Voltage-gated potassium channel
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Structure of the voltage-gated K <sup>+</sup> channel Eag1 reveals an alternative voltage sensing mechanism Open
A different gate design The voltage-gated potassium channel Eag1 is overexpressed in tumor cells from a range of cancers, and inhibiting Eag1 reduces tumor growth. Whicher and Mackinnon determined the structure of a mammalian Eag1 bound to…
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Early-Onset Epileptic Encephalopathy Caused by Gain-of-Function Mutations in the Voltage Sensor of K <sub>v</sub> 7.2 and K <sub>v</sub> 7.3 Potassium Channel Subunits Open
Mutations in K v 7.2 ( KCNQ2 ) and K v 7.3 ( KCNQ3 ) genes, encoding for voltage-gated K + channel subunits underlying the neuronal M-current, have been associated with a wide spectrum of early-onset epileptic disorders ranging from benign…
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A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family Open
The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic chara…
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Structure of the Shaker Kv channel and mechanism of slow C-type inactivation Open
Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory and is implicated in various human n…
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Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer Open
Voltage-gated potassium channel Kv1.3 is an integral membrane protein, which is selectively permeable for potassium ions and is activated upon a change of membrane potential. Channel activation enables transportation of potassium ions down…
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The Role of Potassium Channels in Arabidopsis thaliana Long Distance Electrical Signalling: AKT2 Modulates Tissue Excitability While GORK Shapes Action Potentials Open
Fast responses to an external threat depend on the rapid transmission of signals through a plant. Action potentials (APs) are proposed as such signals. Plant APs share similarities with their animal counterparts; they are proposed to depen…
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Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation Open
Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle …
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Voltage-Gated Potassium Channels as Regulators of Cell Death Open
Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane poten…
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Regulation of voltage‐gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders Open
Voltage‐gated potassium ( K V ) channels are key regulators of vascular smooth muscle contractility and vascular tone, and thus have major influence on the microcirculation. K V channels are important determinants of vascular smooth muscle…
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KCNQs: Ligand- and Voltage-Gated Potassium Channels Open
Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens. Although they are firm…
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Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia Open
Our results reveal that the high expression and function of Kv7 channels in the LCA and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone.
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CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics Open
The importance of ion channels in the hallmarks of many cancers is increasingly recognised. This article reviews current knowledge of the expression of members of the voltage-gated calcium channel family (CaV) in cancer at the gene and pro…
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Potassium Channels as a Target for Cancer Therapy: Current Perspectives Open
Potassium (K+) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K+ channel), Kir (inw…
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Epigenetic restoration of voltage‐gated potassium channel Kv1.2 alleviates nerve injury‐induced neuropathic pain Open
Voltage‐gated potassium channels (Kv) are important regulators of neuronal excitability for its role of regulating resting membrane potential and repolarization. Recent studies show that Kv channels participate in neuropathic pain, but the…
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miR‐1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries Open
Key points The expression of miR‐1 is increased in lungs from the Hyp/Su5416 PAH rat model. Pulmonary artery smooth muscle cells from this animal model are more depolarized and show decreased expression and activity of voltage‐dependent po…
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The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms Open
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expre…
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The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel Open
Voltage-gated potassium (KV) channels are membrane proteins that respond to changes in membrane potential by enabling K+ ion flux across the membrane. Polyunsaturated fatty acids (PUFAs) induce channel opening by modulating the voltage-sen…
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Voltage-dependent gating and gating charge measurements in the Kv1.2 potassium channel Open
Much has been learned about the voltage sensors of ion channels since the x-ray structure of the mammalian voltage-gated potassium channel Kv1.2 was published in 2005. High resolution structural data of a Kv channel enabled the structural …
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Kv1.3: a multifunctional channel with many pathological implications Open
Ion channels are transmembrane proteins that form aqueous pores driving ions through the plasma membrane in favor of an electrochemical gradient. Thus, voltage-dependent potassium channels (Kv) con...
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Structure-activity relationship studies of four novel 4-aminopyridine K+ channel blockers Open
4-Aminopyridine (4AP) is a specific blocker of voltage-gated potassium channels (K V 1 family) clinically approved for the symptomatic treatment of patients with multiple sclerosis (MS). It has recently been shown that [ 18 F]3F4AP, a radi…
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Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug Open
Significance Voltage-gated potassium channels (Kv) open with membrane depolarization and allow the flow of K + ions. Ion flow is tightly governed by time-dependent entry into nonconducting inactivated states. Here, we focus on Kv1.3, a cha…
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The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating Open
EAG (ether-à-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels. Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the r…
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Voltage-Gated Ptassium Channels Kv1.3 - Potentially New Molecular Target in Cancer Diagnostics and Therapy Open
Voltage-gated potassium channels, Kv1.3, which were discovered in 1984, are integral membrane proteins which are activated ("open") upon change of the cell membrane potential, enabling a passive flux of potassium ions across the cell membr…
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Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling Open
In the last 5 years inhibitors of the potassium channel KV1.3 have been shown to reduce neuroinflammation in rodent models of ischemic stroke, Alzheimer's disease, Parkinson's disease and traumatic brain injury. At the systemic level these…
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The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration Open
Voltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (P…
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Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study Open
Thermal block of unmyelinated axons may serve as a modality for control, suggesting a means for providing therapies for pain. Computational modeling predicted that potassium channels are necessary for mediating thermal block of propagating…
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APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1 Open
The human ether-à-go-go channel (hEag1 or KV10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors. Peptides that are able to selectively inhibit this channel can be lead compounds in…
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Carbon nanoparticles enhance potassium uptake via upregulating potassium channel expression and imitating biological ion channels in BY-2 cells Open
Background Carbon nanoparticles (CNPs) have been reported to boost plant growth, while the mechanism that CNPs enhanced potassium uptake for plant growth has not been reported so far. Results In this study, the function that CNPs promoted …
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Sequence determinants of subtype‐specific actions of KCNQ channel openers Open
Key points Retigabine is a KCNQ voltage‐gated potassium channel opener that was recently approved as an add‐on therapeutic for patients with drug‐resistant epilepsy. Retigabine exhibits very little specificity between most KCNQ channel sub…
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Potassium channels: Novel targets for tumor diagnosis and chemoresistance Open
In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells. The expression and dysfunction of potassiu…