Pharmacoepidemiology
View article: Association Between DPPs-4 Inhibitors and Bullous Pemphigoid: Reporting Odds Ratio Analysis Using EudraVigilance Database
Association Between DPPs-4 Inhibitors and Bullous Pemphigoid: Reporting Odds Ratio Analysis Using EudraVigilance Database Open
Background/Objectives: Bullous pemphigoid (BP) is an autoimmune blistering skin disease. The association between dipeptidyl peptidase 4 inhibitors (DPP-4 inhibitors) and bullous pemphigoid (BP) has been studied in many countries; however, …
View article: Looking at the big picture: demonstrating benefits of Bayesian latent cluster spatio-temporal analysis for understanding maternal prescription opioids misuse
Looking at the big picture: demonstrating benefits of Bayesian latent cluster spatio-temporal analysis for understanding maternal prescription opioids misuse Open
View article: Supplementary Figure S4 from Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-Based Study
Supplementary Figure S4 from Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-Based Study Open
Supplementary Figure S4: Antibiotics use in relation to survival outcomes in stage I-III colorectal cancer (crude and completecase multivariable analyses). (A) Antibiotics use in relation to overall survival. (B) Antibiotics use in relatio…
View article: Antipsychotic Drugs and Diabetic Ketoacidosis: A Disproportionality Analysis of the FDA Adverse Event Reporting System
Antipsychotic Drugs and Diabetic Ketoacidosis: A Disproportionality Analysis of the FDA Adverse Event Reporting System Open
Objectives: To evaluate reports of diabetic ketoacidosis (DKA) associated with antipsychotic drug (APD) use submitted to the U.S. Food and Drug Administration’s Adverse Event Reporting System (FAERS). Methods: A retrospective pharmacovigil…
View article: Association between potentially inappropriate medication use and all-cause mortality among older adults with dyslipidemia: a nationwide cohort study
Association between potentially inappropriate medication use and all-cause mortality among older adults with dyslipidemia: a nationwide cohort study Open
Background Potentially inappropriate medications (PIMs) are known to be associated with adverse outcomes in older adults, yet evidence among those with dyslipidemia—who often experience polypharmacy—remains limited. Methods We conducted a …
View article: Antidepressants and hypertensive disorders in pregnancy: a retrospective cohort analysis
Antidepressants and hypertensive disorders in pregnancy: a retrospective cohort analysis Open
Objective This retrospective cohort study investigated relationships between antidepressant use in pregnancy and hypertensive disorders of pregnancy. Design/setting/sample Observational cohort study examining births in an outer-metropolita…
View article: Impact of COVID-19 lockdown on methadone and buprenorphine prescriptions in England primary cares: an interrupted time series analysis
Impact of COVID-19 lockdown on methadone and buprenorphine prescriptions in England primary cares: an interrupted time series analysis Open
Background The COVID-19 lockdown prompted changes in accessing opioid agonist therapy in England, but the lockdown and further adaptations could exacerbate inequalities in opioid agonist therapy availability across practices with different…
View article: Age disparities in adverse reactions of drugs used in pain therapies in Switzerland
Age disparities in adverse reactions of drugs used in pain therapies in Switzerland Open
Pain therapies are prescribed to a significant proportion of the population but also associated with adverse drug reactions (ADRs). The prescription of pain therapies requires careful consideration of their safety profiles in the context o…
View article: Mandatory specialist approval requirements reduce valproate prescribing: population-based evaluation of a National Patient Safety Alert
Mandatory specialist approval requirements reduce valproate prescribing: population-based evaluation of a National Patient Safety Alert Open
Background Valproate exposure during pregnancy causes major congenital malformations in 11% and neurodevelopmental disorders in 30–40% of exposed children. Despite regulatory interventions, including the European 2018 Pregnancy Prevention …
View article: Medication use from conception to the first antenatal appointment: agreement between maternal self-report to midwife and prescribing records in Northern Ireland in 2011-2016
Medication use from conception to the first antenatal appointment: agreement between maternal self-report to midwife and prescribing records in Northern Ireland in 2011-2016 Open
