Proof of concept ≈ Proof of concept
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First patients treated with a 1.5 T MRI-Linac: clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment Open
The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration with Elekta and Philips. The idea behind this integrated device is to offer unr…
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Proof-of-Stake Consensus Mechanisms for Future Blockchain Networks: Fundamentals, Applications and Opportunities Open
The rapid development of blockchain technology and their numerous emerging applications has received huge attention in recent years. The distributed consensus mechanism is the backbone of a blockchain network. It plays a key role in ensuri…
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Harnessing bistability for directional propulsion of soft, untethered robots Open
Significance A major challenge in soft robotics is the integration of sensing, actuation, control, and propulsion. Here, we propose a material-based approach for designing soft robots. We show an untethered, soft swimming robot, which can …
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Delegated Proof of Stake With Downgrade: A Secure and Efficient Blockchain Consensus Algorithm With Downgrade Mechanism Open
Blockchain technology has a wide range of applications in the fields of finance, credit reporting and intellectual property, etc. As the core of blockchain, consensus algorithm affects the security and performance of blockchain system dire…
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Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis Open
We report here the development of coreactant-based electrogenerated chemiluminescence (ECL) as a surface-confined microscopy to image single cells and their membrane proteins. Labeling the entire cell membrane allows one to demonstrate tha…
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Design and Implementation of an Integrated IoT Blockchain Platform for Sensing Data Integrity Open
With the rapid development of communication technologies, the Internet of Things (IoT) is getting out of its infancy, into full maturity, and tends to be developed in an explosively rapid way, with more and more data transmitted and proces…
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Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis Open
Selective reactions on structures of high complexity can move beyond the mind's eye and proof-of-principle. Enhanced understanding of noncovalent interactions and their interdependence, revealed through analysis of multiple parameters, sho…
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5G-assisted telementored surgery Open
Safe and effective implementation of remote surgery and telementoring can have significant limitations. Fifth-generation (5G) wireless networks could be useful in overcoming these drawbacks. As a proof of concept, the authors present techn…
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Design and implementation of a standardized framework to generate and evaluate patient-level prediction models using observational healthcare data Open
Objective To develop a conceptual prediction model framework containing standardized steps and describe the corresponding open-source software developed to consistently implement the framework across computational environments and observat…
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A direct coupled electrochemical system for capture and conversion of CO2 from oceanwater Open
Capture and conversion of CO 2 from oceanwater can lead to net-negative emissions and can provide carbon source for synthetic fuels and chemical feedstocks at the gigaton per year scale. Here, we report a direct coupled, proof-of-concept e…
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Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy Open
We demonstrate the pharmacologic potential of the purified cell-penetrating Omomyc mini-protein to directly inhibit MYC function in vitro and in vivo.
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Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study Open
Purpose: Preclinical studies suggest PARP inhibition (PARPi) induces immunostimulatory micromilieu in ovarian cancer thus complementing activity of immune checkpoint blockade. We conducted a phase II trial of PARPi olaparib and anti–PD-L1 …
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Phenomic Selection Is a Low-Cost and High-Throughput Method Based on Indirect Predictions: Proof of Concept on Wheat and Poplar Open
Genomic selection - the prediction of breeding values using DNA polymorphisms - is a disruptive method that has widely been adopted by animal and plant breeders to increase productivity. It was recently shown that other sources of molecula…
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Intracardiac pulsed field ablation: Proof of feasibility in a chronic porcine model Open
Intracardiac PFA can be feasibly delivered from a circular catheter to create fibrotic lesions that have acute electrical effects, without injury to nontargeted tissue.
