Notch signaling pathway
View article: Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer
Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer Open
Resistance to androgen receptor (AR)-targeted therapies such as enzalutamide in castration-resistant prostate cancer (CRPC) often arises through lineage plasticity, yet the molecular mechanisms that define this process remain incompletely …
View article: Data from: An autoinhibitory feedback mechanism preserves intestinal stem cell maintenance and fate commitment
Data from: An autoinhibitory feedback mechanism preserves intestinal stem cell maintenance and fate commitment Open
This dataset contains the Seurat objects necessary to recreate all figures from the publication. The files included are as follows: Ctrl_NotchKO_integrated_scent: The primary integrated Seurat object containing Control and Notch KO samples…
View article: <i>Lrig1</i> -expressing quiescent stem cells maintain vocal fold mucosal homeostasis via <i>Notch</i> signaling
<i>Lrig1</i> -expressing quiescent stem cells maintain vocal fold mucosal homeostasis via <i>Notch</i> signaling Open
Identifying progenitor cells in laryngeal and vocal fold (VF) mucosa is essential for advancing stem cell–based therapies for VF diseases. In this study, we used Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1) gene to label …
View article: Figure S2 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Figure S2 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways Open
Figure S2. Lurbinectedin sensitivity (IC50) correlation with MYC expression and changes in expression of NE markers.
View article: Supplementary Tables 1-3 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Supplementary Tables 1-3 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways Open
Supplementary Tables 1-3
View article: Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1
Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1 Open
Acute myeloid leukemia (AML) is an aggressive cancer with very poor outcomes. To identify additional drivers of leukemogenesis, we analyzed sequencing data from 1,727 unique individual AML patients, which revealed mutations in ubiquitin li…
View article: Figure S3 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Figure S3 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways Open
Figure S3: Lurbinectedin treatment induces regulators of the DNA damage response pathway.
View article: Sustained EGFR Signaling Expands Otx2+ and Chx10+ Retinal Progenitors in the Postnatal Mouse Retina
Sustained EGFR Signaling Expands Otx2+ and Chx10+ Retinal Progenitors in the Postnatal Mouse Retina Open
The regenerative potential of the mammalian retina is limited, yet identifying signaling pathways that influence progenitor cell behavior remains an important step toward understanding the mechanisms of retinal development and plasticity. …
View article: Novel Translational Concept: Axon-to-Muscle Exosomal Signaling as an Emerging Therapeutic Target in Spinal Muscular Atrophy
Novel Translational Concept: Axon-to-Muscle Exosomal Signaling as an Emerging Therapeutic Target in Spinal Muscular Atrophy Open
Spinal muscular atrophy (SMA) has transitioned from a uniformly fatal disease to a treatable condition, yet incomplete neuromuscular recovery underscores the limits of current SMN-restorative therapies. Emerging data implicate disrupted ax…
View article: Figure S1 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
Figure S1 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways Open
Figure S1. Lurbinectedin decreases cell viability in a time and dose-dependent manner.
View article: 233 Pharmacological Targeting of Notch Pathway by Nirogacestat Counteracts Skin Fibrosis:
New Evidence from Preclinical Models of Recessive Dystrophic Epidermolysis Bullosa
233 Pharmacological Targeting of Notch Pathway by Nirogacestat Counteracts Skin Fibrosis:
New Evidence from Preclinical Models of Recessive Dystrophic Epidermolysis Bullosa Open
View article: Single-cell transcriptomic dissection of two waves of endothelial-hematopoietic transition in a murine yolk sac
Single-cell transcriptomic dissection of two waves of endothelial-hematopoietic transition in a murine yolk sac Open
The yolk sac drives vertebrate embryonic hematopoiesis through primitive hematopoiesis and endothelial-to-hematopoietic transition (EHT) waves. However, dynamic cellular and molecular changes during EHT of the yolk sac remain to be elucida…
View article: UGGT1 mediates N-glycosylation of LGALS3BP to induce angiogenesis in liver cancer via the NOTCH signaling pathway
UGGT1 mediates N-glycosylation of LGALS3BP to induce angiogenesis in liver cancer via the NOTCH signaling pathway Open
Background Liver cancer (LC) is one of the leading causes of cancer-related deaths worldwide. Its complex vascular regulatory network and drug resistance severely limit clinical efficacy. Although LGALS3BP is highly expressed in various ma…
View article: Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming Open
Human pluripotent stem cells (hPSCs) serve as a powerful model for studying human neuronal differentiation, yet the temporal control of this process remains poorly understood. This study compares two differentiation systems with distinct t…
View article: NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head
NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head Open
Steroid‑induced osteonecrosis of the femoral head (SONFH) is a progressive hip condition marked by osteocyte apoptosis from poor blood supply, leading to femoral head collapse and hip joint dysfunction. Examination of the GSE123568 dataset…
