Progenitor cell
View article: Interleukin‐8 Overexpressing Collagen Microgel‐Based Cellular Microtissue Accelerates the Healing of Diabetic Foot Ulcers
Interleukin‐8 Overexpressing Collagen Microgel‐Based Cellular Microtissue Accelerates the Healing of Diabetic Foot Ulcers Open
Diabetic foot ulcers (DFUs) represent a major clinical challenge due to impaired healing and limited therapeutic options. Although stem cell therapy offers regenerative potential, its efficacy is restricted by poor survival and engraftment…
View article: Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation
Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation Open
Background Subjects with Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), experience a wide range of symptoms, including fatigue and respiratory disturbances, affecting their quality of life. Despite the increa…
View article: Adult Telomerase Positive Stem Cells: Introduction and Location
Adult Telomerase Positive Stem Cells: Introduction and Location Open
Endogenous adult telomerase positive stem cells (aTPSCs) are naturally occurring and are located throughout the body. Three categories of aTPSCs were discovered: totipotent stem cells (TSCs, 0.1-2.0-microns) that will form all somatic cell…
View article: Clonal hematopoiesis may precede the diagnosis of aplastic anemia by several years
Clonal hematopoiesis may precede the diagnosis of aplastic anemia by several years Open
Aplastic anemia (AA) is a bone marrow failure syndrome resulting from the immune destruction of hematopoietic stem cells. Clonal hematopoiesis (CH) is characterized by expansion of progenitor hematopoietic stem cells that harbor leukemogen…
View article: Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies Open
Neurodevelopmental proteasomopathies are a group of disorders caused by variants in proteasome subunit genes, that disrupt protein homeostasis and brain development through poorly characterized mechanisms. Here, we report 26 distinct varia…
View article: Therapeutic potential and mechanistic insights into adipose-derived stem cells and mesenchymal stem cell-derived exosomes in patients with Crohn’s disease-associated fistulas: challenges and future perspectives
Therapeutic potential and mechanistic insights into adipose-derived stem cells and mesenchymal stem cell-derived exosomes in patients with Crohn’s disease-associated fistulas: challenges and future perspectives Open
View article: Assessment of hiPSC-derived kidney organoids from cryopreserved progenitors using MALDI-MSI
Assessment of hiPSC-derived kidney organoids from cryopreserved progenitors using MALDI-MSI Open
View article: STEM-PD trial protocol: A multi-centre, single arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell derived dopaminergic cells for Parkinson’s disease
STEM-PD trial protocol: A multi-centre, single arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell derived dopaminergic cells for Parkinson’s disease Open
Introduction: Parkinson’s disease is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia …
View article: Flicking the switch for B-cell development
Flicking the switch for B-cell development Open
The production of B cells is essential for a functional immune system. This process relies on the coordinated activity of a handful of transcription factors that act in part by modifying the chromatin landscape of lymphoid progenitors to a…
View article: Publisher Correction: Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy
Publisher Correction: Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy Open
View article: CTCF-RNA interactions orchestrate cell-specific chromatin loop organization
CTCF-RNA interactions orchestrate cell-specific chromatin loop organization Open
CCCTC-binding factor (CTCF) is essential for chromatin organization. CTCF interacts with endogenous RNAs, and deletion of its ZF1 RNA binding region (∆ZF1) disrupts chromatin loops in mouse embryonic stem cells (ESCs). However, the functio…
View article: Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer
Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer Open
Resistance to androgen receptor (AR)-targeted therapies such as enzalutamide in castration-resistant prostate cancer (CRPC) often arises through lineage plasticity, yet the molecular mechanisms that define this process remain incompletely …
View article: Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells
Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells Open
Stem-like progenitors are self-renewing cytotoxic T cells that expand as effector cells during successful checkpoint immunotherapy 1,2 . Emerging evidence suggests that tumour-draining lymph nodes support the continuous generation of these…
View article: NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms
NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms Open
The development of Philadelphia chromosome-negative classical myeloproliferative neoplasms (MPN) involves an inflammatory process that facilitates outgrowth of the malignant clone and correlates with clinical outcome measures. This raises …
View article: Data from: An autoinhibitory feedback mechanism preserves intestinal stem cell maintenance and fate commitment
Data from: An autoinhibitory feedback mechanism preserves intestinal stem cell maintenance and fate commitment Open
This dataset contains the Seurat objects necessary to recreate all figures from the publication. The files included are as follows: Ctrl_NotchKO_integrated_scent: The primary integrated Seurat object containing Control and Notch KO samples…
View article: Clonal Hematopoiesis Associated with TP53 Mutation Promotes Tissue Repair in Acute Cardiovascular Diseases
Clonal Hematopoiesis Associated with TP53 Mutation Promotes Tissue Repair in Acute Cardiovascular Diseases Open
