Biological activity
View article: Dataset on dextromethorphan as a novel pharmacological inhibitor of F1FO-ATPase
Dataset on dextromethorphan as a novel pharmacological inhibitor of F1FO-ATPase Open
This dataset contains data from the evaluation of the inhibitory effect of dextromethorphan (DXM) on the hydrolytic and synthesis activity of mitochondrial F1FO-ATPase, isolated from porcine heart. The aim of the research was to investigat…
View article: Effect of Acid/Alkali Extraction of Polysaccharides from Jackfruit Filum and Its Structure and Biological Activity
Effect of Acid/Alkali Extraction of Polysaccharides from Jackfruit Filum and Its Structure and Biological Activity Open
This experiment focused on the preparation of polysaccharides from jackfruit filum using both acid and alkaline extraction methods. After determining the polysaccharide yield, the structures of the polysaccharides were analyzed and compare…
View article: Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts
Phytochemical Profiling and Pharmacological Evaluation of Caesalpinia Bonducella Seed Extracts Open
In this work, aqueous and methanolic solvents are used to examine the phytochemical makeup and pharmacological potential of Caesalpinia bonducella seed extract. Long acknowledged for their therapeutic value, traditional medical systems lik…
View article: Synthesis, biological evaluation, and molecular docking of novel coumarin-based bisimine derivatives
Synthesis, biological evaluation, and molecular docking of novel coumarin-based bisimine derivatives Open
View article: Figure S2 from Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity
Figure S2 from Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity Open
Supplementary Figure S2
View article: Syntheses, Complexation and Biological Activity of Aminoquinoline: A Mini-Review
Syntheses, Complexation and Biological Activity of Aminoquinoline: A Mini-Review Open
Aminoquinolines represent a prominent category of heterocyclic compounds that have been the focus of extensive research in recent decades due to their diverse and significant biological activities.These compounds are isomeric, distinguishe…
View article: Syntheses, Complexation and Biological Activity of Aminoquinoline: A Mini-Review
Syntheses, Complexation and Biological Activity of Aminoquinoline: A Mini-Review Open
Aminoquinolines represent a prominent category of heterocyclic compounds that have been the focus of extensive research in recent decades due to their diverse and significant biological activities.These compounds are isomeric, distinguishe…
View article: Antioxidant, Wound Healing and Cytotoxic Properties of Onosma heterophylla
Antioxidant, Wound Healing and Cytotoxic Properties of Onosma heterophylla Open
The study was aimed to determine the antioxidant, anticarcinogenic and wound healing activities of aqueous extracts prepared using Onosma heterophylla aerial parts. Aqueous extracts were prepared using infusion and maceration methods. Tota…
View article: Figure S1 from Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity
Figure S1 from Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity Open
Supplementary Figure S1
View article: Supplementary Data from IMiDs Augment CD3-Bispecific Antibody–Induced CD8<sup>+</sup> T-Cell Cytotoxicity and Expansion by Enhancing IL2 Production
Supplementary Data from IMiDs Augment CD3-Bispecific Antibody–Induced CD8<sup>+</sup> T-Cell Cytotoxicity and Expansion by Enhancing IL2 Production Open
Supplementary Data
View article: Figure S3 from Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity
Figure S3 from Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity Open
Supplementary Figure S3
View article: “Hyphae Intertwined, Biomolecules Co-Born”—New Polyketides Induction by Co-Culture of the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48 and Pestalotiopsis sp. HHL-101 at Both Volatile and Non-Volatile Levels
“Hyphae Intertwined, Biomolecules Co-Born”—New Polyketides Induction by Co-Culture of the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48 and Pestalotiopsis sp. HHL-101 at Both Volatile and Non-Volatile Levels Open
The co-culture technique, mimicking natural microbial interactions, has proven to be successful at activating silent biosynthetic gene clusters (BGCs) to produce novel metabolites or enhance the yield of specific metabolites. To effectivel…
View article: Modification, analysis and properties of Piper nigrum polysaccharide
Modification, analysis and properties of Piper nigrum polysaccharide Open
Currently, researchers have not yet found the antioxidant activity and structure of Piper nigrum L. polysaccharides (PNLP) and their modified derivatives. PNLP possesses advantages such as simple and stable structure, ease of separation an…
View article: Identification of Novel TAT-I24-Related Peptides with Antiviral Activities
Identification of Novel TAT-I24-Related Peptides with Antiviral Activities Open
To identify novel peptides with potential antiviral activities, a database search was performed based on the primary sequence of the peptide I24 (CLAFYACFC), the effective part of the antiviral peptide TAT-I24 consisting of peptide I24 and…
View article: Diverse Effects of Various Toll-Like Receptor 2 Ligands on Neuronal Activity and Cell Death
Diverse Effects of Various Toll-Like Receptor 2 Ligands on Neuronal Activity and Cell Death Open
The role of Toll-like receptor 2 (TLR2) in the central nervous system (CNS) is critical in several conditions including neurological disorders such as pain, and neurodegenerative disorders such as Parkinson’s disease. Therefore, understand…
View article: A novel liposomal hydrogel loaded with deer blood peptides prevents UVB-induced skin photoaging
A novel liposomal hydrogel loaded with deer blood peptides prevents UVB-induced skin photoaging Open
View article: Coumarins at the interface of chemistry and biology: Applied approaches to synthesis and bioactivity
Coumarins at the interface of chemistry and biology: Applied approaches to synthesis and bioactivity Open
Background: Coumarins and their derivatives represent a diverse class of bioactive molecules linking synthetic organic chemistry with modern biomedical applications. Their versatile benzopyran-2-one scaffold allows extensive chemical modif…