IntroductionData reliability must be considered before using administrative healthcare databases to study medication utilisation and safety during pregnancy. ObjectivesTo compare medication use reported by the mother and recorded by midwiv…
View article: Applying High‐Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and <scp>COVID</scp> ‐19 Outcomes
Applying High‐Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and <span>COVID</span> ‐19 Outcomes Open
Background In pharmacoepidemiologic studies of COVID‐19, there were concerns about bias from residual confounding. We investigated the effects of inhaled corticosteroids (ICS) on COVID‐19 outcomes, applying high‐dimensional propensity scor…
View article: Bisphosphonate-related ocular adverse events: a pharmacovigilance study based on the FAERS database
Bisphosphonate-related ocular adverse events: a pharmacovigilance study based on the FAERS database Open
This retrospective study aimed to identify and characterize signals of ocular adverse events (AEs) related to bisphosphonates (BPs) using FDA Adverse Event Reporting System (FAERS) data (2004Q1-2024Q3) to inform future safety investigation…
View article: Issue Information
Issue Information Open
View article: Drug-induced polycystic ovary syndrome: a real-world pharmacovigilance study based on the FAERS database
Drug-induced polycystic ovary syndrome: a real-world pharmacovigilance study based on the FAERS database Open
Objective Previous studies have shown an association between polycystic ovary syndrome (PCOS) and the use of various medications. However, there is still a lack of systematic research exploring this relationship in depth. This study aims t…
View article: A Pharmacovigilance Study of Immune Checkpoint Inhibitor‐Associated Cholangitis: Insights From the FDA Adverse Event Reporting System
A Pharmacovigilance Study of Immune Checkpoint Inhibitor‐Associated Cholangitis: Insights From the FDA Adverse Event Reporting System Open
Aim Immune checkpoint inhibitor (ICI)‐associated cholangitis is a rare immune‐related adverse event (irAE). However, large‐scale clinical studies specifically investigating this toxicity are still lacking. The aim was to describe ICI‐assoc…
View article: A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022
A whole population-based cohort study of the trajectory of the prevalence and the incidence of mental illness, challenging behaviour, and psychotropic medication prescribing in adults with intellectual disabilities in the Czech Republic between 2010 and 2022 Open
View article: A survey on drug interactions and determinant factors in outpatient prescriptions for copd patients at Cho Ray Hospital in 2023
A survey on drug interactions and determinant factors in outpatient prescriptions for copd patients at Cho Ray Hospital in 2023 Open
This study aimed to characterize the prevalence, clinical features, and associated risk factors of clinically significant drug-drug interactions (DDIs) among outpatients with chronic obstructive pulmonary disease (COPD). A retrospective cr…
View article: Disproportionality analysis of biliary adverse events associated with fibrates using the JADER and FAERS databases
Disproportionality analysis of biliary adverse events associated with fibrates using the JADER and FAERS databases Open
Introduction Fibrates are effective triglyceride-lowering drugs, but they may affect bile acid metabolism, raising concerns about biliary adverse drug events (ADEs). Objective In this study, we used spontaneous reporting system databases t…
View article: Gastrointestinal and Skin Safety Evaluation of Pirfenidone versus Nintedanib: An Analysis of Real-World Pharmacovigilance and Randomized Controlled Trials
Gastrointestinal and Skin Safety Evaluation of Pirfenidone versus Nintedanib: An Analysis of Real-World Pharmacovigilance and Randomized Controlled Trials Open
This study compares their safety profiles using real-world pharmacovigilance data and meta-analysis to guide clinical use. Adverse drug event (ADE) reports for pirfenidone (2008-Q1 2025) and nintedanib (2014-Q1 2025) were extracted from th…
View article: Comparative safety profile of levofloxacin versus moxifloxacin in first-line tuberculosis therapy: a pharmacovigilance study of the FAERS database
Comparative safety profile of levofloxacin versus moxifloxacin in first-line tuberculosis therapy: a pharmacovigilance study of the FAERS database Open
Objective This study aimed to compare the safety profiles of two fluoroquinolone-containing regimens, HREL (isoniazid, rifampicin, ethambutol, levofloxacin) and HREM (isoniazid, rifampicin, ethambutol, moxifloxacin), in the treatment of dr…
