Butyrate
View article: Acute effects of butyrate on intestinal permeability in patients with irritable bowel syndrome assessed by a novel colonoscopy research model.
Acute effects of butyrate on intestinal permeability in patients with irritable bowel syndrome assessed by a novel colonoscopy research model. Open
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder for which effective treatment strategies are insufficient. Butyrate, a microbiota-derived short-chain fatty acid believed to strengthen the intestinal barrier function…
View article: Integrated multi-omics reveals distinct maternal and neonatal gut microbial and metabolic signatures associated with small for gestational age status
Integrated multi-omics reveals distinct maternal and neonatal gut microbial and metabolic signatures associated with small for gestational age status Open
Introduction Children born small for gestational age (SGA) have an elevated risk of developing metabolic disorders in later life. However, the underlying gut microbiota and metabolomic alterations in SGA mother-infant dyads remain poorly u…
View article: Supplementary Table 1 from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis
Supplementary Table 1 from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis Open
Supplementary Table 1 shows the power calculation for the associations of PWY-5022 and propionate with CRC risk.
View article: Data from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis
Data from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis Open
Background:Mechanistic data indicate the benefit of short-chain fatty acids (SCFA) produced by gut microbial fermentation of fiber on colorectal cancer, but direct epidemiologic evidence is limited. A recent study identified SNPs for two S…
View article: Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Figure S1. Volcano plot showing the difference in the relative abundance of butyrate producers between sustained MRD negative and MRD positive/non-sustained MRD negative.
View article: mGem: <i>Faecalibacterium</i> , an important protector of gut health
mGem: <i>Faecalibacterium</i> , an important protector of gut health Open
Faecalibacterium is among the most abundant bacterial genera in the healthy human colon, comprising approximately 10–15% of the total gut microbiota. Species within this genus ferment complex carbohydrates, including pectin, to produce but…
View article: Butyrate combined with niacin promotes colonic metabolism and antimicrobial peptide expression to alleviate ETEC-induced colonic barrier dysfunction in weaned piglets
Butyrate combined with niacin promotes colonic metabolism and antimicrobial peptide expression to alleviate ETEC-induced colonic barrier dysfunction in weaned piglets Open
Background Butyrate is the primary energy substrate in the colon, whereas niacin can enhance energy metabolic flux by increasing nicotinamide adenine dinucleotide (NAD) synthesis. Therefore, this study aimed to investigate the effects of c…
View article: Multi-omics insights into the role of microencapsulated sodium butyrate on production performance in aged quails
Multi-omics insights into the role of microencapsulated sodium butyrate on production performance in aged quails Open
View article: Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine “Cafeteria” Model of MASLD
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine “Cafeteria” Model of MASLD Open
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, characterized by excessive fat storage in the form of lipid droplets (LDs) in hepatocytes; it is also called Metabolic-Associated…
View article: Multi-omics insights into the role of microencapsulated sodium butyrate on production performance in aged quails
Multi-omics insights into the role of microencapsulated sodium butyrate on production performance in aged quails Open
View article: Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets Open
Supplementary Table S1-S4
View article: Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor
Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor Open
The pregnane X receptor (PXR), a key hepatic nuclear receptor, exhibits a highly plastic ligand-binding domain (LBD) that recognizes diverse endogenous and exogenous ligands, contributing to interindividual variations in xenobiotic metabol…
View article: Cross-species engraftment biases and metabolic divergence in gnotobiotic mice humanized with ulcerative colitis microbiota
Cross-species engraftment biases and metabolic divergence in gnotobiotic mice humanized with ulcerative colitis microbiota Open
Ulcerative colitis (UC) is a chronic inflammatory disease of the human colon. Dysbiotic gut microbiota play a central role in its pathogenesis, and alterations in microbial composition and function are closely linked to disease activity. H…
View article: Draft genome sequence of <i>Agathobacter rectalis</i> H10.1 isolated from the feces of a child with ulcerative colitis in remission
Draft genome sequence of <i>Agathobacter rectalis</i> H10.1 isolated from the feces of a child with ulcerative colitis in remission Open
Agathobacter rectalis is a beneficial gut bacterium, known to produce butyrate and thereby enhance gut health. Here, we report the draft genome sequence of A. rectalis strain H10.1 isolated from the feces of an individual with ulcerative c…
View article: Regulatory mechanisms of the gut microbiota-short chain fatty acids signaling axis in slow transit constipation and progress in multi-target interventions
Regulatory mechanisms of the gut microbiota-short chain fatty acids signaling axis in slow transit constipation and progress in multi-target interventions Open
Slow-transit constipation (STC) is an increasingly prevalent disorder that imposes a substantial health and economic burden. Mounting evidence highlights the “gut microbiota–short-chain fatty acid (SCFA)–motility” axis as a central pathoph…
View article: Lung cancer and the Gut-microbiota-lung Axis: emerging evidence and potential clinical implications
Lung cancer and the Gut-microbiota-lung Axis: emerging evidence and potential clinical implications Open
Lung cancer remains the leading cause of cancer-related deaths globally, with a 5-years survival rate of only around 20%. Merging cohort and Mendelian-randomization studies indicate that gut dysbiosis is associated with—though not yet prov…
View article: Rumen-Protected Methionine Supplementation in the Diet Improved the Production Performance of Dairy Goats by Optimizing the Amino Acid Profile and Lipid Metabolism and Modulating the Colonic Microbiome
