Glucuronic acid
View article: Microencapsulation of Peanut Worm (Siphonosoma australe) Extract from Indonesian Marine Waters as a Natural Umami Flavor Enhancer Obtained by Spray Drying
Microencapsulation of Peanut Worm (Siphonosoma australe) Extract from Indonesian Marine Waters as a Natural Umami Flavor Enhancer Obtained by Spray Drying Open
The peanut worm (Siphonosoma australe), a marine organism endemic to the coastal waters of Sulawesi, Indonesia, is rich in glutamic acid, making it a promising natural source of umami flavor. This study aimed to develop and characterize sp…
View article: Effect of a chondroitin sulfate chain linked to the bikunin core peptide on gene expression in lipopolysaccharide-treated uterine cervical fibroblasts
Effect of a chondroitin sulfate chain linked to the bikunin core peptide on gene expression in lipopolysaccharide-treated uterine cervical fibroblasts Open
View article: Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway Open
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid. To investigate the molecular mechanisms enabling this adaptation, we conducte…
View article: Identification of the D-glucuronyl C5-epimerase that introduces iduronic acid into N-linked glycans decorating archaeal glycoproteins
Identification of the D-glucuronyl C5-epimerase that introduces iduronic acid into N-linked glycans decorating archaeal glycoproteins Open
In Halobacterium salinarum, halophilic archaea that grow in saturated salt solutions, glycoproteins are modified by an N-linked tetrasaccharide that includes iduronic acid (IdoA). This represents the only known example of IdoA, a sugar bet…
View article: A Molecular Description of Substrate Recognition and Utilization by Hyaluronan Synthase
A Molecular Description of Substrate Recognition and Utilization by Hyaluronan Synthase Open
In human tissues, cells are surrounded by a heterogenous microenvironment of proteins, proteoglycans and polysaccharides. This so-called extracellular matrix (ECM) bears an essential role in tissue organization, specialization and repair p…
View article: UDP-glucuronic acid availability underlies sex difference in renal expression of nonsulfated Human Natural Killer-1 (HNK-1) glycans
UDP-glucuronic acid availability underlies sex difference in renal expression of nonsulfated Human Natural Killer-1 (HNK-1) glycans Open
Nonsulfated Human Natural Killer-1 (nsHNK-1) glycan is a unique trisaccharide structure terminating in glucuronic acid and synthesized by glucuronyltransferase GlcAT-S. This glycan is specifically expressed in the mouse kidney, particularl…
View article: Polysaccharide from the edible insect Protaetia brevitarsis seulensis enhances interferon signaling in macrophages to inhibit norovirus infection 9014
Polysaccharide from the edible insect Protaetia brevitarsis seulensis enhances interferon signaling in macrophages to inhibit norovirus infection 9014 Open
Description Edible insects are increasingly recognized as promising nutraceutical sources with immune-modulating effects. This study focuses on the purification and structural analysis of polysaccharides from the larvae of Protaetia brevit…
View article: [169Yb]Yb-labeled glucuronic acid functionalized hydroxyapatite nanoparticles for potential use in nanoscale brachytherapy
[169Yb]Yb-labeled glucuronic acid functionalized hydroxyapatite nanoparticles for potential use in nanoscale brachytherapy Open
View article: Ibuprofen Loaded Sodium Alginate Sponges for Acute Wound Treatment
Ibuprofen Loaded Sodium Alginate Sponges for Acute Wound Treatment Open
In this study, ibuprofen-loaded sodium alginate sponge formulations were developed for use in wound healing. Sodium alginate solutions at two different concentrations were dried using a lyophilizer to obtain drug delivery systems in the fo…
View article: Structural Characterization and Ameliorative Effects of Mesona chinensis Benth Polysaccharide Against Deoxynivalenol-Induced Oxidative Stress in Intestinal Epithelial Cells
Structural Characterization and Ameliorative Effects of Mesona chinensis Benth Polysaccharide Against Deoxynivalenol-Induced Oxidative Stress in Intestinal Epithelial Cells Open
Objectives: Deoxynivalenol (DON) is a ubiquitous mycotoxin detected in the environment and foodstuffs. DON exposure can lead to chronic intestinal inflammation. Therefore, intervention strategy needs to be established to prevent the intest…
View article: Green Extraction of Tea Polysaccharides Using Ultrasonic-Assisted Deep Eutectic Solvents and an Analysis of Their Physicochemical and Antioxidant Properties
