Brain natriuretic peptide
View article: Efficacy of levosimendan for acute decompensated heart failure with preserved ejection fraction in the elderly: a single-center retrospective analysis
Efficacy of levosimendan for acute decompensated heart failure with preserved ejection fraction in the elderly: a single-center retrospective analysis Open
Aims Current guidelines recommend medical treatment for heart failure with preserved ejection fraction (HFpEF) but do not address inotropic drug use during acute HF episodes. This real-world study aimed to evaluate the effects of levosimen…
View article: Atrial Fibrillation in COVID-19: Mechanisms, Clinical Impact, and Monitoring Strategies
Atrial Fibrillation in COVID-19: Mechanisms, Clinical Impact, and Monitoring Strategies Open
The coronavirus disease 2019 (COVID-19) pandemic has revealed a close and multifaceted relationship between viral infection, systemic inflammation, and cardiovascular health. Among the cardiac complications of severe acute respiratory synd…
View article: Yixintai treats chronic heart failure in rats by regulating gut microbiota and bile acid
Yixintai treats chronic heart failure in rats by regulating gut microbiota and bile acid Open
Introduction Yixintai (YXT) medicine for chronic heart failure (CHF), has demonstrated safety and efficacy in the treatment of CHF. However, its precise mechanistic actions require further elucidation. Methods This study identified compone…
View article: Psychocardiological impact of depression on medication adherence, ventricular function, and readmission in heart failure: A retrospective cohort study
Psychocardiological impact of depression on medication adherence, ventricular function, and readmission in heart failure: A retrospective cohort study Open
BACKGROUND Depression is a highly prevalent and clinically significant psychiatric comorbidity in patients with heart failure (HF), exerting multidimensional effects that extend beyond emotional symptoms to influence physiological outcomes…
View article: Chronic Kidney Disease and Cardiac Remodeling Potentiate Cognitive Impairment Progression: Disentangling the Sex-Specific Crosstalk of Kidney-Heart-Brain Axis
Chronic Kidney Disease and Cardiac Remodeling Potentiate Cognitive Impairment Progression: Disentangling the Sex-Specific Crosstalk of Kidney-Heart-Brain Axis Open
Chronic kidney disease (CKD)-mediated oxidative stress, uremic toxicity, inflammation, and cardiovascular (CV) damage connect the kidney-heart-brain axis that contributes to cognitive impairment (CI) and progression to major neurological d…
View article: Beyond Traditional Risk Factors: Inflammation, Asymmetric Dimethylarginine, and N-Terminal pro–B-Type Natriuretic Peptide Predict Cardiovascular Risk in Chronic Kidney Disease
Beyond Traditional Risk Factors: Inflammation, Asymmetric Dimethylarginine, and N-Terminal pro–B-Type Natriuretic Peptide Predict Cardiovascular Risk in Chronic Kidney Disease Open
View article: The evolution of cardiac changes after breast cancer adjuvant radiotherapy – A six-year follow-up study
The evolution of cardiac changes after breast cancer adjuvant radiotherapy – A six-year follow-up study Open
Introduction: This prospective study investigated the long-term effects of adjuvant radiotherapy (RT) on cardiac function and biomarkers in early breast cancer patients over a six-year follow-up. Methods: Seventy-three women treated with R…
View article: The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients
The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients Open
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocar…
View article: Identification of NSTE-ACS patients with totally occluded infarct-related artery: the role of the SAVE risk score in improved risk stratification
Identification of NSTE-ACS patients with totally occluded infarct-related artery: the role of the SAVE risk score in improved risk stratification Open
Objective The aim of this study is to investigate the clinical characteristics of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients with totally occluded infarct-related artery (IRA-TOCA) and validate the novel SAVE risk…
View article: Xinli formula’s efficacy in heart failure: analysis via Guangdong TCM hospital database
Xinli formula’s efficacy in heart failure: analysis via Guangdong TCM hospital database Open
Objective To evaluate the efficacy of the “Xinli Formula” in improving cardiac function, symptoms, and quality of life in patients with heart failure using a hospital database. Methods A retrospective study included 210 patients (2017–2022…
