Whole body imaging
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Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care Open
PET is widely considered the most sensitive technique available for noninvasively studying physiology, metabolism, and molecular pathways in the living human being. However, the utility of PET, being a photon-deficient modality, remains co…
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First Human Imaging Studies with the EXPLORER Total-Body PET Scanner* Open
Within the EXPLORER Consortium, the construction of the world's first total-body PET/CT scanner has recently been completed. The 194-cm axial field of view of the EXPLORER PET/CT scanner is sufficient to cover, for the first time, the enti…
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Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View Open
The world's first total-body PET scanner with an axial field of view (AFOV) of 194 cm is now in clinical and research use at our institution. The uEXPLORER PET/CT system is the first commercially available total-body PET scanner. Here we p…
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Guidelines for Acquisition, Interpretation, and Reporting of Whole-Body MRI in Myeloma: Myeloma Response Assessment and Diagnosis System (MY-RADS) Open
Acknowledging the increasingly important role of whole-body MRI for directing patient care in myeloma, a multidisciplinary, international, and expert panel of radiologists, medical physicists, and hematologists with specific expertise in w…
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Radiation Dosimetry and Biodistribution of <sup>68</sup>Ga-FAPI-46 PET Imaging in Cancer Patients Open
Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic imaging and therapy because they can constitute as much as 90% of a tumor mass. The serine protease fibroblast activation protein (FAP) is overexpr…
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Total-Body Dynamic Reconstruction and Parametric Imaging on the uEXPLORER Open
The world's first 194-cm-long total-body PET/CT scanner (uEXPLORER) has been built by the EXPLORER Consortium to offer a transformative platform for human molecular imaging in clinical research and health care. Its total-body coverage and …
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PennPET Explorer: Human Imaging on a Whole-Body Imager Open
The PennPET Explorer, a prototype whole-body imager currently operating with a 64-cm axial field of view, can image the major body organs simultaneously with higher sensitivity than that of commercial devices. We report here the initial hu…
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Whole-Body PET/MR Imaging: Quantitative Evaluation of a Novel Model-Based MR Attenuation Correction Method Including Bone Open
The novel MR-based AC method for whole-body PET/MR imaging, combining Dixon-based soft-tissue segmentation and model-based bone estimation, improves PET quantification in whole-body hybrid PET/MR imaging, especially in bony tissue and near…
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Initial Experience with Volumetric <sup>68</sup>Ga-PSMA I&T PET/CT for Assessment of Whole-Body Tumor Burden as a Quantitative Imaging Biomarker in Patients with Prostate Cancer Open
A quantitative imaging biomarker is desirable to provide a comprehensive measure of whole-body tumor burden in patients with metastatic prostate cancer, and to standardize the evaluation of treatment-related changes. Therefore, we evaluate…
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Evolution in Computed Tomography Open
The advent of computed tomography (CT) has revolutionized radiology. Starting as head-only scanners, modern CT systems are now capable of performing whole-body examinations within a couple of seconds in isotropic resolution. Technical adva…
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Synthetic CT generation from non-attenuation corrected PET images for whole-body PET imaging Open
Attenuation correction (AC) of PET/MRI faces challenges including inter-scan motion, image artifacts such as truncation and distortion, and erroneous transformation of structural voxel-intensities to PET mu-map values. We propose a deep-le…
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Comparison of Whole-Body<sup>18</sup>F FDG PET/MR Imaging and Whole-Body<sup>18</sup>F FDG PET/CT in Terms of Lesion Detection and Radiation Dose in Patients with Breast Cancer Open
Purpose To compare fluorine 18 ((18)F) fluorodeoxyglucose (FDG) combined positron emission tomography (PET) and magnetic resonance (MR) imaging with (18)F FDG combined PET and computed tomography (CT) in terms of organ-specific metastatic …
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Imaging in multiple myeloma: How? When? Open
Bone disease is the most frequent feature of multiple myeloma (MM) and represents a marker of end-organ damage; it is used to establish the diagnosis and to dictate the immediate need for therapy. For this reason, imaging plays a significa…
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Semiautomatically Quantified Tumor Volume Using <sup>68</sup>Ga-PSMA-11 PET as a Biomarker for Survival in Patients with Advanced Prostate Cancer Open
Prostate-specific membrane antigen (PSMA)-targeting PET imaging is becoming the reference standard for prostate cancer staging, especially in advanced disease. Yet, the implications of PSMA PET-derived whole-body tumor volume for overall s…
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Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation–maximization reconstruction Open
Whole-body (WB) dynamic PET has recently demonstrated its potential in translating the quantitative benefits of parametric imaging to the clinic. Post-reconstruction standard Patlak (sPatlak) WB graphical analysis utilizes multi-bed multi-…
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Total-Body PET Multiparametric Imaging of Cancer Using a Voxelwise Strategy of Compartmental Modeling Open