Clonal hematopoiesis (CH), arising from hematopoietic progenitor cells with acquired mutations, resulting in clonal expansion, and displaying functionally altered hematopoietic cells, is traditionally associated with adverse health outcome…
View article: Non-Crosslinked Hyaluronic Acid Redensity 1<sup>®</sup> Supports Cell Viability, Proliferation, and Collagen Deposition in Early Burn Management
Non-Crosslinked Hyaluronic Acid Redensity 1<sup>®</sup> Supports Cell Viability, Proliferation, and Collagen Deposition in Early Burn Management Open
Background/Objectives: Burn injuries pose a significant challenge due to tissue damage and impaired healing. Cell-based therapies offer promise by delivering therapeu-tic cells to the wound site. However, effective cell delivery remains a …
View article: ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development
ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development Open
View article: Mapping embryonic mouse lung development using enhanced spatial transcriptomics
Mapping embryonic mouse lung development using enhanced spatial transcriptomics Open
The mature mammalian lung contains ~50 different cell types that are located in precise positions along and around the airway epithelial tree. Here, we investigated how these spatial patterns are progressively established during developmen…
View article: <i>Lrig1</i> -expressing quiescent stem cells maintain vocal fold mucosal homeostasis via <i>Notch</i> signaling
<i>Lrig1</i> -expressing quiescent stem cells maintain vocal fold mucosal homeostasis via <i>Notch</i> signaling Open
Identifying progenitor cells in laryngeal and vocal fold (VF) mucosa is essential for advancing stem cell–based therapies for VF diseases. In this study, we used Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1) gene to label …
View article: Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma
Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma Open
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, exhibiting clinical and genomic heterogeneity. Of the four major subgroups, Group 3 tumors (MYC-MB), display high levels of MYC and metastasis rates. Despite tre…
View article: Supplementary Figure S15 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Supplementary Figure S15 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts Open
In-silico cytometry data validation. A) Experimental workflow and multi parameter flow cytometry gating strategy used to sort Lin+ and Lin- from CD34+ MNC and to explore HSPC composition. B) Scatter plot comparing results from multi-parame…
View article: Hematopoietic cell transplantation in first relapse of (CBF- and other) AML
Hematopoietic cell transplantation in first relapse of (CBF- and other) AML Open
View article: In vivo modeling of stress erythropoiesis through targeted gene editing of rat hematopoietic stem cells
In vivo modeling of stress erythropoiesis through targeted gene editing of rat hematopoietic stem cells Open
In response to anemia, the erythroid lineage significantly expands. This growth is driven by extramedullary erythropoiesis in mice, but is additionally regulated within the bone marrow (BM) of rats, a process likely conserved in humans due…
View article: Regulation of Alternative Polyadenylation Events by PABPC1 Affects Erythroid Progenitor Cell Expansion
Regulation of Alternative Polyadenylation Events by PABPC1 Affects Erythroid Progenitor Cell Expansion Open
Erythropoiesis is precisely regulated by multilayered networks. It is crucial for maintaining steady-state hemoglobin levels and ensuring effective oxygen transport. Alternative polyadenylation (APA) is a post-transcriptional regulatory me…
View article: Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1
Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1 Open
Acute myeloid leukemia (AML) is an aggressive cancer with very poor outcomes. To identify additional drivers of leukemogenesis, we analyzed sequencing data from 1,727 unique individual AML patients, which revealed mutations in ubiquitin li…
View article: Poly(A) tail regulation in stem cells and early development
Poly(A) tail regulation in stem cells and early development Open
Eukaryotic mRNAs are polyadenylated at their 3’-ends, and the poly(A) tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation. Here, we describe the biological processes and major pro…
View article: 3D spatial organization of heterogeneous nkx2.5+ progenitors in the zebrafish heart field pre-patterns cardiovascular development
3D spatial organization of heterogeneous nkx2.5+ progenitors in the zebrafish heart field pre-patterns cardiovascular development Open
Nkx2.5+ progenitor cells are specified in the bilateral zebrafish heart field, which contributes to multiple cardiovascular derivatives. After specification, the field physically separates into a cardiac fraction that migrates to the midli…
View article: Impact of delayed cord clamping on mesenchymal, hemopoietic progenitor, and immune cells in very preterm neonates
Impact of delayed cord clamping on mesenchymal, hemopoietic progenitor, and immune cells in very preterm neonates Open
Objective We aimed to investigate the impact of delayed cord clamping (DCC) on the levels of blood mesenchymal (MSCs), hemopoietic progenitor (HPCs), and immune cells in very preterm neonates. Methods We prospectively examined 21 neonates …
View article: Influence of Oxidation Resistance 1 on disease progression in chronic myeloid leukemia
Influence of Oxidation Resistance 1 on disease progression in chronic myeloid leukemia Open
Survival in chronic myeloid leukemia (CML) was dramatically improved by development of tyrosine kinase inhibitors (TKIs) directed to the BCR::ABL1 oncogene. Unfortunately, ~30% of CML patients develop TKI-resistance during prolonged treatm…