Interstitial cell of Cajal
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Current clinical management of gastrointestinal stromal tumor Open
Gastrointestinal stromal tumors (GISTs) are the most common malignant subepithelial lesions (SELs) of the gastrointestinal tract. They originate from the interstitial cells of Cajal located within the muscle layer and are characterized by …
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Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal Open
We previously discovered that Xiaozhang Tie (XZT) was helpful for cirrhotic ascites, with obvious abdominal distention relief, suggesting that it may improve gastrointestinal (GI) motility. However, the underlying mechanisms of GI motility…
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Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis Open
Significance The demonstration of a robust neurogenesis program in the adult gut and the existence of an enteric neural precursor cell (ENPC) responsible for the same has profound biological and clinical implications. This demonstrates the…
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The enteric nervous system Open
Of all the organ systems in the body, the gastrointestinal tract is the most complicated in terms of the numbers of structures involved, each with different functions, and the numbers and types of signaling molecules utilized. The digestio…
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Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system Open
Objective The enteric nervous system (ENS) undergoes neuronal loss and degenerative changes with age. The cause of this neurodegeneration is poorly understood. Muscularis macrophages residing in close proximity to enteric ganglia maintain …
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Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells Open
Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial ce…
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Clinical Diagnosis of Gastrointestinal Stromal Tumor (GIST): From the Molecular Genetic Point of View Open
Gastrointestinal stromal tumors (GISTs) originating from the interstitial cells of Cajal are mesenchymal tumors of the gastrointestinal tract and have been found to harbor c-KIT mutations and KIT (CD117) expression since 1998. Later, PDGFR…
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Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility Open
Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures are currently available, c…
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Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures Open
Transcriptome-scale data can reveal essential clues into understanding the underlying molecular mechanisms behind specific cellular functions and biological processes. Transcriptomics is a continually growing field of research utilized in …
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Diabetic and idiopathic gastroparesis is associated with loss of <span>CD</span>206‐positive macrophages in the gastric antrum Open
Background Animal studies have increasingly highlighted the role of macrophages in the development of delayed gastric emptying. However, their role in the pathophysiology of human gastroparesis is unclear. Our aim was to determine changes …
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Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca<sup>2+</sup>transients and slow waves in adult mouse small intestine Open
Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit + electrical pacemakers that express the Ano1/TMEM16A Ca 2+ -activated Cl – channel, whose functions in the gastrointestinal tract remain incompletely und…
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Differential diagnosis of gastrointestinal stromal tumor by histopathology and immunohistochemistry Open
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs account for approximately 80% of the clinically relevant GI mesenchymal tumors. Although most GISTs show spindle cell …
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Cajal bodies and snRNPs - friends with benefits Open
Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last …
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Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation Open
Gut microbiota and short‐chain fatty acids (SCFAs) are associated with the development of various human diseases. In this study, we examined the role of astragaloside IV in modulating mouse gut microbiota structure and the generation of SC…
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Clinical Presentation of Gastrointestinal Stromal Tumors Open
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. They constitute 1-2% of all gastrointestinal neoplasms but are the most common subtype of soft tissue sarcomas, accounting for…
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The Intestinal Stem Cell Niche: A Central Role for Foxl1-Expressing Subepithelial Telocytes Open
The columnar epithelium of the alimentary tract, extending from stomach to colon, is constantly renewed by proliferation of stem and progenitor cells, which give rise to the various differentiated cell types as required by the regional spe…
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In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety Open
Transplanted ENCCs successfully engrafted into recipient ganglionic and aganglionic gut showing appropriate spread, localisation and, importantly, functional integration without any long-term safety issues. This study provides key support …
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Depleted interstitial cells of Cajal and fibrosis in the pylorus: Novel features of gastroparesis Open
Background Depletion and ultrastructural changes of interstitial cells of Cajal ( ICC ) in the gastric body and antrum have been observed in gastroparesis. This research was performed to investigate the ICC population in the muscularis pro…
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Gastrointestinal Stromal Tumors—A Mini Review Open
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. They are potentially malignant, and have an unpredictable evolution. The origin of these tumors is in the interstitial cells o…
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Spontaneous Ca<sup>2+</sup> transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine Open
Key points Interstitial cells of Cajal at the level of the deep muscular plexus (ICC‐DMP) in the small intestine generate spontaneous Ca 2+ transients that consist of localized Ca 2+ events and limited propagating Ca 2+ waves. Ca 2+ transi…
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Recent advances in the management of gastrointestinal stromal tumor Open
Gastrointestinal stromal tumor (GIST) is a rare but an important clinical entity seen in our clinical practice. It is the most common mesenchymal tumor of the gastrointestinal tract and most common malignancy of the small intestine. Althou…
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Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called “Telocytopathies” Open
In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the…
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Hirschsprung’s Disease—Recent Understanding of Embryonic Aspects, Etiopathogenesis and Future Treatment Avenues Open
Hirschsprung’s disease is a neurocristopathy, caused by defective migration, proliferation, differentiation and survival of neural crest cells, leading to gut aganglionosis. It usually manifests rapidly after birth, affecting 1 in 5000 liv…
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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice Open
The enteric nervous system (ENS) plays an important role in regulating gastrointestinal (GI) motility and can function independently of the central nervous system. Changes in ENS function are a major cause of GI symptoms and disease and ma…
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ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter Open
Key points The internal anal sphincter develops tone important for maintaining high anal pressure and continence. Controversy exists regarding the mechanisms underlying tone development. We examined the hypothesis that tone depends upon el…
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Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis Open
Somatic mutations of KIT are frequently found in mastocytosis and gastrointestinal stromal tumor (GIST), while germline mutations of KIT are rare, and only found in few cases of familial GIST and mastocytosis. Although ligand-independent a…
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Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease Open
Muscularis propria throughout the entire gastrointestinal tract including the esophagus is comprised of circular and longitudinal muscle layers. Based on the studies conducted in the colon and the small intestine, for more than a century, …
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The Telocytes: Ten Years after Their Introduction in the Scientific Literature. An Update on Their Morphology, Distribution, and Potential Roles in the Gut Open
Ten years ago, the term ‘telocyte’ was introduced in the scientific literature to describe a ‘new’ cell type described in the connective tissue of several organs by Popescu and Faussone-Pellegrini (2010). Since then, 368 papers containing …
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Nitrergic Enteric Neurons in Health and Disease—Focus on Animal Models Open
Nitrergic enteric neurons are key players of the descending inhibitory reflex of intestinal peristalsis, therefore loss or damage of these neurons can contribute to developing gastrointestinal motility disturbances suffered by patients wor…
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Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon Open
Interstitial cells of Cajal (ICC) generate pacemaker activity responsible for phasic contractions in colonic segmentation and peristalsis. ICC along the submucosal border (ICC-SM) contribute to mixing and more complex patterns of colonic m…