Bipolar disorder
View article: Cognitive Impairment in Aging Bipolar Disorder: Clinical Profile, Risk Factors, and Differentiation from Neurodegenerative Dementia - A Case Report and literature review
Cognitive Impairment in Aging Bipolar Disorder: Clinical Profile, Risk Factors, and Differentiation from Neurodegenerative Dementia - A Case Report and literature review Open
Introduction: Bipolar disorder (BD) in older individuals is frequently associated with cognitive impairment; nevertheless, the attributes, trajectory, and specificity of this deterioration remain contentious. The investigation into a bipol…
View article: Cognitive Impairment in Aging Bipolar Disorder: Clinical Profile, Risk Factors, and Differentiation from Neurodegenerative Dementia - A Case Report and literature review
Cognitive Impairment in Aging Bipolar Disorder: Clinical Profile, Risk Factors, and Differentiation from Neurodegenerative Dementia - A Case Report and literature review Open
Introduction: Bipolar disorder (BD) in older individuals is frequently associated with cognitive impairment; nevertheless, the attributes, trajectory, and specificity of this deterioration remain contentious. The investigation into a bipol…
View article: Obsessive-compulsive disorder and bipolar disorder comorbidity: Diagnostic challenges, clinical implications and therapeutic strategies
Obsessive-compulsive disorder and bipolar disorder comorbidity: Diagnostic challenges, clinical implications and therapeutic strategies Open
Background: Bipolar disorder frequently presents with psychiatric comorbidities, among which obsessive-compulsive disorder (OCD) poses significant diagnostic and therapeutic challenges. The concurrent presentation of these…
View article: Obsessive-compulsive disorder and bipolar disorder comorbidity: Diagnostic challenges, clinical implications and therapeutic strategies
Obsessive-compulsive disorder and bipolar disorder comorbidity: Diagnostic challenges, clinical implications and therapeutic strategies Open
Background: Bipolar disorder frequently presents with psychiatric comorbidities, among which obsessive-compulsive disorder (OCD) poses significant diagnostic and therapeutic challenges. The concurrent presentation of these disorders compli…
View article: Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report
Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report Open
Background: Cocaine is a potent psychostimulant known to precipitate acute psychiatric manifestations, including manic or psychotic episodes. Hematological complications are rare but increasingly described, particularly thrombocytopenia as…
View article: Integrating dermatology and psychiatry: Clinical impact of dermatoses in hospitalized patients with mental illness
Integrating dermatology and psychiatry: Clinical impact of dermatoses in hospitalized patients with mental illness Open
Background: Psychodermatology highlights the bidirectional interactions between psychiatric disorders and cutaneous diseases. Patients with severe mental illness are at increased risk of dermatological conditions due to neuro-immunological…
View article: Trajectories of affective disorders—the central structures of CRC/TRR 393
Trajectories of affective disorders—the central structures of CRC/TRR 393 Open
The recurrent and often unpredictable course of affective disorders poses a critical challenge for long-term patient care. The CRC/TRR 393 consortium has established an ambitious longitudinal study, the German Mental Health Cohort (GEMCO),…
View article: Altered expression of LINC03091 and LINC03090 LncRNAs in bipolar disorder: a case-control study
Altered expression of LINC03091 and LINC03090 LncRNAs in bipolar disorder: a case-control study Open
Long non-coding RNAs (lncRNAs) are widely expressed and play an essential role in gene regulation through various transcriptional and post-transcriptional mechanisms. Recent findings have highlighted the role of lncRNAs in sustaining cellu…
View article: Food for thought: re-emergence of tardive dyskinesia amid nutritional rehabilitation of atypical anorexia nervosa; a case report
Food for thought: re-emergence of tardive dyskinesia amid nutritional rehabilitation of atypical anorexia nervosa; a case report Open
Background Atypical anorexia nervosa is an eating disorder that involves significant restriction of food intake leading to clinically significant weight loss despite remaining at a normal or above normal weight for age or height. Part of r…
View article: Temporal Elements of Speech in Mania
Temporal Elements of Speech in Mania Open
Computational analysis of speech enables precise, objective measurements of a behavioral signal closely linked to manic episodes. In a prospective cohort study conducted in Rochester, MN ( ClinicalTrials.gov Identifier: NCT05956340 ) , eig…
View article: Perinatal determinants of depressive disorder profile in high-income women: testing current cut-off thresholds
Perinatal determinants of depressive disorder profile in high-income women: testing current cut-off thresholds Open
View article: Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder
Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder Open
View article: Cardiometabolic disorder comorbidity within affective disorders: analysis of 1.6 million participants in the Our Future Health cohort
Cardiometabolic disorder comorbidity within affective disorders: analysis of 1.6 million participants in the Our Future Health cohort Open
Background Affective disorders - including bipolar disorder, depression and anxiety disorders - are associated with increased risk of cardiometabolic disorders and premature mortality. Aim To assess prevalence and the association of cardio…
View article: Manic episode revealing a pituitary adenoma: From a clinical case and literature review
Manic episode revealing a pituitary adenoma: From a clinical case and literature review Open
Pituitary adenomas are common intracranial tumors, yet psychiatric manifestations as presenting symptoms remain uncommon and often overlooked. We report the case of a 37-year-old man with no prior medical or psychiatric history who initial…
View article: Antidepressants and hypertensive disorders in pregnancy: a retrospective cohort analysis
Antidepressants and hypertensive disorders in pregnancy: a retrospective cohort analysis Open
Objective This retrospective cohort study investigated relationships between antidepressant use in pregnancy and hypertensive disorders of pregnancy. Design/setting/sample Observational cohort study examining births in an outer-metropolita…
