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View article: Data from Dietary Factors and Early-Onset Colorectal Cancer in the United States—an Ecologic Analysis
Data from Dietary Factors and Early-Onset Colorectal Cancer in the United States—an Ecologic Analysis Open
Background:Incidence of early-onset colorectal cancer (EOCRC; e.g., diagnosed before age 50) in the United States has increased substantially since the 1990s but the underlying reasons remain unclear.Methods:We examined the ecologic associ…
View article: Data from 5-Alpha Reductase Inhibitors and Prostate Cancer Mortality among Men with Regular Access to Screening and Health Care
Data from 5-Alpha Reductase Inhibitors and Prostate Cancer Mortality among Men with Regular Access to Screening and Health Care Open
Background:How 5-alpha reductase inhibitor (5-ARI) use influences prostate cancer mortality is unclear. The objective of this study was to determine whether men taking 5-ARIs with regular health care access have increased prostate cancer m…
View article: Data from Increasing Incidence of Gallbladder Cancer among Non-Hispanic Blacks in the United States: A Birth Cohort Phenomenon
Data from Increasing Incidence of Gallbladder Cancer among Non-Hispanic Blacks in the United States: A Birth Cohort Phenomenon Open
Background:Gallbladder cancer incidence varies among racial/ethnic subgroups in the United States (US). We investigated trends in gallbladder cancer incidence rates in 50 states from 2001 to 2018.Methods:Age-adjusted incidence rates and tr…
View article: Assessing the representativeness of trials of Sodium-glucose Cotransporter-2 inhibitors in type 2 diabetes: a comparison of individual-level trial data and people newly prescribed treatment in a Welsh routine care database
Assessing the representativeness of trials of Sodium-glucose Cotransporter-2 inhibitors in type 2 diabetes: a comparison of individual-level trial data and people newly prescribed treatment in a Welsh routine care database Open
Background Randomised controlled trials are often criticised for excluding people with multiple long-term conditions. This study used individual participant data for 25 trials of sodium glucose co-transporter-2 inhibitors (SGLT2i) to compa…
View article: Quantifying Structural Selection Bias in Observational Cohort Data: A Ponderation Analysis of Age- Specific Incidence Rates to Inform Vaccine Safety Verification
Quantifying Structural Selection Bias in Observational Cohort Data: A Ponderation Analysis of Age- Specific Incidence Rates to Inform Vaccine Safety Verification Open
Background: A recent nationwide cohort study reported an unadjusted Hazard Ratio (HR) of 2.714 for Vitiligo incidence following COVID-19 vaccination, indicating a major safety concern. This finding was based on cohorts with an ≈ 11-year ag…
View article: Sex-disaggregated age-standardized crude suicide rates in Sierra Leone, 2000–2019
Sex-disaggregated age-standardized crude suicide rates in Sierra Leone, 2000–2019 Open
Background This study aims to determine the prevalence and sex-based disparities in age-standardized crude suicide rates in Sierra Leone from 2000 to 2019. Methods This study employed a time-trend design utilizing nationally representative…
View article: Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study
Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study Open
Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who a…
View article: Does tattoo exposure increase the risk of cutaneous melanoma? A population-based case-control study
Does tattoo exposure increase the risk of cutaneous melanoma? A population-based case-control study Open
The incidence of cutaneous melanoma (CM) has risen sharply over the past 30 years, coinciding with the rapidly growing tattoo trend. In Sweden, 20% of the population is tattooed. Repeated reports of the presence of carcinogenic chemicals, …
View article: Analysis of Risk Factors for Colorectal Cancer Associated with Ulcerative Colitis Using Machine Learning: A Retrospective Longitudinal Study Using a National Database in Japan
Analysis of Risk Factors for Colorectal Cancer Associated with Ulcerative Colitis Using Machine Learning: A Retrospective Longitudinal Study Using a National Database in Japan Open
Background/Objectives: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that significantly increases the colorectal cancer (CRC) risk. This study used nationwide data on intractable diseases to clarify the clinical epidemiol…
View article: Real-World Outcomes of Lower Lenvatinib Doses in Advanced Neuroendocrine Tumors: A Multinational Retrospective Study
Real-World Outcomes of Lower Lenvatinib Doses in Advanced Neuroendocrine Tumors: A Multinational Retrospective Study Open
Objective Neuroendocrine tumors (NET) are heterogeneous neoplasms with increasing incidence and limited treatment options for advanced, progressive disease. Lenvatinib, a multitargeted TKI, demonstrat-ed high efficacy but substantial toxic…
