DNA origami
View article: Ultra-fast Isothermal Formation of DNA Nanostructures in Culture Media: Application to in situ Assembly of DNA Origami with Living Cells
Ultra-fast Isothermal Formation of DNA Nanostructures in Culture Media: Application to in situ Assembly of DNA Origami with Living Cells Open
Synthetic DNA strands are programmable and biocompatible building blocks that can be combined through hybridization to form user-defined nanostructures, but their assembly traditionally requires cell-incompatible conditions, imposing a len…
View article: DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition
DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition Open
The rapid evolution and antigenic diversity of influenza A viruses (IAVs) continue to challenge antiviral strategies, highlighting the need for broadly effective and modular therapeutic platforms. While single‐domain nanobodies and DNA apt…
View article: Structural Modifications and Geometrical Changes in DNA Quadruple Folding in the Context of Sustainable Development Goals (SDGs)S
Structural Modifications and Geometrical Changes in DNA Quadruple Folding in the Context of Sustainable Development Goals (SDGs)S Open
The four natural DNA bases A-Adenosine ,T-Thymine, G-Guanine, C-Cytosine are associate in base pairs as (A=T and G≡C), allowing the attached DNA strands to assemble into the canonical double helix of DNA which is duplex of DNA, also known …
View article: Algorithm-driven DNA nanostructure design for advanced functionality
Algorithm-driven DNA nanostructure design for advanced functionality Open
Form and function are intimately linked—a guiding principle across both biology and engineering. While evolution and human ingenuity have shaped this landscape through function-driven form selection, AI-driven generative design expands it …
View article: Structural Modifications and Geometrical Changes in DNA Quadruple Folding in the Context of Sustainable Development Goals (SDGs)S
Structural Modifications and Geometrical Changes in DNA Quadruple Folding in the Context of Sustainable Development Goals (SDGs)S Open
The four natural DNA bases A-Adenosine ,T-Thymine, G-Guanine, C-Cytosine are associate in base pairs as (A=T and G≡C), allowing the attached DNA strands to assemble into the canonical double helix …
View article: DNA Origami Assembly inside Liposomes via Nanopore-Mediated DNA Transportation
DNA Origami Assembly inside Liposomes via Nanopore-Mediated DNA Transportation Open
Assembly of DNA origami nanostructures inside giant unilamellar vesicles (GUVs) is demonstrated by supplying approximately 200 unique staple strands from the external environment. Optimization of the lipid composition (DOPC : POPG : Choles…
View article: Smart nanofluidic systems powered by DNA origami for targeted intracellular delivery: a newer approach
Smart nanofluidic systems powered by DNA origami for targeted intracellular delivery: a newer approach Open
The convergence of DNA nanotechnology with nanofluidics has catalyzed a transformative shift in precision drug delivery. DNA origami, a self-assembled nanoscale architecture constructed via programmable base pairing, offers atomically prec…
View article: Simulation and Design Files for "Intrinsic Twist and Scaffold Continuity Govern the Conformational Dynamics of DNA Origami Nanosheets"
Simulation and Design Files for "Intrinsic Twist and Scaffold Continuity Govern the Conformational Dynamics of DNA Origami Nanosheets" Open
This dataset contains the simulation files used in the study“Intrinsic Twist and Scaffold Continuity Govern the Conformational Dynamics of DNA Origami Nanosheets.”All simulations were performed using the coarse-grained
View article: Simulation and Design Files for "Intrinsic Twist and Scaffold Continuity Govern the Conformational Dynamics of DNA Origami Nanosheets"
Simulation and Design Files for "Intrinsic Twist and Scaffold Continuity Govern the Conformational Dynamics of DNA Origami Nanosheets" Open
This dataset contains the simulation files used in the study“Intrinsic Twist and Scaffold Continuity Govern the Conformational Dynamics of DNA Origami Nanosheets.”All simulations were performed using the coarse-grained oxDNA model to inves…
View article: Interlinking helical spin textures in nanopatterned chiral magnets
Interlinking helical spin textures in nanopatterned chiral magnets Open
