Infiltration (HVAC)
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Classifying Cancers Based on T-cell Infiltration and PD-L1 Open
Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies…
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Cold Tumors: A Therapeutic Challenge for Immunotherapy Open
Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains relatively low in most cases. A major factor involved in initial resistance to ICP in…
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Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration Open
Tumors are stiff and data suggest that the extracellular matrix stiffening that correlates with experimental mammary malignancy drives tumor invasion and metastasis. Nevertheless, the relationship between tissue and extracellular matrix st…
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Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures Open
Our analysis sheds light on the immune infiltration patterns of 19 human cancers and unravels mRNA signatures with prognostic utility and immunotherapeutic biomarker potential in ccRCC.
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A Review on Hydrological Models Open
Various ongoing researches are there on topics like which model will give more compatible results with that of observed discharges. It was argued that even complex modeling does not provide better results. Climate change and soil heterogen…
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Impacts of urbanisation on hydrological and water quality dynamics, and urban water management: a review Open
As urban space continues to expand to accommodate a growing global population, there remains a real need to quantify and qualify the impacts of urban space on natural processes. The expansion of global urban areas has resulted in marked al…
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Turning cold tumors into hot tumors by improving T-cell infiltration Open
Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend on the infiltration of T cells capable of recognizing and kil…
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Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma Open
In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dyn…
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Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies Open
Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After stroke, neutrophils respond rapidly promoting blood–bra…
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Illuminating hydrological processes at the soil‐vegetation‐atmosphere interface with water stable isotopes Open
Water stable isotopes ( 18 O and 2 H) are widely used as ideal tracers to track water through the soil and to separate evaporation from transpiration. Due to the technical developments in the last two decades, soil water stable isotope dat…
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Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression Open
The signaling mechanisms between prostate cancer cells and infiltrating immune cells may illuminate novel therapeutic approaches. Here, utilizing a prostate adenocarcinoma model driven by loss of Pten and Smad4, we identify polymorphonucle…
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Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration Open
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a loss of motor and sensory function. Although extensive research to develop treatments for SCI has been performed, to date, none of these treatment…
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Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma Open
Objective Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed deat…
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New insights into M1/M2 macrophages: key modulators in cancer progression Open
Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. The mutual interactions with tumor cells and stromal microenvironment contribute to phenotypically polarization of …
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Implementing Plant Hydraulics in the Community Land Model, Version 5 Open
Version 5 of the Community Land Model (CLM5) introduces the plant hydraulic stress (PHS) configuration of vegetation water use, which is described and compared with the corresponding parameterization from CLM4.5. PHS updates vegetation wat…
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Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells Open
Chimeric antigen receptor (CAR)‐redirected T lymphocytes (CAR T cells) show modest therapeutic efficacy in solid tumors. The desmoplastic structure of the tumor and the immunosuppressive tumor microenvironment usually account for the reduc…
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Tumor-Infiltrating Natural Killer Cells Open
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing targ…
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Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer Open
Significance Although immune checkpoint blockade (ICB) along with nab-paclitaxel has increased progression-free survival in triple-negative breast cancer patients, a large fraction of metastatic breast cancer (mBC) patients do not benefit …
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More friend than foe: the emerging role of neutrophils in tissue repair Open
Neutrophils are the most abundant immune cells in humans and serve as first responders to a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules, neutrophils invade sites of inflammation to eradicate pathogens …
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Neutrophil‐Based Drug Delivery Systems Open
White blood cells (WBCs) are a major component of immunity in response to pathogen invasion. Neutrophils are the most abundant WBCs in humans, playing a central role in acute inflammation induced by pathogens. Adhesion to vasculature and t…
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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade Open
Intravenous infusion of oncolytic reovirus in patients leads to infection of brain tumors, infiltration by cytotoxic T cells, and up-regulation of PD-L1.
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Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair Open
The immune system plays a pivotal role in the initiation, development and resolution of inflammation following insult or damage to organs. The heart is a vital organ which supplies nutrients and oxygen to all parts of the body. Heart failu…
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Fatty Infiltration of Skeletal Muscle: Mechanisms and Comparisons with Bone Marrow Adiposity Open
Skeletal muscle and bone share common embryological origins from mesodermal cell populations and also display common growth trajectories early in life. Moreover, muscle and bone are both mechanoresponsive tissues, and the mass and strength…
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Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer Open
Our results suggest that the presence of intratumoral TLOs represents a microenvironment that has an active immune reaction, and shows a relatively intact vascular network retained.
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Identification and Verification of Immune-Related Gene Prognostic Signature Based on ssGSEA for Osteosarcoma Open
Osteosarcoma is the most common malignant bone tumor in children and adolescence. Multiple immune-related genes have been reported in different cancers. The aim is to identify an immune-related gene signature for the prospective evaluation…
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Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy Open
Quantitative SRS microscopy can detect human brain tumor infiltration with high sensitivity and specificity, even in tissues appearing grossly normal.
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Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases Open
The immune microenvironment of the brain differs from that of other organs and the role of tumor-infiltrating lymphocytes (TILs) in brain metastases (BM), one of the most common and devastating complication of cancer, is unclear. We invest…
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Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms Open
OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that may cause devastating intracranial hemorrhage, thus producing considerable suffering and anxiety in those affected by the disease or an increased likelih…
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Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies Open
With the broad application of cancer immunotherapies such as immune checkpoint inhibitors in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) has become enormously important for determining the optimal…
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Cellular infiltration in traumatic brain injury Open
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident cells to release cytokines and chemokines. These in turn rapidly recruit neutro…