Chemokine
View article: Supplementary Figure 2 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Supplementary Figure 2 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma Open
Loss of tumor-derived CCL5 reduces tumor cell proliferation in TE-1 cells.
View article: Supplementary Figure 4 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Supplementary Figure 4 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma Open
Targeted CCR5 inhibition replicates CCL5 loss with reduced tumor cell proliferation in vitro and in vivo.
View article: Supplementary Figure 1 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Supplementary Figure 1 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma Open
Confirmation of CCL5 knockout clones.
View article: Supplementary Figure 3 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Supplementary Figure 3 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma Open
ERK1/2 signaling pathway in CCL5 knockout cells.
View article: Figure S1 from S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
Figure S1 from S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells Open
The binding activity of S-531011 against various chemokine receptors, PD-1, PD-L1, CTLA4, or mouse CCR8
View article: Supplementary Tables from CXCL10 Recruitment of γδ T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression
Supplementary Tables from CXCL10 Recruitment of γδ T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression Open
supplementary tables 1-5
View article: Characterization of Ty21a immunostimulatory effects in the mouse bladder
Characterization of Ty21a immunostimulatory effects in the mouse bladder Open
Intravesical treatment with Salmonella enterica Ty21a, an oral typhoid-fever vaccine, has shown therapeutic potential against bladder tumors mainly through local immune-cell recruitment, particularly CD8 + T-cells. However, the mechanisms …
View article: Supplementary Figures from CXCL10 Recruitment of γδ T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression
Supplementary Figures from CXCL10 Recruitment of γδ T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression Open
supplementary figures and legends
View article: Macrophage migration inhibitory factor–CD74 axis drives vascular smooth muscle cell–induced M1 macrophage polarization to exacerbate intracranial aneurysm inflammation
Macrophage migration inhibitory factor–CD74 axis drives vascular smooth muscle cell–induced M1 macrophage polarization to exacerbate intracranial aneurysm inflammation Open
Background Intracranial aneurysms (IAs) develop and progress through pathological processes, including inflammation and abnormal changes in the vascular structure. The cytokine Macrophage Migration Inhibitory Factor (MIF) is implicated in …
View article: Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons
Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons Open
Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upre…
View article: SERPINE1 Drives Molecular Synergies in Colorectal Cancer
SERPINE1 Drives Molecular Synergies in Colorectal Cancer Open
Colorectal cancer is a complex disease shaped by genetic changes and crosstalk among tumor cells, stromal factors and infiltrating cellular elements within the tumor environment. In this review, we explore an integrative network of genes a…
View article: Fucosylation Enhances CD34⁺ Hematopoietic Stem Cell Homing and Longevity via E-Selectin–Mediated Adhesion and Signaling
Fucosylation Enhances CD34⁺ Hematopoietic Stem Cell Homing and Longevity via E-Selectin–Mediated Adhesion and Signaling Open
Background Hematopoietic stem cell transplantation (HSCT) is a cornerstone treatment for blood disorders and hematological malignancies, although its efficacy is limited by inefficient stem cell homing to the bone marrow. We previously dem…
View article: Supplementary Data from T cell–Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile
Supplementary Data from T cell–Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile Open
Figure S1, S2, S3
View article: T-cell responses are insufficient to generate protective immunity to SARS-CoV-2
T-cell responses are insufficient to generate protective immunity to SARS-CoV-2 Open
Neutralizing antibodies are established correlates of protection against SARS-CoV-2, yet T-cell responses are also thought to contribute substantially to limiting disease severity and enhancing durability of protection. To examine whether …
View article: Distinct patterns of endothelial response to endotoxin in aged mice as compared to young mice
Distinct patterns of endothelial response to endotoxin in aged mice as compared to young mice Open
Aging exacerbates organ injury in endotoxemia, but it is not clear whether endotoxemia is associated with a specific, age-related profile of the endothelial response. Therefore, the aim of the study was to assess the pattern of endothelial…
View article: Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays
Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays Open
Inflammation plays a crucial role in homeostasis and defense responses; however, exaggerated and chronic inflammation contribute to the development and worsening of various diseases. Acanthospermum australe (Loefl.) Kuntze ( A. australe ) …
View article: Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses Open