Nanoscale topologically non-trivial magnetization configurations generate significant interest due to both the fundamental properties of their knotted structures and their potential applications in ultra-efficient computing devices. While …
View article: Enhancing the miRNA Detection Sensitivity of DNA Origami Book Biosensors Using Lock Modifications and a Polymer Additive
Enhancing the miRNA Detection Sensitivity of DNA Origami Book Biosensors Using Lock Modifications and a Polymer Additive Open
DNA origami‐based biosensors provide a powerful and programmable platform for sensitive and specific molecular diagnostics. In this study, a dynamic DNA origami book biosensor is validated for direct detection of microRNA21 (miR‐21) in com…
View article: Interlinking helical spin textures in nanopatterned chiral magnets
Interlinking helical spin textures in nanopatterned chiral magnets Open
Nanoscale topologically non-trivial magnetization configurations generate significant interest due to both the fundamental properties of their knotted structures and their potential applications in ultra-efficient computing devices. While …
View article: From Fold to Function: Dynamic Modeling and Simulation-Driven Design of Origami Mechanisms
From Fold to Function: Dynamic Modeling and Simulation-Driven Design of Origami Mechanisms Open
Origami-inspired mechanisms can transform flat sheets into functional three-dimensional dynamic structures that are lightweight, compact, and capable of complex motion. These properties make origami increasingly valuable in robotic and dep…
View article: Inter-Instrument Quantification of Fluorescence Read-out Signal Using DNA Origami Calibrator Beads
Inter-Instrument Quantification of Fluorescence Read-out Signal Using DNA Origami Calibrator Beads Open
Comparing experimental results across different instruments and laboratories is challenging due to variations in instrument sensitivity and resolution, particularly for analyzing nano-sized and dimly fluorescing particles like viruses and …
View article: From Fold to Function: Dynamic Modeling and Simulation-Driven Design of Origami Mechanisms
From Fold to Function: Dynamic Modeling and Simulation-Driven Design of Origami Mechanisms Open
Origami-inspired mechanisms can transform flat sheets into functional three-dimensional dynamic structures that are lightweight, compact, and capable of complex motion. These properties make origami increasingly valuable in robotic and dep…
View article: Computer‐Aided Design Software and Simulation Tools for DNA Nanoparticles
Computer‐Aided Design Software and Simulation Tools for DNA Nanoparticles Open
DNA nanostructures, particularly DNA origami nanoparticles, have been increasingly employed as structural constituents for sophisticated applications in materials science, therapeutics, drug discovery and delivery, as well as oncology trea…
View article: A Molecular Machine Directs the Synthesis of a Rotaxane
A Molecular Machine Directs the Synthesis of a Rotaxane Open
Preorganization by assembly or templating strategies is frequently used in the synthesis of rotaxanes. While these approaches have led to complex interlocked molecules, they are often limited by strict compositional requirements of templat…
View article: Microrheology of entangled DNA solutions
Microrheology of entangled DNA solutions Open
Fundamental properties of DNA-based materials, including DNA sequence, length, and topology, as well as external factors such as ionic strength and temperature, collectively influence their behaviour. However, how these factors affect the …
View article: Recent advances in graphene origami structures: A review
Recent advances in graphene origami structures: A review Open
View article: From toroids to helical tubules: Kirgami-inspired programmable assembly of two-periodic curved crystals from DNA origami
From toroids to helical tubules: Kirgami-inspired programmable assembly of two-periodic curved crystals from DNA origami Open
This repository contains images and measurement data for the publication “From toroids to helical tubules: Kirigami-inspired programmable assembly of two-periodic curved crystals” (https://arxiv.org/abs/2506.16403). In this article, we use…
View article: From toroids to helical tubules: Kirgami-inspired programmable assembly of two-periodic curved crystals from DNA origami