View article: Congestion and systemic inflammation in acute heart failure: correlations and prognostic role
Congestion and systemic inflammation in acute heart failure: correlations and prognostic role Open
Background The reciprocal correlation between systemic inflammation and heart failure (HF) is a hotline research topic although the exact role in risk stratification and prognosis within the acute setting is a matter of debate. This study …
View article: Obesity, aldosterone, and natriuretic peptide in patients with heart failure and reduced ejection fraction
Obesity, aldosterone, and natriuretic peptide in patients with heart failure and reduced ejection fraction Open
Aims Experimental evidence suggests that adipose tissue may secrete aldosterone, and mineralocorticoid receptor antagonists (MRAs) appear to be more effective in patients with obesity. Therefore, we examined aldosterone levels according to…
View article: Associations between Cognitive Frailty and Circulating Cardiovascular Biomarkers in a Memory Clinic Cohort
Associations between Cognitive Frailty and Circulating Cardiovascular Biomarkers in a Memory Clinic Cohort Open
Background: Cognitive frailty (CF), the co-occurrence of physical frailty and mild cognitive impairment (MCI) without dementia, is an at-risk state for adverse outcomes. While frailty and MCI are individually linked to cardiovascular dysfu…
View article: Protein biomarkers in pulmonary arterial hypertension: advances, clinical relevance, and translational challenges
Protein biomarkers in pulmonary arterial hypertension: advances, clinical relevance, and translational challenges Open
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by pulmonary vasoconstriction and right ventricular dysfunction. Although classical circulating biomarkers such as brain natriuretic peptide …
View article: Evaluating the Predictive Significance of Biomarkers for Vascular Complications in Diabetic Patients
Evaluating the Predictive Significance of Biomarkers for Vascular Complications in Diabetic Patients Open
The complications remain a leading cause of morbidity and mortality among individuals with diabetes, particularly type 2 diabetes (T2D). As the global burden of diabetes continues to rise, early identification of patients at risk for compl…
View article: Development of an artificial intelligence-based early diagnostic system for light-chain amyloidosis
Development of an artificial intelligence-based early diagnostic system for light-chain amyloidosis Open
Light-chain (AL) amyloidosis is a rare disease and its early diagnosis remains challenging. This study aimed to develop an artificial intelligence (AI)-based diagnostic assistance system to improve the early diagnosis of AL amyloidosis and…
View article: Evaluating the Predictive Significance of Biomarkers for Vascular Complications in Diabetic Patients
Evaluating the Predictive Significance of Biomarkers for Vascular Complications in Diabetic Patients Open
The complications remain a leading cause of morbidity and mortality among individuals with diabetes, particularly type 2 diabetes (T2D). As the global burden of diabetes continues to rise, early identification of patients at risk for…
View article: Long-term outcomes and prognostic predictors in patients with fibrosing mediastinitis associated pulmonary hypertension: a multicenter cohort study
Long-term outcomes and prognostic predictors in patients with fibrosing mediastinitis associated pulmonary hypertension: a multicenter cohort study Open
Background Fibrosing mediastinitis (FM) is a rare condition that may be complicated by pulmonary hypertension (PH). This multicenter study aimed to investigate the clinical features, long-term survival outcomes, and prognostic factors in p…
View article: <scp>MiR</scp> ‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis
<span>MiR</span> ‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis Open
Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐i…
View article: Impact of Finerenone in Patients with Heart Failure and Reduced/Mildly Reduced Ejection Fraction, Diabetes Mellitus, and Chronic Kidney Disease
Impact of Finerenone in Patients with Heart Failure and Reduced/Mildly Reduced Ejection Fraction, Diabetes Mellitus, and Chronic Kidney Disease Open
Background: Heart failure (HF) remains a major global health challenge with substantial morbidity, mortality, and healthcare burden. Finerenone, a novel non-steroidal mineralocorticoid receptor antagonist (MRA), has demonstrated cardiovasc…