Green Extraction of Tea Polysaccharides Using Ultrasonic-Assisted Deep Eutectic Solvents and an Analysis of Their Physicochemical and Antioxidant Properties Open
In this study, the ultrasonic-assisted extraction of deep eutectic solvents (UADES) for tea polysaccharides was optimized, and their physicochemical properties and antioxidant activities were analyzed. The optimal DES comprised choline chl…
View article: Exploration of a Postbiotic Derived from Enterococcus faecium HDRsEf1 and Its Probiotic Mechanisms
Exploration of a Postbiotic Derived from Enterococcus faecium HDRsEf1 and Its Probiotic Mechanisms Open
This study aimed to identify the heat-resistant bioactive components of Enterococcus faecium HDRsEf1 (HDRsEf1) and investigate their beneficial mechanism. Heat-treated culture supernatants of HDRsEf1 significantly suppressed CXCL-1 express…
View article: Revitalizing Pleurotus eryngii polysaccharides: gamma irradiation boosts antidiabetic and antioxidant potential
Revitalizing Pleurotus eryngii polysaccharides: gamma irradiation boosts antidiabetic and antioxidant potential Open
View article: Effect of 2H2O solvent on protein conformational sampling linked to catalysis by UDP-glucuronic acid 4-epimerase
Effect of 2H2O solvent on protein conformational sampling linked to catalysis by UDP-glucuronic acid 4-epimerase Open
View article: Ultrasound-Assisted Polysaccharide Extraction from Grape Skin and Assessment of In Vitro Hypoglycemic Activity of Polysaccharides
Ultrasound-Assisted Polysaccharide Extraction from Grape Skin and Assessment of In Vitro Hypoglycemic Activity of Polysaccharides Open
Grapes are commonly processed into shelf-stable products such as raisins, wine, juice, and syrup-canned syrup goods. During processing, byproducts like skins and seeds are generated, which contain bioactive compounds including polysacchari…
View article: The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by <scp>UDP</scp> ‐glucuronic acid 4‐epimerase
The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by <span>UDP</span> ‐glucuronic acid 4‐epimerase Open
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes the NAD + ‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) through a mechanism involving C4‐oxidation, 4‐keto‐intermediate rotation, and su…
View article: Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine
Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine Open
View article: Role of glucuronoxylomannan and steryl glucosides in protecting against cryptococcosis
Role of glucuronoxylomannan and steryl glucosides in protecting against cryptococcosis Open
The development of vaccines for fungal diseases, including cryptococcosis, is an emergent line of research and development. In previous studies, we showed that a Cryptococcus mutant lacking the SGL1 gene ( ∆sgl1 ) accumulates certain glyco…
View article: Structural Elucidation of Heteropolysaccharides from the Peach-Shaped Dictyophora indusiata and Its Anti-Inflammatory Activity
Structural Elucidation of Heteropolysaccharides from the Peach-Shaped Dictyophora indusiata and Its Anti-Inflammatory Activity Open
Dictyophora indusiata is commonly utilized as a functional food in China and other Asian countries. The peach-shaped phase of this fungus is nutritionally and taste-wise similar to its mature fruiting bodies. However, there is limited rese…
View article: Studies on effect of biomolecules and ozone on nutrient rich fruits kombucha production and its biochemistry
Studies on effect of biomolecules and ozone on nutrient rich fruits kombucha production and its biochemistry Open
Kombucha, a metabolically dynamic fermented nutraceutical system, represents a highly complex bio-reactive milieu in which microbial consortia orchestrate multi-layered biochemical, immunological, and metabolic transformations. The symbiot…
View article: Studies on effect of biomolecules and ozone on nutrient rich fruits kombucha production and its biochemistry
Studies on effect of biomolecules and ozone on nutrient rich fruits kombucha production and its biochemistry Open
Kombucha, a metabolically dynamic fermented nutraceutical system, represents a highly complex bio-reactive milieu in which microbial consortia orchestrate multi-layered biochemical, immunological, and metabolic transformations. The symbiot…
View article: Non-Animal Hyaluronic Acid from Tremella fuciformis: A New Source with a Structure and Chemical Profile Comparable to Hyaluronic Acid
Non-Animal Hyaluronic Acid from Tremella fuciformis: A New Source with a Structure and Chemical Profile Comparable to Hyaluronic Acid Open