View article: Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep
Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep Open
Sleep is a critical yet often underestimated physiological parameter in psychiatric disorders. In their article, Gokcay et al examined sleep quality in bipolar disorder patients treated with lithium or valproic acid, showing lithium’s adva…
View article: Corrigendum to “Does bipolar disorder accelerate cellular aging? A systematic review and meta-analysis of telomere length” [European Neuropsychopharmacology; 2025;99:21-30]
Corrigendum to “Does bipolar disorder accelerate cellular aging? A systematic review and meta-analysis of telomere length” [European Neuropsychopharmacology; 2025;99:21-30] Open
View article: Evaluation of sleep quality in patients diagnosed with bipolar disorder and major depression during remission period
Evaluation of sleep quality in patients diagnosed with bipolar disorder and major depression during remission period Open
BACKGROUND Sleep disturbances and residual functional impairment are increasingly recognized as important determinants of outcome in mood disorders, even during remission. Persistent disruptions in sleep may reflect underlying pathophysiol…
View article: Causal Associations Between Smoking, Brain Structural Alterations and Psychiatric Disorders: Evidence From a Mediation Analysis
Causal Associations Between Smoking, Brain Structural Alterations and Psychiatric Disorders: Evidence From a Mediation Analysis Open
Both epidemiological and Mendelian randomization (MR) studies have confirmed the association between smoking and psychiatric disorders, yet the underlying mechanism remains poorly understood. To address this gap, this study aimed to evalua…
View article: Delusional Infestation, Psychiatric Comorbidity, and Dementia: A Review of 146 Swedish Patients
Delusional Infestation, Psychiatric Comorbidity, and Dementia: A Review of 146 Swedish Patients Open
Delusional infestation is a rare but severe dermatopsychiatric disorder. The diagnosis is associated with great suffering for the patients and their relatives, as well as substantial use of healthcare resources. It has been observed that p…
View article: Risk of neurological and psychiatric diagnoses in COVID-19 survivors: A multicenter retrospective cohort study using electronic health records
Risk of neurological and psychiatric diagnoses in COVID-19 survivors: A multicenter retrospective cohort study using electronic health records Open
BACKGROUND The neurological and psychiatric sequelae of coronavirus disease 2019 (COVID-19) have been documented, yet further data are needed to thoroughly evaluate the impact of COVID-19 on brain health years after the infection. AIM To e…
View article: Disentangling Perinatal Depression from General Major Depression: A GWAS Meta-Analysis and Genetic Correlation Approach in European Datasets
Disentangling Perinatal Depression from General Major Depression: A GWAS Meta-Analysis and Genetic Correlation Approach in European Datasets Open
Perinatal depression (PND), defined as depression occurring during the perinatal period, has a higher heritability than general major depressive disorder (MDD) yet remains understudied. This study aimed to increase power in PND GWAS and ex…
View article: Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options
Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options Open
Customized treatment plans tailored to each patient's needs, preferences, goals and circumstances should be considered for the treatment of antipsychotic and mood stabilizer-associated weight gain.
View article: Therapeutic timing limitations of postnatal darbepoetin in a valproic acid rat model of Autism Spectrum Disorder
Therapeutic timing limitations of postnatal darbepoetin in a valproic acid rat model of Autism Spectrum Disorder Open
Autism spectrum disorder (ASD) arises from complex genetic and environmental factors that disrupt neural development during early brain maturation. Erythropoietin (EPO) has been studied for its neuroprotective effects and more recently for…
View article: Mood states recognition based on Mandarin speech and deep learning in patients with bipolar disorder
Mood states recognition based on Mandarin speech and deep learning in patients with bipolar disorder Open
View article: Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities
Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities Open
Neuropsychiatric disorders such as autism spectrum disorder (ASD), generalized anxiety disorder (GAD), major depressive disorder (MDD), and schizophrenia (SZ) frequently co-occur with dermatological conditions, including atopic dermatitis,…
View article: AI at the Bedside of Psychiatry: Comparative Meta-analysis of Imaging vs Non-imaging Machine-Learning Models for Differentiating Bipolar vs Unipolar Depression at First Episode v1
AI at the Bedside of Psychiatry: Comparative Meta-analysis of Imaging vs Non-imaging Machine-Learning Models for Differentiating Bipolar vs Unipolar Depression at First Episode v1 Open
First-episode bipolar disorder (BD) is frequently misclassified as unipolar major depressive disorder (MDD). Artificial intelligence/machine-learning (AI/ML) models trained on imaging (e.g., MRI, EEG) and non-imaging (e.g., EHR/clinical, v…
View article: Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder
Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder Open
Psilocybin, a naturally occurring psychedelic compound, has received attention as a novel therapeutic option for Major Depressive Disorder (MDD), particularly in cases where traditional treatments prove ineffective. The study aims to evalu…
View article: Understanding Relationships Between Birth Trauma, Helplessness, and Perinatal Mental Health Disorders
Understanding Relationships Between Birth Trauma, Helplessness, and Perinatal Mental Health Disorders Open
Background: Birth trauma and perinatal mental health disorders (PMHDs) are significant public health concerns, yet their interrelationships and underlying psychosocial mechanisms remain underexplored. This study examined associations betwe…
View article: Suicidality and/or Death-Related Thoughts in Health Workers After Pandemics: The Role of DYMERS
Suicidality and/or Death-Related Thoughts in Health Workers After Pandemics: The Role of DYMERS Open
Background/Objectives: Healthcare workers (HCWs) experienced marked psychological distress during and after the COVID-19 pandemic, including high levels of burnout, depression, and suicidal ideation. Italy, one of the first Western countri…