View article: Influence of Rare Earth Elements on Prebiotic Reaction Networks Resembling the Biologically Relevant Krebs Cycle
Influence of Rare Earth Elements on Prebiotic Reaction Networks Resembling the Biologically Relevant Krebs Cycle Open
Rare earth elements (REEs) are not rare, but rather abundant in the earth's crust and excellent catalysts for a multitude of organic reactions. They have been recently shown to be used in the active sites of bacterial enzymes and thus esse…
View article: Microwave-assisted synthesis and dual in silico–in vitro profiling of vanillin azo-Schiff base hybrids for antimicrobial potential
Microwave-assisted synthesis and dual in silico–in vitro profiling of vanillin azo-Schiff base hybrids for antimicrobial potential Open
Researchers have demonstrated substantial interest in bioactive compounds derived from natural resources, such as vanillin, owing to their significant potential in drug development. Here, we report the efficient synthesis of hybrid azo-Sch…
View article: The Effect of Lipid Extract of Nannochloropsis oceanica Marine Microalgae on Glutathione and Thioredoxin-Dependent Antioxidant Systems in UVB-Irradiated Keratinocytes
The Effect of Lipid Extract of Nannochloropsis oceanica Marine Microalgae on Glutathione and Thioredoxin-Dependent Antioxidant Systems in UVB-Irradiated Keratinocytes Open
UVB radiation present in sunlight is the main pro-oxidative and pro-inflammatory factor that reaches human skin cells, including keratinocytes. Therefore, protective compounds eliminating the negative impact of UVB radiation are constantly…
View article: Identification of a novel dual-targeting peptide inhibitor of SARS-CoV-2 RBD and NRP1 through structure-based virtual screening
Identification of a novel dual-targeting peptide inhibitor of SARS-CoV-2 RBD and NRP1 through structure-based virtual screening Open
Background The continuous mutations of SARS-CoV-2 have enhanced its transmissibility and immune escape capabilities. Its invasion into cells relies on the binding of the receptor-binding domain (RBD) of the spike (S) protein to host recept…
View article: Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays
Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays Open
Inflammation plays a crucial role in homeostasis and defense responses; however, exaggerated and chronic inflammation contribute to the development and worsening of various diseases. Acanthospermum australe (Loefl.) Kuntze ( A. australe ) …
View article: Scientific advancement on the way to molecular vitaminology at the Department of Vitamins and Coenzymes of the Palladin Institute of Biochemistry
Scientific advancement on the way to molecular vitaminology at the Department of Vitamins and Coenzymes of the Palladin Institute of Biochemistry Open
Modern advances in molecular vitaminology are characterized by a marked expansion in understanding the molecular mechanisms underlying the actions of vitamins and their biologically active derivatives as highly effective compounds that en…
View article: Microbial Biotransformation of the Sesquiterpene Carotol: Generation of Hydroxylated Metabolites with Potential Cytotoxic and Target-Specific Binding Activities
Microbial Biotransformation of the Sesquiterpene Carotol: Generation of Hydroxylated Metabolites with Potential Cytotoxic and Target-Specific Binding Activities Open
Carotol, the major sesquiterpene alcohol in carrot essential oil, possesses notable cytotoxic activity against various cancer cell lines, yet its metabolic fate remains poorly understood. This study explored microbial biotransformation as …
View article: Dual‐Functional Food‐Derived Bioactive Peptides: Expanding Beyond Biological Activity
Dual‐Functional Food‐Derived Bioactive Peptides: Expanding Beyond Biological Activity Open
Food‐derived bioactive peptides (FBPs) are a diverse group of peptides with proven physiological benefits in vitro or in vivo. Although much research has focused on peptides with various biological activities, emerging strategies emphasize…
View article: Genotoxic mechanisms of Erythrophleum suaveolens stem bark extracts and fractions in MCF-7 breast cancer cells via mitochondrial and non-mitochondrial pathways
Genotoxic mechanisms of Erythrophleum suaveolens stem bark extracts and fractions in MCF-7 breast cancer cells via mitochondrial and non-mitochondrial pathways Open
View article: Syntheses, Complexation and Biological Activity of Aminoquinoline: A Mini-Review
Syntheses, Complexation and Biological Activity of Aminoquinoline: A Mini-Review Open
Aminoquinolines represent a prominent category of heterocyclic compounds that have been the focus of extensive research in recent decades due to their diverse and significant biological activities.These compounds are isomeric, distinguishe…
View article: Decoding the anti-inflammatory properties of sesquiterpene coumarins from the active fractions of Ferula assa-foetida through integrated experimental and in silico analyses
Decoding the anti-inflammatory properties of sesquiterpene coumarins from the active fractions of Ferula assa-foetida through integrated experimental and in silico analyses Open
Ferula assa-foetida known as Asafoetida has a long-established history in folk medicine as a therapeutically useful drug in many disorders. The current paper explored the in vivo and in vitro anti-inflammatory activities of the plant. Liqu…
View article: Synthetic Access to Morpholine and Oxazolidine Derivatives as Next-Generation Antifungal Scaffolds
Synthetic Access to Morpholine and Oxazolidine Derivatives as Next-Generation Antifungal Scaffolds Open
View article: Antioxidant, Anticholinesterase and Antiproliferative Properties of the Wild Mushroom Hygrocybe Conica
Antioxidant, Anticholinesterase and Antiproliferative Properties of the Wild Mushroom Hygrocybe Conica Open
In this study, antioxidant, anticholinesterase and antiproliferative properties of ethanol extracts of Hygrocybe conica were determined. The ethanol extract of the mushroom was extracted by Soxhlet apparatus. Antioxidant activities were de…