View article: Spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis
Spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis Open
Juvenile idiopathic arthritis (JIA) is the most prevalent chronic inflammatory arthritis of childhood, yet the spatial organization in the synovium remains poorly understood. Here, we perform subcellular-resolution spatial transcriptomic p…
View article: MAML1 drives Notch and Hedgehog oncogenic pathways by inhibiting Itch activity in triple-negative breast cancer
MAML1 drives Notch and Hedgehog oncogenic pathways by inhibiting Itch activity in triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous breast cancer subtype with poor patient outcomes. TNBC heterogeneity arises from multiple dysregulated pathways, including Notch and Hedgehog, which contribute to tumo…
View article: Disruption of Notch signaling by KGF induces a developmental pause in thymocytes
Disruption of Notch signaling by KGF induces a developmental pause in thymocytes Open
Keratinocyte growth factor (KGF) has been proposed as a therapeutic adjuvant to enhance T cell immune reconstitution, particularly following stem cell transplantation. Here, we demonstrate that the long-term KGF-induced increase in thymic …
View article: Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction
Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction Open
Myocardial infarction (MI) is a leading cause of death globally and is characterized by extensive cardiomyocyte death, fibrosis, and diminished cardiac function, leading to heart failure. The limited regenerative capacity and excessive fib…
View article: Genetic dissection of microglia cannibalism reveals an IL10 signaling axis controls microglia lifespan
Genetic dissection of microglia cannibalism reveals an IL10 signaling axis controls microglia lifespan Open
The development of complex organs, like the brain, demands a robust system for tissue remodeling and cellular debris clearance. In the brain, this function is performed by microglia, which must clear diverse debris substrates, including th…
View article: Novel Insights into Using CRISPR-Mediated Modulation of Dopaminergic Signaling Pathways to Enhance the Therapeutic Efficacy of ONC201 in the Treatment of Diffuse Intrinsic Pontine Glioma (DIPG)
Novel Insights into Using CRISPR-Mediated Modulation of Dopaminergic Signaling Pathways to Enhance the Therapeutic Efficacy of ONC201 in the Treatment of Diffuse Intrinsic Pontine Glioma (DIPG) Open
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating childhood brain cancers, with a median survival of less than one year and almost no long-term survivors. Classified as a subtype of diffuse midline glioma (DMG) and cha…
View article: Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes
Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes Open
Activating mutations of Notch are drivers of the blood cell cancer, T-ALL, and some solid tumours. The Negative Regulatory Region (NRR) of the extracellular domain (ECD) and the PEST region of the intracellular domain (ICD) are mutation ho…
View article: Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes
Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes Open
Activating mutations of Notch are drivers of the blood cell cancer, T-ALL, and some solid tumours. The Negative Regulatory Region (NRR) of the extracellular domain (ECD) and the PEST region of the intracellular domain (ICD) are mutation ho…
View article: Reviewer #2 (Public review): Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes
Reviewer #2 (Public review): Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes Open
View article: Reviewer #3 (Public review): Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes
Reviewer #3 (Public review): Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes Open
View article: The Two-Way Role of Jagged1 in Cancer: A Focus on CRC
The Two-Way Role of Jagged1 in Cancer: A Focus on CRC Open
Colorectal cancer (CRC) remains one of the most prevalent and lethal malignancies. Accumulating genetic evidence supports a multistep model of tumor progression, in which early APC loss leads to chromosomal instability and adenoma formatio…
View article: Reviewer #1 (Public review): Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes
Reviewer #1 (Public review): Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes Open
View article: Antegonial Notch Depth and Mandibular Growth: A Longitudinal Multilevel Modelling Approach
Antegonial Notch Depth and Mandibular Growth: A Longitudinal Multilevel Modelling Approach Open
Introduction: The antegonial notch has been proposed as a morphological indicator of mandibular growth, yet its developmental trajectory and predictive value remain insufficiently explored. This study examined how the antegonial notch chan…
View article: Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Neoplasia by Targeting the γ-Secretase Complex: A Systematic Review
Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Neoplasia by Targeting the γ-Secretase Complex: A Systematic Review Open
Background. NOTCH receptors play a pivotal role in carcinogenesis. Upon ligand binding, a cascade of proteolytic cleavages mediated by ADAM proteases and the γ-secretase complex activates the receptor, culminating in the release of the NOT…
View article: Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells
Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells Open
Background The regulation of receptor expression is crucial for fine-tuned signal transduction. Notch signaling is a key signaling pathway involved in retinal development. Compared to the knowledge on this signaling pathway in the differe…