The successes of magnetic resonance imaging and modern optical imaging of human brain function have stimulated the development of complementary modalities that offer molecular specificity, fine spatiotemporal resolution, and sufficient pen…
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Deep Learning in Biomedical Optics Open
This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging,…
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Noninvasive High-Speed Photoacoustic Tomography of Cerebral Hemodynamics in Awake-Moving Rats Open
We present a noninvasive method of photoacoustic tomography (PAT) for imaging cerebral hemodynamics in awake-moving rats. The wearable PAT (wPAT) system has a size of 15 mm in height and 33 mm in diameter, and a weight of ~ 8 g (excluding …
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Recent Advances in Photoacoustic Tomography Open
Photoacoustic tomography (PAT) that integrates the molecular contrast of optical imaging with the high spatial resolution of ultrasound imaging in deep tissue has widespread applications in basic biological science, preclinical research, a…
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Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images Open
We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast …
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Compressed sensing and sparsity in photoacoustic tomography Open
Increasing the imaging speed is a central aim in photoacoustic tomography. This issue is especially important in the case of sequential scanning approaches as applied for most existing optical detection schemes. In this work we address thi…
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Deep learning protocol for improved photoacoustic brain imaging Open
One of the key limitations for the clinical translation of photoacoustic imaging is penetration depth that is linked to the tissue maximum permissible exposures (MPE) recommended by the American National Standards Institute (ANSI). Here, w…
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Photoacoustic computed tomography of human extremities Open
We present a method of imaging angiographic structures in human extremities, including hands, arms, legs, and feet, using a newly developed photoacoustic computed tomography (PACT) system. The system features deep penetration (1.8 cm in mu…
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Highly sensitive and miniature microfiber-based ultrasound sensor for photoacoustic tomography Open
A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing. The compact size and large evanescent field of microfiber provide an excellent platform for the interaction between optical …
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Portable and Affordable Light Source-Based Photoacoustic Tomography Open
Photoacoustic imaging is a hybrid imaging modality that offers the advantages of optical (spectroscopic contrast) and ultrasound imaging (scalable spatial resolution and imaging depth). This promising modality has shown excellent potential…