Optofluidics
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Silicon Photonic Biosensors Using Label-Free Detection Open
Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosi…
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Rapid, Quantitative, and Ultrasensitive Point‐of‐Care Testing: A Portable SERS Reader for Lateral Flow Assays in Clinical Chemistry Open
The design of a portable Raman/SERS‐LFA reader with line illumination using a custom‐made fiber optic probe for rapid, quantitative, and ultrasensitive point‐of‐care testing (POCT) is presented. The pregnancy hormone human chorionic gonado…
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Portable smartphone quantitation of prostate specific antigen (PSA) in a fluoropolymer microfluidic device Open
We present a new, power-free and flexible detection system named MCFphone for portable colorimetric and fluorescence quantitative sandwich immunoassay detection of prostate specific antigen (PSA). The MCFphone is composed by a smartphone i…
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Ultrafast-laser-inscribed 3D integrated photonics: challenges and emerging applications Open
Since the discovery that tightly focused femtosecond laser pulses can induce a highly localised and permanent refractive index modification in a large number of transparent dielectrics, the technique of ultrafast laser inscription has rece…
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Three-dimensional femtosecond laser processing for lab-on-a-chip applications Open
The extremely high peak intensity associated with ultrashort pulse width of femtosecond laser allows us to induce nonlinear interaction such as multiphoton absorption and tunneling ionization with materials that are transparent to the lase…
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Freestyle 3D laser traps: tools for studying light-driven particle dynamics and beyond Open
We show that a freestyle laser trap, including high-intensity and phase gradient forces along arbitrary curves, is able to confine multiple particles and drive their motion with the ability to speed them up or slow them down. This Letter r…
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Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap Open
By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation …
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Single-molecule optofluidic microsensor with interface whispering gallery modes Open
Significance Optical microresonators have emerged as promising platforms for label-free detection of molecules. However, approaching optimum sensitivity is hindered due to the weak tail of evanescent fields. Here, we report the implementat…
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Microfluidic Isolation and Enrichment of Nanoparticles Open
Over the past decades, nanoparticles have increased in implementation to a variety of applications ranging from high-efficiency electronics to targeted drug delivery. Recently, microfluidic techniques have become an important tool to isola…
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Sensitivity and Limit of Detection of biosensors based on ring resonators Open
In this work, we present a study of the Sensitivity (S) and Limit of Detection (LOD) of microring based photonic biosensors as a function of the waveguide composition and dimensions. The target is Aflatoxin, which is a toxin of major conce…
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Two-Photon Polymerization Metrology: Characterization Methods of Mechanisms and Microstructures Open
The ability to create complex three-dimensional microstructures has reached an unprecedented level of sophistication in the last 15 years. For the most part, this is the result of a steady development of the additive manufacturing techniqu…
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Field detection devices for screening the quality of medicines: a systematic review Open
Background Poor quality medicines have devastating consequences. A plethora of innovative portable devices to screen for poor quality medicines has become available, leading to hope that they could empower medicine inspectors and enhance s…
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All-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers Open
We present an all-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers integrated into a microfluidic chip.
