Mineralocorticoid
View article: Intercellular communication from myotubes to fibroblasts is differentially impacted by mineralocorticoid receptor signaling and muscular dystrophy
Intercellular communication from myotubes to fibroblasts is differentially impacted by mineralocorticoid receptor signaling and muscular dystrophy Open
View article: The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice
The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice Open
In the mouse model of HFD-induced obesity and heart failure, finerenone improves weight loss-induced recovery of cardiac function.
View article: Single-Center Experience in Five Patients Diagnosed with Lipoid Congenital Adrenal Hyperplasia Due to Steroidogenic Acute Regulatory Protein (STAR) Gene Variants: A Rare Cause of Adrenal Insufficiency
Single-Center Experience in Five Patients Diagnosed with Lipoid Congenital Adrenal Hyperplasia Due to Steroidogenic Acute Regulatory Protein (STAR) Gene Variants: A Rare Cause of Adrenal Insufficiency Open
Lipoid congenital adrenal hyperplasia (LCAH) is the rarest and most severe form of congenital adrenal hyperplasia (CAH), characterized by impaired adrenal and gonadal steroidogenesis. This case series aims to present our clinical experienc…
View article: Mineralocorticoid receptor blockade quiesces parietal epithelial cell activation
Mineralocorticoid receptor blockade quiesces parietal epithelial cell activation Open
View article: Unmasking Hormonal Mechanisms of Hypertension in Obesity
Unmasking Hormonal Mechanisms of Hypertension in Obesity Open
Background Understanding hormonal mechanisms of obesity-related hypertension may inform the optimal approach to targeted therapy. Objectives To interrogate hormonal phenotypes of obesity-related hypertension. Methods 77 participants with o…
View article: Aldosterone Synthase Deficiency Type I in a Neonate: Diagnostic, Genetic, and Therapeutic Insights From a Novel CYP11B2 Variant
Aldosterone Synthase Deficiency Type I in a Neonate: Diagnostic, Genetic, and Therapeutic Insights From a Novel CYP11B2 Variant Open
View article: Diuretics — A Review of the Current Knowledge
Diuretics — A Review of the Current Knowledge Open
Diuretics are medicines that make the body pass more urine and salt. They work by blocking sodium (salt) reabsorption in different parts of the kidney: • Proximal tubule – SGLT2 inhibitors, carbonic anhydrase inhibitors. • Loop of Henle – …
View article: Diuretics — A Review of the Current Knowledge
Diuretics — A Review of the Current Knowledge Open
Diuretics are medicines that make the body pass more urine and salt. They work by blocking sodium (salt) reabsorption in different parts of the kidney: • Proximal tubule – SGLT2 inhibitors, carbonic anhydrase inhibitors. • Loop of Henle – …
View article: Genetic Variants in the Renin Angiotensin Aldosterone System and their Impact on Mineralocorticoid Receptor Antagonist Response After Myocardial Infarction: A Comprehensive Review
Genetic Variants in the Renin Angiotensin Aldosterone System and their Impact on Mineralocorticoid Receptor Antagonist Response After Myocardial Infarction: A Comprehensive Review Open
View article: From crisis to catch-up: Reversing salt-wasting in an Indian infant with CMO II deficiency – A case report
From crisis to catch-up: Reversing salt-wasting in an Indian infant with CMO II deficiency – A case report Open
Aldosterone synthase deficiency (ASD) is a rare autosomal recessive disorder due to CYP11B2 gene mutations, presenting with life-threatening salt-wasting in infancy. Corticosterone methyl oxidase (CMO) II deficiency is a subtype characteri…
View article: Obesity, aldosterone, and natriuretic peptide in patients with heart failure and reduced ejection fraction
Obesity, aldosterone, and natriuretic peptide in patients with heart failure and reduced ejection fraction Open
Aims Experimental evidence suggests that adipose tissue may secrete aldosterone, and mineralocorticoid receptor antagonists (MRAs) appear to be more effective in patients with obesity. Therefore, we examined aldosterone levels according to…
View article: Obesity-Related Aldosteronism is Associated with Adverse Cardiac Structure, Function, and Adiposity
Obesity-Related Aldosteronism is Associated with Adverse Cardiac Structure, Function, and Adiposity Open
Background Obesity-related aldosteronism may increase risk for adverse cardiometabolic outcomes. We investigated the association between dysregulated aldosterone production and cardiac structure, function, and adiposity under controlled ph…
View article: Comparing the Long-Term Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors Versus Mineralocorticoid Receptor Antagonists as Add-On Therapies in the Management of Heart Failure: A Systematic Review
Comparing the Long-Term Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors Versus Mineralocorticoid Receptor Antagonists as Add-On Therapies in the Management of Heart Failure: A Systematic Review Open
View article: The Nonsteroidal Mineralocorticoid Receptor Blocker Esaxerenone reduces glomerular hyperfiltration and albuminuria
The Nonsteroidal Mineralocorticoid Receptor Blocker Esaxerenone reduces glomerular hyperfiltration and albuminuria Open
Background and Hypothesis Diabetic kidney disease (DKD) is a major cause of chronic kidney disease with glomerular hyperfiltration contributing to its progression. Esaxerenone, a non-steroidal mineralocorticoid receptor antagonist (MRA), r…
View article: KHINDIVI A HYDROCORTISONE DRUG
KHINDIVI A HYDROCORTISONE DRUG Open
Khindivi (Oral Solution of Hydrocortisone) Khindivi is an oral hydrocortisone formulation designed specifically for children with adrenocortical insufficiency who are five years of age or older. Khindivi, a synthetic glucocorticoid, suppor…
