Tissue remodeling
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Wound healing - A literature review Open
Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix …
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Inflammation and metabolism in tissue repair and regeneration Open
Tissue repair after injury is a complex, metabolically demanding process. Depending on the tissue’s regenerative capacity and the quality of the inflammatory response, the outcome is generally imperfect, with some degree of fibrosis, which…
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The long noncoding RNA <i>Wisper</i> controls cardiac fibrosis and remodeling Open
A super-enhancer–associated long noncoding RNA, Wisper , controls cardiac fibrosis and pathological remodeling in the damaged heart.
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The fibrotic tumor stroma Open
Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical forces and create a biochemical milieu that, together, sh…
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<i>In Situ</i> Imaging of Tissue Remodeling with Collagen Hybridizing Peptides Open
Collagen, the major structural component of nearly all mammalian tissues, undergoes extensive proteolytic remodeling during developmental states and a variety of life-threatening diseases such as cancer, myocardial infarction, and fibrosis…
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Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise‐induced muscle damage management Open
Increase in the practice of sport by more and more numerous people in the Western countries is associated with an increase in muscle injuries, and in demand for improving muscle function and acceleration of muscle recovery after damage. Mo…
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The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer Open
The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and pentraxins. These molecules are involved in innate immune responses by recogniz…
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The Platelet Response to Tissue Injury Open
In recent years, various studies have increasingly explained platelet functions not only in their central role as a regulator in cellular hemostasis and coagulation. In fact, there is growing evidence that under specific conditions, platel…
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Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases Open
Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary…
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Role and New Insights of Pirfenidone in Fibrotic Diseases Open
Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition o…
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BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling Open
Bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases, here called BTPs, include the proteases originally identified for their roles in the C-terminal maturation of fibrillar procollagens ("procollagen C-proteinase"). Though numero…
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Trabecular bone organoid model for studying the regulation of localized bone remodeling Open
A tissue-engineered model of the trabecular bone microenvironment elucidates spatiotemporal aspects of bone remodeling processes.
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The Role of Trypsin:Chymotrypsin in Tissue Repair Open
Torrent Pharmaceuticals Limited.
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Extracellular matrix dynamics in vascular remodeling Open
Vascular remodeling is the adaptive response to various physiological and pathophysiological alterations that are closely related to aging and vascular diseases. Understanding the mechanistic regulation of vascular remodeling may be favora…
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Tissue engineering toward temporomandibular joint disc regeneration Open
Tissue-engineered implants integrate with native tissue, are capable of adaptive remodeling, and improve healing of temporomandibular joint disc defects in minipigs.
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Retinoid Receptors in Bone and Their Role in Bone Remodeling Open
Vitamin A (retinol) is a necessary and important constituent of the body which is provided by food intake of retinyl esters and carotenoids. Vitamin A is known best for being important for vision, but in addition to the eye, vitamin A is n…
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Morphogenesis of 3D vascular networks is regulated by tensile forces Open
Significance Sorely lacking are techniques to engineer tissue grafts bearing a means to receive adequate blood supply during implantation and after integration with host tissue. Efforts to optimize graft tissue vascularization have manipul…
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Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood Open
Using a well-characterized cohort of patients with biopsy-proven NAFLD, this study demonstrates that hepatic scar in NASH is actively remodeled even in advanced fibrosis, a disease that is generally regarded as static and slowly progressiv…
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The expanding world of tissue‐resident macrophages Open
The term ‘macrophage’ encompasses tissue cells that typically share dependence on the same transcriptional regulatory pathways (e.g. the transcription factor PU.1) and growth factors (e.g. CSF1/IL‐34). They share a core set of functions th…
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Heart Valve Biomechanics and Underlying Mechanobiology Open
Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They have a remarkable ability to withstand the demanding mechanical environment of the heart, achieving lifetime durability by processes involving t…
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HIF2A–LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy Open
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease associated with autoimmune thyroid disorders. It is a potentially blinding condition, for which no effective pharmacological treatment has been esta…
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Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue Open
Fiber tension enables tissue scaling Tissue development, homeostasis, and repair require cells to sense mechanical forces. Although many molecular actors implicated in cell mechanosensitivity have been extensively studied, the basis by whi…
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A fly's view of neuronal remodeling Open
Developmental neuronal remodeling is a crucial step in sculpting the final and mature brain connectivity in both vertebrates and invertebrates. Remodeling includes degenerative events, such as neurite pruning, that may be followed by regen…
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Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism Open
Streptococcus agalactiae , also known as group B Streptococcus (GBS), is a common pathogen during pregnancy where infection can result in chorioamnionitis, preterm premature rupture of membranes (PPROM), preterm labor, stillbirth, and neon…
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Interleukin‐33 regulates tissue remodelling and inhibits angiogenesis in the eye Open
Age‐related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization. Although activa…
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The Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis Open
Significance: Excessive and prolonged proinflammatory responses are associated with oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such condition favors tissue destruction and consequently bacterial spread. …
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Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma Open
Asthma increases worldwide without any definite reason and patient numbers double every 10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but none of them inhibited airway wall remodeling in clinical studie…
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Adipose-derived stem cells increase angiogenesis through matrix metalloproteinase-dependent collagen remodeling Open
Adipose-derived stem cells (ASCs) are key regulators of extracellular matrix remodeling that modulates neovascularization during tissue regeneration.
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Matrix metalloproteinases in fish biology and matrix turnover Open
Matrix metalloproteinases have important functions for tissue turnover in fish, with relevance both for the fish industry and molecular and cellular research on embryology, inflammation and tissue repair. These metalloproteinases have been…
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Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients Open
The Pro-C3 protein fragment provided clinically relevant diagnostic accuracy as a single marker of liver fibrosis. A model combining Pro-C3 and C4M along with patient's age, body mass index and gender increased the diagnostic power for ide…