Nociception
View article: Intact endogenous pain inhibition in complex regional pain syndrome type 1.
Intact endogenous pain inhibition in complex regional pain syndrome type 1. Open
Our results indicate that in individuals with chronic CRPS type 1, endogenous pain inhibition is intact and comparable with healthy individuals. Therefore, pathomechanisms underlying chronic CRPS are likely related to increased pain facili…
View article: Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury
Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury Open
Background Osteoarthritis (OA) is the leading cause of pain worldwide. However, clinical discordance between pain and cartilage damage presents challenges in determining the mechanisms of OA pain, thus creating a need for well-controlled m…
View article: Application of the Analgesia Nociception Index and Visual Analog Scale to Assess Pain During Hysteroscopy Under Local Anesthesia
Application of the Analgesia Nociception Index and Visual Analog Scale to Assess Pain During Hysteroscopy Under Local Anesthesia Open
Background/Objectives: Pain assessment during hysteroscopy facilitates rapid operator intervention (e.g., repeated anesthesia, administration of additional analgesics, or termination of the procedure), thereby improving patient comfort. Tr…
View article: Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons
Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons Open
Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upre…
View article: Withdrawal Note: NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons
Withdrawal Note: NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons Open
View article: Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses Open
Background Proinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsurgical pain. Produced primarily by activated macrophages and microglia, these mediators drive hyperexcitation of noci…
View article: A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer
A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer Open
A potential analgesic medicinal substance has been discovered, the ouabain–Ca 2+ chelate complex (EO). As we have found, the specific EO binding to the Na,K-ATPase (NKA) in nanomolar concentrations triggers several signaling cascades in th…
View article: Mixed-mechanism analgesics for mixed pain
Mixed-mechanism analgesics for mixed pain Open
The concept of “mixed pain” simultaneously highlights the benefit of integration of emerging advances in basic science (in particular, physiologic mechanisms) with advances in clinical care (symptomatology and diagnosis), and highlights so…
View article: Electrical Spinal Imaging: A noninvasive, high-resolution approach that enables electrophysiological mapping of the human spinal cord
Electrical Spinal Imaging: A noninvasive, high-resolution approach that enables electrophysiological mapping of the human spinal cord Open
The spinal cord is the key bridge between the brain and the body. However, scientific understanding of healthy spinal cord function has historically been limited because noninvasive measures of its neural activity have proven exceptionally…
View article: Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence
Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence Open
Introduction Neonatal intensive care units (NICUs) provide life-saving care for preterm and sick neonates, but many medical procedures are painful and stress-inducing. Even a routine NICU procedure, such as the “heel lancing” blood-draw pr…
View article: Spinal Dorsal Horn Neurons Receiving Descending Input from the Primary Somatosensory Cortex Contribute to Aβ Fiber-Induced Neuropathic Allodynia in Male Rats
Spinal Dorsal Horn Neurons Receiving Descending Input from the Primary Somatosensory Cortex Contribute to Aβ Fiber-Induced Neuropathic Allodynia in Male Rats Open
Mechanical allodynia is the predominant symptom of neuropathic pain following peripheral nerve injury (PNI) and is characterized by pain evoked by innocuous sensory signals transmitted through low-threshold mechanoreceptive primary afferen…
View article: EXPRESS: Exploring circRNA_19601 as a therapeutic target in diabetic neuropathic pain: insights from rat and cell models
EXPRESS: Exploring circRNA_19601 as a therapeutic target in diabetic neuropathic pain: insights from rat and cell models Open
Background: Diabetic neuropathic pain (DNP) is a common complication of diabetes with significant impact on patients' quality of life. Current treatments have limitations, and exploring new mechanisms and targets is crucial. Objective: Our…
View article: EXPRESS: Evodiamine attenuates chemotherapy-induced peripheral neuropathy by mediating macrophage M2 polarization and inhibiting the upregulation of the p38 MAPK-TRPV1 axis in rat dorsal root ganglia
EXPRESS: Evodiamine attenuates chemotherapy-induced peripheral neuropathy by mediating macrophage M2 polarization and inhibiting the upregulation of the p38 MAPK-TRPV1 axis in rat dorsal root ganglia Open
Purpose: To investigate evodiamine's analgesic effects and molecular mechanisms on chemotherapy-induced peripheral neuropathy (CIPN), focusing on the p38/MAPK-TRPV1 signaling axis and macrophage polarization in dorsal root ganglia (DRG). M…
View article: Musical intervention to reduce stress during botulinum toxin injection for spasticity: Protocol for a randomized controlled trial (MUSIBOT)
Musical intervention to reduce stress during botulinum toxin injection for spasticity: Protocol for a randomized controlled trial (MUSIBOT) Open
Introduction Botulinum toxin injections are a common treatment for managing spasticity resulting from central nervous system damage, including stroke, multiple sclerosis, and traumatic brain injury. However, the injections are associated w…
View article: Evaluation of the Nociception Level Index ( <scp>NOL</scp> ) for Intraoperative Analgesia Monitoring in Pediatrics
Evaluation of the Nociception Level Index ( <span>NOL</span> ) for Intraoperative Analgesia Monitoring in Pediatrics Open