View article: Bridging pharmacovigilance and genetic insight: investigating drugs and indications for breast cancer risk in women with autoimmune diseases
Bridging pharmacovigilance and genetic insight: investigating drugs and indications for breast cancer risk in women with autoimmune diseases Open
Our study uncovered several immune-related drugs associated with increased breast cancer reporting in women with AIDs. This risk may be explained by several potential drug targets with causal roles, or by the shared genetic comorbidity bet…
View article: Safety profile of metformin in adolescents with type 2 diabetes: A pharmacovigilance analysis of the FDA Adverse Event Reporting System
Safety profile of metformin in adolescents with type 2 diabetes: A pharmacovigilance analysis of the FDA Adverse Event Reporting System Open
Background Although metformin is the first-line medicine for type 2 diabetes (T2D), its safety profile in adolescents remains poorly understood. This study seeks to investigate the adverse events linked to metformin use in adolescents diag…
View article: Non-adherence to oral antidiabetic medications among patients with type 2 diabetes: evidence from a nationwide multicentre study in a lower-middle-income country
Non-adherence to oral antidiabetic medications among patients with type 2 diabetes: evidence from a nationwide multicentre study in a lower-middle-income country Open
Non-adherence to oral antidiabetic medication is prevalent and influenced by diverse personal, socioeconomic, and health-related factors. Targeted interventions addressing modifiable risk factors could improve adherence, ultimately reduce …
View article: Pharmacological risks of khat–oral antidiabetic drug interactions among patients at Gondar university referral hospital
Pharmacological risks of khat–oral antidiabetic drug interactions among patients at Gondar university referral hospital Open
Not applicable.
View article: COVID-19 Infections Still Occur: How Do Pregnant and Non-Pregnant Individuals Compare? A Study from the Canadian Mother–Child Initiative on Drug Safety in Pregnancy (CAMCCO)
COVID-19 Infections Still Occur: How Do Pregnant and Non-Pregnant Individuals Compare? A Study from the Canadian Mother–Child Initiative on Drug Safety in Pregnancy (CAMCCO) Open
Over 100 million pregnant people worldwide remain at risk of COVID-19. We compared the prevalence of severe COVID-19 in pregnancy and in people of reproductive age, and the risk of adverse pregnancy/neonatal outcomes in those with/without …
View article: Cardiovascular Drug–Drug Interactions (DDIs) in Coronary Heart Disease Patients with Hypertension
Cardiovascular Drug–Drug Interactions (DDIs) in Coronary Heart Disease Patients with Hypertension Open
Coronary heart disease (CHD) accompanied by hypertension often necessitates the use of multiple cardiovascular agents. The concurrent use of multiple drugs increases the risk of drug-drug interactions (DDIs), which may alter drug metabolis…
View article: Potential Drug-Drug Interactions in Elderly Patients Treated with Anti- Glaucoma Agents: A Cross-Sectional Study in North of Iran
Potential Drug-Drug Interactions in Elderly Patients Treated with Anti- Glaucoma Agents: A Cross-Sectional Study in North of Iran Open
Background and aim: Glaucoma is one of the world's leading causes of blindness. This disease applies especially to older individuals who often require systemic drugs for other co-morbidities. In this age group, risks of polypharmacy can gi…
View article: Prescription Patterns of Antiseizure Medication in Adult Patients with Epilepsy in Kazakhstan (2021–2023)
Prescription Patterns of Antiseizure Medication in Adult Patients with Epilepsy in Kazakhstan (2021–2023) Open
Background/Objectives: Epilepsy is a major neurological disorder associated with significant comorbidity and treatment challenges. In low- and middle-income countries, access to newer antiseizure medications (ASMs) remains limited, and pre…
View article: Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the <scp>WHO</scp> pharmacovigilance database
Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the <span>WHO</span> pharmacovigilance database Open
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportional…
View article: Pain and opioids after surgery (PANDOS)
Pain and opioids after surgery (PANDOS) Open
BACKGROUND Persistent pain and opioid use after surgery have been well documented in North America, but there are limited data in Europe. OBJECTIVES In the Pain and Opioids after Surgery (PANDOS) study, our objectives are to document these…