Explanipedia

A Mesoscale Framework for Psychedelic Drug Action in the Human Brain Open

Rui Dai, Rodrigo Cofré, Christopher Timmermann, Robin L. Carhart-Harris, Anthony G. Hudetz , et al. · 2025

The mechanism of psychedelic drug action is a dynamic area of neuroscience, with two major lines of investigation: (1) laboratory studies at the molecular and cellular level, and (2) human neuroimaging studies of functional brain networks.…

A comparative assessment of the antidepressant efficacy of ketamine, psilocybin, and fluoxetine in a chronic stress model Open

Małgorzata Domżalska, Joanna Kwiatkowska, Iwona Cichon, Ewa Sokołowska · 2025

Depression is a debilitating mental disorder affecting millions worldwide, yet current pharmacological treatments, such as selective serotonin reuptake inhibitors (SSRIs), often exhibit delayed onset and limited efficacy. The chronic socia…

Psilocybin reduces comorbid chronic pain and depression in mice Open

Jorge Ferreira, Jorge Ferreira · 2025

Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community Open

Daniel J. Kruger, Gina Mersereau, Ashley Sullivan, Julie Barron, Moss Herberholz , et al. · 2025

Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the f…

Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder Open

Sana Rasheed, Rida Arif, Ahmed Asad Raza, Abedin Samadi · 2025

Psilocybin, a naturally occurring psychedelic compound, has received attention as a novel therapeutic option for Major Depressive Disorder (MDD), particularly in cases where traditional treatments prove ineffective. The study aims to evalu…

Brain-MGF: Multimodal Graph Fusion Network for EEG-fMRI Brain Connectivity Analysis Under Psilocybin Open

Yap Sin Yee, Noman, Fuad, Loo Junn Yong, Stoliker, Devon, Khajehnejad, Moein , et al. · 2025

Psychedelics, such as psilocybin, reorganise large-scale brain connectivity, yet how these changes are reflected across electrophysiological (electroencephalogram, EEG) and haemodynamic (functional magnetic resonance imaging, fMRI) network…

Brain-MGF: Multimodal Graph Fusion Network for EEG-fMRI Brain Connectivity Analysis Under Psilocybin Open

Yap Sin Yee, Noman, Fuad, Loo Junn Yong, Stoliker, Devon, Khajehnejad, Moein , et al. · 2025

Psychedelics, such as psilocybin, reorganise large-scale brain connectivity, yet how these changes are reflected across electrophysiological (electroencephalogram, EEG) and haemodynamic (functional magnetic resonance imaging, fMRI) network…

Psilocybin alters visual contextual computations Open

Marco Aqil, Gilles de Hollander, Nina Vreugdenhil, Tomas Knapen, Serge O. Dumoulin · 2025

Psilocybin alters perception and brain dynamics. Here, we investigate the effects of psilocybin using psychophysics, ultra-high field functional MRI, and computational modeling. We find that psilocybin alters contextual perception in the E…

Psilocybin in Alcohol Use Disorder Maintains Abstinence Efficacy: A Scoping Review Open

Jacques Suspene, Sarah Huet, Sabine Berteina-Raboin, Amine Benyamina, Patrick Baril , et al. · 2025

Alcohol use disorder is a psychiatric condition characterized by excessive alcohol consumption. The drugs that are used to treat it often fail to prevent relapse. At the same time, psilocybin is increasingly being investigated for the trea…

Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists? Open

Silvia Natoli, Arturo Cuomo, Maurizio Marchesini, Livio Luongo, Giuliano Lo Bianco , et al. · 2025

Background: Chronic pain affects nearly one in five adults worldwide and remains a major healthcare burden due to its persistence, multidimensional impact, and resistance to conventional therapies. The opioid crisis has further highlighted…

Exploring the first use of psychedelic macrodoses in Latin American adults: Sociodemographic profiles, consumption factors, and subjective experiences Open

Oscar Véliz-García, Marcos Domic-Siede · 2025

This study explores the first-time use of psychedelic macrodoses among Latin American adults, addressing a gap in the literature regarding naturalistic use outside clinical settings. A total of 4,810 participants from six Latin American co…

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness Open

Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Ivan Mindlin , et al. · 2025

Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), have limited treatment options and are characterized by low complexity of brain activity. Recent research suggests tha…

Collective Voices of Healing: Psilocybin Discourse and Meaning-Making on Reddit Open

Gevorgyan, Natalya, Gevorgyan, Narek · 2025

This research brief analyzes over 19,000 Reddit posts across 40 psychology-related topics to identify the dominant mental-health struggles expressed in public discourse. Using large-scale topic analysis and engagement metr…

Collective Voices of Healing: Psilocybin Discourse and Meaning-Making on Reddit Open

Gevorgyan, Natalya, Gevorgyan, Narek · 2025

This research brief analyzes over 19,000 Reddit posts across 40 psychology-related topics to identify the dominant mental-health struggles expressed in public discourse. Using large-scale topic analysis and engagement metrics from more tha…

Looking Again at Psychedelics: Psychedelics Are Not Psychiatric Treatments Open

Ryan Mark · 2025

Simon Yugler (Psychedelics and the Soul, 2024) is right to criticise psychedelic tourism, shallow integration, poor training standards, spiritual bypassing, and the misuse of Indigenous traditions. Yet his Jungian framing remains limited. …

