Neutrophil elastase
View article: Bone marrow aspirate Cit-H3 was identified as a novel biomarker of minimal residual disease in neuroblastoma
Bone marrow aspirate Cit-H3 was identified as a novel biomarker of minimal residual disease in neuroblastoma Open
Background Neuroblastoma (NB) is the most prevalent extracranial solid tumor in children. Neutrophils release neutrophil extracellular traps (NETs) following intense or prolonged activation. Neutrophil elastase (ELA2) and citrullinated his…
View article: Injury to tissue caused by device penetration of the skin triggers formation of extracellular traps
Injury to tissue caused by device penetration of the skin triggers formation of extracellular traps Open
Continuous glucose monitoring (CGM) systems are vital for diabetes management, but sensor performance is often compromised by host immune responses following insertion. This study investigates early tissue and immune reactions, focusing on…
View article: Aging changes the mechanism that underlies JAK2 modulation of neutrophil function
Aging changes the mechanism that underlies JAK2 modulation of neutrophil function Open
Janus kinase 2 (JAK2) has been linked to various neutrophil functions, but the intracellular mechanisms underlying its modulation are unknown. Neutrophils are essential cells for host defense. Neutrophil effector functions include migratio…
View article: Performance Study of Noninvasive Salivary Biomarkers in Laryngopharyngeal Reflux
Performance Study of Noninvasive Salivary Biomarkers in Laryngopharyngeal Reflux Open
Background The diagnosis of laryngopharyngeal reflux disease (LPRD) mostly uses invasive techniques. Our aim was to carry out a performance study of noninvasive saliva biomarkers in LPRD patients and to investigate clinical utility. Method…
View article: Regulation mechanism of IL-36 by neutrophil extracellular trapping in a mice of sepsis-induced ARDS
Regulation mechanism of IL-36 by neutrophil extracellular trapping in a mice of sepsis-induced ARDS Open
Background Sepsis-induced acute respiratory distress syndrome (ARDS) is characterized by uncontrolled pulmonary inflammation and neutrophil-driven pathology. Neutrophil extracellular traps (NETs) have been implicated in ARDS progression, b…
View article: Injectable cationic dynamic hydrogel with supramolecular drug loading reprograms neutrophil fate to alleviate diabetic periodontitis
Injectable cationic dynamic hydrogel with supramolecular drug loading reprograms neutrophil fate to alleviate diabetic periodontitis Open
The pervasive infiltration of tissue-destructive yet microbicidal-impaired neutrophil extracellular traps (NETs) constitutes a primary mechanistic driver of diabetic periodontitis refractoriness. Apoptosis facilitates nonphlogistic turnove…
View article: It’s a Trap!—Potential of Cathepsins in NET Formation
It’s a Trap!—Potential of Cathepsins in NET Formation Open
Neutrophils are first-line immune effectors in innate immunity, employing migration, phagocytosis, and neutrophil extracellular trap (NET) formation to combat infections and mediate inflammatory responses. NET formation, the regulated extr…
View article: Myeloperoxidase impairs mucociliary transport on human airway epithelium
Myeloperoxidase impairs mucociliary transport on human airway epithelium Open
Dampening neutrophil-driven inflammation in the airways remains a challenge in treating cystic fibrosis (CF) lung disease. Myeloperoxidase (MPO) is a neutrophilic enzyme that produces reactive oxygen species and is highly concentrated in C…
View article: Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1
Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1 Open
Background and objective Asthma exacerbations due to cold air exposure are well recognized; however, the underlying mechanisms remain unclear. We investigate the role of the transient receptor potential ankyrin1 (TRPA1) channel in cold air…
View article: Biochemical Modifications of Homocysteine Drive Neutrophil Extracellular Trap Formation in Ischemic Stroke
Biochemical Modifications of Homocysteine Drive Neutrophil Extracellular Trap Formation in Ischemic Stroke Open
Excessive production of neutrophil extracellular traps (NETs) contributes to immunothrombosis activation in ischemic stroke pathogenesis. The metabolic and mechanistic regulators of NET formation in relation to platelet activation during i…
View article: Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease
Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease Open
