Ocular hypertension
View article: Spontaneous Globe Rupture in End-Stage Glaucoma: A RARE Case of Neglected Chronic Ocular Hypertension
Spontaneous Globe Rupture in End-Stage Glaucoma: A RARE Case of Neglected Chronic Ocular Hypertension Open
Background: Spontaneous globe rupture (SGR) is a very rare but devastating complication, most often observed in eyes with advanced disease where the scleral wall has become progressively weakened. In long-standing glauco…
View article: Distribution of Ocular Perfusion Pressure and Its Effect on Primary Open Angle Glaucoma Among Adult’s Patients at KCMC Referral Hospital 2024-2025
Distribution of Ocular Perfusion Pressure and Its Effect on Primary Open Angle Glaucoma Among Adult’s Patients at KCMC Referral Hospital 2024-2025 Open
Aims: To evaluate the distribution of ocular perfusion pressure and its effect on primary open-angle glaucoma among adult patients at KCMC eye department. Study Design: Case-control and cross-sectional designs. Place and Duration of Study:…
View article: Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma
Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma Open
Metformin, a first-line treatment for type 2 diabetes, has gained attention as a promising neuroprotective agent due to its pleiotropic effects - including anti-inflammatory, anti-apoptotic, and autophagy-enhancing properties. Here we prov…
View article: Long-term effectiveness of the trabecular micro-bypass (iStent): 3-year real world data in glaucoma and ocular hypertension
Long-term effectiveness of the trabecular micro-bypass (iStent): 3-year real world data in glaucoma and ocular hypertension Open
Purpose This study evaluates the effectiveness and safety profile of the iStent inject® combined with cataract surgery, with 3 years of follow-up in a large patient cohort (n = 464) of various glaucoma phenotypes and disease severity. Meth…
View article: Hypotension and antiphlogistic potential of empagliflozin ocular film: swelling and release kinetics
Hypotension and antiphlogistic potential of empagliflozin ocular film: swelling and release kinetics Open
Background and Purpose: Empagliflozin (EMP) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for the management of type 2 diabetes mellitus. The danger of glaucoma in type 2 diabetes mellitus patients is known to be reduced using…
View article: Prevalence and Factors Associated with Elevated Intraocular Pressure among Patients Attending General Outpatient Clinic at Kilimanjaro Christian Medical Center Hospital (KCMC) 2024-2025
Prevalence and Factors Associated with Elevated Intraocular Pressure among Patients Attending General Outpatient Clinic at Kilimanjaro Christian Medical Center Hospital (KCMC) 2024-2025 Open
Aims: To evaluate the prevalence and factors associated with elevated intraocular pressure among patients attending Kilimanjaro Christian Medical Center (KCMC) zonal referral hospital at general outpatient clinic, 2024-2025. Study Design: …
View article: Evaluation of the Optic Nerve Head in Patients with Pseudoexfoliation Syndrome
Evaluation of the Optic Nerve Head in Patients with Pseudoexfoliation Syndrome Open
Patients and Methods: A cross-sectional descriptive study was conducted on 28 patients (41 eyes) diagnosed with pseudoexfoliation syndrome. All subjects underwent visual acuity testing, intraocular pressure measurement, clinical examinatio…
View article: Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025)
Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025) Open
Purpose: To analyze the ocular adverse effects induced by psychotropic medications and describe their mechanisms according to drug classes. Methods: A retrospective descriptive study involving 20 patients …
View article: Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure
Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure Open
Ocular overexposure to corticosteroids may compromise IOP homeostasis by impairing TM expression and function of TREK-1. Pharmacological activation of TREK-1 facilitates conventional outflow and could help lower IOP in eyes with steroid-in…