Quantitative dynamic PET with compartmental modeling has the potential to enable multiparametric imaging and more accurate quantification than static PET imaging. Conventional methods for parametric imaging commonly use a single kinetic mo…
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A Prospective Comparison of 18F-prostate-specific Membrane Antigen-1007 Positron Emission Tomography Computed Tomography, Whole-body 1.5 T Magnetic Resonance Imaging with Diffusion-weighted Imaging, and Single-photon Emission Computed Tomography/Computed Tomography with Traditional Imaging in Primary Distant Metastasis Staging of Prostate Cancer (PROSTAGE) Open
In this report, we compared the diagnostic performance of conventional and advanced imaging. It was found that 18F-prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET-CT) was superior…
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Deep neural network for automatic volumetric segmentation of whole-body CT images for body composition assessment Open
This deep neural network model enabled the automatic volumetric segmentation of body composition on whole-body CT images, potentially expanding adjunctive sarcopenia assessment on PET-CT scan and volumetric assessment of metabolism in whol…
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Total-Body Quantitative Parametric Imaging of Early Kinetics of <sup>18</sup>F-FDG Open
Parametric imaging has been shown to provide better quantitation physiologically than SUV imaging in PET. With the increased sensitivity from a recently developed total-body PET scanner, whole-body scans with higher temporal resolution bec…
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Patient motion effects on the quantification of regional myocardial blood flow with dynamic PET imaging Open
Purpose: Patient motion is a common problem during dynamic positron emission tomography (PET) scans for quantification of myocardial blood flow (MBF). The purpose of this study was to quantify the prevalence of body motion in a clinical se…
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Molecular Imaging of Bone Metastases and Their Response to Therapy Open
Bone metastases are common, especially in more prevalent malignancies such as breast and prostate cancer. They cause significant morbidity and draw on health-care resources. Molecular and hybrid imaging techniques, including SPECT/CT, PET/…
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Whole-Body SPECT/CT versus Planar Bone Scan with Targeted SPECT/CT for Metastatic Workup Open
Purpose . The use of SPECT/CT in bone scans has been widespread in recent years, but there are no specific guidelines concerning the optimal acquisition protocol. Two strategies have been proposed: targeted SPECT/CT for equivocal lesions d…
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Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer: the Streamline diagnostic accuracy studies Open
Background Whole-body magnetic resonance imaging is advocated as an alternative to standard pathways for staging cancer. Objectives The objectives were to compare diagnostic accuracy, efficiency, patient acceptability, observer variability…
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Comparison of PET/MRI With PET/CT in the Evaluation of Disease Status in Lymphoma Open
PET/MRI is a reliable alternative to PET/CT in the evaluation of patients with lymphoma. Diffusion-weighted imaging did not alter diagnostic accuracy. With comparable accuracy in detection of disease sites and added benefit of radiation do…
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In vivo whole-body optoacoustic scanner with real-time volumetric imaging capacity Open
Accurate visualization of biological events occurring on a sub-second scale requires high frame rate acquisition of image data from living tissues. Yet, fast imaging performance commonly comes at the cost of limited field-of-view and reduc…
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Whole-Body Parametric Imaging of <sup>18</sup>F-FDG PET Using uEXPLORER with Reduced Scanning Time Open
Parametric imaging of the net influx rate (Ki ) in 18F-FDG PET has been shown to provide improved quantification and specificity for cancer detection compared with SUV imaging. Current methods of generating parametric images usually requir…
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Multiparametric Whole-body MRI with Diffusion-weighted Imaging and ADC Mapping for the Identification of Visceral and Osseous Metastases From Solid Tumors Open
We have demonstrated that multiparametric WB-MRI is feasible for oncologic staging to identify bony and visceral metastasis in breast, prostate, pancreatic, and colorectal cancers. WB-MRI can be tailored to fit the patient, such that an "i…
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Comparison of whole body magnetic resonance imaging (WBMRI) to whole body computed tomography (WBCT) or 18 F-fluorodeoxyglucose positron emission tomography/CT ( 18 F-FDG PET/CT) in patients with myeloma: Systematic review of diagnostic performance Open
Studies were heterogeneous, the majority lacking an independent reference standard. Future prospective trials should address these limitations and assess the impact of WBMRI on management.
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Feasibility of Acquisitions Using Total-Body PET/CT with an Ultra-Low<sup>18</sup>F-FDG Activity Open
The present study aimed to evaluate the feasibility of ultra-low 18F-FDG activity in total-body PET/CT oncologic studies. Methods: Thirty patients with cancer were enrolled prospectively and underwent a total-body PET/CT scan 60 min after …
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Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats Open
Objective— Thrombosis is a leading cause of morbidity and mortality worldwide. Current diagnostic strategies rely on imaging modalities that are specific for distinct vascular territories, but a thrombus-specific whole-body imaging approac…