Flow chemistry
View article: Synthetic Frontiers in Natural Product Chemistry: Mastering Molecular Complexity for Therapeutic Advancement
Synthetic Frontiers in Natural Product Chemistry: Mastering Molecular Complexity for Therapeutic Advancement Open
Natural products (NPs) offer an unparalleled reservoir of chemical diversity for novel therapeutic agents. Their intricate molecular architectures, characterized by multiple stereocenters, constrained ring systems, and diverse functionalit…
View article: Parameter optimisation of a microreactor based continuous synthesis of bromooctyl glucoside by Fischer glycosylation
Parameter optimisation of a microreactor based continuous synthesis of bromooctyl glucoside by Fischer glycosylation Open
Bromalkyl glycosides are promising molecules for use as functionalised spacers in the production of glycomimetics. The here presented optimised process can serve as the basis for the technical synthesis of bromoalkyl glycosides in a micror…
View article: Polymeric Iridium Catalysts for C–H Borylation of Arenes under Batch and Continuous Flow Conditions
Polymeric Iridium Catalysts for C–H Borylation of Arenes under Batch and Continuous Flow Conditions Open
Arylboronates are key intermediates in the synthesis of pharmaceuticals and functional materials, yet their direct C–H borylation typically requires air-sensitive homogeneous iridium catalysts, limiting catalyst recovery and scalability. H…
View article: Sustainable Conjugated Polymer Synthesis in OPV: A Case Study from Conventional to Flow and Microwave-Assisted Synthesis
Sustainable Conjugated Polymer Synthesis in OPV: A Case Study from Conventional to Flow and Microwave-Assisted Synthesis Open
View article: Addressing Sustainability Challenges in Peptide Synthesis with Flow Chemistry and Machine Learning
Addressing Sustainability Challenges in Peptide Synthesis with Flow Chemistry and Machine Learning Open
The high cost and the large amount of toxic waste generated during peptide production overshadow the current technology, requiring the reduction of excess reagents and the replacement of the solvents used. Advances have been made to replac…
View article: Flow Process for Production of Crisaborole Using Organolithium Chemistry with Control over Impurity Formation
Flow Process for Production of Crisaborole Using Organolithium Chemistry with Control over Impurity Formation Open
View article: Continuous flow photooxygenation with advanced rose bengal-anchored polymer colloids
Continuous flow photooxygenation with advanced rose bengal-anchored polymer colloids Open
Continuous flow technologies and reusable core–shell polymer colloids functionalized with Rose Bengal are combined for sustainable singlet oxygen-mediated photooxidation of biobased substrates.
View article: Photochemical Flow Synthesis of Trisubstituted Oxazoles Enabled by High-Power UV–B LED Modules
Photochemical Flow Synthesis of Trisubstituted Oxazoles Enabled by High-Power UV–B LED Modules Open
The use of a newly developed UV-B LED module for the continuous flow synthesis of a variety of trisubstituted oxazole products from readily available isoxazoles is reported. Crucially, this work demonstrates for the first time that these U…
View article: Flow regime in the ISO standard 22197–1:2016 photocatalytic Reactor: PIV-Visualisation, Modelling, and Application
Flow regime in the ISO standard 22197–1:2016 photocatalytic Reactor: PIV-Visualisation, Modelling, and Application Open
View article: A Continuous Manufacturing Line Generating Organozinc Species in Flow: Enhancing the Simmons-Smith Reaction Including Post-Reaction Processing
A Continuous Manufacturing Line Generating Organozinc Species in Flow: Enhancing the Simmons-Smith Reaction Including Post-Reaction Processing Open
View article: Flow Reactor Study of NH<sub>3</sub>/DEE Oxidation Chemistry
Flow Reactor Study of NH<sub>3</sub>/DEE Oxidation Chemistry Open
The pursuit of environmentally sustainable alternatives to conventional fuels is essential today. Ammonia emerges as a promising candidate, though its inherent disadvantages must be addressed. Co-firing ammonia with fuels exhibiting superi…
View article: Atmospheric-pressure and continuous-flow synthesis of 1,3-diphenylurea from CO2 and aniline over CeO2 catalyst assisted by 2-cyanopyridine and its life cycle perspective on pathways toward lower CO2 emissions
Atmospheric-pressure and continuous-flow synthesis of 1,3-diphenylurea from CO2 and aniline over CeO2 catalyst assisted by 2-cyanopyridine and its life cycle perspective on pathways toward lower CO2 emissions Open
View article: Automated high-purity fast-flow synthesis of cyclic peptide-PNA conjugates for drug discovery and nanotechnology
Automated high-purity fast-flow synthesis of cyclic peptide-PNA conjugates for drug discovery and nanotechnology Open
View article: Front Cover: Streamlining Vorinostat Synthesis: A Chemoenzymatic Continuous Flow Approach (Eur. J. Org. Chem. 27/2025)
Front Cover: Streamlining Vorinostat Synthesis: A Chemoenzymatic Continuous Flow Approach (Eur. J. Org. Chem. 27/2025) Open
View article: Model-based disturbance-conscious design space exploration for drug substance flow synthesis using the Grignard reaction
Model-based disturbance-conscious design space exploration for drug substance flow synthesis using the Grignard reaction Open
View article: Microwave assisted flow synthesis of Ir-IrOx electrocatalysts for acidic oxygen evolution reaction: synthesis conditions and electrocatalytic performance correlation
Microwave assisted flow synthesis of Ir-IrOx electrocatalysts for acidic oxygen evolution reaction: synthesis conditions and electrocatalytic performance correlation Open