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Recent Developments in Optofluidic Lens Technology Open
Optofluidics is a rapidly growing versatile branch of adaptive optics including a wide variety of applications such as tunable beam shaping tools, mirrors, apertures, and lenses. In this review, we focus on recent developments in optofluid…
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A brief history of liquid computers Open
A substrate does not have to be solid to compute. It is possible to make a computer purely from a liquid. I demonstrate this using a variety of experimental prototypes where a liquid carries signals, actuates mechanical computing devices a…
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High-throughput screening for improved microbial cell factories, perspective and promise Open
High-throughput screening is a critical part of any industrial strain engineering effort, helping ensure the lowest cost product is produced in the shortest amount of time. Small-scale testing that correlates to manufacturing scale allows …
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Nanovortex‐Driven All‐Dielectric Optical Diffusion Boosting and Sorting Concept for Lab‐on‐a‐Chip Platforms Open
The ever‐growing field of microfluidics requires precise and flexible control over fluid flows at reduced scales. Current constraints demand a variety of controllable components to carry out several operations inside microchambers and micr…
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Microfluidic Based Optical Microscopes on Chip Open
Last decade's advancements in optofluidics allowed obtaining an ever increasing integration of different functionalities in lab on chip devices to culture, analyze, and manipulate single cells and entire biological specimens. Despite the i…
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Tapered optical fiber waveguide coupling to whispering gallery modes of liquid crystal microdroplet for thermal sensing application Open
We demonstrate efficient coupling to the optical whispering gallery modes (WGMs) of nematic liquid crystal (NLC) microdroplets immersed in an immiscible aqueous environment. An individual NLC microdroplet, confined at the tip of a microcap…
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Ultra-sensitive chemical and biological analysis<i>via</i>specialty fibers with built-in microstructured optofluidic channels Open
A specialty fiber with a built-in microfluidic channel enables ultra-sensitive, low-loss and compact all-in-fiber in-line optofluidic chemical and biological sensing.
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Dielectrowetting: The past, present and future Open
Liquid dielectrophoresis is a bulk force acting on dipoles within a dielectric liquid inside a non-uniform electric field. When the driving electrodes are interdigitated, bulk liquid dielectrophoresis is converted to an interface-localised…
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Nanophotonic Array-Induced Dynamic Behavior for Label-Free Shape-Selective Bacteria Sieving Open
Current particle sorting methods such as microfluidics, acoustics, and optics focus on exploiting the differences in the mass, size, refractive index, or fluorescence staining. However, there exist formidable challenges for them to sort la…
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Longitudinal Monitoring of Biofilm Formation via Robust Surface-Enhanced Raman Scattering Quantification of <i>Pseudomonas aeruginosa</i>-Produced Metabolites Open
Detection of bacterial metabolites at low concentrations in fluids with complex background allows for applications ranging from detecting biomarkers of respiratory infections to identifying contaminated medical instruments. Surface-enhance…
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Laser streaming: Turning a laser beam into a flow of liquid Open
New optofluidic coupling of photoacoustics to acoustic streaming enables laser-driven jet flow via plasmonic-acoustic cavity.
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Biological Photonic Crystal‐Enhanced Plasmonic Mesocapsules: Approaching Single‐Molecule Optofluidic‐SERS Sensing Open
Surface‐enhanced Raman scattering (SERS) sensing in microfluidic devices, namely optofluidic‐SERS, suffers an intrinsic tradeoff between mass transport and hot spot density, both of which are required for ultrasensitive detection. To overc…
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High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip Open
We present an optofluidic chip consisting of a quasi-Bessel beam for multi-range separation of sub-100 nm gold nanoparticles and pathogens with microscopic vibration.
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Experimental evidence for Abraham pressure of light Open
The question of how much momentum light carries in media has been debated for over a century. Two rivalling theories, one from 1908 by Hermann Minkowski and the other from 1909 by Max Abraham, predict the exact opposite when light enters a…
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Trends in Nanophotonics‐Enabled Optofluidic Biosensors Open
Optofluidic sensors integrate photonics with micro/nanofluidics to realize compact devices for the label‐free detection of molecules and the real‐time monitoring of dynamic surface binding events with high specificity, ultrahigh sensitivit…
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Floating Droplet Array: An Ultrahigh-Throughput Device for Droplet Trapping, Real-time Analysisand Recovery Open
We describe the design, fabrication and use of a dual-layered microfluidic device for ultrahigh-throughput droplet trapping, analysis, and recovery using droplet buoyancy. To demonstrate the utility of this device for digital quantificatio…
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Advantages of optical fibers for facile and enhanced detection in droplet microfluidics Open
Droplet microfluidics offers a unique opportunity for ultrahigh-throughput experimentation with minimal sample consumption and thus has obtained increasing attention, particularly for biological applications. Detection and measurements of …