View article: Clinical impact of prophylactic antibiotics in kidney transplantation: A retrospective observational cohort study with historical comparison
Clinical impact of prophylactic antibiotics in kidney transplantation: A retrospective observational cohort study with historical comparison Open
Purpose Optimal perioperative antibiotic prophylaxis in kidney transplantation remains undefined despite routine antibiotic administration to prevent infections. In this retrospective observational cohort study with historical comparison, …
View article: Sport-related Concussion Can be Prevented by Injury Prevention Program: A Systematic Review and Meta-analysis of Prospective, Controlled Studies
Sport-related Concussion Can be Prevented by Injury Prevention Program: A Systematic Review and Meta-analysis of Prospective, Controlled Studies Open
Background Sport-related concussions (SRCs) have emerged as a global health concern in sports medicine. Effective injury prevention programs have the potential to reduce the risk of SRCs, but, their efficacy remains inconclusive. Therefore…
View article: In-hospital mortality from healthcare-associated infection by multidrug-resistant Pseudomonas aeruginosa: a competing risks analysis of a 4-year propensity-matched cohort study in southern China
In-hospital mortality from healthcare-associated infection by multidrug-resistant Pseudomonas aeruginosa: a competing risks analysis of a 4-year propensity-matched cohort study in southern China Open
Background: Healthcare-associated infections (HAIs) caused by multidrug-resistant Pseudomonasaeruginosa (MDRPa) pose enormous challenges in healthcare. We examined the incidence and relative mortality rates of patients with MDRPa HAI compa…
View article: Sweat Na+/K+ ratio as a practical biological index for estimating sweating rate and salt loss rate
Sweat Na+/K+ ratio as a practical biological index for estimating sweating rate and salt loss rate Open
Objectives: A simple method to clinically evaluate the sweating rate and the salt loss rate via sweating will enable the early detection of heat-related illness in workers. We measured K+ concentration in sweat and calculated Na+/K+ ratio …
View article: Global and regional burdens of opioid use disorder from 1990 to 2021, with future forecasts to 2050: a systematic analysis for the global burden of disease study 2021
Global and regional burdens of opioid use disorder from 1990 to 2021, with future forecasts to 2050: a systematic analysis for the global burden of disease study 2021 Open
Introduction This study comprehensively investigated the magnitude and temporal trends of the global burden of opioid use disorder (OUD) from 1990 to 2021 and predicted the disease burden in the next 29 years. Methods The data originated f…
View article: Incidence and risk factors for chronic kidney disease in individuals with type 1 diabetes: A population‐based study in Salford, Manchester
Incidence and risk factors for chronic kidney disease in individuals with type 1 diabetes: A population‐based study in Salford, Manchester Open
Aims Chronic kidney disease (CKD) is a serious and common complication of type 1 diabetes (T1D). Despite improvements in diabetes management, the prevalence of CKD in people with T1D remains high. However, large‐scale, real‐world data from…
View article: Global, regional, and national burdens of late-onset epilepsy in adults aged 65 years and older from 1990 to 2021: A population-based study
Global, regional, and national burdens of late-onset epilepsy in adults aged 65 years and older from 1990 to 2021: A population-based study Open
Objective Epilepsy remains one of the most widespread and severe neurological disorders worldwide. This study aims to evaluate the burden of late-onset epilepsy (LOE) and investigate its temporal trends and inequalities among older adults …
View article: Effect of Sihogyeji-tang on functional dyspepsia: a systematic review and meta-analysis
Effect of Sihogyeji-tang on functional dyspepsia: a systematic review and meta-analysis Open
Introduction Functional dyspepsia (FD) has a global prevalence of approximately 15% and is characterized by chronic symptoms with an unclear etiology. Herbal medicines, owing to their multifaceted mechanisms, are promising therapeutic opti…
View article: The impact of the COVID-19 pandemic on telework and short sickness absences among Finnish knowledge workers
The impact of the COVID-19 pandemic on telework and short sickness absences among Finnish knowledge workers Open
Introduction Longitudinal studies are rare for associations between telework and sickness absence (SA). This prospective cohort study aimed to investigate short (1–3 days) SA from 2019 to 2023 among a cohort of Finnish knowledge workers an…
View article: The impact of a SmartPhone applicatiOn for skin cancer risk assessmenT on the healthcare system (SPOT-study): A randomized controlled trial
The impact of a SmartPhone applicatiOn for skin cancer risk assessmenT on the healthcare system (SPOT-study): A randomized controlled trial Open