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Proof-of-Principle Experimental Demonstration of Twin-Field Type Quantum Key Distribution Open
The twin-field (TF) quantum key distribution (QKD) protocol and its variants are highly attractive because they can beat the well-known fundamental limit of the secret key rate for point-to-point QKD without quantum repeaters (repeaterless…
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ERTMS/ETCS Virtual Coupling: Proof of Concept and Numerical Analysis Open
Railway infrastructure operators need to push their network capacity up to their limits in high-traffic corridors. Virtual coupling is considered among the most relevant innovations to be studied within the European Horizon 2020 Shift2Rail…
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A Survey on Long-Range Attacks for Proof of Stake Protocols Open
Despite common arguments about the prevalence of blockchain technology, in terms of security, privacy, and immutability, in reality, several attacks can be launched against them. This paper provides a systematic literature review on long-r…
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Proof of Concept for an Ultrasensitive Technique to Detect and Localize Sources of Elastic Nonlinearity Using Phononic Crystals Open
The appearance of nonlinear effects in elastic wave propagation is one of the most reliable and sensitive indicators of the onset of material damage. However, these effects are usually very small and can be detected only using cumbersome d…
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Using Blockchain Technology to Manage Clinical Trials Data: A Proof-of-Concept Study Open
Blockchain technology presents an opportunity to address some of the common threats to the integrity of data collected in clinical trials and ensure that the analysis of these data comply with prespecified plans. Further technical work is …
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A Blockchain Framework for Patient-Centered Health Records and Exchange (HealthChain): Evaluation and Proof-of-Concept Study Open
Background Blockchain has the potential to disrupt the current modes of patient data access, accumulation, contribution, exchange, and control. Using interoperability standards, smart contracts, and cryptographic identities, patients can s…
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The first case of ischemia-free organ transplantation in humans: A proof of concept Open
Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure and is associated with significant mortality and morbidity post-transplantation. We hypothesize that IRI is avoidable if the blood supp…
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Proof-of-concept for facile perovskite solar cell recycling Open
Recyclability of perovskite solar cells is demonstrated in a simple lab-scale process. Successful recovery of valuable components as well as cell performance underline the technology's potential as sustainable PV.
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eDNAir: proof of concept that animal DNA can be collected from air sampling Open
Environmental DNA (eDNA) is one of the fastest developing tools for species biomonitoring and ecological research. However, despite substantial interest from research, commercial and regulatory sectors, it has remained primarily a tool for…
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Performing particle image velocimetry using artificial neural networks: a proof-of-concept Open
Traditional programs based on feature engineering are under performing on a steadily increasing number of tasks compared with Artificial Neural Networks (ANNs), in particular for image analysis. Image analysis is widely used in Fluid Mecha…
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Planning for change in a formal verification of the raft consensus protocol Open
We present the first formal verification of state machine safety for the Raft consensus protocol, a critical component of many distributed systems. We connected our proof to previous work to establish an end-to-end guarantee that our imple…
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A unified machine-learning protocol for asymmetric catalysis as a proof of concept demonstration using asymmetric hydrogenation Open
Design of asymmetric catalysts generally involves time- and resource-intensive heuristic endeavors. In view of the steady increase in interest toward efficient catalytic asymmetric reactions and the rapid growth in the field of machine lea…
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Gold Nanotheranostics: Proof-of-Concept or Clinical Tool? Open
Nanoparticles have been making their way in biomedical applications and personalized medicine, allowing for the coupling of diagnostics and therapeutics into a single nanomaterial—nanotheranostics. Gold nanoparticles, in particular, have u…
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An improvement of the convergence proof of the ADAM-Optimizer Open
A common way to train neural networks is the Backpropagation. This algorithm includes a gradient descent method, which needs an adaptive step size. In the area of neural networks, the ADAM-Optimizer is one of the most popular adaptive step…
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Blockchain-Based Traceability System That Ensures Food Safety Measures to Protect Consumer Safety and COVID-19 Free Supply Chains Open
The world is facing an unprecedented socio-economic crisis caused by the novel coronavirus infection (COVID-19). The virus is also spreading through the import and export food supply chains. The Chinese authorities have discovered the COVI…
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A Survey on Blockchain Consensus with a Performance Comparison of PoW, PoS and Pure PoS Open
Blockchain technology started as the backbone for cryptocurriencies and it has emerged as one of the most interesting technologies of the last decade. It is a new paradigm able to modify the way how industries transact. Today, the industri…