Pathogenic fungus ≈ Pathogenic fungus
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Secondary metabolites in fungus-plant interactions Open
Fungi and plants are rich sources of thousands of secondary metabolites. The genetically coded possibilities for secondary metabolite production, the stimuli of the production, and the special phytotoxins basically determine the microscopi…
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Metarhizium brunneum (Ascomycota; Hypocreales) Treatments Targeting Olive Fly in the Soil for Sustainable Crop Production Open
Soil treatments with Metarhizium brunneum EAMa 01/58-Su strain conducted in both Northern and Southern Spain reduced the olive fly (Bactrocera oleae) population density emerging from the soil during spring up to 70% in treated plots compar…
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Insect Pathogenic Fungi: Genomics, Molecular Interactions, and Genetic Improvements Open
Entomopathogenic fungi play a pivotal role in the regulation of insect populations in nature, and representative species have been developed as promising environmentally friendly mycoinsecticides. Recent advances in the genome biology of i…
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Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality Open
Significance As insecticide resistance is rapidly spreading, alternative tools for mosquito control are urgently needed. Beauveria bassiana is equally effective at killing insecticide-resistant and insecticide-susceptible mosquitoes. Bette…
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Plant Pathogenic Fungi Open
Fungi are among the dominant causal agents of plant diseases. To colonize plants and cause disease, pathogenic fungi use diverse strategies. Some fungi kill their hosts and feed on dead material (necrotrophs), while others colonize the liv…
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Transcriptome and Metabolite Profiling of the Infection Cycle of<i>Zymoseptoria tritici</i>on Wheat Reveals a Biphasic Interaction with Plant Immunity Involving Differential Pathogen Chromosomal Contributions and a Variation on the Hemibiotrophic Lifestyle Definition Open
The hemibiotrophic fungus Zymoseptoria tritici causes Septoria tritici blotch disease of wheat (Triticum aestivum). Pathogen reproduction on wheat occurs without cell penetration, suggesting that dynamic and intimate intercellular communic…
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Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study Open
Our results demonstrate that silver nanoparticles are potent inhibitors of C. albicans biofilm formation. SEM observations are consistent with an overall loss of structure of biofilms mostly due to disruption of the outer cell membrane/wal…
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Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity Open
Significance Oosporein, a red 1,4-bibenzoquinone derivative, was first identified from fungi in the 1960s and exhibits antibiotic, antiviral, antifungal, and insecticidal activities. We report, to our knowledge, for the first time the nove…
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The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum Open
This fully completed F. graminearum PH-1 genome and manually curated annotation, available at Ensembl Fungi, provides the optimum resource to perform interspecies comparative analyses and gene function studies.
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Divergent and Convergent Evolution of Fungal Pathogenicity Open
Fungal pathogens of plants and animals have multifarious effects; they cause devastating damages to agricultures, lead to life-threatening diseases in humans, or induce beneficial effects by reducing insect pest populations. Many virulence…
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Microbial Small Talk: Volatiles in Fungal–Bacterial Interactions Open
There is increasing evidence that volatile organic compounds (VOCs) play an important role in the interactions between fungi and bacteria, two major groups of soil inhabiting microorganisms. Yet, most of the research has been focused on ef…
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Carbon translocation from a plant to an insect-pathogenic endophytic fungus Open
Metarhizium robertsii is a common soil fungus that occupies a specialized ecological niche as an endophyte and an insect pathogen. Previously, we showed that the endophytic capability and insect pathogenicity of Metarhizium are coupled to …
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DHN melanin biosynthesis in the plant pathogenic fungus <i>Botrytis cinerea</i> is based on two developmentally regulated key enzyme (PKS)‐encoding genes Open
Summary B otrytis cinerea is the causal agent of gray mold disease in various plant species and produces grayish macroconidia and/or black sclerotia at the end of the infection cycle. It has been suggested that the pigmentation is due to t…
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A circadian oscillator in the fungus <i>Botrytis cinerea</i> regulates virulence when infecting <i>Arabidopsis thaliana</i> Open
Significance Circadian clocks are molecular machineries that allow organisms to anticipate daily cyclic challenges and to temporally modulate different processes. Thus, plant defense mechanisms against pathogens have been reported to vary …
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Reactive oxygen species generated in chloroplasts contribute to tobacco leaf infection by the necrotrophic fungus <i>Botrytis cinerea</i> Open
Summary Reactive oxygen species ( ROS ) play fundamental roles in plant responses to pathogen infection, including modulation of cell death processes and defense‐related gene expression. Cell death triggered as part of the hypersensitive r…
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The Role of Pathogen-Secreted Proteins in Fungal Vascular Wilt Diseases Open
A limited number of fungi can cause wilting disease in plants through colonization of the vascular system, the most well-known being Verticillium dahliae and Fusarium oxysporum. Like all pathogenic microorganisms, vascular wilt fungi secre…
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The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans Open
Melanins are synthesized macromolecules that are found in all biological kingdoms. These pigments have a myriad of roles that range from microbial virulence to key components of the innate immune response in invertebrates. Melanins also ex…
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A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions Open
A multipartite DNA virus was isolated from a plant pathogenic fungus, which is infectious as cloned DNA and purified virions.