From toroids to helical tubules: Kirgami-inspired programmable assembly of two-periodic curved crystals from DNA origami Open
This repository contains images and measurement data for the publication “From toroids to helical tubules: Kirigami-inspired programmable assembly of two-periodic curved crystals” (https://arxiv.org/abs/2506.16403). In this article, we use…
View article: Enzyme-powered DNA origami nanostructures for enhanced mucosal diffusion
Enzyme-powered DNA origami nanostructures for enhanced mucosal diffusion Open
Crossing mucosal barriers is a central challenge for oral drug delivery, where nanoparticle design must balance stability with mobility in complex fluids. Here, we demonstrate DNA origami as a programmable platform to investigate these pro…
View article: Effects of Oligolysine-Polyethylene Glycol Coating on the Biodistribution of Wireframe DNA Origami Nanosheets in Zebrafish Embryos
Effects of Oligolysine-Polyethylene Glycol Coating on the Biodistribution of Wireframe DNA Origami Nanosheets in Zebrafish Embryos Open
DNA origami-based nanotechnology is a versatile tool for exploring fundamental biological questions and holds significant promise for future biomedical applications. Here, we leverage the optical transparency of the embryonic zebrafish to …
View article: Topology Determines DNA Origami Diffusion in Intestinal Mucus
Topology Determines DNA Origami Diffusion in Intestinal Mucus Open
Efficient nanomedicine delivery across mucosal barriers remains a challenge due to the complex and poorly understood relationship between nanoparticle design and mucus transport. Here, we present DNA origami as a platform to investigate ho…
View article: Using DNA origami to study nanoscale organization of plasma membranes
Using DNA origami to study nanoscale organization of plasma membranes Open
Plasma membrane (PM) lipids and proteins are organized into nanoscale regions called nanodomains, which regulate essential cellular processes by controlling local membrane organization. Despite advances in super-resolution microscopy and s…
View article: Multivalent DNA Origami Enables Single-Molecule Dissection of Integrin αvβ6–Receptor Tyrosine Kinase Crosstalk in Cancer Biology
Multivalent DNA Origami Enables Single-Molecule Dissection of Integrin αvβ6–Receptor Tyrosine Kinase Crosstalk in Cancer Biology Open
Nanoscale organization of integrin-mediated receptor crosstalk is crucial for controlling cellular signaling in cancer biology. Previously, interactions between integrin αvβ6 and receptor tyrosine kinases (RTKs) have been implicated in can…
View article: DNA Origami Tension Sensors (DOTS) for Single-Molecule Force Measurements at Fluid Intermembrane Junctions
DNA Origami Tension Sensors (DOTS) for Single-Molecule Force Measurements at Fluid Intermembrane Junctions Open
A key event in triggering adaptive immunity is the binding of a T cell receptor (TCR) to its antigen at the T cell-target cell interface. Mechanical forces are critical for TCR-antigen interactions, where piconewton (pN) forces modulate im…
View article: Controlled reassociation of multistranded, polycrossover DNA molecules into double helices
Controlled reassociation of multistranded, polycrossover DNA molecules into double helices Open
Shape-changing DNA nanostructures have found applications in biosensing, drug delivery, cell modulation and data storage. A key aspect of this reconfiguration is the interaction of DNA nanostructures with other biomolecules or chemical sti…
View article: Vancomycin‐Modified DNA Origami Nanostructures for Targeting Bacterial Pathogens
Vancomycin‐Modified DNA Origami Nanostructures for Targeting Bacterial Pathogens Open
The specific binding of DNA origami nanostructures (DONs) to bacteria is an important prerequisite for their application in pathogen targeting and antimicrobial drug delivery. So far, targeting bacteria with DONs has been achieved exclusiv…
View article: Azobenzene DNA Intercalator/Cyclodextrin Pseudo‐Rotaxane: From Photoswitchable Chirality and Fluorescence to DNA Melting Control
Azobenzene DNA Intercalator/Cyclodextrin Pseudo‐Rotaxane: From Photoswitchable Chirality and Fluorescence to DNA Melting Control Open
Pseudo‐rotaxanes are reversibly interlocked molecules with at least one linear molecule threaded into a macrocycle and, contrary to rotaxanes, an advantageous ability to be dissociated. Cyclodextrins constitute attracting macrocyclic host …