Tremella fuciformis is high in polysaccharides, which have a structure made up of a straight chain of (1→3) α-D-mannan and side chains of glucuronic acid, xylose, and fucose. This study aimed to evaluate whether the non-animal hyaluronic a…
View article: Functionalization of cellulose nanocrystals with N-vinylcaprolactam, spermine dendrons, and glucuronic acid for tumor targeting and controlled release of gemcitabine
Functionalization of cellulose nanocrystals with N-vinylcaprolactam, spermine dendrons, and glucuronic acid for tumor targeting and controlled release of gemcitabine Open
One of the main challenges in prostate cancer treatment is achieving precise drug delivery and controlled release of chemotherapeutic agents to enhance their efficacy, while reducing systemic toxicity. In this study, an advanced nanodrug d…
View article: Structural Characteristics, Gelling Properties, In Vitro Antioxidant Activity and Immunomodulatory Effects of Rhamnogalacturonan-I Rich Pectic Polysaccharides Alkaline-Extracted from Wax Apple (Syzygium samarangense)
Structural Characteristics, Gelling Properties, In Vitro Antioxidant Activity and Immunomodulatory Effects of Rhamnogalacturonan-I Rich Pectic Polysaccharides Alkaline-Extracted from Wax Apple (Syzygium samarangense) Open
To upgrade the utilization of Syzygium samarangense in food industries, the key biological component, i.e., polysaccharide, was extracted from the fruit by alkaline treatment, and its structural characteristics, physicochemical properties,…
View article: Rhodiola crenulata polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis in mice by repairing the intestinal barrier and regulating the intestinal microecology
Rhodiola crenulata polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis in mice by repairing the intestinal barrier and regulating the intestinal microecology Open
Polysaccharides, vital biological macromolecules ubiquitous in organisms, have garnered attention as potential therapeutic candidates for ulcerative colitis (UC). However, the therapeutic potential of Rhodiola crenulata polysaccharides (RC…
View article: A Novel Polysaccharide Purified from Tricholoma matsutake: Structural Characterization and In Vitro Immunological Activity
A Novel Polysaccharide Purified from Tricholoma matsutake: Structural Characterization and In Vitro Immunological Activity Open
Tricholoma matsutake, as a rare wild edible mushroom, is popular due to its unique flavor and taste, as well as high nutritional and economic value. Investigating the relationship between the complex structure and in vitro immunological ac…
View article: Identification of Acidic Triterpenoid Saponins from <i>Silene vulgaris</i> Using a Methylation-Based Isolation and LC-MS Analysis Strategy
Identification of Acidic Triterpenoid Saponins from <i>Silene vulgaris</i> Using a Methylation-Based Isolation and LC-MS Analysis Strategy Open
The Silene genus plants in the Caryophyllaceae family are a large genus with over 850 species. It has been known that Silene genus plants contain triterpenoid saponins. These saponins have glucuronic acid in the sugar chain and are difficu…
View article: Editor’s Choice Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research
Editor’s Choice Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research Open
Heparan sulfate 6-endosulfatases (SULFs) remove 6-O-sulfo groups from heparan sulfate polysaccharide chains. SULFs modify the functions of heparan sulfate and contribute to the development of cancers, organ development and endothelial infl…
View article: Polysaccharides from Exocarpium Citri Grandis: Graded Ethanol Precipitation, Structural Characterization, Inhibition of α-Glucosidase Activity, Anti-Oxidation, and Anti-Glycation Potentials
Polysaccharides from Exocarpium Citri Grandis: Graded Ethanol Precipitation, Structural Characterization, Inhibition of α-Glucosidase Activity, Anti-Oxidation, and Anti-Glycation Potentials Open
The endocarp of Exocarpium Citri Grandis (ECG) is abundant in various bioactive components, such as polysaccharides; however, there are few studies on them. Thus, it is highly necessary to carry out further research on the structural chara…
View article: The Effect of Alginate/Hyaluronic Acid Proportion on Semi-Interpenetrating Hydrogel Properties for Articular Cartilage Tissue Engineering
The Effect of Alginate/Hyaluronic Acid Proportion on Semi-Interpenetrating Hydrogel Properties for Articular Cartilage Tissue Engineering Open
One of the emergent regenerative treatments for the restoration of the articular cartilage is tissue engineering (TE), in which hydrogels can functionally imitate the extracellular matrix (ECM) of the native tissue and create an optimal mi…