Telomere
View article: Supplementary Table1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Supplementary Table1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma Open
Supplementary Table1
View article: Figure S1-S5 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Figure S1-S5 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma Open
Supplementary Data
View article: Figure S1-S5 and Table S1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Figure S1-S5 and Table S1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma Open
Supplementary Figure Legends
View article: <i>Schizosaccharomyces pombe</i> Telomerase RNA: Secondary Structure and Flexible-Scaffold Function
<i>Schizosaccharomyces pombe</i> Telomerase RNA: Secondary Structure and Flexible-Scaffold Function Open
View article: Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor–stroma interactions and carcinogenesis
Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor–stroma interactions and carcinogenesis Open
We aimed to generate immortalized stromal cell lines from the ovarian and fallopian tube tissues of a single patient using Sendai virus (SeV) vectors and identify candidate stromal genes involved in ovarian carcinogenesis. Tissues were col…
View article: ATRX Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to TEAD Inhibition in Soft Tissue Sarcomas
ATRX Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to TEAD Inhibition in Soft Tissue Sarcomas Open
ATRX is one of the most frequently altered genes in sarcoma and encodes an ATP-dependent chromatin remodeler implicated in maintaining heterochromatin. However, ATRX alterations have not been leveraged for sarcoma treatment. We observed lo…
View article: Supplementary Table from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
Supplementary Table from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer Open
Supplementary Table from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
View article: Supplementary Table from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
Supplementary Table from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer Open
Supplementary Table from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
View article: Data from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
Data from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer Open
Background:Telomere shortening is linked to aging and may be associated with increased risk for cancer. Most cancer studies have used telomere length in leukocytes rather than in the target tissue of cancer origin.Methods:A case–control st…
View article: Supplementary Figure from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
Supplementary Figure from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer Open
Supplementary Figure from Race Differences in Telomere Length in Benign Prostate Biopsies and Subsequent Risk of Prostate Cancer
View article: Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes
Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes Open
Genome three-dimensional organization is essential for eukaryotic gene expression. The chromosomes of the pathogen Trypanosoma brucei contain hundreds of silent variant surface glycoprotein (VSG) genes in subtelomeric regions. T. brucei tr…
View article: Asymmetrical end structures of leading and lagging telomeres in Saccharomyces cerevisiae dictate the nature of the end replication problem
Asymmetrical end structures of leading and lagging telomeres in Saccharomyces cerevisiae dictate the nature of the end replication problem Open
View article: Telomere length, hibernation, and cognitive function in young edible dormice (Glis glis)
Telomere length, hibernation, and cognitive function in young edible dormice (Glis glis) Open
Telomeres protect chromosomes from damage and shortening during cell division and are suggested to relate to aging and cognitive performance. Hibernating species, such as the edible dormouse ( Glis glis ), exhibit remarkable telomere plast…
View article: Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption
Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption Open
Adverse conditions within the embryonic environment can alter embryogenesis, programming systemic physiological changes that may manifest as disease states in adult life. The process of developmental programming represents an important fac…
View article: Somatic genetic rescue in ZCCHC8-associated telomere biology disorders
Somatic genetic rescue in ZCCHC8-associated telomere biology disorders Open
Here we show that somatic genetic rescue is frequent in telomere biology disorders (TBDs) caused by germline ZCCHC8 variants. Our results highlight the critical intrinsic role of ZCCHC8 in human hematopoiesis and a potential mechanism for …
View article: Supplementary Figure S10 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
Supplementary Figure S10 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma Open
Correlation between age, telomere length and 1q gain subtype. A. Correlation between telomere length and chromosome 1 rearrangement subtype B. Correlation between age and chromosome 1 rearrangement subtype
View article: Effects of TA-65 on telomere length, functional outcomes, and inflammation: a systematic review and meta-analysis
Effects of TA-65 on telomere length, functional outcomes, and inflammation: a systematic review and meta-analysis Open
While TA-65 demonstrates telomerase-activating efficacy, particularly in older adults, its failure to improve functional aging metrics underscores limitations of unimodal biomarker targeting. The absence of dose-dependent toxicity or short…
View article: Corrigendum to “Does bipolar disorder accelerate cellular aging? A systematic review and meta-analysis of telomere length” [European Neuropsychopharmacology; 2025;99:21-30]
Corrigendum to “Does bipolar disorder accelerate cellular aging? A systematic review and meta-analysis of telomere length” [European Neuropsychopharmacology; 2025;99:21-30] Open
View article: Is the combination of Myelodysplastic syndromes and pulmonary fibrosis accidental or inevitable?