Background Artificial intelligence (AI)-based mobile health (mHealth) smartphone apps for skin cancer detection are increasingly available to the general population, but their impact on care is unclear. Methods The SPOT study is an investi…
View article: How structured cultural changes can reduce cesarean section rate in a Danish tertiary hospital
How structured cultural changes can reduce cesarean section rate in a Danish tertiary hospital Open
Background Cesarean section is rising globally, with the risk of over-use and subsequent iatrogenic consequences for child and maternal health and future pregnancies. This study aims to evaluate the impact of a 12-step initiative implement…
View article: Geographic variation in potentially preventable hospitalisations in Indonesia: a multilevel analysis using National Health Insurance Sample Data
Geographic variation in potentially preventable hospitalisations in Indonesia: a multilevel analysis using National Health Insurance Sample Data Open
Objectives Indonesian data on potentially preventable hospitalisations (PPH), a widely used indicator for measuring primary health care (PHC) quality, are lacking. This study aimed to describe Indonesia’s PPH rates and to quantify variatio…
View article: Epidemiological trends, attributable risks, decomposition analysis, and forecasts of Alzheimer’s disease and other dementias burden in China, 1990 to 2036: A population-based observational study
Epidemiological trends, attributable risks, decomposition analysis, and forecasts of Alzheimer’s disease and other dementias burden in China, 1990 to 2036: A population-based observational study Open
This study analyzes the burden of Alzheimer disease and other dementias (ADOD) in China using Global Burden of Disease 2021 data. The data on ADOD in China from 1990 to 2021 was collected from the Global Burden of Disease 2021. The inciden…
View article: Association between seasonal influenza vaccination and neonatal outcomes in Shanghai, China
Association between seasonal influenza vaccination and neonatal outcomes in Shanghai, China Open
While international and domestic recommendations advocating for influenza vaccination during pregnancy, the vaccination rate among this demographic in China remains low, mainly due to concerns about fetal safety. This retrospective cohort …
View article: Sustained effect of a multifaceted VAP prevention program over more than seven years including the COVID-19 pandemic
Sustained effect of a multifaceted VAP prevention program over more than seven years including the COVID-19 pandemic Open
We report the long-term impact of a multifaceted intervention bundle containing nine measures to reduce the incidence of ventilator-associated pneumonia (VAP) in mechanically ventilated patients admitted to the intensive care division at G…
View article: Impact of umeclidinium/vilanterol dual bronchodilator therapy on pulmonary function and inflammatory responses in stable COPD patients
Impact of umeclidinium/vilanterol dual bronchodilator therapy on pulmonary function and inflammatory responses in stable COPD patients Open
Chronic obstructive pulmonary disease (COPD) represents a significant global health burden necessitating optimized therapeutic interventions. Contemporary guidelines advocate for individualized bronchodilator therapy, yet comparative real-…
View article: Global Burden of Multiple Myeloma in Older Adults From 1990 to 2021 and Modelled Projection to 2050
Global Burden of Multiple Myeloma in Older Adults From 1990 to 2021 and Modelled Projection to 2050 Open
Background Multiple myeloma (MM) is a prevalent hematological malignancy, particularly affecting the elderly. This study aimed to evaluate the burden and trends of MM in individuals aged 60 and older, using data from the Global Burden of D…
View article: Effectiveness of FitterLife: A Community-Based Virtual Weight Management Programme for Overweight Adults
Effectiveness of FitterLife: A Community-Based Virtual Weight Management Programme for Overweight Adults Open
Background: The high prevalence of overweight and obesity in Singapore necessitates scalable primary prevention strategies. This study evaluated the short-term effectiveness of FitterLife, a 12-week, digitally delivered, group-based behavi…
View article: COVID-19 outcomes by immigrant generation in Sweden: a national cohort population-based study
COVID-19 outcomes by immigrant generation in Sweden: a national cohort population-based study Open
There is a scarcity of studies examining the impact of the COVID-19 pandemic on the descendants of immigrants, a group representing a growing segment of the population in many countries. This study utilized a national cohort event history …
View article: Association between cannabis use and ocular inflammatory disease: a large-scale cohort study
Association between cannabis use and ocular inflammatory disease: a large-scale cohort study Open