Arterial stiffness ≈ Arterial stiffness
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Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness Open
M uch has been published in the past 20 years on the use of measurements of arterial stiffness in animal and human research studies.This summary statement was commissioned by the American Heart Association to address issues concerning the …
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Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness Open
Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC) tran…
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Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans Open
The effects of simulated microgravity on the static and dynamic properties of large arteries are still mostly unknown. The present study evaluated, using an integrated vascular approach, changes in structure and function of the common caro…
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Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood Open
Among teenagers and young adults who had been diagnosed with diabetes during childhood or adolescence, the prevalence of complications and comorbidities was higher among those with type 2 diabetes compared with type 1, but frequent in both…
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Arterial Stiffness and Cardiovascular Risk in Hypertension Open
Arterial stiffness, a leading marker of risk in hypertension, can be measured at material or structural levels, with the latter combining effects of the geometry and composition of the wall, including intramural organization. Numerous stud…
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Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes Open
Aims To determine the effects of empagliflozin on blood pressure ( BP ) and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes mellitus ( T2DM ). Methods We conducted a post hoc analysis of data from a p…
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Sex Differences in Blood Pressure Trajectories Over the Life Course Open
In contrast with the notion that important vascular disease processes in women lag behind men by 10 to 20 years, sex-specific analyses indicate that BP measures actually progress more rapidly in women than in men, beginning early in life. …
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Hypertension in older adults: Assessment, management, and challenges Open
Hypertension in older adults is related to adverse cardiovascular outcomes, such as heart failure, stroke, myocardial infarction, and death. The global burden of hypertension is increasing due to an aging population and increasing prevalen…
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SGLT-2 inhibitors and cardiovascular risk: Proposed pathways and review of ongoing outcome trials Open
Given the multi-faceted pathogenesis of atherosclerosis in type 2 diabetes mellitus (T2DM), it is likely that interventions to mitigate this risk must address cardiovascular (CV) risk factors beyond glucose itself. Sodium glucose cotranspo…
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Age-related vascular stiffening: causes and consequences Open
Arterial stiffening occurs with age and is closely associated with the progression of cardiovascular disease. Stiffening is most often studied at the level of the whole vessel because increased stiffness of the large arteries can impose in…
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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice Open
We tested the hypothesis that supplementation of nicotinamide mononucleotide (NMN), a key NAD(+) intermediate, increases arterial SIRT1 activity and reverses age-associated arterial dysfunction and oxidative stress. Old control mice (OC) h…
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Pulse Wave Velocity in Atherosclerosis Open
Early detection of subclinical atherosclerosis is important to reduce patients' cardiovascular risk. However, current diagnostic strategy focusing on traditional risk factors or using risk scoring is not satisfactory. Non-invasive imaging …
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Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease Open
Epidemiological studies have documented that insulin resistance and diabetes not only constitute metabolic abnormalities but also predispose to hypertension, vascular stiffness, and associated cardiovascular disease. Meanwhile, excessive a…
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Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases Open
Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vasc…
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Vascular biology of ageing—Implications in hypertension Open
Ageing is associated with functional, structural and mechanical changes in arteries that closely resemble the vascular alterations in hypertension. Characteristic features of large and small arteries that occur with ageing and during the d…
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Elastin, arterial mechanics, and cardiovascular disease Open
Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on th…
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Interaction Between Hypertension and Arterial Stiffness Open
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Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans Open
Key points A recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular‐related and all‐cause mortality; however, the specific cardiovascular adaptations that cause this chronic protection are currently unknown.…
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The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes Open
Arterial remodeling refers to the structural and functional changes of the vessel wall that occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a pivotal role in regulating the remodeling processes of t…
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Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging Open
Functional status is considered the main determinant of healthy aging. Impairment in skeletal muscle and the cardiovascular system, two interrelated systems, results in compromised functional status in aging. Increased oxidative stress and…
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Sex differences in mechanisms of arterial stiffness Open
Arterial stiffness progressively increases with aging and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the time course of aging‐related arterial stiffness and the ass…
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Association of Ozone Exposure With Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults Open
Short-term ozone exposure at levels not associated with lung function changes was associated with platelet activation and blood pressure increases, suggesting a possible mechanism by which ozone may affect cardiovascular health.
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Brachial-Ankle Pulse Wave Velocity: Myths, Misconceptions, and Realities Open
A variety of techniques to evaluate central arterial stiffness have been developed and introduced. None of these techniques, however, have been implemented widely in regular clinical settings, except for brachial-ankle pulse wave velocity …
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Gut microbial diversity is associated with lower arterial stiffness in women Open
Gut microbiome diversity is inversely associated with arterial stiffness in women. The effect of gut microbiome composition on PWV is only minimally mediated by MetS. This first human observation linking the gut microbiome to arterial stif…
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Large Artery Stiffness Assessment Using SphygmoCor Technology Open
Large artery stiffness assessment has been an integral part of the SphygmoCor technology since 1998. Aortic stiffness is approximated with non-invasive measurement of carotid-femoral pulse wave velocity, with improvements made with time to…
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Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality Open
Background Vascular aging results in stiffer arteries and may have a role in the development of cardiovascular disease ( CVD ). Arterial stiffness index ( ASI ), measured by finger photoplethysmography, and pulse pressure ( PP ) are 2 inde…
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Arterial Stiffness and Hypertension in the Elderly Open
Hypertension prevalence increases with age. Age and high blood pressure are the two main determinants of arterial stiffness. In elderly hypertensives, large arteries stiffen and systolic and pulse pressures increase, due to wave reflection…
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How to Measure Arterial Stiffness in Humans Open
Despite the wide recognition of larger artery stiffness as a highly clinically relevant and independent prognostic biomarker, it has yet be incorporated into routine clinical practice and to take a more prominent position in clinical guide…
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Association of Estimated Pulse Wave Velocity With Survival Open
These results suggest that, in the SPRINT trial, ePWV predicted outcomes independent of the Framingham Risk Score, indicating an incremental role of markers of aortic stiffness on cardiovascular risk. Better survival of individuals whose e…
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Arterial structure and function in vascular ageing: are you as old as your arteries? Open
Advancing age may be the most potent independent predictor of future cardiovascular events, a relationship that is not fully explained by time‐related changes in traditional cardiovascular risk factors. Since some arteries exhibit differen…