Rumen-Protected Methionine Supplementation in the Diet Improved the Production Performance of Dairy Goats by Optimizing the Amino Acid Profile and Lipid Metabolism and Modulating the Colonic Microbiome Open
This study aimed to investigate the effects of rumen-protected methionine (RPM) on the production performance of lactating dairy goats. Thirty first-time lactating Guanzhong dairy goats with identical kidding dates and comparable body weig…
View article: Small intestine is not colon: a new <i>in vitro</i> model of the human ileum microbiome integrating the mucosal microenvironment and feeding status
Small intestine is not colon: a new <i>in vitro</i> model of the human ileum microbiome integrating the mucosal microenvironment and feeding status Open
The small intestinal microbiota plays a key role in human health but is understudied due to the invasiveness of sampling. There is no available model of the human ileal microbiome simulating the key nutritional and physicochemical paramete…
View article: Effect of dietary supplementation with Vitex negundo L. var. cannabifolia extract on the growth performance, blood chemistry, gut morphology, and gut microbiota of broilers
Effect of dietary supplementation with Vitex negundo L. var. cannabifolia extract on the growth performance, blood chemistry, gut morphology, and gut microbiota of broilers Open
The aim of this study is to evaluate the effects of Vitex negundo L. var. cannabifolia extract (VNE) on the growth performance, antioxidant status, blood chemistry, and cecal microbiota of broilers. A total of 240 one-day-old partridge bro…
View article: Age Versus Immunity: Dietary Influences on Immunosenescence
Age Versus Immunity: Dietary Influences on Immunosenescence Open
Background: Immunosenescence, or the age-related weakening of the immune system, leads to greater susceptibility to chronic diseases, infections, and metabolic disorders. This process involves changes in the number and function of lymphocy…
View article: Lactobacillus helveticus Alleviates Collagen-Induced Arthritis in Rats Through Inflammation Modulation and Gut Microbiota Regulation
Lactobacillus helveticus Alleviates Collagen-Induced Arthritis in Rats Through Inflammation Modulation and Gut Microbiota Regulation Open
Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic synovitis, with growing evidence underscoring the role of gut microbiota dysbiosis and impaired intestinal barrier function in driving inflamma…
View article: Thermophilic fermentation enhanced by eggshell-derived hydroxyapatite for sustainable hydrogen production
Thermophilic fermentation enhanced by eggshell-derived hydroxyapatite for sustainable hydrogen production Open
This study presents the eco-friendly synthesis of Hydroxyapatite (HAP) using chicken eggshell biowaste as a sustainable calcium source to enhance biohydrogen production. The stoichiometric ratio of Ca/P was determined to be 1.67 by evaluat…
View article: Effects of Adding Butyrate or Exogenous Fibrolytic Enzymes on Ruminal Epithelium, Metabolism, and Microbiota of Beef Cattle
Effects of Adding Butyrate or Exogenous Fibrolytic Enzymes on Ruminal Epithelium, Metabolism, and Microbiota of Beef Cattle Open
Feedlot cattle produce high concentrations of short-chain fatty acids (SCFAs) through ruminal fermentation, with butyrate playing a crucial role in epithelial development and SCFA absorption. This study evaluated the effects of dietary sod…
View article: Changes in microbiota associated with the use of intragastric balloons
Changes in microbiota associated with the use of intragastric balloons Open
Obesity is a chronic disease characterized by excessive accumulation of adipose tissue. Intragastric balloon (IGB) implantation is one of the methods used to treat obesity. The aim of the study was to investigate whether the composition of…
View article: Peimine Alleviates DSS-Induced Colitis by Modulating Gut Microbiota and Attenuating Inflammation and Oxidative Stress
Peimine Alleviates DSS-Induced Colitis by Modulating Gut Microbiota and Attenuating Inflammation and Oxidative Stress Open
Peimine (PM), a steroidal alkaloid derived from aged garlic (Allium sativum L.), demonstrates potent therapeutic efficacy against ulcerative colitis (UC) through multi-target mechanisms. Integrating network pharmacology and in vivo validat…
View article: Cadmium toxicity to the human gut microbiome varies depending on composition
Cadmium toxicity to the human gut microbiome varies depending on composition Open
Cadmium (Cd) is a toxic heavy metal with detrimental impacts on the gut microbiota. We investigated the compositional and functional effects of acute Cd exposure on human fecal microbiotas using 24-hour in vitro cultures from 21 healthy ad…
View article: Epigenetic orchestrator and drug enhancer: dual roles of butyrate in regulating post-translational modification and optimizing therapeutic delivery
Epigenetic orchestrator and drug enhancer: dual roles of butyrate in regulating post-translational modification and optimizing therapeutic delivery Open
View article: Impact of carbapenem-resistant <i>Klebsiella pneumoniae</i> infection on gut microbiota and host immunity: a case-control study
Impact of carbapenem-resistant <i>Klebsiella pneumoniae</i> infection on gut microbiota and host immunity: a case-control study Open
Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global health threat with limited treatment options. While the gut microbiota is a reservoir for opportunistic pathogens and a regulator of host immunity, the reciproc…
View article: Untargeted Metabolomics Identifies Faecal Filtrate-Derived Metabolites That Disrupt Clostridioides difficile Metabolism and Confer Gut Barrier Cytoprotection
Untargeted Metabolomics Identifies Faecal Filtrate-Derived Metabolites That Disrupt Clostridioides difficile Metabolism and Confer Gut Barrier Cytoprotection Open
Recurrent Clostridioides difficile infection (rCDI) remains a major therapeutic challenge. Although faecal microbiota transplantation (FMT) is highly effective and thought to restore microbial composition and metabolic function, the mechan…
View article: Butyrate-preconditioned human adipose-derived stem cell-conditioned medium enhances myocardial perfusion after infarction
Butyrate-preconditioned human adipose-derived stem cell-conditioned medium enhances myocardial perfusion after infarction Open
Introduction: Adipose-derived stem cell-conditioned medium (ASC-CM) is promising for cardiac repair via paracrine mechanisms. However, variability in efficacy limits its clinical translation. We investigated whether preconditioning human A…