Neutrophils are the most abundant circulating leukocytes and essential components of innate immunity. Through mechanisms such as phagocytosis, reactive oxygen species (ROS) production, degranulation, and neutrophil extracellular trap (NET)…
View article: Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis Open
View article: A sensitive, fast, and efficient method for studying NETosis ex vivo by flow cytometry and live cell imaging 2450
A sensitive, fast, and efficient method for studying NETosis ex vivo by flow cytometry and live cell imaging 2450 Open
Description In a process termed NETosis, neutrophils expel neutrophil extracellular traps (NETs) - chromatin fibers decorated with antimicrobials and proteases, including neutrophil elastase - in an effort to trap and eliminate pathogens. …
View article: Single-cell transcriptome reveals a role for neutrophil elastase in immune homeostasis and shaping of host early responses to vaccines 4334
Single-cell transcriptome reveals a role for neutrophil elastase in immune homeostasis and shaping of host early responses to vaccines 4334 Open
Description Induction of mucosal immunity is generally believed to require stimulation of mucosal inductive sites through vaccines administered via a mucosal route. We recently reported that supplementation with a neutrophil elastase inhib…
View article: Bafilomycin A1 triggers Streptococcus mutans-induced neutrophil extracellular trap (NET) production 9124
Bafilomycin A1 triggers Streptococcus mutans-induced neutrophil extracellular trap (NET) production 9124 Open
Description Neutrophil extracellular traps (NETs) promote thrombosis and contribute to infectious disease progression. Our previous study showed that commensal oral streptococci entering the bloodstream induces NET formation on injured hea…
View article: Neutrophil dysregulation and sustained inflammation in PASC with pulmonary complications 2457
Neutrophil dysregulation and sustained inflammation in PASC with pulmonary complications 2457 Open
Description Neutrophil dysregulation plays a central role in COVID-19 severity, yet its role in post-acute sequelae of SARS-CoV-2 infection (PASC) remains unclear. To investigate neutrophil contribution in PASC with pulmonary complications…
View article: Siglec-F exerts protective effects on elastase-induced lung inflammation and emphysema in mice 2288
Siglec-F exerts protective effects on elastase-induced lung inflammation and emphysema in mice 2288 Open
Description Airspace macrophages (AMs) are crucial for host defense, but protection must occur with minimal physiological disruption. Indeed, activated AMs release proteases that cause alveolar destruction in patients with emphysema. Sigle…
View article: G-CSF-induced emergency granulopoiesis modulates neutrophil effector function in mice 3345
G-CSF-induced emergency granulopoiesis modulates neutrophil effector function in mice 3345 Open
Description Neutrophils function as first responders of the immune system by deploying cytotoxic armaments and orchestrating local inflammation. Their functionality is programmed during daily production in the bone marrow through granulopo…
View article: Investigating functional NETosis pathways and siRNA mediated suppression of NETosis in feline and HL-60 neutrophil in vitro models of SARS-CoV-2 infection 2738
Investigating functional NETosis pathways and siRNA mediated suppression of NETosis in feline and HL-60 neutrophil in vitro models of SARS-CoV-2 infection 2738 Open
Description Neutrophil extracellular trap (NET) formation, or NETosis, aids pathogen clearance, while causing tissue damage when excessive, as seen in severe cases of COVID-19. This study investigates SARS-CoV-2-induced NETosis, via ROS-de…
View article: Estrogen Receptor α (ERα) Signaling and Tumor Cell-Derived Factors Mediate Pro-Tumor Neutrophil Activation in the Setting of Lymphangioleiomyomatosis (LAM) 2809
Estrogen Receptor α (ERα) Signaling and Tumor Cell-Derived Factors Mediate Pro-Tumor Neutrophil Activation in the Setting of Lymphangioleiomyomatosis (LAM) 2809 Open
Description Lymphangioleiomyomatosis (LAM) is a rare multisystemic disease associated with cystic tumor formation in the lungs caused by small smooth muscle tumors. LAM exclusively affects biological females; however, the origin of tumors …
View article: Pharmacokinetic Evaluation of Neutrophil Elastase Inhibitor in Sprague-Dawley Rats 9033
Pharmacokinetic Evaluation of Neutrophil Elastase Inhibitor in Sprague-Dawley Rats 9033 Open