Background Proinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsurgical pain. Produced primarily by activated macrophages and microglia, these mediators drive hyperexcitation of noci…
View article: C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation
C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation Open
Background The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA). CCR4 (C‐C chemokine receptor 4), which is predominantly exp…
View article: STING Restricts EV-A71 Infection by Regulating T Cell Development and Enhancing Immune Cell Effector Function
STING Restricts EV-A71 Infection by Regulating T Cell Development and Enhancing Immune Cell Effector Function Open
Previous studies have reported that Enterovirus A71 (EV-A71) infection could activate STING-related signaling pathways in vitro, but the role of STING in EV-A71 infection in vivo and the associated immune regulatory mechanisms remain uncle…
View article: Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape
Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape Open
The progression of endometrial cancer (EC) is significantly affected by the inflammatory microenvironment (IME), which is essential for facilitating immune evasion and developing resistance to therapeutic interventions. Components that pro…
View article: Inflammatory and neuroimmune imbalance in diabetic incontinence: insights from serum biomarker profiling
Inflammatory and neuroimmune imbalance in diabetic incontinence: insights from serum biomarker profiling Open
View article: Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation
Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation Open
Peritoneal dialysis (PD), as a renal replacement therapy, relies heavily on the structural and functional integrity of the peritoneum. In some patients, however, the peritoneum may undergo adverse remodeling and fibrotic thickening, result…
View article: CCL2 supports colorectal cancer proliferation, invasion and metastasis through activating lncRNA GSTM3TV2/ATF4 signaling
CCL2 supports colorectal cancer proliferation, invasion and metastasis through activating lncRNA GSTM3TV2/ATF4 signaling Open
Objective: Despite extensive research and advances in biological knowledge, therapeutic strategies, and prognostic outcomes, colorectal cancer (CRC) remains a common malignancy around the world. Elucidating molecular determinants promoting…
View article: Data from Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
Data from Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer Open
The MYC oncogene is frequently amplified in triple-negative breast cancer (TNBC). Here, we show that MYC suppression induces immune-related hallmark gene set expression and tumor-infiltrating T cells in MYC-hyperactivated TNBCs. Mec…
View article: Prognostic value of monocyte chemoattractant protein-1 in sepsis: a systematic review and meta-analysis
Prognostic value of monocyte chemoattractant protein-1 in sepsis: a systematic review and meta-analysis Open
View article: The CCL17/CCL22–CCR4 Axis in Pain Pathogenesis: A Comprehensive Review of Immune-Mediated Mechanisms and Therapeutic Opportunities
The CCL17/CCL22–CCR4 Axis in Pain Pathogenesis: A Comprehensive Review of Immune-Mediated Mechanisms and Therapeutic Opportunities Open
The role of C–C motif chemokine ligand (CCL) 17 and CCL22 signalling has been demonstrated in allergic disorders, such as asthma and atopic dermatitis, as well as multiple types of neoplastic disorders. New evidence has identified that CCL…
View article: Mapping Interactions Between Cytokines, Chemokines, Growth Factors, and Conventional Biomarkers in COVID-19 ICU-Patients
Mapping Interactions Between Cytokines, Chemokines, Growth Factors, and Conventional Biomarkers in COVID-19 ICU-Patients Open
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyperinflammation with cytokine and chemokine release, alongside elevations in conventional laboratory biomarkers such as C-reactive protein (CRP), ferritin, and proca…
View article: Genetically‐Programmed Hypervesiculation of <i>Lactiplantibacillus Plantarum</i> Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model
Genetically‐Programmed Hypervesiculation of <i>Lactiplantibacillus Plantarum</i> Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model Open
Inflammatory bowel diseases (IBD) affect over 6 million people globally and current treatments achieve only 10‐20% rates of durable disease remission. Bacterial extracellular vesicles (BEVs) from probiotic lactic acid bacteria (LAB) are a …
View article: Exploring the causal relationship between gut microbiota, circulating inflammatory proteins, and colorectal neuroendocrine tumors: a Mendelian randomization study
Exploring the causal relationship between gut microbiota, circulating inflammatory proteins, and colorectal neuroendocrine tumors: a Mendelian randomization study Open
The gut microbiota may influence the occurrence and development of colorectal neuroendocrine tumors (CR-NETs), with inflammatory mediators potentially playing an important intermediary role. However, the current research evidence is insuff…
View article: Supplementary Figure S3 from CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Supplementary Figure S3 from CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy Open
Supplementary Figure S3. In vivo effect of acalabrutinib on the VLA-4 activation upon BCR and chemokine signaling