View article: Post-PCI Inflammation and Diastolic Dysfunction in Patients with Metabolic Risk Factors: A Retrospective Observational Study
Post-PCI Inflammation and Diastolic Dysfunction in Patients with Metabolic Risk Factors: A Retrospective Observational Study Open
Background and Objectives: Left ventricular diastolic dysfunction (LVDD) is a known precursor of heart failure with preserved ejection fraction (HFpEF), particularly in patients with metabolic comorbidities. Acute coronary syndrome (ACS) a…
View article: The role of serum uric acid in survival prediction in patients with acute myocardial infarction accompanied by heart failure with preserved ejection fraction
The role of serum uric acid in survival prediction in patients with acute myocardial infarction accompanied by heart failure with preserved ejection fraction Open
Background Heart failure with preserved ejection fraction (HFpEF) is defined as presenting with clinical symptoms and signs of heart failure with a concomitant left ventricular ejection fraction ≥50%. However, the prognostic role of serum …
View article: Elevated B-Type Natriuretic Peptide as a Predictor of Unfavorable Outcomes in Post-Acute Stroke Patients
Elevated B-Type Natriuretic Peptide as a Predictor of Unfavorable Outcomes in Post-Acute Stroke Patients Open
View article: Correlation analysis of serum NT-pro-BNP, IGFBP-7 and CTRP12 levels in chronic heart failure patients
Correlation analysis of serum NT-pro-BNP, IGFBP-7 and CTRP12 levels in chronic heart failure patients Open
Objective: To investigate serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP), insulin-like growth factor binding protein-7 (IGFBP-7), and C1q tumor necrosis factor-related protein 12 (CTRP12) levels and significance in patients wi…
View article: Evaluation of N-terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) as a Biomarker of Cardiac Dysfunction Across Heart Failure Phenotypes
Evaluation of N-terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) as a Biomarker of Cardiac Dysfunction Across Heart Failure Phenotypes Open
View article: VIRTUE: An Innovative Ejection Fraction-Based Index for Predicting Outcomes in Acute Heart Failure
VIRTUE: An Innovative Ejection Fraction-Based Index for Predicting Outcomes in Acute Heart Failure Open
Background/Objectives: Acute heart failure (AHF) is a heterogeneous clinical syndrome, and prognosis varies depending on the ejection fraction phenotype. Although the N-terminal pro–B-type natriuretic peptide (NT-proBNP) remains the benchm…
View article: Mavacamten treatment in obstructive hypertrophic cardiomyopathy for up to 30 weeks: An integrated analysis of cardiac magnetic resonance data from a diverse population in randomized clinical trials
Mavacamten treatment in obstructive hypertrophic cardiomyopathy for up to 30 weeks: An integrated analysis of cardiac magnetic resonance data from a diverse population in randomized clinical trials Open
Background Mavacamten, the first-in-class cardiac myosin inhibitor, is approved for the treatment of patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM). Previous cardiac magnetic resonance (CMR) imaging analyses in ind…
View article: Integrated efficacy and safety analysis of mavacamten monotherapy in patients with obstructive hypertrophic cardiomyopathy
Integrated efficacy and safety analysis of mavacamten monotherapy in patients with obstructive hypertrophic cardiomyopathy Open
Background Mavacamten has been shown to improve cardiac function, symptoms, cardiac biomarkers, and patient-reported outcomes in patients with obstructive hypertrophic cardiomyopathy (HCM) across multiple phase 3 studies with up to 3 years…
View article: Biomarkers of atrial remodelling and risk of cardiovascular death in patients with hypertension: the LOOP study
Biomarkers of atrial remodelling and risk of cardiovascular death in patients with hypertension: the LOOP study Open
Background Hypertension is associated with changes in biomarkers of atrial remodelling like left atrial (LA) strain, pro-brain natriuretic peptide (pro-BNP), and high-sensitivity C-reactive protein (hsCRP). All of these biomarkers have bee…
View article: Echocardiographic AMYLI score in systemic light-chain amyloidosis: clinical relevance and risk stratification
Echocardiographic AMYLI score in systemic light-chain amyloidosis: clinical relevance and risk stratification Open
Background While the AMYLoidosis Index (AMYLI) has been extensively utilized for screening cardiac amyloidosis (CA). However, the relationship between this parameter and amyloid burden, as well as its prognostic value, remains elusive. Pur…