View article: Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025)
Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025) Open
Purpose: To analyze the ocular adverse effects induced by psychotropic medications and describe their mechanisms according to drug classes. Methods: A retrospective descriptive study involving 20 patients followed between January 2023 and …
View article: Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025)
Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025) Open
Purpose: To analyze the ocular adverse effects induced by psychotropic medications and describe their mechanisms according to drug classes. Methods: A retrospective descriptive study involving 20 patients followed between January 2023 and …
View article: Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025)
Ocular Adverse Effects of Psychotropic Drugs: A Clinical Study of 20 Cases (2023–2025) Open
Purpose: To analyze the ocular adverse effects induced by psychotropic medications and describe their mechanisms according to drug classes. Methods: A retrospective descriptive study involving 20 patients …
View article: Increase of retinal layer thickness in a rat model of acute intraocular hypertension
Increase of retinal layer thickness in a rat model of acute intraocular hypertension Open
We investigated the retinal response to acute elevation of intraocular pressure (IOP) in rat eyes. IOP elevation was induced in the right eyes of adult Wistar rats using laser photocoagulation of the trabecular meshwork, while the left eye…
View article: Organophosphate pesticide exerts toxic effect on the optic nerve of glaucoma rats by promoting oxidative stress and inflammation
Organophosphate pesticide exerts toxic effect on the optic nerve of glaucoma rats by promoting oxidative stress and inflammation Open
Background Glaucoma, a leading cause of irreversible blindness, involves progressive retinal ganglion cell (RGC) loss. Beyond intraocular pressure (IOP), environmental risk factors like pesticide exposure are increasingly implicated. Dimet…
View article: Correlations between Amyloid-β Peptide Levels in Aqueous Humor, Retinal Thickness, and Visual Field Loss in Patients with Glaucoma
Correlations between Amyloid-β Peptide Levels in Aqueous Humor, Retinal Thickness, and Visual Field Loss in Patients with Glaucoma Open
Amyloid-β (Aβ) accumulation is a well-established cause of neurotoxicity in the brain and a major factor in Alzheimer's disease. However, its role in ocular neurodegeneration remains unclear. In this prospective study, we evaluated the cor…
View article: Topical Use of Injectable Dexmedetomidine in Combination with Dorzolamide for the Treatment of Glaucoma in Dogs
Topical Use of Injectable Dexmedetomidine in Combination with Dorzolamide for the Treatment of Glaucoma in Dogs Open
This study investigated the efficacy of the isolated topical use of 2% dorzolamide eye drops three times a day compared to the combination of 100 µg/ml dexmedetomidine (originally formulated for injectable use and applied topically twice a…
View article: MORPHOFUNCTIONAL CHANGES OF THE OCULAR DRAINAGE SYSTEM AND OCULAR HYPERTENSION IN THYROID EYE DISEASE
MORPHOFUNCTIONAL CHANGES OF THE OCULAR DRAINAGE SYSTEM AND OCULAR HYPERTENSION IN THYROID EYE DISEASE Open
Purpose. To perform a clinical and functional evaluation of ocular tone disturbances and their consequences in patients with thyroid eye disease (TED), with an emphasis on determining the role of structural changes in Schlemm’s canal in th…
View article: Quantitative Analysis of Retinal Nerve Fiber Layer Thickness Using SPECTRALIS Glaucoma Module Premium Edition and SPECTRALIS Standard Glaucoma Module
Quantitative Analysis of Retinal Nerve Fiber Layer Thickness Using SPECTRALIS Glaucoma Module Premium Edition and SPECTRALIS Standard Glaucoma Module Open
Although highly correlated, GMPE reported thicker global and sectoral RNFL measurements than SGM, which is important when comparing longitudinal OCT follow-up using these modules.
