Prime (order theory)
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Network Slicing in 5G: Survey and Challenges Open
5G is envisioned to be a multi-service network supporting a wide range of verticals with a diverse set of performance and service requirements. Slicing a single physical network into multiple isolated logical networks has emerged as a key …
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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes Open
While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that DNA mismatch repair (MMR) impedes prime editing and promotes und…
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Zinc–air batteries: are they ready for prime time? Open
Zn–air batteries are under revival.
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The TESS Objects of Interest Catalog from the TESS Prime Mission Open
We present 2,241 exoplanet candidates identified with data from the\nTransiting Exoplanet Survey Satellite (TESS) during its two-year prime mission.\nWe list these candidates in the TESS Objects of Interest (TOI) Catalog, which\nincludes b…
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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice Open
Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or local insertions or deletions within the genome based on the temp…
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Phage-assisted evolution and protein engineering yield compact, efficient prime editors Open
Prime editing enables a wide variety of precise genome edits in living cells. Here we use protein evolution and engineering to generate prime editors with reduced size and improved efficiency. Using phage-assisted evolution, we improved ed…
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A Brief Introduction to the COM-B Model of Behaviour and the PRIME Theory of Motivation Open
The COM-B model of behaviour is widely used to identify what needs to change in order for a behaviour change intervention to be effective. It identifies three factors that need to be present for any behaviour to occur: capability, opportun…
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Development of Plant Prime-Editing Systems for Precise Genome Editing Open
Prime-editing systems have the capability to perform efficient and precise genome editing in human cells. In this study, we first developed a plant prime editor 2 (pPE2) system and test its activity by generating a targeted mutation on an …
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Compstatin: a C3‐targeted complement inhibitor reaching its prime for bedside intervention Open
There is a growing awareness that complement plays an integral role in human physiology and disease, transcending its traditional perception as an accessory system for pathogen clearance and opsonic cell killing. As the list of pathologies…
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Top-Down Proteomics: Ready for Prime Time? Open
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Engineering herbicide resistance via prime editing in rice Open
Although CRISPR-Cas9 has revolutionized our ability to generate site-specific double-strand breaks, precise editing of the genome remains challenging in most eukaryotes, including plants (Shan et al., 2013). In plants homology-directed rep…
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RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares Open
Longitudinal genomic analysis of rheumatoid arthritis flares revealed PRIME cells in the blood during the period before a flare and suggested a model in which these cells become activated by B cells in the weeks before a flare and subseque…
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Precision genome engineering in rice using prime editing system Open
Dear editor, Making precise changes in the genomes of organisms is challenging for most genome editing tools. Recently, a search-and-replace method, also known as prime editing, was developed that can introduce user-defined sequence into a…
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THE SHARP BOUND FOR THE HANKEL DETERMINANT OF THE THIRD KIND FOR CONVEX FUNCTIONS Open
We prove the sharp inequality $|H_{3,1}(f)|\leq 4/135$ for convex functions, that is, for analytic functions $f$ with $a_{n}:=f^{(n)}(0)/n!,~n\in \mathbb{N}$ , such that $$\begin{eqnarray}Re\bigg\{1+\frac{zf^{\prime \prime }(z)}{f^{\prime …
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Quantum Annealing for Prime Factorization Open
We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling ( k ≥ 3) terms to quadratic terms using a…
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Integration of mental health into primary care in low- and middle-income countries: The PRIME mental healthcare plans Open
Summary This supplement outlines the development and piloting of district mental healthcare plans from five low- and middle-income countries, together with the methods for their design, evaluation and costing. In this editorial we consider…
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A brief introduction to the COM-B Model of behaviour and the PRIME Theory of motivation Open
The COM-B model of behaviour is widely used to identify what needs to change in order for a behaviour change intervention to be effective. It identifies three factors that need to be present for any behaviour to occur: capability, opportun…
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Efficient prime editing in mouse brain, liver and heart with dual AAVs Open
Realizing the promise of prime editing for the study and treatment of genetic disorders requires efficient methods for delivering prime editors (PEs) in vivo. Here we describe the identification of bottlenecks limiting adeno-associated vir…
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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo Open
Prime editing enables precise installation of genomic substitutions, insertions and deletions in living systems. Efficient in vitro and in vivo delivery of prime editing components, however, remains a challenge. Here we report prime editor…
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A New Model of Jupiter's Magnetic Field at the Completion of Juno's Prime Mission Open
A spherical harmonic model of the magnetic field of Jupiter is obtained from vector magnetic field observations acquired by the Juno spacecraft during 32 of its first 33 polar orbits. These Prime Mission orbits sample Jupiter's magnetic fi…
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Primality, Fractality, and Image Analysis Open
This paper deals with the hidden structure of prime numbers. Previous numerical studies have already indicated a fractal-like behavior of prime-indexed primes. The construction of binary images enables us to generalize this result. In fact…
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Basic principle and good practices of rheology for polymers for teachers and beginners Open
We present a basic principle and good practices of the rheology of polymers, particularly for teachers or lecturers at colleges or universities for educational purposes, as well as for beginner researchers who may refer to this article as …
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Prime editing: advances and therapeutic applications Open
Clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas)-mediated genome editing has revolutionized biomedical research and will likely change the therapeutic and diagnostic landscape. However, CRISPR-Cas…
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Global approach to top-quark flavor-changing interactions Open
We adopt a fully gauge-invariant effective-field-theory approach for parametrizing top-quark flavor-changing-neutral-current interactions. It allows for a global interpretation of experimental constraints (or measurements) and the systemat…
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Prime Focus Spectrograph (PFS) for the Subaru telescope: overview, recent progress, and future perspectives Open
Volume Number: 9908 - Date Published: 1 December 2016 - Softcover: 292 papers (3496) pages - ISBN: 9781510601956
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THIRD ORDER HANKEL DETERMINANT FOR CERTAIN UNIVALENT FUNCTIONS Open
The estimate of third Hankel determinant $$H_{3,1}(f)=\left|a_1\;a_2\;a_3\\a_2\;a_3\;a_4\\a_3\;a_4\;a_5\right|$$ of the analytic function $f(z)=z+a2z^2+a3z^3+{\cdots}$, for which ${\Re}(1+zf^{{\prime}{\prime}}(z)/f^{\prime}(z))>-1/2$ are i…
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The EU’s current crisis and its policy effects: research design and comparative findings Open
The paper summarises a collaborative international research project comparing the impact of the ongoing conglomerate of crises in nine EU policies. All of them saw significant crisis-induced pressures and challenges. Beyond changes in disc…
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Evaluation of district mental healthcare plans: The PRIME consortium methodology Open
Background Few studies have evaluated the implementation and impact of real-world mental health programmes delivered at scale in low-resource settings. Aims To describe the cross-country research methods used to evaluate district-level men…
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Errors have been made, others will be blamed: Issue engagement and blame shifting in prime minister speeches during the economic crisis in Europe Open
This article investigates prime ministers’ communication strategies during the most recent economic crisis in Europe. It argues that when electoral risk is high but governments’ policy options are severely limited, prime ministers will use…
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QUASI-SYMMETRIC FUNCTIONS AND MOD <b><i>p </i></b>MULTIPLE HARMONIC SUMS Open
We present a number of results about (finite) multiple harmonic sums modulo a\nprime, which provide interesting parallels to known results about multiple zeta\nvalues (i.e., infinite multiple harmonic series). In particular, we prove a\n"d…