Psilocybin Experiential Therapist Training: Insights from a World-First Study Open

Georgia Ioakimidis-MacDougall, John Gardner, Paul Liknaitzky · 2025

First-hand experience with psychedelics may help clinicians develop skills and knowledge needed to work with the profound changes to conscious awareness occasioned by psychedelics. However, the topic remains contentious and underexplored. …

Effects of psilocybin and related compounds on cerebroprotection during ischemic stroke (Stage 1 Registered Report) Open

Ruslan Rust · 2025

Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin Open

Krishna Prasad Bhavaraju, Natasha L. Mason, Pablo Mallaroni, Dietmar Heinke, Stefan W. Toennes , et al. · 2025

Psilocybin induces profound alterations in consciousness, yet prevailing neural models often describe a monolithic change in brain connectivity that may not fully capture the multifaceted nature of the psychedelic state. To test the hypoth…

Looking Again at Psychedelics: Psychedelics Are Not Psychiatric Treatments Open

Ryan Mark · 2025

Simon Yugler (Psychedelics and the Soul, 2024) is right to criticise psychedelic tourism, shallow integration, poor training standards, spiritual bypassing, and the misuse of Indigenous traditions. Yet his Jungian framing remains limited. …

Standardization of Psilocybin Dosing in a Natural Product–Based Retreat Setting: A Practical Method for Dose Quantification and Adjustment Across Sessions Open

Sergio R Pérez Rosal, Sonya C. Faber · 2025

Natural variation in psilocybin content across mushroom samples presents a significant challenge to consistent dosing in both research and retreat settings. In this observational report, we describe a pragmatic approach for quantifying psi…

Looking Again at Psychedelics: Psychedelics Are Not Psychiatric Treatments Open

Ryan Mark · 2025

Simon Yugler (Psychedelics and the Soul, 2024) is right to criticise psychedelic tourism, shallow integration, poor training standards, spiritual bypassing, and the misuse of Indigenous traditions. Yet his Jungian framing remains limited. …

Negative affective bias in depression following treatment with psilocybin or escitalopram – a secondary analysis from a randomized trial Open

Marieke A. G. Martens, Bruna Giribaldi Cunha, David Erritzoe, David Nutt, Robin Carhart‐Harris , et al. · 2025

Recent clinical trial data suggests that ratings on depression scales are lowered after psilocybin therapy compared to placebo, though it is unclear what neuropsychological mechanisms underpin these effects. This study compared psilocybin,…

Virtual reality and psychedelics: new perspectives and new possibilities in the treatment of alcohol use disorder Open

Scott Matthews, Scott Matthews, Antonino Greco, Antonino Greco, Antonino Greco , et al. · 2025

Psychedelic-assisted therapy is a remarkably promising treatment for substance use disorders and for alcohol use disorder (AUD) in particular. Research supporting psychedelics as a safe and effective pharmacotherapy for AUD and its comorbi…

Comparative Efficacy of Psilocybin and MDMA in PTSD Treatment: A Systematic Review of Long-Term Outcomes Open

Aspen, Presley, Jennifer Kim, Pham, Mitchell · 2025

Pharmacodynamic biomarker — or psychotherapeutic process? Comment on “The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression” Open

Max Wolff, Samuli Kangaslampi · 2025

Novel qNMR Method to Quantify Psilocybin and Psilocin in Psychedelic Mushrooms Open

Luisina Rodríguez, Guillermo Morera, Sandra Lupo, Danilo Davyt, Ignacio Carrera , et al. · 2025

5mC and 5hmC Detection Highlights How Psychedelics Affect Brain Epigenetic Patterns Open

Bertocchi, Uri, Schwartz, Amit, Umschweif, Gali, Lerer, Bernard, Ebenstein, Yuval · 2025

Background: Psilocybin, a serotonergic psychedelic compound, has demonstrated long-term antidepressant effects, yet its underlying mechanisms remain unclear. Emerging evidence suggests that epigenetic modifications, partic…

5mC and 5hmC Detection Highlights How Psychedelics Affect Brain Epigenetic Patterns Open

Bertocchi, Uri, Schwartz, Amit, Umschweif, Gali, Lerer, Bernard, Ebenstein, Yuval · 2025

Background: Psilocybin, a serotonergic psychedelic compound, has demonstrated long-term antidepressant effects, yet its underlying mechanisms remain unclear. Emerging evidence suggests that epigenetic modifications, particularly 5-methylcy…

Qualitative Insights into Psilocybin and LSD Experiences: Enhanced Connection and Emotion Processing Reported by Spanish-Speaking Survey Respondents Open

Meghan Dellacrosse, Shoval Gilead, Rafaelle Lancelotta, Ana María Ortiz Bernal, Christopher Timmermann , et al. · 2025

Pro-dopaminergic pharmacological interventions for anhedonia in depression: a living systematic review and network meta-analysis of human and animal studies. Open

Ostinelli, Edoardo G, Salanti, Georgia, Macleod Malcolm, Chiocchia, Virginia, Smith, Katharine A , et al. · 2025

Background It is unclear whether pro-dopaminergic drugs reduce anhedonia in major depressive disorder (MDD) and further, if so, to what extent this is the case.Methods With lived experienced experts we co-produced two living systematic rev…