View article: Efficacy of the novel MIGS implant Wistend compared to Kahook Dual Blade in the treatment of experimental ocular hypertension in rabbits
Efficacy of the novel MIGS implant Wistend compared to Kahook Dual Blade in the treatment of experimental ocular hypertension in rabbits Open
To evaluate and compare the efficacy of novel microinvasive glaucoma surgery (MIGS) device implants Wistend and Kahook Dual Blade (KDB) in an experimental ocular hypertension model. Twelve New Zealand white rabbits were randomized into fou…
View article: The White Coat Effect Influences Intraocular Pressure Measurements in Dogs: Comparing Tonometry Values Obtained in the Clinic Versus Home
The White Coat Effect Influences Intraocular Pressure Measurements in Dogs: Comparing Tonometry Values Obtained in the Clinic Versus Home Open
Objective To determine the effect of clinic versus home environments on intraocular pressure (IOP) measurements in normotensive dogs. Animals Forty client‐owned normotensive dogs. Methods In a prospective crossover study, 40 normotensive d…
View article: XEN‑45 implantation for refractory secondary glaucoma
XEN‑45 implantation for refractory secondary glaucoma Open
View article: PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension
PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension Open
Glaucoma is associated with ocular hypertension and lowering intraocular pressure is a key objective of glaucoma therapies. Recent studies have established a role for the Schlemm's canal endothelium in this pressure increase and have shown…
View article: Structure-Function Relationship Between Handheld Photopic Negative Response and Macular GCIPL Thickness in Chronic Optic Neuropathy
Structure-Function Relationship Between Handheld Photopic Negative Response and Macular GCIPL Thickness in Chronic Optic Neuropathy Open
Purpose To determine whether photopic negative response (PhNR) parameters obtained using a handheld electroretinography (ERG) device serve as quantitative indicators of retinal ganglion cell (RGC) function and residual optic nerve integrit…
View article: Effects of short-term moderate versus high intraocular pressure elevation on flicker-induced changes in full- field electroretinogram
Effects of short-term moderate versus high intraocular pressure elevation on flicker-induced changes in full- field electroretinogram Open
Purpose Transient flickering light stimulation (FLS) enhances the electrical activity in the middle retinal layer (MRL) of wild-type mice. This study investigates how short-term moderate and high intraocular pressure (IOP) elevation influe…
View article: Evaluation of risk factors for ocular morbidities and its impact on the lives of medical students: An academic collateral.
Evaluation of risk factors for ocular morbidities and its impact on the lives of medical students: An academic collateral. Open
Background One billion people worldwide have preventable vision impairment. Ocular morbidities are a significant problem in the public health sector, especially among medical students. The study objectives were to identify the prevailing o…
View article: DIGITAL VISUALIZATION IN THE ASSESSMENT OF CORNEAL TRANSPARENCY IN GLAUCOMATOUS CHANGES
DIGITAL VISUALIZATION IN THE ASSESSMENT OF CORNEAL TRANSPARENCY IN GLAUCOMATOUS CHANGES Open
The congenital glaucoma is a leading etiologic factor in childhood visual impairment, accounting for 10 to 20% of childhood blindness cases. One of the most severe complications of this disease is glaucomatous keratopathy, a complex of mor…
View article: DIGITAL VISUALIZATION IN THE ASSESSMENT OF CORNEAL TRANSPARENCY IN GLAUCOMATOUS CHANGES
DIGITAL VISUALIZATION IN THE ASSESSMENT OF CORNEAL TRANSPARENCY IN GLAUCOMATOUS CHANGES Open
The congenital glaucoma is a leading etiologic factor in childhood visual impairment, accounting for 10 to 20% of childhood blindness cases. One of the most severe complications of this disease is glaucomatous keratopathy, a complex of mor…
View article: Inflammatory optic neuritis and scleritis following commencement of semaglutide: a case report
Inflammatory optic neuritis and scleritis following commencement of semaglutide: a case report Open
Given the documented increased risk of non-arteritic ischaemic optic neuropathy (NAION), the widespread use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has raised concerns regarding their ophthalmic safety. This study presents…
View article: Assessment of Intraocular Pressure Measurement Between Goldmann Applanation Tonometer and Portable Non-Contact Tonometer (TH1U)
Assessment of Intraocular Pressure Measurement Between Goldmann Applanation Tonometer and Portable Non-Contact Tonometer (TH1U) Open
PNCT demonstrates high consistency with GAT and offers a reliable alternative for IOP monitoring. Its portability, non-contact operation, and automatic measurement function make it particularly suitable for home-based and long-term glaucom…
View article: A systematic review of vaccine-associated ocular adverse events: Patterns, Pathogenesis, and Public Health Considerations
A systematic review of vaccine-associated ocular adverse events: Patterns, Pathogenesis, and Public Health Considerations Open
Vaccination remains one of the most effective strategies of modern medicine in controlling infectious disease outbreaks. However, numerous case reports have described ocular adverse events following administration of COVID-19, influenza, a…