View article: Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials
Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials Open
Sensorimotor synchronization to music, referring to the temporal alignment of movement with auditory rhythms, has been associated with immersive engagement and enhanced pleasure. In the present study, we investigated its analgesic effects …
View article: Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome
Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Open
Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to PCS. Quantitative s…
View article: Dysregulation of Hedonic Processing in Chronic Pain: Insights from Preclinical Data
Dysregulation of Hedonic Processing in Chronic Pain: Insights from Preclinical Data Open
Chronic pain has been increasingly recognized not only as a sensory disorder but also as a condition that profoundly disrupts affective and motivational processes. Preclinical research indicates that persistent nociceptive input drives mal…
View article: Effects of different anesthetics on remifentanil-induced postinfusion hyperalgesia in patients undergoing percutaneous endoscopic interlaminar discectomy: a randomized controlled trial
Effects of different anesthetics on remifentanil-induced postinfusion hyperalgesia in patients undergoing percutaneous endoscopic interlaminar discectomy: a randomized controlled trial Open
Background Continuous infusion of remifentanil during anesthesia potentially leads to remifentanil-induced postinfusion hyperalgesia (RPH), which may be regulated by anesthesia maintenance drugs. In this study, we investigated the effects …
View article: Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing
Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing Open
This study investigated the effects of experimentally induced acute pain on body image and sensory testing. A total of 91 pain-free participants were randomly assigned to 1 of 3 groups: injection (pain), sham injection, or control. Measure…
View article: Reassessment confirms motivational trade-offs and modulation of nociception in bumble bees
Reassessment confirms motivational trade-offs and modulation of nociception in bumble bees Open
View article: Decoding the fibroblast/mast cell signaling pathway of acupuncture
Decoding the fibroblast/mast cell signaling pathway of acupuncture Open
Acupuncture has been practiced for thousands of years with documented therapeutic effects, yet its underlying biological mechanisms remain poorly understood. Here, we show that acupuncture stimulation converts local mechanical forces into …
View article: Nationwide Survey of Atopic Myelitis and Plexin <scp>D1</scp> ‐Immunoglobulin G‐Related Pain
Nationwide Survey of Atopic Myelitis and Plexin <span>D1</span> ‐Immunoglobulin G‐Related Pain Open
Objective To elucidate the features of plexin D1‐immunoglobulin (Ig)G‐associated neuropathic pain and its relationship to atopic myelitis (AM) in a nationwide Japanese survey. Methods A preliminary survey questionnaire was sent to 1574 sel…
View article: Antinociceptive efficacy, chemistry, potential toxicity, and quality control procedures of Clinopodium macrostemum and Clinopodium mexicanum: A comparative analysis
Antinociceptive efficacy, chemistry, potential toxicity, and quality control procedures of Clinopodium macrostemum and Clinopodium mexicanum: A comparative analysis Open
View article: Spinal dorsal horn IGF1 mediates the preventive effect of electroacupuncture on cisplatin-induced peripheral neuropathy via neuronal IGF1R in mice
Spinal dorsal horn IGF1 mediates the preventive effect of electroacupuncture on cisplatin-induced peripheral neuropathy via neuronal IGF1R in mice Open
Background Our previous study demonstrated that neuronal G protein-coupled receptor kinase (GRK2) upregulation alleviated chemotherapy-induced peripheral neuropathy (CIPN) in mice, which was characterized by numbness and pain in distal hin…
View article: Updates on the Proposed Botulinum Toxin A Mechanisms of Action in Orofacial Pain: A Review of Animal Studies
Updates on the Proposed Botulinum Toxin A Mechanisms of Action in Orofacial Pain: A Review of Animal Studies Open
Experimental animal models of orofacial pain have been instrumental in elucidating biological pathways underlying the antinociceptive effect of botulinum neurotoxin type A (BoNT/A). Although several mechanisms have been proposed to explain…
View article: Increased Expression of TRPV1 in the Central Nucleus of the Amygdala Is Involved in Orthodontic Pain in Rats
Increased Expression of TRPV1 in the Central Nucleus of the Amygdala Is Involved in Orthodontic Pain in Rats Open
Transient receptor potential vanilloid type 1 (TRPV1) is known to gate nociceptive signals, while the central amygdala (CeA) plays a key role in encoding pain and avoidance behaviors; however, whether TRPV1 within CeA mediate orthodontic t…
View article: NRB‑1A: In Silico Design for Five‑Minute Migraine Intervention
NRB‑1A: In Silico Design for Five‑Minute Migraine Intervention Open
Background Migraine pain escalates through rapid activation of calcitonin gene–related peptide signaling within trigeminal pathways, driving vasodilation, neurogenic inflammation, and nociceptor sensitization that can amplify within minute…
View article: Diffusion tensor imaging of white matter integrity and pain-related outcomes in chronic nonspecific neck pain
Diffusion tensor imaging of white matter integrity and pain-related outcomes in chronic nonspecific neck pain Open
Chronic neck pain is associated with neuroplastic changes in brain structure, but its alterations in white matter integrity remain unclear. This study aimed to investigate white matter microstructural changes in patients with chronic nonsp…
View article: NRB‑1A: In Silico Design for Five‑Minute Migraine Intervention
NRB‑1A: In Silico Design for Five‑Minute Migraine Intervention Open
Background Migraine pain escalates through rapid activation of calcitonin gene–related peptide signaling within trigeminal pathways, driving vasodilation, neurogenic inflammation, and nociceptor sensitiz…