Cancer biomarkers
View article: Table S4 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility
Table S4 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility Open
Table S4. PWAS meta-FDR<0.05 proteins with endometrial cancer associations.
View article: Supplementary Figure from Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening
Supplementary Figure from Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening Open
Supplementary Figure from Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening
View article: Elevated tumor-associated androgen receptor activity correlates with poor immune infiltration and immunotherapy response across cancer types
Elevated tumor-associated androgen receptor activity correlates with poor immune infiltration and immunotherapy response across cancer types Open
The role of androgen receptor (AR) signaling in modulating antitumor immune responses has received increasing attention in recent years; however, its broader impact across diverse cancer types and between sexes remains largely unexplored. …
View article: Comparative Analysis of Pathology Foundation Models for Automated Detection of Tertiary Lymphoid Structures in H&E-Stained Digital Pathology Images
Comparative Analysis of Pathology Foundation Models for Automated Detection of Tertiary Lymphoid Structures in H&E-Stained Digital Pathology Images Open
Tertiary lymphoid structures (TLS) have been observed in solid tumors and have been associated with better outcomes in patients treated with immunotherapy, but their dynamic nature makes identifying TLS in clinical samples challenging. Rec…
View article: Supplementary Figure S1 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility
Supplementary Figure S1 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility Open
Supplementary Figure S1: Workflow illustrating the methods.
View article: Supplementary Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
Supplementary Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening Open
Supplementary Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
View article: Table S2 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility
Table S2 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility Open
Table S2. Replication of cancer PWAS results in independent cohort with meta-analysis FDR<0.05.
View article: Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis
Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis Open
Coexisting lung cancer and pulmonary tuberculosis (LC‐PTB) is clinically challenging in diagnosis and treatment, and its mechanisms are unclear. This study aimed to explore its immune and molecular basis to identify diagnostic biomarkers. …
View article: Supplementary Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
Supplementary Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening Open
Supplementary Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
View article: Label free paper sensor and light driven material for the rapid screening of S100P cancer biomarker in saliva
Label free paper sensor and light driven material for the rapid screening of S100P cancer biomarker in saliva Open
View article: Table S5 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility
Table S5 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility Open
Table S5. PhenomeXcan TWAS results for 8 genes that had cancer associations.
View article: Table S3 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility
Table S3 from Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility Open
Table S3. PWAS meta-FDR<0.05 proteins with ovarian cancer associations.
View article: Identification of a two-gene biomarker correlated with sensitivity to combined PARP7 inhibition and AHR activation in cancer cells
Identification of a two-gene biomarker correlated with sensitivity to combined PARP7 inhibition and AHR activation in cancer cells Open
PARP7 inhibitors (PARP7i) and AHR agonists (AHRa) can synergistically suppress growth of some cancer cell lines, but not others. Here, we derived a two-gene transcriptional score to predict the synergistic response and characterized the mo…
View article: Data from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study
Data from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study Open
Background:Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer…
View article: Supplementary Figure from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
Supplementary Figure from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening Open
Supplementary Figure from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
View article: UALCAN Mobile, an app for cancer proteogenomic data analysis
UALCAN Mobile, an app for cancer proteogenomic data analysis Open
Cancer is a complex disease affecting various organs and is a major cause of death worldwide. During cancer initiation, disease progression, and tumor metastasis, various genomic and proteomic alterations are observed. Recent technological…
View article: Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening
Data from Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening Open
Background:Low-dose CT (LDCT) screening trials have shown that lung cancer early detection saves lives. However, a better stratification of the screening population is still needed. In this respect, we generated and prospectively validated…
View article: Supplementary Figure S1 from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study
Supplementary Figure S1 from Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study Open
Supplementary Figure S1 shows pre-surgery and 12-month biomarker concentrations correlated with the CTXD 12 months after surgery at Huntsman Cancer Institute.