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Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development Open
SUMMARY Invasive fungal infections cause significant morbidity and mortality in part due to a limited antifungal drug arsenal. One therapeutic challenge faced by clinicians is the significant host toxicity associated with antifungal drugs.…
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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus Open
New strategies are needed to counter the escalating threat posed by drug-resistant fungi. The molecular chaperone Hsp90 affords a promising target because it supports survival, virulence and drug-resistance across diverse pathogens. Inhibi…
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Candida albicans Hyphae: From Growth Initiation to Invasion Open
Candida albicans is a commensal resident of the human gastrointestinal and genital tracts. Under conditions such as dysbiosis, host immune perturbances, or the presence of catheters/implanted medical devices, the fungus may cause debilitat…
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Emerging Trends in Molecular Interactions between Plants and the Broad Host Range Fungal Pathogens Botrytis cinerea and Sclerotinia sclerotiorum Open
Fungal plant pathogens are major threats to food security worldwide. Sclerotinia sclerotiorum and Botrytis cinerea are closely related Ascomycete plant pathogens causing mold diseases on hundreds of plant species. There is no genetic sourc…
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The phytopathogenic fungus Sclerotinia sclerotiorum detoxifies plant glucosinolate hydrolysis products via an isothiocyanate hydrolase Open
Brassicales plants produce glucosinolates and myrosinases that generate toxic isothiocyanates conferring broad resistance against pathogens and herbivorous insects. Nevertheless, some cosmopolitan fungal pathogens, such as the necrotrophic…
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Life Cycle of<i>Cryptococcus neoformans</i> Open
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and cellular and molecular biology of C. neoformans have dramatically imp…
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Secondary metabolite arsenal of an opportunistic pathogenic fungus Open
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene cl…
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Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus Open
Asexual spores (conidia) are reproductive structures that play a crucial role in fungal distribution and survival. As fungal conidia are, in most cases, etiological agents of plant diseases and fungal lung disease, their stress resistance …
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Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus <i>Cryptococcus neoformans</i> Open
The ability to adapt to a changing environment provides a selective advantage to microorganisms. In the case of many pathogens, a large change in their environment occurs when they move from a natural setting to a setting within a human ho…
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Subtilisin-like Pr1 proteases marking the evolution of pathogenicity in a wide-spectrum insect-pathogenic fungus Open
Subtilisin-like Pr1 proteases of insect-pathogenic fungi are a large family of extracellular cuticle-degrading enzymes that presumably determine a capability of hyphal invasion into insect hemocoel through normal cuticle infection, but rem…
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Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus<i>Candida albicans</i> Open
Candida albicans is an opportunistic yeast and the major human fungal pathogen in the USA, as well as in many other regions of the world. Infections with C. albicans can range from superficial mucosal and dermatological infections to life-…
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Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi Open
Small-molecule signaling is one major mode of communication within the polymicrobial consortium of soil and rhizosphere. While microbial secondary metabolite (SM) production and responses of individual species have been studied extensively…