View article: Towards a better prevention in cardio-kidney metabolic syndrome: Role of aldosterone and albuminuria
Towards a better prevention in cardio-kidney metabolic syndrome: Role of aldosterone and albuminuria Open
View article: KHINDIVI A HYDROCORTISONE DRUG
KHINDIVI A HYDROCORTISONE DRUG Open
Khindivi (Oral Solution of Hydrocortisone) Khindivi is an oral hydrocortisone formulation designed specifically for children with adrenocortical insufficiency who are five years of age or older. Khindivi, a synthetic glucocorticoid, suppor…
View article: Corrigendum to The Effect of Mineralocorticoid Receptor Antagonists on Heart Failure with Nonreduced Ejection Fraction: A Systematic Review and Meta-Analysis. CJC Open Volume 7, Issue 10, October 2025, Pages 1332-1344
Corrigendum to The Effect of Mineralocorticoid Receptor Antagonists on Heart Failure with Nonreduced Ejection Fraction: A Systematic Review and Meta-Analysis. CJC Open Volume 7, Issue 10, October 2025, Pages 1332-1344 Open
View article: Data for Manuscript: Osmolarity controls oscillatory calcium signaling to reduce autonomous aldosterone production in zona glomerulosa cells
Data for Manuscript: Osmolarity controls oscillatory calcium signaling to reduce autonomous aldosterone production in zona glomerulosa cells Open
Data for figures in Osmolarity controls oscillatory calcium signaling to reduce autonomous aldosterone production in zona glomerulosa cells; https://doi.org/10.1210/endocr/bqaf147
View article: A Mineralocorticoid-Dependent Effect of Prestress on Avoidance Responding in Rats
A Mineralocorticoid-Dependent Effect of Prestress on Avoidance Responding in Rats Open
Rats made more free-operant avoidance responses if they were given a brief prestress 30 min before the test than if they were undisturbed before the test. This effect of prestress occurred in normal rats whether foot shock, air blast, or s…
View article: Mineralocorticoid effects of fludrocortisone and hydrocortisone in primary adrenal insufficiency: EU-AIR patient data
Mineralocorticoid effects of fludrocortisone and hydrocortisone in primary adrenal insufficiency: EU-AIR patient data Open
Purpose Patients with primary adrenal insufficiency (PAI) require mineralocorticoid replacement therapy in addition to glucocorticoids. These therapies should be considered in combination because most glucocorticoids also possess mineraloc…
View article: The Effect of Glucocorticoid and Mineralocorticoid Receptor Antagonists in the Skin of Aged Female Mice
The Effect of Glucocorticoid and Mineralocorticoid Receptor Antagonists in the Skin of Aged Female Mice Open
The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are ligand-activated transcription factors that regulate epidermal homeostasis, inflammation, and function. Prior studies using epidermal-specific conditional single and …
View article: Intrarenal Generation of Aldosterone Contributes to Ischemia-Induced Hypertension and Nephropathy in Mice
Intrarenal Generation of Aldosterone Contributes to Ischemia-Induced Hypertension and Nephropathy in Mice Open
Background The past few years have witnessed a significant advancement in aldosterone (Aldo)-targeted therapies for the management of treatment-resistant hypertension and chronic kidney disease, which often exist in tandem. While Aldo is b…
View article: Aldosterone in Chronic Kidney Disease
Aldosterone in Chronic Kidney Disease Open
Chronic kidney disease (CKD) is a global health challenge, marked by significant morbidity and mortality and a rising economic burden. Despite established therapies such as renin–angiotensin system (RAS) inhibitors and SGLT2 inhibitors, a …
View article: What is the best long-term treatment for congenital adrenal hyperplasia?
What is the best long-term treatment for congenital adrenal hyperplasia? Open
Long-term treatment for congenital adrenal hyperplasia often includes glucocorticoid and, when necessary, mineralocorticoid replacement therapy, with evolving options like modified-release hydrocortisone and Crinecerfont improving manageme…
View article: What is the best long-term treatment for congenital adrenal hyperplasia?
What is the best long-term treatment for congenital adrenal hyperplasia? Open
Long-term treatment for congenital adrenal hyperplasia often includes glucocorticoid and, when necessary, mineralocorticoid replacement therapy, with evolving options like modified-release hydrocortisone and Crinecerfont improving manageme…
View article: Efficacy and safety of mineralocorticoid receptor antagonists in kidney transplant patients: an updated meta-analysis of randomized controlled trials
Efficacy and safety of mineralocorticoid receptor antagonists in kidney transplant patients: an updated meta-analysis of randomized controlled trials Open
View article: The role of Mineralocorticoid Receptor pathway in Ocular Rosacea
The role of Mineralocorticoid Receptor pathway in Ocular Rosacea Open
Ocular rosacea (OR) is a chronic inflammatory disease of the ocular surface and the eyelids, favored by UV exposure. It can affect vision, damage the cornea and has a significant impact on quality of life. OR is linked to meibomian gland d…
View article: Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor
Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor Open
Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and pr…
View article: Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates Diabetic Nephropathy via suppressing SLC7A11-mediated ferroptosis
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates Diabetic Nephropathy via suppressing SLC7A11-mediated ferroptosis Open
Diabetic tubulopathy (DT) has recently been identified as a critical pathological feature of diabetic nephropathy (DN). Ferroptosis has emerged as an important pathological factor in DT, implicated in various metabolic disorders, including…