View article: Exploring the role of circular RNAs in endometrial cancer progression and chemoresistance: Implications for targeted therapies
Exploring the role of circular RNAs in endometrial cancer progression and chemoresistance: Implications for targeted therapies Open
Endometrial cancer stands as a prevalent malignant tumor of the female genital tract, while showing growing incidence statistics. Circular RNAs (circRNAs) demonstrate translational value as biomarkers and therapeutic targets in endometrial…
View article: Immobilization-free SELEX for aptamer discovery targeting colorectal cancer-derived small extracellular vesicles
Immobilization-free SELEX for aptamer discovery targeting colorectal cancer-derived small extracellular vesicles Open
Background Despite the increasing prominence of small extracellular vesicles (sEVs) and liquid biopsies for early cancer diagnosis, the development of high-performance molecular probes specifically targeting sEVs remains limited. In this s…
View article: Data from Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer
Data from Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer Open
Purpose:Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, especially using …
View article: MSICKB: A Curated Knowledgebase for Exploring Molecular Heterogeneity and Biomarker Discovery in Microsatellite Instability Cancers
MSICKB: A Curated Knowledgebase for Exploring Molecular Heterogeneity and Biomarker Discovery in Microsatellite Instability Cancers Open
Background Microsatellite instability (MSI) is a critical form of genomic instability and a key biomarker for predicting patient prognosis and response to immunotherapy in cancer. However, significant heterogeneity in clinical outcomes exi…
View article: Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers
Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers Open
Clinical in vitro diagnosis is essential in early diagnosis and prognostic assessment, yet antibody‐based assays face limitations in multiplexity and scalability. To address the growing demand for modern molecular diagnostics, a multivalen…
View article: Increased plasma concentrations of acyl-coenzyme A binding protein (ACBP) predict future lung cancer development in smokers at risk of cardiovascular disease
Increased plasma concentrations of acyl-coenzyme A binding protein (ACBP) predict future lung cancer development in smokers at risk of cardiovascular disease Open
These findings independently validate ACBP/DBI as a circulating biomarker of future LC development in at-risk individuals. Clinically, ACBP/DBI quantification could refine risk-adapted lung cancer screening strategies, guiding the frequenc…
View article: Exploratory Covalent Docking of Michael-Acceptor Natural Products at Reactive Cysteines in Cancer Tyrosine Kinases
Exploratory Covalent Docking of Michael-Acceptor Natural Products at Reactive Cysteines in Cancer Tyrosine Kinases Open
Tyrosine kinases (TKs) and cyclin-dependent kinases (CDKs) contain reactive cysteines that can be exploited by targeted covalent inhibitors. In this exploratory computational study, we asked whether selected natural-product-like (NP-like) …
View article: Machine Learning-Optimized Metabolic Biomarker Panel for Precision Screening of Early-Stage Pancreatic Cancer in New-Onset Diabetes
Machine Learning-Optimized Metabolic Biomarker Panel for Precision Screening of Early-Stage Pancreatic Cancer in New-Onset Diabetes Open
Machine Learning-Optimized Metabolic Biomarker Panel for Precision Screening of Early-Stage Pancreatic Cancer in New-Onset DiabetesMachine Learning-Optimized Metabolic Biomarker Panel for PrecisionMachine Learning-Optimized Metabolic Bioma…
View article: Machine Learning-Optimized Metabolic Biomarker Panel for Precision Screening of Early-Stage Pancreatic Cancer in New-Onset Diabetes
Machine Learning-Optimized Metabolic Biomarker Panel for Precision Screening of Early-Stage Pancreatic Cancer in New-Onset Diabetes Open
Machine Learning-Optimized Metabolic Biomarker Panel for Precision Screening of Early-Stage Pancreatic Cancer in New-Onset DiabetesMachine Learning-Optimized Metabolic Biomarker Panel for PrecisionMachine Learning-Optimized Metabolic Bioma…
View article: Leveraging and partitioning polygenic risk scores to identify proteomic mediators of cancer risk
Leveraging and partitioning polygenic risk scores to identify proteomic mediators of cancer risk Open
Background: Large-scale genome-wide association studies (GWAS) have identified numerous common susceptibility variants associated with various cancers but underlying molecular mechanisms remain largely unknown. Methods: Here we investigate…
View article: Integrated spatial proteomic analysis of breast cancer heterogeneity unravels cancer cell phenotypic plasticity
Integrated spatial proteomic analysis of breast cancer heterogeneity unravels cancer cell phenotypic plasticity Open
Tumor heterogeneity drives drug resistance and relapse, influencing immune evasion and tumor progression. While intratumor heterogeneity has been extensively studied at the genomic level, its functional outcomes and interactions with the t…
View article: Serum autoantibody profiles in cancer patients treated with immune checkpoint inhibitors: a cross-sectional study
Serum autoantibody profiles in cancer patients treated with immune checkpoint inhibitors: a cross-sectional study Open
Background The relationship between autoantibody profiles and immune checkpoint inhibitor (ICI) therapy in cancer patients remains incompletely characterized. This cross-sectional study investigated serum autoantibody (AAb) prevalence and …