Is the combination of Myelodysplastic syndromes and pulmonary fibrosis accidental or inevitable? Open
Introduction: We diagnosed and managed a patient with pulmonary fibrosis combined with myelodysplastic syndrome (MDS). This paper aims to investigate, through analysis of our clinical case, a review of the existing literature, and relevant…
View article: Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes
Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes Open
Background In the in vitro expansion of mesenchymal stem cells (MSCs), replicative or stress-induced senescence poses a significant challenge, leading to the loss of their cellular properties and therapeutic functions. Currently, there is …
View article: Crossover interference mediates multiscale patterning along meiotic chromosomes
Crossover interference mediates multiscale patterning along meiotic chromosomes Open
Meiotic crossover interference is a one-dimensional spatial patterning process that produces evenly-spaced crossovers. Quantitative analysis of diagnostic molecules along budding yeast chromosomes reveals that this process sets up two inte…
View article: Replication data for The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study
Replication data for The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study Open
supporting raw data for Western blot and immunofluorescence
View article: FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum
FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum Open
Transposable elements (TEs) are dynamic components of eukaryotic genomes, playing a crucial role in genome evolution and plasticity, particularly in unstable regions such as chromosome ends. In the globally significant fungal pathogen Fusa…
View article: Telomere Length and Mitochondrial Copy Number as Potential Biomarkers for Male Infertility in Iraqi Men
Telomere Length and Mitochondrial Copy Number as Potential Biomarkers for Male Infertility in Iraqi Men Open
Background/Objectives: Male infertility is one of the major problems in Iraqi health and society; it is caused by several factors, such as acquired, environmental, and genetic factors. Awareness of the crucial role of telomeres and mitocho…
View article: Oxidative Stress–Telomere Axis in IVF: Molecular Mechanisms, Biomarkers, and Clinical Translation
Oxidative Stress–Telomere Axis in IVF: Molecular Mechanisms, Biomarkers, and Clinical Translation Open
The reduction in oocyte competence and ovarian reserve coincides with reproductive ageing; nevertheless, the molecular mechanisms underlying this phenomenon remain poorly understood. Our testable mechanistic hypothesis is that the oxidativ…
View article: Supplementary Figure S4 from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer
Supplementary Figure S4 from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer Open
Effect of different inducers of senescence on the bystander effect of ADCs.
View article: DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study
DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study Open
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise. This hypertensive exposure in pregnancy has known lon…
View article: Supplementary Data from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Supplementary Data from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis Open
Supplementary figures and captions for supplementary tables
View article: Identification of Fibrillarin and Cajal Bodies Under DNA Replication Stress Conditions in Root Meristem Cells of Allium cepa
Identification of Fibrillarin and Cajal Bodies Under DNA Replication Stress Conditions in Root Meristem Cells of Allium cepa Open
The correct course of DNA replication is crucial to maintaining the integrity of the genome. Any abnormality in this process inevitably leads to replication stress (RS). Hydroxyurea (HU) is a replication stressor widely used to inhibit DNA…
View article: Religiosity, Telomere Length and Preterm Birth Among Mexican and African American Women in Texas
Religiosity, Telomere Length and Preterm Birth Among Mexican and African American Women in Texas Open
We conducted a cross sectional study of 175 pregnant women (100 Mexican and 75 African American women) recruited from three prenatal clinics in Central and East Texas. This study explored the relationships between religiosity, telomere len…