Nanotoxicology ≈ Nanotoxicology
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Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology Open
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules …
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A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives Open
With the development of nanotechnology, silver nanoparticles (Ag-NPs) have become one of the most in-demand nanoparticles owing to their exponential number of uses in various sectors. The increased use of Ag-NPs-enhanced products may resul…
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Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure Open
Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among the various ENMs, silver nanoparticles (AgNPs) have become one of the most explored nanotechnology-derived nanostructu…
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Interaction of Nanomaterials with Plants: What Do We Need for Real Applications in Agriculture? Open
The number of published researching works related with applications of nanomaterials in agriculture is increasing every year. Most of such works focus on the synthesis of nanodevices, their characteristics as nanocarriers for controlled re…
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Toxicity of Nanoparticles and an Overview of Current Experimental Models. Open
Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. Tetrazolium-based assays such as MTT, MTS, and WST-1 are used…
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Antibacterial properties and toxicity from metallic nanomaterials Open
The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising…
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Safe Nanoparticles: Are We There Yet? Open
The field of nanotechnology has grown over the last two decades and made the transition from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles, have emerged as promising tools with broad applications in drug…
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Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models Open
Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, …
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Toxicology of silica nanoparticles: an update Open
Large-scale production and use of amorphous silica nanoparticles (SiNPs) have increased the risk of human exposure to SiNPs, while their health effects remain unclear. In this review, scientific papers from 2010 to 2016 were systematically…
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Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components Open
The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly in areas where traditional diagnostics and treatment approaches have limited success. The success of nanomaterials in medical product…
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Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials Open
Here, we provide a review of the latest research findings on the toxicological profiles of carbon-based nanomaterials, highlighting both the cellular toxicities and immunological effects of carbon nanomaterials. This review provides inform…
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Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review Open
The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery…
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Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung Open
In this study we provide guidance on the biologically most relevant dose metric for pulmonary toxicity of biopersistent, spherical nanoparticles (NPs). A retrospective analysis of nine in vivo studies on particle-induced, acute pulmonary t…
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Transformation pathways and fate of engineered nanoparticles (ENPs) in distinct interactive environmental compartments: A review Open
The ever increasing production and use of nano-enabled commercial products release the massive amount of engineered nanoparticles (ENPs) in the environment. An increasing number of recent studies have shown the toxic effects of ENPs on dif…
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The Toxicity of Nanoparticles Depends on Multiple Molecular and Physicochemical Mechanisms Open
Nanotechnology is an emerging discipline that studies matters at the nanoscale level. Eventually, the goal is to manipulate matters at the atomic level to serve mankind. One growing area in nanotechnology is biomedical applications, which …
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Toxicity of copper oxide nanoparticles: a review study Open
Copper oxide nanoparticles (CuO NPs) use has exponentially increased in various applications (such as industrial catalyst, gas sensors, electronic materials, biomedicines, environmental remediation) due to their flexible properties, i.e. l…
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Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge Open
There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. https://doi.org/10.1289/EHP424.
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In vitro and in vivo toxicity assessment of nanoparticles Open
Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their …
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Pharmaceutical aspects of silver nanoparticles Open
Silver nanoparticles are particles in the size ranging between 1 and 100 nm. The two major methods used for synthesis of silver nanoparticle are the physical and chemical methods with the disadvantage that they are expensive and can also h…
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Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology Open
Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distributi…
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Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials Open
In the last decades, the staggering progress in nanotechnology brought around a wide and heterogeneous range of nanoparticle-based platforms for the diagnosis and treatment of many diseases. Most of these systems are designed to be adminis…
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Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications Open
This tutorial review highlights the key aspects of nanotoxicity and the importance of its systematic assessment for metal–organic framework (MOF) nanoparticles to pave the way towards their potential applications in a safe and sustainable …
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Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation Open
The development of different kinds of nanoparticles, showing different physico-chemical properties, has fostered their large use in many fields, including medicine. As a consequence, inorganic nanoparticles (e.g., metals or semiconductors)…
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The Toxicity of Silica Nanoparticles to the Immune System Open
Silicon-based materials and their oxides are widely used in drug delivery, dietary supplements, implants and dental fillers. Silica nanoparticles (SiNPs) interact with immunocompetent cells and induce immunotoxicity. However, the toxic eff…
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Nanoparticle Toxicology Open
Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due to this constant exposure, it is critically important to understand the potential acute and chron…
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Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model Open
Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, …
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Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model Open
While two-dimensional graphene oxide (GO) is used increasingly in biomedical applications, there is uncertainty on how specific physicochemical properties relate to biocompatibility in mammalian systems. Although properties such as lateral…
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Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine Open
Advances in nanomedicine, coupled with novel methods of creating advanced materials at the nanoscale, have opened new perspectives for the development of healthcare and medical products. Special attention must be paid toward safe design ap…
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Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles Open
Protein corona formation is critical for the design of ideal and safe nanoparticles (NPs) for nanomedicine, biosensing, organ targeting, and other applications, but methods to quantitatively predict the formation of the protein corona, esp…
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Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review Open
In the last two decades, nanotechnologies demonstrated various applications in different fields, including detection, sensing, catalysis, electronics, and biomedical sciences. However, public concerns regarding the well-being of human may …