View article: Comparing the Polyoxometalate-Catalyzed Oxidation of C5-Containing Biomass to Formic Acid in a Taylor-Flow Microreactor and a Stirred-Tank Reactor
Comparing the Polyoxometalate-Catalyzed Oxidation of C5-Containing Biomass to Formic Acid in a Taylor-Flow Microreactor and a Stirred-Tank Reactor Open
Biomass valorization using polyoxometalate-based (POM) catalysts is a promising strategy for green and sustainable chemistry. In the modified OxFA process, various biogenic substrates can be selectively oxidized to the sustainable hydrogen…
View article: A Novel Flow Chemistry Approach to Covalent Functionalization of 3D Graphene Aerogels
A Novel Flow Chemistry Approach to Covalent Functionalization of 3D Graphene Aerogels Open
Tuning the surface chemistry of 3D graphene structures, such as hydrogels and aerogels, is critical for advancing their chemical and physical properties, which are essential for material design. Here, we present an innovative in-flow coval…
View article: Nitrogen-doped Carbon-supported Metal Catalysts for Synthetic Organic Chemistry and Application to Continuous-flow Reactions
Nitrogen-doped Carbon-supported Metal Catalysts for Synthetic Organic Chemistry and Application to Continuous-flow Reactions Open
View article: WANTED: Flow Chemistry Reaction Data
WANTED: Flow Chemistry Reaction Data Open
Flow reaction data could have an outsized impact in the datasets which train the reaction prediction, chemical synthesis planning, and experiment design tools of tomorrow. This paper discusses why we should be increasing the availability o…
View article: Kinetic Investigation of the Asymmetric Hydrogenation of Benzylphenylephrone in Continuous Flow
Kinetic Investigation of the Asymmetric Hydrogenation of Benzylphenylephrone in Continuous Flow Open
In the pharmaceutical industry, efficient, fast, and cost-effective API manufacturing processes are crucial for maintaining competitiveness. However, traditional production methods are often dominated by multi-purpose batch processes and e…
View article: Generation and Use of Reactive Intermediates Exploiting Flow Technology
Generation and Use of Reactive Intermediates Exploiting Flow Technology Open
Continuous flow technology has matured into a valuable and widely exploited technology across academic and industrial laboratories. The safe and on-demand generation of reactive intermediates using miniaturized flow set-ups is of particula…
View article: Continuous synthesis of gold nanorods in a two-phase millifluidic flow reactor
Continuous synthesis of gold nanorods in a two-phase millifluidic flow reactor Open
View article: Continuous Flow Singlet Oxygen Photooxygenation Reactions: Recent Advances and Applications
Continuous Flow Singlet Oxygen Photooxygenation Reactions: Recent Advances and Applications Open
Photooxygenation reactions are sustainable alternatives to standard oxidation methods for the synthesis of crucial building blocks, natural products and drugs. This review is intended to provide readers with the latest advances on the deve…
View article: A Scalable Dynamic Cascade Flow Reactor for Challenging Continuous Heterogeneous Processes
A Scalable Dynamic Cascade Flow Reactor for Challenging Continuous Heterogeneous Processes Open
Continuous processes (often referred to as flow chemistry) offers multiple advantages over batch processes and are of particular interest for industrial applications as they provide a more direct path towards process intensification, incre…
View article: Synthesis of Defective MOF-801 via Air–Liquid Segmented Flow for Catalytic Transfer Hydrogenation of Furfural
Synthesis of Defective MOF-801 via Air–Liquid Segmented Flow for Catalytic Transfer Hydrogenation of Furfural Open
As one of the most important platform chemicals, furfural (FAL) can be converted into high-value-added products such as furfuryl alcohol (FOL) through multiple pathways. Zirconium-based MOF-801 demonstrates exceptional catalytic potential …
View article: A Telescoped Strategy for the Preparation of Five‐Membered Hetero‐ and Carbocycles via Hydrogen Atom Transfer Photocatalysis in Flow
A Telescoped Strategy for the Preparation of Five‐Membered Hetero‐ and Carbocycles via Hydrogen Atom Transfer Photocatalysis in Flow Open
Five‐membered heterocycles such as pyrroles and thiophenes, along with cyclopentenones, are key scaffolds in pharmaceutical chemistry. However, the synthesis of these motifs via diversity oriented synthesis is hindered by the limited acces…
View article: Etherification of Bio‐Based Furanic Compounds via Continuous Flow
Etherification of Bio‐Based Furanic Compounds via Continuous Flow Open
The ultimate goal of biorefinery is to move away from a fossil‐based industry aiming to a more sustainable one centered on the use of renewable feedstocks. It is well known that numerous bio‐based platform chemicals can be obtained from bi…
View article: Flow Synthesis of Pharmaceutical Intermediate Catalyzed by Immobilized DERA: Comparison of Different Immobilization Techniques and Reactor Designs
Flow Synthesis of Pharmaceutical Intermediate Catalyzed by Immobilized DERA: Comparison of Different Immobilization Techniques and Reactor Designs Open
The enzymatic synthesis of statin intermediates offers a sustainable alternative to traditional multistep chemical methods. This study investigates the continuous flow synthesis of statin precursors in a millireactor using 2-deoxy-D-ribose…
View article: Machine Learning-Driven Optimization of Continuous-Flow Photoredox Amine Synthesis
Machine Learning-Driven Optimization of Continuous-Flow Photoredox Amine Synthesis Open
Photoredox catalysis plays an important role in the synthesis of pharmaceutically relevant compounds such as C-(sp3)-rich tertiary amines. The difficulty of identifying underlying mechanistic models for such novel transformation…