Description Introduction Sivelestat is a neutrophil elastase inhibitor that reduces elastase activation and neutrophil aggregation during inflammatory responses. Our long-term goal is to test whether sivelestat can attenuate polytrauma ind…
View article: Electronic cigarette (E-Cigarette) vapor amplifies inflammation and the pathogenic extracellular vesicle signature associated with LPS-driven lung injury 3771
Electronic cigarette (E-Cigarette) vapor amplifies inflammation and the pathogenic extracellular vesicle signature associated with LPS-driven lung injury 3771 Open
Description Background E-cigarette use has surged as an alternative to traditional smoking, but the pulmonary effects of e-cigarette vapor remain poorly understood. Previous work has shown that bacterial components like lipopolysaccharide …
View article: Preclinical evaluation of two new neutrophil elastase inhibitors synthesized by palladium-mediated [11C]cyanations
Preclinical evaluation of two new neutrophil elastase inhibitors synthesized by palladium-mediated [11C]cyanations Open
View article: Dual-Functional Cerium Oxide Nanoparticles with Antioxidant and DNase I activities to Prevent and degrade Neutrophil Extracellular Traps
Dual-Functional Cerium Oxide Nanoparticles with Antioxidant and DNase I activities to Prevent and degrade Neutrophil Extracellular Traps Open
Neutrophils play a central role in immunothrombosis through the formation of neutrophil extracellular traps (NETs), a process known as NETosis. Upon stimulation, neutrophils release decondensed chromatin structures enriched with proteolyti…
View article: Dual-Functional Cerium Oxide Nanoparticles with Antioxidant and DNase I activities to Prevent and degrade Neutrophil Extracellular Traps
Dual-Functional Cerium Oxide Nanoparticles with Antioxidant and DNase I activities to Prevent and degrade Neutrophil Extracellular Traps Open
Neutrophils play a central role in immunothrombosis through the formation of neutrophil extracellular traps (NETs), a process known as NETosis. Upon stimulation, neutrophils release decondensed chromatin structures enriched with proteolyti…
View article: Cytosolic proliferating cell nuclear antigen (PCNA) orchestrates neutrophil hyperactivation in COVID-19.
Cytosolic proliferating cell nuclear antigen (PCNA) orchestrates neutrophil hyperactivation in COVID-19. Open
Neutrophils are central mediators of the hyperinflammatory response in severe SARS-CoV-2 infection. We report elevated cytosolic levels of proliferating cell nuclear antigen (PCNA) in neutrophils from patients with severe and critical COVI…
View article: Procoagulant platelets and neutrophil extracellular traps restrict fetal growth in a murine model of hypertensive diseases of pregnancy
Procoagulant platelets and neutrophil extracellular traps restrict fetal growth in a murine model of hypertensive diseases of pregnancy Open
Background Hypertensive diseases of pregnancy (HDP) like preeclampsia lead to fetal growth restriction (FGR), where elevated thromboxane A2 (TXA2) levels trigger maternal hypertension, recurrent placental ischemia/reperfusion injury, and f…
View article: Neutrophil elastase promotes low molecular weight cyclin E1 formation to accelerate osteosarcoma proliferation
Neutrophil elastase promotes low molecular weight cyclin E1 formation to accelerate osteosarcoma proliferation Open
Introduction Osteosarcoma (OS) is the most common primary bone malignancy, characterized by aggressive local invasion and a high propensity for metastasis. We previously reported that cyclin E1 is upregulated in osteosarcoma. In this study…
View article: Potential of Tomato Seed Extract for Wrinkle Care through Human Neutrophil Elastase Inhibition: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Potential of Tomato Seed Extract for Wrinkle Care through Human Neutrophil Elastase Inhibition: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Open
Numerous cosmetic products claim to improve aging-induced wrinkles, and recent research has explored the potential of oral intake for wrinkle improvement. In our previous study, we investigated the effects of tomato seed extract (TSE), whi…
View article: The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion
The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion Open
In many acute and chronic inflammatory disorders, recruitment of neutrophils plays a critical role in preventing disease severity and ensuring survival. On the other hand, neutrophil accumulation during inflammation can also favor disease …